Efficacy and safety of adjunctive treatment with the fatty acid amide hydrolase inhibitor JNJ-42165279 in participants with major depressive disorder with anxious distress: A double-blind, placebo-controlled, randomised study.
Schmidt ME; Gargano C; Zhou X; Palmer JA; Saad ZS; Vieta E; Drevets WC; Stuyckens K · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
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Abstract (excerpt)
JNJ-42165279 is a potent, selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for degradation of the endocannabinoid N-arachidonoylethanolamide (anandamide), which plays a role in regulation of fear and anxiety…
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Metadata source: Europe PMC · DOI 10.1016/j.euroneuro.2026.112771