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WASTE Journal

Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Efficacy analysis of CAR-T cells against CD123-positive malignant tumors and exploration of the feasibility of combination therapy with venetoclax.

Zhang M, Chai X, Zhang X et al. · 2026 · Annals of hematology

Chimeric antigen receptor T cells (CAR-T cells) have been widely applied in hematologic malignancies. It has shown limited efficacy in the treatment of myeloid neoplasms. We retrospectively analyzed the safety and efficacy of CD123 CAR-T…

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Negative / Null Result ReportMedicine

Impact of an Individualized Dietary Intervention on Body Composition and Clinical Outcomes in Patients with Neovascular Age-Related Macular Degeneration: A Pilot Study.

Szulim D, Kucharska E, Machalińska A et al. · 2026 · Nutrients

Background/Objectives : Age-related macular degeneration (AMD) is a leading cause of permanent deterioration of central vision in elderly people. While anti-VEGF therapy remains the standard of care for neovascular AMD, disease progression…

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Negative / Null Result ReportMedicine

The Impact of a Unique Military Treatment Facility-Based Sports Medicine Model on Readiness in the Army: A Prospective Longitudinal Analysis Comparing 2 Military Health System Entry Portal Pathways on the Duration of Healthcare Management and the Incidence of Recurrence Within 24 Months.

Suttles S, Boeth RR, Frazier M et al. · 2026 · Military medicine

Objective Describe an innovative Sports Medicine clinic design implemented in an outpatient Physical Therapy (PT) clinic within a Military Treatment Facility (MTF) for both referral and direct access (DA) entry portal pathways, and to…

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Negative / Null Result ReportMedicine

Effect of hydrogen peroxide disinfectant on the flexural strength of different custom impression tray materials fabricated using conventional and digital methods.

Lengerli Efe A, Özen Sütüven E, Uçar Y et al. · 2026 · International journal of computerized dentistry

Aim The aim was to evaluate the effect of hydrogen peroxide disinfectant exposure for 60 minutes -representing the longest exposure time recommended for achieving the widest antimicrobial spectrum- on the flexural strength (FS) of…

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Negative / Null Result ReportOpen accessMedicine

Haptic perception of 2.5D surface feature height.

Hwang I, Yun S, Park J · 2026 · Scientific reports

The present study investigates the human haptic perception of 2.5D dome-shaped surface features in terms of difference and absolute thresholds. We conducted two experiments to measure the thresholds, analyzing the effect of sample base…

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Negative / Null Result ReportOpen accessMedicine

ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension.

Yaman İ, Korkmaz H, Akağaç AE et al. · 2026 · Journal of cardiovascular development and disease

Background Pulmonary arterial hypertension (PAH) is a rare and progressive disorder characterized by increased pulmonary vascular resistance and vascular remodeling. Genetic polymorphisms, epigenetic modifications, and ion channel…

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Negative / Null Result ReportOpen accessMedicine

Association between Helicobacter pylori infection and thyroid dysfunction in adults visiting a tertiary care hospital in Karachi, Pakistan: a cross-sectional study.

Jahangeer A, Jabeen R, Fatima S et al. · 2026 · BMC endocrine disorders

Background Thyroid dysfunction and Helicobacter pylori (H. pylori) infection are both highly prevalent in Pakistan. Several studies have proposed a potential immunological link between H. pylori infection and autoimmune thyroid disease,…

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Negative / Null Result ReportOpen accessMedicine

Immunohistochemical expression of Stomatin-Like protein 2 and trophoblast cell surface antigen 2 in papillary thyroid carcinoma in comparison to other thyroid lesions.

Elmetwally AA, Khashaba MH, Wagih HM et al. · 2026 · Diagnostic pathology

BACKGROUND: Thyroid carcinoma is a common tumor affecting the Egyptian population accounting for 2% of newly diagnosed cases of cancer in Egypt yearly and constituting 7.73% of 5 year prevalence in Egypt. Stomatin-Like Protein 2 (SLP-2)…

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Negative / Null Result ReportMedicine

The Association Between the STOP-Bang Score and the Integrated Pulmonary Index in Patients Undergoing Endobronchial Ultrasound with Sedation: The STOP OSA-IPI Cohort Study.

Ozden Sertcelik U, Turker M, Sertcelik A et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Perspectives : Obstructive sleep apnea (OSA) is a prevalent condition associated with increased perioperative risks. Endobronchial ultrasound (EBUS), a diagnostic and staging procedure requiring deep sedation, may pose…

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Negative / Null Result ReportMedicine

Study of phosphorylated ribosomal protein S6 (pS6) in the clinical outcomes of patients undergoing hepatectomy for metastatic colorectal cancer.

Henriques Cavalcanti Torres de Melo R, de Barros Silva PG, Neto HFEC et al. · 2026 · World journal of surgical oncology

Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with up to 50% of patients developing metastatic disease, predominantly involving the liver. Hepatectomy remains the gold standard for resectable…

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Negative / Null Result ReportMedicine

Mechanical diagnosis and therapy as a clinical diagnostic approach in lumbar disc herniation: association with radiological findings.

Aghdasi Z, Negahban H, Movahedi Aliabadi M et al. · 2026 · The Journal of manual & manipulative therapy

Background Lumbar disc herniation (LDH) is a leading causes of low back pain (LBP). Conservative approaches, such as the McKenzie Method of Mechanical Diagnosis and Therapy (MDT), are widely used as first-line treatments. MDT is based on…

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Negative / Null Result ReportMedicine

The Association of G Protein-Coupled Estrogen Receptor (GPER) Polymorphisms with Ionizing Radiation Exposure in Healthcare Workers.

Öztürk Ü, Kurutaş EB, Üremiş N et al. · 2026 · Journal of clinical medicine

Background/Objectives: The G protein-coupled estrogen receptor (GPER) is known to interact with cellular stress responses and DNA damage pathways. Therefore, exposure to ionizing radiation may modulate the biological consequences of…

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Negative / Null Result ReportMedicine

Impact of Preoperative Depression on Motor Recovery Following Brachial Plexus Reconstruction: A 24-Month Prospective Cohort Study.

Jianmongkol S, Wattanakamolchai S, Wainipitapong S et al. · 2026 · Hand (New York, N.Y.)

Background Depression is frequently diagnosed in patients experiencing traumatic injury and chronic neuropathic pain. Psychological factors may undermine patient motivation, potentially adversely affecting surgical outcomes. This study…

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Negative / Null Result ReportMedicine

Independent and joint associations of social participation and depressive symptoms with incident stroke risk in older adults: a prospective cohort study based on CHARLS and ELSA.

Ma L, Ma Y, Huang Z et al. · 2026 · BMC public health

Stroke remains a leading cause of death and disability among older adults. Depressive symptoms and low social participation have been linked to stroke risk via behavioral and biological pathways. This study examined the independent and…

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Negative / Null Result ReportMedicine

A Pilot Study Investigating the Clinically Significant Association Between Overweight, Hyperlipidemia, and Insulin Resistance in Dogs With Chronic Liver Disease.

Cogozzo A, Habermaass V, Dini R et al. · 2026 · Veterinary medicine international

The liver plays a central role in glucose and lipid metabolism. In human medicine, glucose metabolism alterations and insulin resistance are commonly associated with chronic liver disease (CLD), particularly in metabolic…

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Negative / Null Result ReportMedicine

Overutilization of helicopter emergency medical services compared to ground transport in moderate-severe penetrating abdominal trauma & associated outcomes.

Hus A, Brown A, Bundschu I et al. · 2026 · Injury

Background Helicopter emergency medical services (HEMS) play a crucial role in trauma transport, accounting for approximately 550,000 transportations annually. However, HEMS holds a disproportionate share of trauma causes, highlighting its…

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