Biologic Therapy in Head and Neck Cancer: A Road with Hurdles
Pol Specenier; Jan B. Vermorken · 2012 · ISRN Oncology
WASTE classifies this as Failed Experiment Report · AI classification, approximate
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Abstract
The epidermal growth factor receptor (EGFR) is overexpressed in the vast majority of cases of squamous cell carcinoma of the head and neck (SCCHN). A high EGFR expression is associated with an unfavorable prognosis. Cetuximab is a chimeric human/murine IgG1 antibody which binds with high affinity to the EGFR. It is the only targeted agent which got approval for the treatment of SCCHN from the regulatory agencies of Europe and the United States, both in locoregionally advanced disease, in association with radiation, and in recurrent/metastatic disease. The outcome of trials involving other EGFR
Abstract by Pol Specenier; Jan B. Vermorken, ISRN Oncology (2012) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.5402/2012/163752