Negative / Null Result ReportOpen accessMedicine
Nina Bjerre Andersen, Lotte Dyhrberg O’Neill, Lise Kirstine Gormsen et al. · 2014 · BMC Medical Education
BACKGROUND: Reflection, the ability to examine critically one's own learning and functioning, is considered important for 'the good doctor'. The Groningen Reflection Ability Scale (GRAS) is an instrument measuring student reflection, which has not yet been validated beyond the original Dutch study. The aim of this study was to adapt GRAS for use in a Danish setting and to investigate the psychometric properties of GRAS-DK. METHODS: We performed a cross-cultural adaptation of GRAS from Dutch to Danish. Next, we collected primary data online, performed a retest, analysed data descriptively, esti
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Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto et al. · 2019 · Lara D. Veeken
OBJECTIVES: To elucidate the association between clinical characteristics and immuno-phenotypes in patients with ANCA-associated vasculitis (AAV). METHODS: Peripheral blood from 36 patients with active AAV and 18 healthy controls was…
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Hiroyuki Egami, Tomoya Matsumoto · 2020 · Sustainability
Lack of cash on hand is a significant obstacle in accessing healthcare services in developing countries. Many expectant mothers in the least developed countries do not receive sufficient care during pregnancy due to financial constraints. If such hurdles in accessing healthcare can be overcome, it will contribute to reduction in maternal and newborn mortality, which is a key target of Sustainable Development Goal 3. This study reports the first assessment of the impact of mobile money services on maternal care utilization. We hypothesize that mobile money adoption would motivate rural Ugandan
View details →Negative / Null Result ReportOpen accessMedicine
Eleni Frangou, Panagiotis Garantziotis, Maria Grigoriou et al. · 2022 · Annals of the Rheumatic Diseases
OBJECTIVES: Patients with lupus nephritis (LN) are in urgent need for early diagnosis and therapeutic interventions targeting aberrant molecular pathways enriched in affected kidneys. METHODS: We used mRNA-sequencing in effector (spleen) and target (kidneys, brain) tissues from lupus and control mice at sequential time points, and in the blood from 367 individuals (261 systemic lupus erythematosus (SLE) patients and 106 healthy individuals). Comparative cross-tissue and cross-species analyses were performed. The human dataset was split into training and validation sets and machine learning was
View details →Negative / Null Result ReportOpen accessMedicine
John K. Forrest, Steven J. Yakubov, G. Michael Deeb et al. · 2026 · Journal of the American College of Cardiology
BACKGROUND: The Evolut Low Risk trial enrolled patients with severe aortic stenosis at low surgical risk. Annual follow-up is planned for 10 years, evaluating the composite of all-cause mortality or disabling stroke and key secondary…
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Pengyu Gong, Fei Wang, Yixin Hua et al. · 2025 · Journal of Nanobiotechnology
The highly fibrotic extracellular matrix (ECM) constitutes a major barrier that restricts the penetration and delivery efficiency of anticancer drugs, particularly in fibrotic tumors such as pancreatic cancer, in which cancer-associated…
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Marelisa Albelo-Martínez, Syed Rizvi · 2025 · Neurotherapeutics
Progressive forms of multiple sclerosis (MS) include primary progressive MS (PPMS) and secondary progressive MS (SPMS). Unlike relapsing-remitting MS (RRMS), progressive MS is recognized by relentless progression with accumulating disability, rare to no relapses nor new activity on MRIs. Clinically, neurologic worsening in MS can occur in the relapsing-remitting (RRMS) phase of disease due to incomplete recovery from neuroinflammatory relapses. However, a progressive disease course is the dominant factor related to accumulating disability. There is persistent central nervous system (CNS) compa
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Mahrukh Riaz, Muhammad Zohaib Iqbal, Agnes S. Klar et al. · 2025 · MedComm
Chronic wounds-such as diabetic foot ulcers (DFUs), pressure ulcers (PUs), and venous leg ulcers (VLUs)-pose a serious clinical challenge due to their prolonged inflammatory phase and impaired healing. Increasing evidence reveals that dysregulated immune responses are central to the pathogenesis of chronic wounds. A complex interplay between innate and adaptive immune cells, including macrophages, neutrophils, and T cells, contributes to chronic inflammation, extracellular matrix (ECM) degradation, and tissue repair failure. While current treatments target symptoms, they often overlook the und
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Thibaut Vaulet, Priyanka Joseph Koshy, Karolien Wellekens et al. · 2025 · Nature Communications
The international Banff classification for kidney transplant pathology discretizes the rejection continuum into distinct diagnostic categories, introducing artificial dichotomization and threshold effects. To better reflect the underlying…
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Saeede Saadati, Rasoul Godini, Anjana Reddy et al. · 2025 · Frontiers in Immunology
Insulin resistance is a central pathological feature of several chronic metabolic disorders, including obesity, type 2 diabetes, polycystic ovary syndrome, and cardiovascular disease. While its pathogenesis is multifactorial, lipid dysregulation and chronic low-grade inflammation are recognised as two major, interconnected processes that impair insulin action across multiple tissues. This review summarises core mechanistic themes linking these processes, with a focus on three key signalling pathways that are particularly relevant to metabolic regulation and to the interplay between lipid metab
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Noha Mahmoud Youssef, Azza Mohammed Abdelmohsen, Ahmed Atteya Ashour et al. · 2026 · PubMed
BACKGROUND: Chronic ankle instability (CAI) is a common sequence of ankle sprain. Conservative treatment of CAI is currently accepted as a primary mean of managing the condition and preventing of recurrence. OBJECTIVES: The purpose of the…
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James D. Doecke, Giovanni Bellomo, Lisa Vermunt et al. · 2025 · Alzheimer s & Dementia
INTRODUCTION: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aβ42/40) may have diagnostic and prognostic value in Alzheimer's disease (AD). Here we assess which markers can best identify AD from controls and other non-AD dementias in a large international multi-center study. METHODS: Plasma samples (n = 1298) were collected from six international centers. Aβ40, Aβ42, GFAP, NfL, and p-tau181 were measured using single molecule array. In each group, AD diagnosis/co-pathology was defined according to cerebrosp
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Marta Celorrio, Kirill Shumilov, Camryn Payne et al. · 2022 · Acta Neuropathologica Communications
Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy for TBI have failed to replicate these results in humans, in part due to the absence of clinically feasible therapeutic windows for administration. Minocycline, an inhibitor of microglial activation, has been shown to be neuroprotective when administered early after experimental TBI but detrimental when administered chronically to human TBI survivors. Rather than focusing on the rescue of primary injury with early administration of therapeutics which may not be clinically feasible, we hypothesiz
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Hezixian Guo, L.-T. Pan, Qiuyi Wu et al. · 2025 · Nutrients
Type 2 diabetes (T2D) is a complex metabolic disease characterized by chronic hyperglycemia due to insulin resistance and inadequate insulin secretion. Beyond the classically implicated organs, emerging evidence highlights the gut as a central player in T2D pathophysiology through its interactions with metabolic organs. The gut hosts trillions of microbes and enteroendocrine cells that influence inflammation, energy homeostasis, and hormone regulation. Disruptions in gut homeostasis (dysbiosis and increased permeability) have been linked to obesity, insulin resistance, and β-cell dysfunction,
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Jinhua Chen, Yu‐Chun Yen, Shing‐Hwa Liu et al. · 2016 · Medicine
The use of induction chemotherapy (CT) is controversial. We compared the survival of head and neck cancer patients receiving docetaxel- or platinum-based induction CT before concomitant chemoradiotherapy (CCRT) with the survival of those receiving upfront CCRT alone. Data from the National Health Insurance and cancer registry databases in Taiwan were linked and analyzed. We enrolled patients who had head and neck cancer between January 1, 2002 and December 31, 2011. Follow-up was from the index date to December 31, 2013. We included head and neck patients diagnosed according to the Internation
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Lucius S. Fekonja, Ziqian Wang, Dogu Baran Aydogan et al. · 2021 · Frontiers in Oncology
Tumors infiltrating the motor system lead to significant disability, often caused by corticospinal tract injury. The delineation of the healthy-pathological white matter (WM) interface area, for which diffusion magnetic resonance imaging (dMRI) has shown promising potential, may improve treatment outcome. However, up to 90% of white matter (WM) voxels include multiple fiber populations, which cannot be correctly described with traditional metrics such as fractional anisotropy (FA) or apparent diffusion coefficient (ADC). Here, we used a novel fixel-based along-tract analysis consisting of cons
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Jessica Cox, Andrew C. Bernard, Anthony J. Bottiggi et al. · 2014 · Journal of the American College of Surgeons
BACKGROUND: The influence of in-house (IH) attendings on trauma patient survival and efficiency measures, such as emergency department length of stay (LOS), ICU LOS, and hospital LOS, has been debated for more than 20 years. No study has…
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Andrew M. Penn, Maximilian B. Bibok, Viera Saly et al. · 2018 · Biomarkers
OBJECTIVE: To validate our previously developed 16 plasma-protein biomarker panel to differentiate between transient ischaemic attack (TIA) and non-cerebrovascular emergency department (ED) patients.METHOD: Two consecutive cohorts of ED…
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Fabienne Marcellin, C. Lions, Éric Rosenthal et al. · 2016 · Drug and Alcohol Review
INTRODUCTION AND AIMS: Despite cannabis use being very common in patients co-infected with HIV and hepatitis C virus (HCV), its effect on these patients' immune systems remains undocumented. Documenting the potential effect of cannabis use…
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Garth Funston, Gary Abel, Emma J. Crosbie et al. · 2021 · Cancers
CA125 is widely used as an initial investigation in women presenting with symptoms of possible ovarian cancer. We sought to develop CA125-based diagnostic prediction models and to explore potential implications of implementing model-based thresholds for further investigation in primary care. This retrospective cohort study used routinely collected primary care and cancer registry data from symptomatic, CA125-tested women in England (2011-2014). A total of 29,962 women were included, of whom 279 were diagnosed with ovarian cancer. Logistic regression was used to develop two models to estimate o
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William R. Freeman, Francesco Bandello, Eric H. Souied et al. · 2023 · Ophthalmology Retina
To evaluate the safety and efficacy of repeat injections of Brimonidine Drug Delivery System (Brimo DDS) Generation 2 (Gen 2) containing 400-μg brimonidine in patients with geographic atrophy (GA) secondary to age-related macular…
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Paul Blanc‐Durand, Axel Van Der Gucht, Antoine Verger et al. · 2018 · PLoS ONE
INTRODUCTION: Aim was to develop a full automatic clustering approach of the time-activity curves (TAC) from dynamic 18F-FET PET and evaluate its association with IDH1 mutation status and survival in patients with gliomas. METHODS: Thirty-seven patients (mean age: 45±13 y) with newly diagnosed gliomas and dynamic 18F-FET PET before any histopathologic investigation or treatment were retrospectively included. Each dynamic 18F-FET PET was realigned to the first image and spatially normalized in the Montreal Neurological Institute template. A tumor mask was semi-automatically generated from Z-sco
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Oliver Shutkever, David J. Gracie, Caroline Young et al. · 2018 · Inflammatory Bowel Diseases
Background: The microbiome is implicated in the pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Whether a distinct microbiome profile is associated with the reporting of IBS-type symptoms in IBD…
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Mikael Fink Vallentin, Asger Granfeldt, Carsten Meilandt et al. · 2022 · Resuscitation
OBJECTIVE: The Calcium for Out-of-hospital Cardiac Arrest (COCA) trial was a randomized, placebo-controlled, double-blind trial of calcium for out-of-hospital cardiac arrest. The primary and secondary outcomes have been reported previously. This article describes the long-term outcomes of the trial. METHODS: Patients aged ≥18 years were included if they had a non-traumatic out-of-hospital cardiac arrest during which they received adrenaline. The trial drug consisted of calcium chloride (5 mmol) or saline placebo given after the first dose of adrenaline and again after the second dose of adrena
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S. Takahashi, Atsushi Kudoh, Yoshio Okawa et al. · 2012 · FEBS Journal
Candida glabrata is often the second or third most common cause of candidiasis after Candida albicans. C. glabrata infections are difficult to treat, often resistant to many azole antifungal agents and are associated with a high mortality…
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Giorgio Aicardi · 2013 · Rejuvenation Research
Despite decades of research, there is no cure for Alzheimer disease (AD), and current pharmacological treatments only partially mask the symptoms while the disease progresses within the brain. AD is associated with impaired clearance of…
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Fabrizio Stocchi, Mario Zappia, Valentina Dall’Armi et al. · 2010 · Movement Disorders
Melevodopa hydrochloride plus carbidopa in effervescent tablets (M/C) is a readily soluble antiparkinsonian tablet formulation. A total of 221 patients with Parkinson's disease and motor fluctuations entered a randomized, double-blind,…
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Nathalie Charlier, Andrew D. Davidson, Kai Dallmeier et al. · 2010 · Journal of General Virology
Chimeric yellow fever virus 17D (YFV-17D) and dengue virus type 2 (DENV2) carrying the surface proteins of Modoc virus (MODV), a not-known-vector (NKV) flavivirus, replicated efficiently in mammalian (Vero-B) and mosquito (C6/36) cells,…
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Paweł Miotła, Katarzyna Romanek-Piva, Michał Bogusiewicz et al. · 2017 · BioMed Research International
Aim . Urinary tract infection (UTI) is considered one of the most common bacterial infections in women. The aim of this study was to investigate the types of uropathogens present, as well as the degree of antimicrobial drug resistance seen among premenopausal (n=2748) and postmenopausal (n=1705) women with uncomplicated UTI. Methods . Urinary samples (n=4453) collected from women with UTI were analyzed in terms of uropathogens present. These were considered as positive if bacterial growth was ≥10 5 colony forming units (CFUs)/mL. Susceptibility and resistance testing for commonly used antibiot
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Pol Specenier, Jan B. Vermorken · 2012 · ISRN Oncology
The epidermal growth factor receptor (EGFR) is overexpressed in the vast majority of cases of squamous cell carcinoma of the head and neck (SCCHN). A high EGFR expression is associated with an unfavorable prognosis. Cetuximab is a chimeric human/murine IgG1 antibody which binds with high affinity to the EGFR. It is the only targeted agent which got approval for the treatment of SCCHN from the regulatory agencies of Europe and the United States, both in locoregionally advanced disease, in association with radiation, and in recurrent/metastatic disease. The outcome of trials involving other EGFR
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