12,264 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Silberlust J, Roberts B, Leybov V et al. · 2026 · Journal of telemedicine and telecare
Virtual urgent care (VUC) has become an increasingly utilized resource for acute care delivery. Frequent utilization of VUC may reflect unmet longitudinal care needs and contribute to fragmented care. While high-utilizer patterns are well…
View details →Song Z, Wang H, Jin M et al. · 2026 · Psychiatry research. Neuroimaging
This study investigates the pathogenic mechanisms underlying major depressive disorder (MDD) and the therapeutic mechanisms of vortioxetine in treatment-naive, first-episode MDD patients. 22 treatment -naive, first-episode MDD patients and…
View details →de Lima Wachholz P, Bierhals ES, de Lima CM et al. · 2026 · Veterinary research communications
The aim of this study was to evaluate the tolerance and efficacy of ezetimibe in reducing cholesterol and/or triglycerides in dogs with hyperlipidemia. Twenty-three dogs with hyperlipidemia were randomly distributed into three groups:…
View details →Berben PBQ, Smolders YL, de Vries IR et al. · 2026 · Acta obstetricia et gynecologica Scandinavica
Introduction Labor epidural analgesia (LEA) is widely used for intrapartum pain management, but its effects on uterine activity (UA) remain unclear. Electrohysterography (EHG) is a promising non-invasive method for intrapartum UA…
View details →Nunthakunatip K, Borhan S · 2026 · Emergency medicine journal : EMJ
A focused literature review assessed whether starting therapeutic anticoagulation (AC) during or soon after hospitalisation for sepsis-induced new-onset atrial fibrillation (AF) affects stroke or bleeding risk. Four observational studies…
View details →Song JM, Li SH, Peng WT et al. · 2026 · Journal of dairy science
The periparturient period in dairy cattle is characterized by significant metabolic stress, often involving a state of negative energy balance, heightened oxidative stress, and systemic inflammation. Supplementation with n-3 PUFA, such as…
View details →Espinoza Ramirez J, Durango M, Santalo O et al. · 2026 · Journal of the American Pharmacists Association : JAPhA
Background Many organizations have developed criteria for pharmacy practice models; however, most of these models are not based on studies evaluating clinical outcomes. Currently, there is no consensus on the ideal pharmacy practice model.…
View details →Chang YJ, Hsu TC, Chan CH et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectiveTo evaluate 3-dimensional pharyngeal airway changes following 2-jaw orthognathic surgery in skeletal Class III patients and to assess their association with surgical movements.DesignRetrospective observational study.SettingSingle…
View details →Shi K, Li J · 2026 · Psychological research
This study adopts the Think/No-Think (TNT) paradigm for the first time to examine whether activation of thematic semantic relation representations is intrusive. In Experiment 1, during the learning phase, participants memorized cue–target…
View details →Özdemir HE, Albayrak MT, Koçluk Y · 2026 · Journal of clinical medicine
Purpose : To investigate whether the season in which photorefractive keratectomy (PRK) with mitomycin C (MMC) is performed influences postoperative corneal transparency considering seasonal variations in ultraviolet (UV) exposure. Methods…
View details →Dong B, Xian Z · 2026 · Journal of visualized experiments : JoVE
Adolescent bipolar disorder is a severe psychiatric condition frequently complicated by school refusal behavior, a debilitating functional impairment that often persists even after the pharmacological stabilization of mood symptoms. While…
View details →Suematsu Y, Minei A, Sumita Y et al. · 2026 · European journal of preventive cardiology
Aims Cardiac rehabilitation (CR) has been shown to improve the prognosis of patients with acute myocardial infarction (AMI). In Japan, the duration of hospitalization has shortened, resulting in a lower participation rate in CR among…
View details →Omerovic E, Råmunddal T, Jha S et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy
Two contemporary randomized trials of β-blocker therapy after myocardial infarction (MI) reached apparently conflicting conclusions. REBOOT, conducted in Spain and Italy, found no reduction in death or major cardiovascular events among…
View details →Mittal H, Thattaruthody F, Akella M et al. · 2026 · Indian journal of ophthalmology
Abstract This experiment was designed to study the effect of mitomycin C (MMC) on conjunctival lymphatics and the lymphangiogenesis potential of synthetic retinoic acid (ec23) in rat eyes. This prospective animal experimental study…
View details →Royo M, Jiménez Á, Molina-Martin A et al. · 2026 · European journal of ophthalmology
PurposeTo analyze the amplitude of accommodation and its changes at a 6-month follow-up in healthy subjects implanted with an anterior chamber pIOL, assessing whether accommodative function is affected. Additionally, changes in visual…
View details →Temizel KA, Dursun P, Ikizoglu G · 2026 · Postepy dermatologii i alergologii
Introduction Chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV) are chronic inflammatory skin disorders. Monoclonal anti-IgE therapy is widely approved for CSU and is increasingly investigated for its broader…
View details →Siqueira RC, Pinho TS, Brandao CC · 2026 · Cureus
Objective The objective of this study was to evaluate the short-term ocular safety, feasibility, and exploratory functional signals associated with intravitreal adalimumab (ADA) in patients with retinitis pigmentosa (RP). Methods This…
View details →Nelles D, Özkan N, Vogelhuber J et al. · 2026 · Heart and vessels
To assess the impact of functional tricuspid regurgitation (FTR) and transcatheter tricuspid valve repair (TTVR) on sympathetic nerve activity (SNA). Increased SNA is associated with adverse outcomes and reduced survival in patients with…
View details →Sun G, Lin W, Peng Y et al. · 2026 · BMC anesthesiology
Postoperative fatigue is a prevalent complication delaying early recovery after gynecological laparoscopic surgery, with no proven effective interventions. To investigate the effect of continuous intraoperative low-dose esketamine on…
View details →Ciccarelli G, Monaco E, Nasso V et al. · 2026 · Journal of experimental orthopaedics
Purpose The purpose of this study was to quantify return-to-play (RTP) time, post-operative performance and market-value trends after proximal hamstring repair in top-tier European league soccer players. It was hypothesized that surgery…
View details →Deruelle P, Arcieri F, Martineau R · 2026 · Gynecologie, obstetrique, fertilite & senologie
Background Hyperemesis gravidarum (HG) remains one of the most disabling complications of the first trimester, with a high risk of recurrence after a prior episode that weighs heavily on family planning and on patients' mental health.…
View details →Pak K, Yoon C, Sadda SR · 2026 · Eye (London, England)
Purpose To evaluate longitudinal change in hard exudate (HEs) volume over 5-years following anti-VEGF treatment for diabetic macular oedema (DMO). Methods This study was a post-hoc analysis of structural optical coherence tomography (OCT)…
View details →Kim HSW, Cha S, Choi JY et al. · 2026 · The Journal of craniofacial surgery
This study compared the upper airway dimensions following maxillomandibular advancement (MMA) surgery in adults with obstructive sleep apnea (OSA) with those of normal controls. Korean adult OSA patients who underwent conventional MMA…
View details →Haflidadottir S, Helgadottir FD, Sighvatsson MB · 2026 · Scandinavian journal of psychology
The global burden of infertility and its associated psychological distress is substantial, yet many individuals face barriers to accessing psychological support. A scalable, low-cost online intervention presents a promising solution. A…
View details →Van Brussel L, Geurden T · 2026 · Ticks and tick-borne diseases
Background Rapid and high efficacy against ticks after attachment has the potential to aid in the prevention of tick-borne pathogen transmission. The objective of the study was to assess the speed-of-kill of Simparica Trio® against Ixodes…
View details →Leal Barbosa V, Westenhofen D, Scherdien Silva P et al. · 2026 · Lasers in medical science
Purpose To evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH). Materials and methods This randomized,…
View details →van Lohuizen Q, Fransen SJ, Yiasemis G et al. · 2026 · European radiology
Objectives To determine whether AI-reconstructed prostate MRI at reduced acquisition times maintains prostate cancer (PCa) detection performance comparable to conventional scans. Materials and methods This multicenter, retrospective,…
View details →Akay T, Arslan RS · 2026 · Scientific reports
Patients with deep perianal abscess (DPA) and transsphincteric fistula typically require incision and drainage as emergency treatment. However, recurrent abscesses and fistulas are common. This study aimed to evaluate the impact of…
View details →Verhulst E, Ten Broek R, Bislenghi G et al. · 2026 · Techniques in coloproctology
Postoperative intraabdominal adhesions remain one of the most common and clinically significant complications following abdominal and pelvic surgery. Adhesions contribute to adhesive small bowel obstruction (aSBO), chronic abdominal pain,…
View details →Ichie K, Asomugha A, Okafor I · 2026 · BMC neuroscience
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder strongly associated with dopaminergic neuronal degeneration and alpha-synuclein pathology. Paraquat (PQ) has been implicated in Parkinsonian neurodegeneration;…
View details →