12,264 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Zander C, Rau A, Lützen N et al. · 2026 · Fluids and barriers of the CNS
BACKGROUND: CSF loss in spontaneous intracranial hypotension (SIH) has been related to alterations in glymphatic flow, which is poorly understood in this disease. Advanced multi-shell diffusion-weighted MRI (dMRI) enables quantification of…
View details →Choo TH, Galfalvy HC, Keilp JG et al. · 2026 · Journal of affective disorders
Depression and its severe outcomes, suicidal ideation and behavior, are exacerbated by stress. A broad literature links dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) stress response system to depression, suicidal…
View details →Guedes Marques M, Maia P, Martins A et al. · 2026 · The journal of vascular access
Background The most common causes of early primary failures of a vascular access (VA) is related to small caliber vessels. Weight gain between dialyses expands both extracellular and blood volume, which may lead to rises in intravascular…
View details →Medina-Valdebenito D, Espinoza-Palavicino T, Terán-Mendoza O et al. · 2026 · Journal of aging and health
ObjectivesThis study examined the influence of hearing status and loneliness on verbal fluency trajectories in adults aged 60 years and older, assessing their contributions to baseline performance and longitudinal change over…
View details →Géczi R, Géczi G, Tóth L · 2026 · Sports (Basel, Switzerland)
The aim of this study was to examine the relative contribution of physical performance, executive functions, and competitive anxiety to competitive success in junior tennis players. A total of 39 national-level junior athletes (20 males,…
View details →Bigdelu L, Ahmadi M, Shahri B et al. · 2026 · Scientific reports
Prediction of cardiovascular diseases (CVD) is a challenge that cardiologists have always faced all the times. Aortic propagation velocity (APV) is an echocardiography index that can be helpful with this regard; however, few studies have…
View details →Karahan Yılmaz S, Güldüren S · 2026 · Nutricion hospitalaria
Introduction Introduction: a growing world population, constraints on natural resources and changing nutritional preferences all point to the need to find an alternative to traditional animal protein sources however food neophobia can come…
View details →Berube M, Bortman JM, Law AC et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy
Background The optimal threshold to blood transfusion in patients after hip fracture surgery is unclear. This study leveraged regression discontinuity to quantify blood transfusion practices across haemoglobin thresholds of 7.0, 8.0, and…
View details →Darch W, Soliman J, Higgins NC et al. · 2026 · Scientific reports
Vascular endothelial cells (VECs) play a critical role in tissue and organ homeostasis, wound healing, and immune function. VECs are commonly utilized for in vitro cell culture and in vivo tissue engineering applications which experience…
View details →Almekaty K, Alhefnawy M, Ismael A et al. · 2026 · Urology
Objective To prospectively assess the clinical outcomes and safety of microsurgical denervation of the penis (MSDP) for treatment of lifelong premature ejaculation (LPE); and to examine the impact of transitioning from partial to more…
View details →Salem AS, Albelasy NF, El-Bialy AA · 2026 · The Angle orthodontist
Objectives To compare the effectiveness of clear aligner (CA) vs removable inclined plane (RP) in improving the dentofacial changes and oral health-related quality of life (OHRQoL) in children with anterior crossbite in the mixed…
View details →Erdem Altınyürek E, Öztürk VÖ · 2026 · BMC oral health
Background Gastritis is characterized by alterations in the gastric microbiota. This dysbiosis in the stomach may affect immune system regulation as well as influence the oral microbiota. Periodontal disease results from dysbiosis of…
View details →Mamun AA · 2026 · 3 Biotech
Drought significantly alters soil microbial activity and carbon cycling, yet its effects across contrasting land-use systems remain insufficiently understood. This study investigated drought-induced changes in microbial communities and…
View details →Tuncsoy M, Tuncsoy B · 2026 · Bulletin of environmental contamination and toxicology
Aluminum (Al) is a widely occurring element in nature and is the most abundant element in the earth's crust after oxygen and silicon. In this study, metal accumulation levels in the gills, liver and muscle tissues and liver SOD, CAT and…
View details →Nersesyan A, Kundi M, Muradyan R et al. · 2026 · Mutagenesis
We investigated the impact of cigarette smoking, daily exposure to tar and nicotine, and the duration of smoking on genetic instability (chromosomal damage-micronuclei, MN, nuclear buds-gene amplification) as well as on disturbances in…
View details →Bakir M, Sağmak S · 2026 · BMC oral health
Background This study aimed to evaluate the effects of different modeling resins on the surface roughness, surface gloss, and color stability of a nanohybrid resin composite. Methods Forty disk-shaped specimens (10 mm diameter × 2 mm…
View details →Kaplan S, de Nascimento J, Contini A · 2026 · Drug safety
Background and objectives Concerns about modafinil and armodafinil use in pregnancy emerged from animal reproductive toxicity and limited human data, including a US registry suggesting increased risk of major congenital malformations…
View details →McDonough W, Gevorkian J, Wong D et al. · 2026 · Surgical laparoscopy, endoscopy & percutaneous techniques
Background As part of the accreditation process for bariatric surgery, patients must go through a preoperative pathway. There will inevitably be patients who are seen in the clinic but never undergo surgery. This rate of attrition is…
View details →Wakui N, Ogino Y, Nagumo H et al. · 2026 · BMC gastroenterology
Background Zinc deficiency is common in chronic liver disease and is closely associated with the progression of hepatic fibrosis and metabolic dysfunction. Although pemafibrate, a selective peroxisome proliferator-activated receptor alpha…
View details →Biedermann M, Sifakakis I, Zinelis S et al. · 2026 · European journal of oral sciences
Rubbing phosphoric acid during etching has been shown to improve surface roughness in prepared enamel. This study aimed to compare intact enamel's surface roughness and resin tag lengths after etching with and without rubbing. Extracted…
View details →Hamid R, Bayramoğlu MN, Şirolu S et al. · 2026 · Journal of clinical medicine
Background: In this study, we radiologically assessed potential increases in microvascularity, extracellular matrix-related changes, and tissue viscoelasticity following carboxytherapy for periorbital hyperpigmentation (POH). We also…
View details →Van Overmeiren T, de Alaiza Ortega SG, Calle S et al. · 2026 · Progress in cardiovascular diseases
Background Mavacamten is a cardiac myosin inhibitor used for patients with obstructive hypertrophic cardiomyopathy (oHCM). The efficacy and safety of this negative inotropic agent in oHCM and concomitant left bundle branch block (LBBB)…
View details →Hernandez Lopez A, Post R, Chung J et al. · 2026 · The Permanente journal
Background Postpartum hemorrhage remains a leading cause of severe maternal morbidity and mortality. The association between mild thrombocytopenia and postpartum blood loss or red blood cell transfusion has not been well studied. Objective…
View details →Akbulut NK, Yıldız I, Yılmaz MT · 2026 · Polish journal of veterinary sciences
Melatonin not only regulates circadian rhythms in animals but also supports reproductive health through its potent antioxidant properties and immunomodulatory effects. In this study, the effects of exogenous melatonin administration on…
View details →Firoozjaei IT, Sabzi Z, Rajabloo M et al. · 2026 · Nursing research and practice
Background During pregnancy, extensive hormonal and metabolic changes can occur. Gestational diabetes can cause maternal and neonatal complications. Follow-ups have shown that women who first develop metabolic diseases during pregnancy…
View details →Şenel SSD, Çetin A · 2026 · BMC psychology
Peer bullying poses a serious risk to adolescents' psychosocial development and school adjustment. However, culturally adapted and evidence-based intervention programs remain limited in non-Western societies. Restorative justice approaches…
View details →Ebrahimi S, Tehrani H, Ghavami V et al. · 2025 · Journal of education and health promotion
Background Brucellosis is a major bacterial infectious disease common to human beings and animals. It is considered a prevalent infection in developing countries. The present research was carried out to explore the effect of an educational…
View details →Bilgin O, Koç M · 2026 · Behavioral sciences (Basel, Switzerland)
Solution-focused brief group counseling is a systematic approach that centers on solutions rather than the problem itself. In this approach, which focuses on the strengths of the clients, the solutions are generated by the clients…
View details →Kawahata D, Biber D · 2026 · Journal of health psychology
The purpose of this study was to evaluate the impact of the Mindless to Mindful (M2M) program on fat mass, executive function, exercise identity, and exercise habit strength. A total of 89 adults consented to participate in the M2M…
View details →Chaudhry AS, Tian W, Adam TH et al. · 2026 · Aesthetic surgery journal
Background Biologic and targeted immune-modulating agents are increasingly used to manage autoimmune diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease. As more patients receiving these therapies undergo elective…
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