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Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Echocardiographic Findings in Small-Breed Dogs With Myxomatous Mitral Valve Disease and the Severity of Mitral Regurgitation, Heart Size and Clinical Signs Myxomatous Mitral Valve Disease in Dogs.

Elyasi B · 2026 · Veterinary medicine and science

Background The main goal of this study was to identify various brightness, motion and Doppler echocardiographic variables in small-breed dogs with myxomatous mitral valve disease. Animals Sixty client-owned small-breed dogs with mitral…

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Negative / Null Result ReportMedicine

EXPRESS: Longitudinal comparison of serum pancreatic lipase activity and pancreatic lipase immunoreactivity with clinical signs in cats with suspicion of pancreatitis.

Kook PH · 2026 · Journal of feline medicine and surgery

ObjectivesIt remains unclear whether pancreatic lipase immunoreactivity (PLI) and lipase activity similarly reflect clinical status and disease severity in cats with suspected pancreatitis. This retrospective cohort study aimed to directly…

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Negative / Null Result ReportMedicine

All-Suture Anchors Exhibit Less Perianchor Fluid Formation Independent of Healing Quality Compared With PEEK Anchors in Arthroscopic Rotator Cuff Repair: A Propensity Score-Matched Comparative Study.

Gül O, Ayazoglu MA, Yazıcı A et al. · 2026 · Journal of shoulder and elbow surgery

Background Perianchor fluid collection may differ according to anchor material following arthroscopic rotator cuff repair (ARCR), but its relationship with tendon healing remains unclear. This study aimed to compare perianchor fluid…

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Negative / Null Result ReportMedicine

Seroprevalence and molecular detection of Toxoplasma gondii in patients with obsessive-compulsive disorder: a case-control study in northern Iran.

Zakariaei Z, Hosseini SH, Alizadeh-Navaei R et al. · 2026 · BMC infectious diseases

Background The infectious hypothesis of obsessive-compulsive disorder (OCD) has gained traction, with Toxoplasma gondii (T. gondii) proposed as a potential risk factor due to its neurotropic properties and ability to alter neurotransmitter…

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Negative / Null Result ReportMedicine

Assessment of active fibrotic remodeling in patients with idiopathic pulmonary fibrosis (IPF)/progressive pulmonary fibrosis (PPF) using dual-time-point [<sup>68</sup>Ga]Ga-FAPI-46-PET/CT.

Grunert M, Horn V, Baudrexl JC et al. · 2026 · European journal of radiology

Background Progressive fibrosing interstitial lung diseases (ILD) continue to have a poor prognosis. To date, there is no imaging method that can reliably detect fibrotic remodeling processes or distinguish between active and dormant…

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Negative / Null Result ReportMedicine

Comparison of neuromelanin-sensitive magnetic resonance imaging using different magnetic resonance protocols on the same patients with Parkinson's disease.

Hirose R, Matsuura K, Ii Y et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)

In Parkinson's disease (PD), neuronal loss occurs in the substantia nigra (SN) and locus coeruleus (LC). Previous studies using neuromelanin-sensitive magnetic resonance imaging (NMI) at 3T MRI have described the measurement methods and…

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Negative / Null Result ReportMedicine

PNEUMOCOCCAL SEROLOGICAL EVALUATION IN VACCINATED CHILDREN DIAGNOSED WITH TRANSIENT HYPOGAMMAGLOBULINEMIA OF INFANCY AND UNCLASSIFIED HYPOGAMMAGLOBULINEMIA.

Öztürk G, Orhon F, Bayrakoğlu D et al. · 2026 · International archives of allergy and immunology

The severity and incidence of invasive pneumococcal infections increase in inborn errors of immunities. However, there are limited number of studies in the literature evaluating pneumococcal antibody levels in patients with a prediagnosis…

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Negative / Null Result ReportOpen accessMedicine

Exploring the significance of fatty acid-binding protein 4 levels as a biomarker for autism spectrum disorder: a cross-sectional study.

Abdelaziz AW, Alkherkhisy MM, El-Sheikh HR et al. · 2026 · BMC psychiatry

Background Lipid metabolism and its regulatory molecules, especially adipokines, have gained significant attention in recent pathogenesis research of autism spectrum disorder (ASD). Aims To evaluate serum fatty acid-binding protein 4…

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Negative / Null Result ReportMedicine

Smell and taste dysfunction after total laryngectomy: A cross-sectional study comparing patient and physician perspectives.

Bilen YE, Sinanoğlu N, Külekci Ç · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Purpose Total laryngectomy disrupts nasal airflow, often resulting in significant olfactory and gustatory dysfunction. While these sensory losses may adversely affect patients' quality of life and psychological well-being, they typically…

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Negative / Null Result ReportMedicine

Comparative Evaluation of Serum Hepcidin and Fecal Calprotectin for Disease Activity Assessment in Inflammatory Bowel Disease.

Akıncıoğlu P, Dağlı Ü, Koca E · 2026 · The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Background/aims Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder commonly associated with iron deficiency anemia and anemia of chronic disease. Hepcidin is a key…

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Negative / Null Result ReportMedicine

The Effect of EMG biofeedback in female patients with stress urinary incontinence: a randomized sham controlled blinded clinical study.

Cigdem-Karacay B, Bayramoglu-Demirdogen E, Konar NM et al. · 2026 · Irish journal of medical science

AIM: The effectiveness of EMG-BF in SUI has not yet been proven. This study aimed to the effectiveness of EMG-BF on pelvic floor muscle activity, pad test, severity of complaints, and quality of life in female patients with Stress Urinary…

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Negative / Null Result ReportMedicine

Efficacy of Testosterone Replacement Therapy Combined With Exercise on Body Composition in Hypogonadal Men.

Shigehara K, Shinzawa R, Sakatoku N et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Objectives We assessed the efficacy of testosterone replacement therapy (TRT) combined with exercise on body composition in hypogonadal men. Methods Two hundred-fourteen patients were enrolled. All patients were divided into four groups:…

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