12,263 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Pennings VHM, Verwijk E, de Bie RMA et al. · 2026 · Journal of Parkinson's disease
BackgroundDespite the frequent decline in verbal fluency after STN-DBS surgery, the cause of decline remains unclear.ObjectiveThis study investigates whether mental speed and executive dysfunctions are underlying mechanisms of the phonemic…
View details →Chen CD, Aguero C, Melloni A et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction Alzheimer's disease (AD) biomarkers are assessed on their ability to detect AD pathophysiology in vivo, with confirmation of AD neuropathology only at autopsy. Methods Positron emission tomography (PET), plasma, and cognitive…
View details →Karunakaran KB, Purushottam M, Balakrishnan N et al. · 2026 · Translational psychiatry
Depressive disorder (DD), Alzheimer's disease (AD), and schizophrenia (SZ) are evolutionarily relevant traits that disrupt neural networks supporting affect and cognition. While genome-wide association studies have identified risk-related…
View details →Thapa M, Adhikari GP, Saroj GC et al. · 2026 · BMC ophthalmology
BACKGROUND: To evaluate reliability and agreement of non-contact tonometry (NCT) and trans-palpebral tonometry (TPT) compared with Goldmann-applanation tonometry (GAT). METHODS: A total of 224 eyes from 112 patients were included between…
View details →Khalid H, Tsai WS, Lamanna F et al. · 2026 · The British journal of ophthalmology
Background/aims To characterise the distribution of retinal non-perfusion and its relationship with neovascularisation elsewhere (NVE) and visual acuity (VA) in referable diabetic retinopathy (DR) using ultra-widefield fluorescein…
View details →Yan Z, Chen T, Ma X et al. · 2026 · Psychology research and behavior management
Purpose Impaired cognitive flexibility is a core feature of obsessive-compulsive disorder (OCD) and may contribute to symptom persistence and variabe therapeutic outcomes. However, traditional measures may adequately capture how cognitive…
View details →Jalan R, Patel VC, Shoaie S · 2026 · The lancet. Gastroenterology & hepatology
This Viewpoint examines the evolving role of rifaximin in cirrhosis, arguing that therapeutic drift has outpaced evidence and antimicrobial stewardship. While rifaximin is effective for secondary prevention of recurrent overt hepatic…
View details →Toyama Y, Taniguchi Y, Morisue M et al. · 2026 · European heart journal. Case reports
Background Magnetic resonance imaging (MRI) is increasingly performed in patients with cardiac implantable electronic devices. Although generally considered safe under specific protocols, electromagnetic interference may still lead to…
View details →Dirican EK · 2026 · Journal of assisted reproduction and genetics
Background Operator-dependent laboratory tasks-embryo selection, vitrification and warming, and intracytoplasmic sperm injection (ICSI)-have been the principal targets of IVF laboratory automation, and a fourth strand of work, integrated…
View details →Pérez-Bellido A, Duato D, Giannelli F et al. · 2026 · Journal of experimental psychology. Learning, memory, and cognition
Statistical learning is the process of extracting regularities from the environment. Although sequential cross-modal regularities are ubiquitous (e.g., the sight of a falling ball followed by the sound of impact), previous research has…
View details →Cuccia F, Cracchiolo AN, Piras A et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Background Radiotherapy (RT) is a cornerstone in cancer management, but late radiation tissue injury (LRTI) remains a relevant clinical issue, affecting approximately 5% of patients and significantly impacting quality of life. Hyperbaric…
View details →Samuels S, Seaton M, Abdel-Rahman SM et al. · 2026 · Therapeutic innovation & regulatory science
Background Legislative initiatives have spurred an increase in pediatric drug development programs. However, some drug products studied in the pediatric population have not received an approved pediatric indication, and efforts have been…
View details →Koncz S, Pothorszki D, Papp N et al. · 2026 · British journal of pharmacology
Background and purpose Ketamine consists of two enantiomers, (R)-ketamine and (S)-ketamine, which exhibit distinct pharmacological properties. Currently, only the (S)-enantiomer has been approved for the treatment of major depressive…
View details →Boisseau W, Darsaut TE, Raymond J · 2026 · Neuro-Chirurgie
Background Non-inferiority (NI) trials are essential to evaluate whether new treatments which may offer some collateral benefit (such as less invasiveness, fewer side effects, availability, ease of administration, or lower cost) do so…
View details →Tolarba JE, Cerniglia L, Hewitt DA et al. · 2025 · Nurse education in practice
Aim This study examined the impact of fully immersive virtual reality (FIVR) on knowledge, decision-making, self-efficacy and engagement compared with traditional onboarding methods. Background Newly graduated nurses often face challenges…
View details →Elattar S, Basha NR, Salem A et al. · 2025 · Cardiology in review
Pulmonary arterial hypertension (PAH), a subset of pulmonary hypertension (PH), remains a progressive and debilitating disease marked by vascular remodeling and elevated pulmonary vascular resistance. Tadalafil, a phosphodiesterase type 5…
View details →Longo G, Pacchiarotti G, Pizzigallo C et al. · 2026 · Journal of orthopaedic surgery and research
Introduction The introduction of computer-assisted navigation (CAS) in total knee arthroplasty (TKA) aimed to improve prosthetic alignment and potentially enhance long-term implant survival. However, the actual clinical benefit beyond 10…
View details →Yoshida K, Hakozaki T, Hasegawa T et al. · 2025 · Journal of clinical monitoring and computing
The aim of the present study was to investigate the utility of the intraoperative high frequency variability index (HFVI) / Analgesia Nociception Index (ANI) for predicting postoperative pain in patients undergoing open liver or pancreatic…
View details →Napora Z, Griffith O, Slobounov S · 2026 · Frontiers in neurology
The transition to active rehabilitation in concussion care requires precise tools to identify patients at risk of persistent post-concussive symptoms (PPCS). While machine learning (ML) offers the potential to personalize prognosis,…
View details →Lemoine L, Adam V, Salleron J et al. · 2025 · Brachytherapy
Purpose Removal of brachytherapy applicator is routinely performed under premedication including Kalinox® gas inhalation without general anesthesia. The applicator removal is nevertheless associated with discomfort, anxiety or pain. We…
View details →Xiao Y, Li Z, Hu B et al. · 2025 · Neurologia medico-chirurgica
For resectable malignant peripheral nerve sheath tumors, the additional benefits of radiotherapy remain controversial. This study aims to investigate whether there is an additional benefit of radiotherapy for resectable malignant…
View details →Stazi F · 2026 · European heart journal supplements : journal of the European Society of Cardiology
Despite the use of oral anticoagulants, the residual risk of recurrent ischaemic stroke in patients with atrial fibrillation (AF) is ∼4% per year; however, in patients who experience a stroke despite oral anticoagulant therapy (OAT), this…
View details →Özkaya AB, Ghaseminejad Y · 2025 · FEBS open bio
Autophagy plays a critical role in maintaining cellular homeostasis and is implicated in various physiological and pathological processes, including cancer, neurodegeneration, and metabolic disorders. Although typically associated with…
View details →Comeau MO, Gascon F, Corbeil M et al. · 2025 · Acta neurochirurgica
Purpose Meningioma resection remains partial in over 25% of cases, with few known predictors of residual disease progression. This study aims to assess if dural attachment, identified on postoperative imaging, influences meningioma…
View details →Lee JW, Kim CJ, Lee BK et al. · 2025 · JACC. Advances
Background Distal radial access (DRA) has emerged as an alternative to transradial access (TRA) in coronary procedures. However, evidence supporting its use in ST-segment elevation myocardial infarction (STEMI) remains limited. Objectives…
View details →El-Hajj VG, El Choueiri J, Vasella F et al. · 2026 · Brain & spine
Introduction Central nervous system (CNS) melanocytomas are rare, pigmented tumors derived from leptomeningeal melanocytes. Although generally benign, they can exhibit locally aggressive behavior and recur. Despite increasing recognition,…
View details →Barber D, Wijeratne T, Singh L et al. · 2025 · Life (Basel, Switzerland)
Sporadic Parkinson's Disease (PD) affects 3% of people over 65 years of age. People are living longer, thanks in large part to improvements in global health technology and health access for non-neurological diseases. Consequently,…
View details →Florens N, Demiselle J · 2026 · Kidney360
Iodinated contrast media have long been feared for causing contrast-induced AKI (CI-AKI), a concern rooted in early reports with high-osmolar agents. Experimental data suggest potential nephrotoxic mechanisms, yet clinical evidence from…
View details →Koretz RL · 2025 · Current opinion in clinical nutrition and metabolic care
Purpose of review To assess the quality of recently published (18 months from date of article request) randomized trials/systematic reviews of such trials that addressed the use of nutritional support in critically ill patients. Recent…
View details →Karim B, Alwi I, Yamin M et al. · 2025 · Acta medica Indonesiana
Background Inflammation plays a role in ST-segment elevation myocardial infarction (STEMI), especially in reperfusion injury (RI). Colchicine, an anti-inflammatory drug, can suppress inflammation during RI. We assessed the effectiveness of…
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