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Browse the failure-mode index

12,264 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Gait and Balance Function Improves After 12 Weeks of Moderate Intensity Endurance Exercise in Persons with HIV-related Distal Symmetrical Polyneuropathy: A Randomised Controlled Trial.

Yakasai AM, Maharaj SS, Danazumi MS · 2026 · American journal of physical medicine & rehabilitation

Objective This study evaluated the efficacy of endurance exercise on balance impairment and gait disturbance among individuals living with Human Immunodeficiency Virus (HIV)-related distal symmetrical polyneuropathy (DSPN). Design This was…

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Negative / Null Result ReportOpen accessMedicine

Effect of a 24-hour praziquantel bath on the haematological and biochemical profile and selected parameters of oxidative stress in grass carp (<i>Ctenopharyngodon idella</i>).

Dobsikova R, Marsalek P, Velisek J et al. · 2026 · Veterinarni medicina

This study assessed the effect of a 24-hour bath with praziquantel (2 and 4 mg/l) on grass carp ( Ctenopharyngodon idella ) by monitoring the haematological parameters, plasma biochemical profile, and oxidative stress indices. Fish were…

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Negative / Null Result ReportMedicine

Research on the effects of signature size on experts' opinions.

Di̇ncer M, Canturk N, Dagalp R et al. · 2026 · Forensic science international

A signature is writing and/or signs that contain the signatory's personal characteristics and are used to indicate that people accept the authenticity of the formal and private transactions made by themselves in their daily lives and…

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Negative / Null Result ReportMedicine

Effects of yoga on pain, sleep quality, and aerobic endurance in young women with primary dysmenorrhea: A randomized controlled trial.

Bicici Ulusahin S, Celik C, Abut CZ et al. · 2026 · Health care for women international

Primary dysmenorrhea (PD) is a prevalent condition in young women, characterized by menstrual pain, sleep disturbances, and reduced physical activity. Yoga has been suggested as a non-pharmacological intervention. We examined the effects…

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Negative / Null Result ReportMedicine

The Effects of Geranylgeraniol Supplementation on Testosterone in Middle-Aged Healthy Adults: An 18-Week, Single-Group Crossover Placebo-Controlled Trial.

Jurgelewicz M, D'Adamo CR, Malaya CA · 2026 · Integrative medicine (Encinitas, Calif.)

Background Geranylgeraniol (GG) is a naturally occurring isoprenoid that is involved in steroid hormone synthesis, the endogenous production of coenzyme Q10 (CoQ10), healthy muscle function, bone metabolism, and cellular energy production.…

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Negative / Null Result ReportMedicine

Barriers, facilitators and promising interventions for reducing sedentary behaviour during and after stroke rehabilitation - A scoping review.

Te Lindert L, van Meijeren-Pont W, Meesters J et al. · 2026 · Disability and rehabilitation

Purpose Reducing sedentary behaviour (SB) in stroke rehabilitation is essential, yet effects of most interventions remain limited. This review used the Behaviour Change Wheel to identify: (1) barriers and facilitators for reducing SB of…

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Negative / Null Result ReportMedicine

SlROP4 negatively regulates drought tolerance in tomato.

Cheng C, Li M, Sun B et al. · 2026 · Plant science : an international journal of experimental plant biology

Rho-like GTPases of plants (ROPs) regulate diverse cellular processes, but their roles in tomato drought responses are largely unknown. In this study, nine ROP genes were identified in tomato (Solanum lycopersicum). Among them, SlROP4, the…

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Negative / Null Result ReportOpen accessMedicine

Effects of Phenolic-Rich Extra Virgin Olive Oil and Prebiotics on Sarcopenia in Older Adults: FOOP-Sarc Project.

Besora-Moreno M, Jiménez-Ten Hoevel C, Queral J et al. · 2026 · Journal of cachexia, sarcopenia and muscle

Background Management of sarcopenia by nutritional and lifestyle interventions is a challenge. The aim is to assess the effectiveness of a phenolic-rich extra virgin olive oil (EVOO), alone or combined with a prebiotic (PREB)…

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Negative / Null Result ReportOpen accessMedicine

Lumbar Plexus Block

Yao PY, Hendrix JM · 2026

The concept of a regional anesthesia technique that provides neural blockade of the entire lumbar plexus, a lumbar plexus block, dates back nearly 50 years. The first description of such a block by Winnie et al in 1973 was an “inguinal…

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Negative / Null Result ReportOpen accessMedicine

Features and trends of marine heat waves and marine cold spells along the Western Iberian Coast from four decades of satellite data.

Biguino B, Haigh ID, Dias JM et al. · 2025 · Scientific reports

Marine Heat Waves (MHWs) have been the focus of numerous studies due to the dramatic consequences they can have on coastal systems. However, Marine Cold Spells (MCSs) can also have harmful effects on the environment while play an important…

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Negative / Null Result ReportMedicine

Inclusion of high-pressure-treated grape pomace to modulate barbecued Frankfurter sausages: insights into oxidation and PAH generation during barbecuing.

Andrés AI, Martín-Mateos MJ, D'Arrigo M et al. · 2026 · Food chemistry

This study evaluated the effects of high hydrostatic pressure (HHP)-treated white (WGP) and red grape pomace (RGP) on oxidative stability, volatile compounds, and polycyclic aromatic hydrocarbons (PAHs) in barbecued Frankfurter sausages.…

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Negative / Null Result ReportOpen accessMedicine

Investigating cycle-to-cycle variation and the impact of endometrial injury through differential gene expression analysis.

Teh WT, Chung J, Donoghue JF et al. · 2026 · Human reproduction (Oxford, England)

Study question Does endometrial gene expression change across consecutive cycles and after endometrial injury? Summary answer Although paired endometrial samples collected from the same woman across two consecutive cycles show greater…

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Negative / Null Result ReportMedicine

Effect of Tai Chi vs. Strength Training on Body Composition, Physical Performance, and Well-Being in Community-Dwelling Older Mexican Women.

Flores-Bello C, Correa-Muñoz E, Sánchez-Rodríguez MA et al. · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives : Tai Chi (TC) practice has been shown to positively affect the physical, psychological, and cognitive health of older adults. However, discrepancies persist regarding its effectiveness compared to strength training…

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Negative / Null Result ReportMedicine

Pharmacokinetics, pharmacodynamics, and radiomitigative efficacy of IEPA in a non-human primate model of acute radiation syndrome.

Wesolowski R, Asang C, Eibl M et al. · 2026 · International journal of radiation biology

Purpose The acute radiation syndrome (ARS) represents a significant public health threat following nuclear exposure, with limited available medical countermeasures (MCMs). Imidazolyl ethanamide pentandioic acid (IEPA), a novel orally…

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