12,266 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Scalia IG, Abdelfattah FE, Farina JM et al. · 2026 · Cardio-oncology (London, England)
BACKGROUND: Severe carcinoid heart disease (CaHD) may require bioprosthetic valve (BPV) replacement. Lutetium-177 (Lu-177) DOTATATE is increasingly utilized in patients with neuroendocrine tumors (NETs); however, its effect on BPVs remains…
View details →Chantre-Justino M, Silvestre RT, Delmonico L et al. · 2026 · World journal of oncology
Background Bone sarcomas are rare and heterogeneous malignant neoplasms of mesenchymal origin, often associated with poor clinical outcomes. Being rare neoplasms, a comprehensive analysis of the molecular mechanisms involved in the tumor…
View details →Akyuz C, Sunamak O, Selman A et al. · 2026 · Journal of clinical medicine
Background : Signet-ring cell colorectal cancer (SRCC) and colorectal cancer with a signet-ring cell component (SRC) are rare histological subtypes associated with poor prognosis. Although these entities are classified separately based on…
View details →Fuchida H, Sawada D, Hirota T et al. · 2026 · Toxicology reports
Objective Lactobacillus gasseri CP2305 (L. gasseri CP2305) has been reported to exert intestinal regulatory, anti-stress, and sleep-improving effects in healthy adults. This study aimed to evaluate the safety of an excessive intake of L.…
View details →Alheany ARA, Abdulkareem AZ, Abdullah ZA et al. · 2026 · Asian Pacific journal of cancer prevention : APJCP
Background Hodgkin lymphoma (HL) arises from germinal center B cells through complex viral, genetic, and environmental factors. This study examines HHV-6B infection and the IL-18 rs1946518 polymorphism as potential contributors to…
View details →McCoy J, Gatt D, Shaw M et al. · 2026 · Pediatric pulmonology
Rationale Primary ciliary dyskinesia (PCD) is a phenotypically diverse disease; the impact of nutritional status on clinical trajectories in patients with PCD is not well defined. The aim of this study is to examine the impact of…
View details →Liu J, Wu Y, Yang D et al. · 2026 · BMC medical imaging
BACKGROUND: Glomerulonephritis (GN) is a major contributor to chronic kidney disease, highlighting the need for reliable biomarker to monitor GN. This study aimed to evaluate the potential of diffusion kurtosis imaging (DKI) for dynamic…
View details →Ojinnaka GC, Okoye OI, Ojinnaka NC et al. · 2026 · Journal of tropical pediatrics
To compare the academic performance of urban primary school children with strabismus and/or amblyopia seen at the Eye Clinic of University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Nigeria, with that of their controls. In…
View details →Ji RT, Xie XF, Jia ZY et al. · 2026 · Huan jing ke xue= Huanjing kexue
Cultivating salt-tolerant rice （STR） is an effective approach to ameliorating coastal saline soils （CSL）. In this study， the CSL without STR cultivation served as the control （CK）， while soils with different rice cultivation years （1-5…
View details →Capraru TD, Bauer TC, Jordan P et al. · 2026 · Frontiers in aging neuroscience
Background Hepatitis E virus (HEV) exposure has been linked to neurologic manifestations and dementia. This study aims to clarify a possible association between HEV and Alzheimer's disease (AD). Methods We performed a single-center…
View details →Peng H, Dong B, Naren G et al. · 2026 · Frontiers in microbiology
Introduction Grassland desertification substantially reduces soil organic carbon (SOC) stocks. However, the responses of two distinct SOC fractions-mineral-associated organic carbon (MAOC) and particulate organic carbon (POC)-to…
View details →Albayrak B, Kader İT, Köroğlu EN et al. · 2026 · BMC oral health
BACKGROUND: The purpose of this in vitro study was to compare the distance and angular accuracy of current intraoral scanners and photogrammetry devices in a full-arch implant model. METHODS: Six multi-unit abutment replicas (Astra Tech…
View details →Drews G, Migliorini F, Götze C et al. · 2026 · BMC musculoskeletal disorders
BACKGROUND: Sex-based analyses in total hip arthroplasty have become increasingly important in understanding the nuanced outcomes and risks associated with this surgical procedure. Recent studies analyzed the complex interplay between…
View details →Ren S, Zhang L, Zhai Y et al. · 2026 · Journal of cardiovascular development and disease
Background Adults with congenital heart disease (CHD) are at markedly increased risk of infective endocarditis (IE); however, data comparing clinical characteristics and outcomes in surgically treated IE patients with and without CHD…
View details →Gezginci Akpinar E, Cabi Z · 2026 · Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates
The aim of this study was to evaluate the effect of virtual reality goggles on pain, anxiety, and comfort in patients undergoing non-sedated upper gastrointestinal tract endoscopy. This randomized controlled study was conducted with 60…
View details →Coppola G, Verna C, Michelotti A et al. · 2026 · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
Background Although esthetic concerns are a primary motivation for seeking orthodontic treatment, few studies with strong protocols have evaluated its impact on facial and smile attractiveness as perceived by laypeople. This study aimed to…
View details →Pisanò CA, Santino ML, Russotto A et al. · 2026 · iScience
Sleep disorders are common in Parkinson's disease (PD) and respond poorly to current pharmacological treatments, partly due to limited understanding of their underlying mechanisms. Using polysomnographic recordings, we investigated the…
View details →Duke DJ, Wang H, Rao L et al. · 2026 · International journal of pharmaceutics
Design of the mouthpiece of a pressurised metered dose inhaler is generally informed by patient needs, followed by manufacturing and product differentiation considerations. However, relatively few studies have investigated whether the size…
View details →Gonsalves V, Flake C, West D et al. · 2026 · Annals of dyslexia
Practitioner knowledge about dyslexia is related to improved educational practices, but few measures of dyslexia knowledge have been validated with rigorous processes. The current study developed the Dyslexia Assessment and Intervention…
View details →Wang HK, Huang SH, Li CY et al. · 2026 · The journal of spinal cord medicine
Context/objective The optimal timing of surgical decompression for traumatic spinal cord injury (TSCI) remains uncertain. This study evaluated the association between ultra-early decompression and neurological outcomes, focusing on early…
View details →Dantagnan CA, Salem C, Charavet C et al. · 2026 · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
Introduction This study aimed to compare the effect of artificial saliva (AS) aging on the trueness and precision of direct-printed aligners vs thermoformed aligners. Methods Four types of aligners were manufactured from the same reference…
View details →Bettiol NB, de Carvalho FA, Siessere S et al. · 2026 · Dentistry journal
Background: The relationship between facial aesthetic procedures and changes in the stomatognathic system has attracted increasing interest, motivating investigations into their functional and structural impacts. This longitudinal…
View details →Lee D, Koo J, Jeon H et al. · 2026 · AAPS PharmSciTech
Tofacitinib (Tofa), a Biopharmaceutics Classification System Class III drug, exhibits pH-dependent solubility and a strong tendency to agglomerate, potentially affecting tablet uniformity, in vitro dissolution behavior, and in vivo…
View details →Nguyen DV, Nguyen HTT · 2026 · JACC. Asia
Background Evidence regarding the effect of mineralocorticoid receptor antagonist therapy on the risk of new-onset diabetes remains inconsistent. Objectives This study aimed to examine the effect of spironolactone on the risk of incident…
View details →Baldeon-Calisto M, Perez-Pérez N, Guevara C · 2026 · Physics in medicine and biology
Objective. Vision foundation models (FMs) have shown strong potential for adapting to diverse downstream tasks without specialized fine-tuning. However, their performance in head and neck cancer (HNC) tumor segmentation remains…
View details →Marghmaleki MS, Rostami S, Mojtahedi MF et al. · 2026 · Recent advances in inflammation & allergy drug discovery
Introduction The study aimed to investigate the effect of vitamin D (Vit D) supplementation on serum levels and gene expression of interleukin-10 (IL-10) and IL-35 in women with unexplained recurrent spontaneous abortion (uRSA). Methods In…
View details →Bartsch F, Scholz C, Gröger LK et al. · 2026 · Frontiers in surgery
Background Since the first data of the BILCAP trial was presented in 2017, capecitabine became standard adjuvant treatment for intrahepatic cholangiocarcinoma (ICC). For ICC, the efficacy of capecitabine on survival outcomes remains…
View details →Ferrillo M, Daly K, Pandis N et al. · 2026 · International orthodontics
Introduction Extractions may be helpful in the relief of crowding and in incisal retraction. While extractions may help to control the vertical dimension, their effect is not clear-cut. Four premolar extractions (FPE) may be more potent in…
View details →Chittenden C, Bills WR, Dangal NK et al. · 2026 · Plant disease
This study investigates the impact of seeding rate, cultivar architecture, and fungicide application on soybean canopy penetration, disease severity, and yield. Field trials conducted in Iowa in 2022, 2023, and 2025 included two soybean…
View details →Ebadi Hasan Abadi M, Ghahremani Z, Borzouei A et al. · 2026 · Scientific reports
The development of pure homozygous lines is a critical objective in plant breeding, yet conventional methodologies for achieving this goal are time-consuming. Double haploid (DH) technology suggests a powerful technique for producing pure…
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