12,263 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Zhuang L, Woo J, Francisco F et al. · 2024 · Journal of clinical apheresis
The majority of the time hematopoietic progenitor cells (HPC) are collected through leukapheresis, where anticoagulants are necessary to prevent clotting of the apheresis circuit and HPC product. Although clotting of the product is a…
View details →Lazarevic Lindblad M, Pålsson E, Lazarevic V et al. · 2026 · Infection prevention in practice
Background Central venous catheters (CVCs) are commonly used in patients with haematological diseases but are associated with infectious complications. The CVC Anti-infection Double Lumen Bundle was introduced in December 2020 to reduce…
View details →Sunwoo JS, Cho YW, Shin WC et al. · 2025 · Journal of clinical neurology (Seoul, Korea)
Background and purpose To evaluate the clinical efficacy and safety of pregabalin in Korean adults with restless legs syndrome (RLS). Methods In this randomized, multicenter, double-blind, placebo-controlled trial, 78 patients with RLS…
View details →Derakhshan A, Zia MJ, Tavakkol Afshari J et al. · 2026 · Medical hypothesis, discovery & innovation ophthalmology journal
Background Primary open-angle glaucoma (POAG) is characterized by increased resistance to aqueous humor outflow. Transforming growth factor beta-1 (TGF-beta1) contributes to this resistance by promoting synthesis and remodeling of the…
View details →de Graaf IM, de Jonghe A, Golüke NMS et al. · 2026 · Journal of clinical medicine
Background: Basal ganglia calcifications (BGCs) are frequently detected on brain CT scans in older adults, but their clinical relevance for mobility and fall risk is unclear. This study investigated the association of BGCs with impaired…
View details →Gaeini Z, Mirmiran P, Azizi F · 2026 · Scientific reports
While emerging evidence from Western populations suggests that higher carbohydrate quality (assessed by indices incorporating fiber, glycemic index, whole grains, and solid carbohydrate sources) is inversely associated with cardiovascular…
View details →Soral S, Bargale S, Dave B et al. · 2026 · Journal of the Indian Society of Pedodontics and Preventive Dentistry
Background Orthodontic treatment has long been associated with visible wires in the mouth. Clear aligners, once limited to mild crowding/spacing, are now supported for correcting more complex malocclusions. While Clear Aligner Therapy…
View details →Manca A, Palermiti A, Corcione S et al. · 2026 · Antibiotics (Basel, Switzerland)
Background/Objectives: Cefiderocol (FDC) is a siderophore-containing cephalosporin that retains activity against many β-lactamase-producing bacteria, such as New Delhi metallo-β-latamase-producing (NDM) K. pneumoniae . Its use in…
View details →Deng, Zhu, Cao et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
The clinical evaluation of lumbar degenerative disease (LDD) severity relies on symptoms and imaging, lacking biologically specific diagnostic markers. This study investigated the role of serum complements in LDD to assess their potential…
View details →Xiuwen Sun, Xiaoling Li, Lingyu Ji et al. · 2018 · PeerJ
Based on the existing research on sound symbolism and crossmodal correspondence, this study proposed an extended research on cross-modal correspondence between various sound attributes and color properties in a group of non-synesthetes. In Experiment 1, we assessed the associations between each property of sounds and colors. Twenty sounds with five auditory properties (pitch, roughness, sharpness, tempo and discontinuity), each varied in four levels, were used as the sound stimuli. Forty-nine colors with different hues, saturation and brightness were used to match to those sounds. Result revea
View details →Xu, Wu, Liu et al. · 2026 · Annals of hematology
In adult patients with early-stage follicular lymphoma (FL), age-related differences in the risk of non-lymphoma-related death (LRD) during the follow-up period after treatment are unclear. We aimed to investigate the interactive effects…
View details →Lijing Ma, Heng Su, Yan Wang et al. · 2020 · European Journal of Inflammation
Variants of the interleukin-1β (IL-1β) gene have been associated with type 2 diabetes (T2D) and coronary artery diseases (CAD). However, association of IL-1β polymorphisms with diabetic patients having CAD clinical manifestation has not been studied yet. In this study, we aim to decipher the role of IL-1β common promoter variants with susceptibility/resistance to development of CAD in T2D patients. T2D patients with (n = 134) or without CAD (n = 533) were enrolled. A total of 513 essentially healthy individuals from the same population were included in this study as control. Plasma levels of I
View details →Beri, Patil, Sharma et al. · 2026 · Journal of glaucoma
Aqueous humor outflow (AHO) is significantly lower in primary angle closure glaucoma (PACG) compared to primary open angle glaucoma (POAG). To quantitatively compare circumferential,perilimbal aqueous humor outflow(AHO) pathways in…
View details →Ginesin, Barsheshet-Karif, Mayer et al. · 2026 · Dentistry journal
Background : Peri-implantitis is a prevalent inflammatory condition leading to progressive bone loss around dental implants. In vivo studies widely use murine peri-implantitis models. Micro-computed tomography (micro-CT) is the gold…
View details →Pinho, Novais, Gonçalves · 2026 · Dentistry journal
Background : Interceptive orthodontic treatment during mixed dentition aims to reduce malocclusion complexity and improve occlusal development. Although Invisalign ® First was introduced for Phase I therapy in growing patients,…
View details →Izbassarova, Imangaliyeva, Bakhshinyan et al. · 2026 · Audiology research
Background/Objectives: Hearing loss is a leading cause of disability worldwide, with speech perception representing a key functional outcome of auditory rehabilitation. While hearing aids improve audibility, outcomes vary substantially…
View details →Sucato, Serra, Buttà et al. · 2026 · Microbiology spectrum
Human papillomavirus (HPV) represents the most prevalent sexually transmitted infection worldwide, often presenting as asymptomatic or subclinical in males. There is still uncertainty about the most suitable biological specimen for an…
View details →Yang · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research
Atypical meningiomas have higher recurrence and mortality than benign variants, and age may influence treatment decisions and outcomes. We evaluated associations between age, treatment modality, and survival in patients with atypical…
View details →Matsubara, Pletschacher, Schaeffer et al. · 2026 · Cardiology in the young
In hypoplastic left heart syndrome with aortic atresia, the non-functional left ventricle may influence right ventricular performance. We evaluated serial changes in tricuspid and mitral valve diameters after the Norwood procedure and…
View details →Zhang, Li, Ma et al. · 2026 · Brain research bulletin
This study used event-related potentials (ERPs), time-frequency analysis, and multivariate pattern analysis (MVPA) to investigate how hypnosis modulates visual and auditory processing. Twenty-two highly hypnotizable participants performed…
View details →Wali, Abbara, Ekhelikar et al. · 2026 · Postgraduate medical journal
Diastolic dysfunction is an important early indicator of heart failure (HF) with preserved ejection fraction (HFpEF). Type 2 diabetes mellitus (T2DM) may contribute to HFpEF, as it is associated with an increased risk of hospitalization…
View details →Elganzory, Baraka, Elkholy et al. · 2026 · La Clinica terapeutica
Helicobacter pylori infection affects nearly half of the global population and is a major cause of peptic ulcer disease and gastric cancer. Increasing antibiotic resistance, particularly to clarithromycin, has reduced the efficacy of…
View details →Kilinc, Günaydin, Demirtas et al. · 2026 · Revista da Associacao Medica Brasileira (1992)
The success of anterior cruciate ligament reconstruction depends on anatomical tunnel placement. The aim of this was to compare the effects of 30° and 70° arthroscopes on femoral and tibial tunnel positioning and their…
View details →Nishimura, Oyama, Hasegawa et al. · 2026 · The Journal of dermatology
Psoriasis is a chronic, immune-mediated inflammatory disease with heterogeneous manifestations. Reliable biomarkers reflecting disease severity and treatment response remain limited. Glycans-carbohydrate structures attached to proteins and…
View details →Cakar, Karagulle, Komek et al. · 2026 · Journal of cardiothoracic surgery
Penetrating injuries to the left thoracoabdominal (LTA) region pose significant diagnostic challenges due to the diaphragm's anatomical location. Early diaphragmatic injuries may be clinically silent and radiologically occult, whereas…
View details →Mc Caughey, Gustainis, Ambrosio et al. · 2026 · Ultrasound quarterly
This study evaluates whether contrast-enhanced ultrasound (CEUS) serves as an effective next-step imaging modality for patients with end-stage renal disease (ESRD) who have indeterminate renal lesions on computed tomography (CT), assessing…
View details →Merres, Koryllos, Galetin et al. · 2026 · Updates in surgery
The use of clips for ligation of segmental arteries in thoracoscopic surgery has not yet been validated in clinical studies and is currently authorized based primarily on technical specifications. Clips are advantageous in endoscopic…
View details →Sercombe, Frankel, Hatzifotis · 2026 · Obesity surgery
There is a complex relationship between gastroesophageal reflux disease (GORD), hiatus hernia, obesity, and metabolic bariatric surgery. We report the outcomes of laparoscopic hiatus hernia repair (HHR) with BIO-A ® mesh in the…
View details →Xing, Zhang, Huang et al. · 2026 · Journal of pediatric gastroenterology and nutrition
Nutritional management is crucial for improving outcomes in children on prolonged mechanical ventilation (PMV); but detailed data are lacking. This study aimed to investigate the nutritional management of children on PMV in China and to…
View details →Zhao, Xu, Zhou et al. · 2026 · Theriogenology
As a member of the Groucho/TLE family, Transducin-like enhancer of split 3 (TLE3) functions as a transcriptional co-repressor that is highly expressed in the testis. It recruits histone deacetylases (HDACs) and binds histones to mediate…
View details →