12,266 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Liu X, Wang Y, Medina AA et al. · 2026 · Pharmacological research
Gut-liver axis disturbance is the unifying pathogenesis of cholestatic liver diseases. The purpose of this study was to explore the underlying mechanisms of the probiotic Lactobacillus amylovorus (LA) and its secreted extracellular…
View details →Timimi S · 2025 · Child and adolescent mental health
Because definitions of mental disorder are inescapably subjective, they can be continuously expanded in response to commercial, guild and social interests and pressures. In this article, I argue that this has resulted in young people…
View details →Fujii T, Nogami Y, Seo T · 2026 · BMJ open
Objectives Cognitive behavioural therapy (CBT) is recommended as a first-line treatment for depression and anxiety disorders, but its utilisation under Japan's national health insurance remains poorly understood. This study aimed to…
View details →Ead AS, Wirkus J, Machuca J et al. · 2026 · The Journal of nutrition
Background Pancreatic ductal adenocarcinoma is a deadly cancer linked to obesity. Adipose tissue contributes to tumor progression by promoting inflammation and supplying lipids and cytokines that support cancer growth. Although omega-6…
View details →Mudupula Vemula SS, Adhikari S, Motkur S et al. · 2026 · Cureus
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction, with high untreated mortality that can…
View details →Alpat SE, Kaya B, Nakkaş HG et al. · 2026 · Burns : journal of the International Society for Burn Injuries
Objective Despite notable advancements in burn care, morbidity and mortality remain high, with progressive tissue loss typically occurring in the first 48 h post-injury. While microneedling and topical retinyl palmitate are recognized for…
View details →Uyanık G, Yüksel M, Abay M et al. · 2026 · Animal reproduction science
This study aimed to evaluate the effects of TAK-683 administered to suckling goats in lactational anestrus on the 4th day (D4) after mating on luteal function, serum progesterone (P₄) levels, and reproductive performance. Forty-five Aleppo…
View details →Gardner JD, Triadafilopoulos G · 2026 · Digestive diseases and sciences
Purpose For unclear reasons, up to 50% of subjects with gastroesophageal reflux disease have an inadequate symptomatic response to treatment with a proton pump inhibitor. Our primary objective was to examine esophageal acid in subjects who…
View details →Huang Y, Chen Q, Chen R et al. · 2025 · BMC gastroenterology
OBJECTIVE: To explore disease severity thresholds beyond which endoscopic intervention fails to reduce mortality in the context of renal insufficiency and upper gastrointestinal bleeding (UGIB), and to develop predictive models for…
View details →Lee KA, Kim YH, Kim HS · 2026 · Clinical rheumatology
Objectives To evaluate the diagnostic concordance between salivary gland ultrasound (SGUS) and minor salivary gland biopsy (MSGB) in suspected primary Sjögren disease (SjD), and to assess the added value of Doppler ultrasound and extended…
View details →Schmidt US, Van Rickstal R, Van Goethem V et al. · 2026 · Palliative medicine
Background Supporting psychoeducational functioning for advanced cancer patients and informal caregivers (dyads) can be challenging. Self-managed digital interventions offer a possible cost-effective alternative but often face low…
View details →Fritz CK, de Leão AAP, Sbalqueiro FVF et al. · 2026 · Jornal de pediatria
Objective This study aims to evaluate the quality of life (QoL) and glycemic control of children and adolescents living with type 1 diabetes mellitus (T1D) before and after an intervention with a multidisciplinary educational program.…
View details →Carra RB, Garcia LÁL, Menezes JR et al. · 2025 · Movement disorders : official journal of the Movement Disorder Society
Background Epidural electrical spinal cord stimulation has been studied for more than a decade for Parkinson's disease symptoms, but compelling evidence for its effectiveness is still lacking. Objective The aim of this study was to…
View details →de Freitas ALS, Guth G, Araújo ALD et al. · 2026 · Archives of oral biology
Objective To investigate the temporal evolution and predictive value of individual histopathological features of oral epithelial dysplasia (OED) during carcinogenesis, and to evaluate the diagnostic utility of optical fluorescence imaging…
View details →Barham E, Khan M, Del-Cristo M et al. · 2026 · Cureus
Chylothorax, a rare complication of hepatic cirrhosis, is often under-recognized in the absence of ascites or other classical signs of portal hypertension. The diagnosis can be challenging due to its infrequent presentation, which…
View details →Lee KK, Lin YN · 2026 · Cureus
Non-purulent skin and soft tissue infections (NP-SSTIs) are commonly managed with antibiotic therapy; however, a subset of patients demonstrate inadequate clinical response and develop refractory disease. At present, no standardized…
View details →Shah R, Das S, Gentile Kruse CF et al. · 2025 · Pediatric neurology
Background Triptans are used to treat migraine attacks, but little to no evidence supports their use for youth with post-traumatic headache (PTH). This study evaluated patterns of use and benefit of triptans in the treatment of acute…
View details →Roth MT, Cardin DB, Borazanci EH et al. · 2020 · The oncologist
Lessons learned This trial evaluating a novel plant extract, PBI-05204, did not meet its primary endpoint of overall survival but did show signals of efficacy in heavily pretreated mPDA. PBI-05204 was generally well tolerated, with the…
View details →Appleman LJ, Kim SE, Harris WB et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose Patients with no evidence of disease (NED) after metastasectomy for renal cell carcinoma are at high risk of recurrence. Pazopanib is an inhibitor of vascular endothelial growth factor receptor and other kinases that improves…
View details →Park K, Özgüroğlu M, Vansteenkiste J et al. · 2021 · Lung cancer (Amsterdam, Netherlands)
Objectives The JAVELIN Lung 200 phase 3 trial did not meet its primary endpoint of improving overall survival (OS) with avelumab vs docetaxel in patients with platinum-treated PD-L1+ NSCLC. We report post hoc analyses assessing the effects…
View details →Ponce H, Cordero R, Tran J et al. · 2025 · Journal of patient experience
In a prior study, communication scholar ratings of clinician communication effectiveness did not correlate with perceived clinician empathy, which is one aspect of patient experience. We repeated the analysis with a different rating of…
View details →Neter E, Youngmann R, Gruper N · 2025 · JMIR formative research
Unlabelled Associations between eHealth literacy and mental health literacy were examined; no significant association was identified between overall eHealth and mental health literacy and only weak associations between specific skills were…
View details →Pienkos S, Swank Z, Hamlin RE et al. · 2025 · Open forum infectious diseases
Plasma samples obtained approximately 3 ( n = 100) and 12 months ( n = 78) after acute SARS-CoV-2 infection were tested for S1, spike, and N antigens. There were no significant differences in plasma proteins or single-cell protein…
View details →Wesley CD, Strange JE, Holt A et al. · 2025 · European heart journal open
Aims Fluoroquinolones (FQ) have been associated with aortic aneurysm and aortic dissection (AA/AD) resulting in an official warning. Recently, large-scale epidemiological studies failed to confirm this. Methods and results The current…
View details →Demattio L, Fietz D, Schuler G et al. · 2024 · Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
A 9.4 mg deslorelin slow-release implant was inserted into an adult, healthy billy goat to achieve temporary infertility and a reduction in sexual behavior. The implant was inserted in late autumn. No significant change in testis size was…
View details →Wang D, Nanavati C, Yang DZ et al. · 2026 · Journal of clinical pharmacology
Impact of concomitant medications (conmeds) on the safety of the investigational agent is often evaluated using subgroup analyses for safety events in patients who received the conmed versus those who did not. Here, we highlight the…
View details →Choi, Gutman, Iglesia et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Studies have shown that sexual function improves after surgical correction for stress urinary incontinence and pelvic organ prolapse. Current data suggest no significant difference in sexual function between transobturator and retropubic…
View details →Shaygantabar, Dianati, Ledari et al. · 2026 · BMC pediatrics
Exclusive enteral nutrition (EEN) induces remission in children with active mild to moderate Crohn's disease (CD), while partial enteral nutrition (PEN) with a free diet have failed to be effective in these patients. The effects of CD…
View details →Caio Gonçalves de Souza, Márcio Passini Gonçalves de Souza, Vanda Jorgetti et al. · 2015 · Acta Ortopédica Brasileira
OBJECTIVE: To determine whether there is a difference on the bone architecture in patients with femoral neck fracture compared to patients with intertrochanteric fractures and assess the importance of aging on bone microarchitecture in patients with proximal femoral fracture.METHODS: Biopsy of the iliac crest was made in seventeen patients between 55 and 90 years old who were admitted to the emergency room with fractures of the proximal end of the femur. After a small fragment was removed, we made a histomorphometric analysis of it.RESULTS: There was no significant difference between patients
View details →Richard R. Chapleau, CharLee A. Martin, Summer R. Hughes et al. · 2019 · BMC Research Notes
Abstract Objective This study sought to determine if there is an association between variants in the apolipoprotein E (ApoE) promoter regions and development of white matter hyperintensities (WMH) in military subjects who have been exposed to high altitude. In an earlier study, we found that ApoE status did not correlate with WMH development, and here we hypothesized that regulation of APOE protein expression may be protective. Results Our cohort of 92 subjects encountered altitude exposures above 25,000 feet mean sea level through their occupations as pilots or altitude chamber technicians. U
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