Negative / Null Result ReportOpen accessMedicine
Khrongwong Musikatavorn, Poj Plitawanon, Suthaporn Lumlertgul et al. · 2021 · Western Journal of Emergency Medicine
INTRODUCTION: The ultrasound measurement of inferior vena cava (IVC) diameter change during respiratory phase to guide fluid resuscitation in shock patients is widely performed, but the benefit on reducing the mortality of sepsis patients is questionable. The study objective was to evaluate the 30-day mortality rate of patients with sepsis-induced tissue hypoperfusion (SITH) and septic shock (SS) treated with ultrasound-guided fluid management (UGFM) using ultrasonographic change of the IVC diameter during respiration compared with those treated with the usual-care strategy. METHODS: This was
View details →Negative / Null Result ReportOpen accessMedicine
Julia Katharina Schwarze, Jens Tijtgat, Gil Awada et al. · 2022 · Journal for ImmunoTherapy of Cancer
Background Intratumoral (IT) myeloid dendritic cells (myDCs) play a pivotal role in initiating antitumor immune responses and relicensing of anti-tumor cytotoxic T lymphocytes within the tumor microenvironment. Talimogene laherparepvec…
View details →Negative / Null Result ReportOpen accessMedicine
Bruno Borghese, Jörg Tost, Magalie de Surville et al. · 2015 · BioMed Research International
Characterizing genetic contributions to endometriosis might help to shorten the time to diagnosis, especially in the most severe forms, but represents a challenge. Previous genome-wide association studies (GWAS) made no distinction between peritoneal endometriosis (SUP), endometrioma (OMA), and deep infiltrating endometriosis (DIE). We therefore conducted a pooled sample-based GWAS and distinguished histologically confirmed endometriosis subtypes. We performed an initial discovery step on 10-individual pools (two pools per condition). After quality control filtering, a Monte-Carlo simulation w
View details →Negative / Null Result ReportOpen accessMedicine
Lisa Eidenschink Brodersen, Robert B. Gerbing, María Laura Pardo et al. · 2020 · Blood Advances
Risk stratification for acute myeloid leukemia (AML) uses molecular and cytogenetic abnormalities identified at diagnosis. Response to therapy informs risk, and morphology continues to be used more frequently than flow cytometry. Herein,…
View details →Negative / Null Result ReportMedicine
Qi Tang, Cédric Julien, Robert Eveleigh et al. · 2015 · Spine
In Brief Study Design. A replication association study that used genomic data generated from French-Canadian case and control cohorts. Objectives. To determine whether the 53 single nucleotide polymorphisms (SNPs) that were previously…
View details →Negative / Null Result ReportOpen accessMedicine
Jai Chand Patel, Meenakshi Shukla, Manish Shukla et al. · 2025 · Frontiers in Bioengineering and Biotechnology
Mesenchymal stem cells (MSCs) are emerging as a powerful tool in regenerative medicine due to their ability to differentiate into mesenchymal lineages, such as bone, cartilage, and fat, along with their low immunogenicity and strong immunomodulatory properties. Unlike traditional cell therapies that rely on engraftment, MSCs primarily function through paracrine signaling-secreting bioactive molecules like vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), and exosomes. These factors contribute to tissue repair, promote angiogenesis, and modulate immune response
View details →Negative / Null Result ReportOpen accessMedicine
Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann et al. · 2025 · JAMA
Importance: Intraoperative hypotension is associated with adverse postoperative outcomes, but whether a proactive strategy to prevent intraoperative hypotension improves outcomes is uncertain. Objective: To determine whether intraoperative…
View details →Negative / Null Result ReportOpen accessMedicine
Mairi Ziaka, Aristomenis K. Exadaktylos · 2024 · Critical Care
Acute respiratory distress syndrome (ARDS) represents a life-threatening inflammatory reaction marked by refractory hypoxaemia and pulmonary oedema. Despite advancements in treatment perspectives, ARDS still carries a high mortality rate, often due to systemic inflammatory responses leading to multiple organ dysfunction syndrome (MODS). Indeed, the deterioration and associated mortality in patients with acute lung injury (LI)/ARDS is believed to originate alongside respiratory failure mainly from the involvement of extrapulmonary organs, a consequence of the complex interaction between initial
View details →Negative / Null Result ReportOpen accessMedicine
Cédric Peleman, Stig Hellemans, Geraldine Veeckmans et al. · 2024 · Cell Death and Differentiation
There is an unmet clinical need for pharmacologic treatment for metabolic dysfunction-associated steatotic liver disease (MASLD). Hepatocyte cell death is a hallmark of this highly prevalent chronic liver disease, but the dominant type of cell death remains uncertain. Here we report that ferroptosis, an iron-catalyzed mode of regulated cell death, contributes to MASLD. Unsupervised clustering in a cohort of biopsy-proven MASLD patients revealed a subgroup with hepatic ferroptosis signature and lower glutathione peroxidase 4 (GPX4) levels. Likewise, a subgroup with reduced ferroptosis defenses
View details →Negative / Null Result ReportOpen accessMedicine
Kosuke Kitamura, Toshiyuki China, Mayuko Kanayama et al. · 2018 · Prostate International
To determine the clinical predictive factors affecting the recovery from postoperative urinary incontinence after robot-assisted radical prostatectomy (RARP). We consecutively analyzed 320 patients who underwent RARP between January 2012…
View details →Negative / Null Result ReportOpen accessMedicine
Stephen J. Nicholls · 2012 · Cleveland Clinic Journal of Medicine
The AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) found, in an interim analysis, no cardiovascular benefit from taking extended-release niacin…
View details →Negative / Null Result ReportOpen accessMedicine
Stefan D. Anker, Javed Butler, Muhammad Usman et al. · 2022 · Nature Medicine
Abstract The EMPEROR-Preserved trial showed that the sodium–glucose co-transporter 2 inhibitor empagliflozin significantly reduces the risk of cardiovascular death or hospitalization for heart failure (HHF) in heart failure patients with left ventricular ejection fraction (LVEF) > 40%. Here, we report the results of a pre-specified analysis that separately evaluates these patients stratified by LVEF: preserved (≥ 50%) ( n = 4,005; 66.9%) or mid-range (41–49%). In patients with LVEF ≥ 50%, empagliflozin reduced the risk of cardiovascular death or HHF (the primary endpoint) by 17% versus plac
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Guodong Sun, Yang Zhang, Shanshan Mo et al. · 2021 · International Journal of General Medicine
PURPOSE: To analyze the risk factors of multiple organ dysfunction syndromes (MODS) caused by sepsis. PATIENTS AND METHODS: A total of 180 patients with sepsis admitted to The First Affiliated Hospital of Harbin Medical University (No. 23,…
View details →Negative / Null Result ReportOpen accessMedicine
Gil Cunha De Santis, Luciana Correa Oliveira de Oliveira, Pedro Manuel Marques Garibaldi et al. · 2022 · Emerging infectious diseases
To assess whether high-dose coronavirus disease (COVID-19) convalescent plasma (CCP) transfusion may benefit patients with severe COVID-19, we conducted a multicenter randomized trial in Brazil. Patients with severe COVID-19 who were within 10 days of initial symptom onset were eligible. Patients in the CCP group received 3 daily doses of CCP (600 mL/d) in addition to standard treatment; control patients received standard treatment only. Primary outcomes were death rates at days 30 and 60 of study randomization. Secondary outcomes were ventilator-free days and hospital-free days. We enrolled 1
View details →Negative / Null Result ReportOpen accessMedicine
Michael Scott Doyle, Bethany N. Swope, Jerome A. Hogsette et al. · 2011 · Journal of Medical Entomology
In 2006-2007, stable flies, Stomoxys calcitrans (L.) (Diptera: Muscidae), were suspected of being enzootic vectors of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) during a die-off of American white pelicans (Pelecanus…
View details →Negative / Null Result ReportMedicine
Alicia K. Klanecky, Dennis E. McChargue, Lindsay Bruggeman · 2012 · American Journal on Addictions
Alcohol use to replace inadequate dissociative capabilities, or chemical dissociation, has been linked to college students with childhood or adolescent sexual abuse (CASA). Insofar as CASA-exposed persons experience a restricted range of…
View details →Negative / Null Result ReportOpen accessMedicine
Luciana Mascia, Vito Fanelli, Alice Mistretta et al. · 2024 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Lung-protective strategies using low Vt and moderate positive end-expiratory pressure (PEEP) are considered best practice in critical care, but interventional trials have never been conducted in patients with acute brain…
View details →Negative / Null Result ReportMedicine
Sergio Leonardi, Pierluigi Tricoci, HD White et al. · 2013 · European Heart Journal
AIMS: The TRA·CER trial compared vorapaxar, a novel platelet protease-activated receptor (PAR)-1 antagonist, with placebo in 12 944 patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACS). In this analysis, we…
View details →Negative / Null Result ReportOpen accessMedicine
Sriram Ramgopal, Cameron Dezfulian, Robert W. Hickey et al. · 2019 · JAMA Network Open
Importance: A high Pao2, termed hyperoxemia, is postulated to have deleterious health outcomes. To date, the association between hyperoxemia during the ongoing management of critical illness and mortality has been incompletely evaluated in children. Objective: To examine whether severe hyperoxemia events are associated with mortality among patients admitted to a pediatric intensive care unit (PICU). Design, Setting, and Participants: A retrospective cohort study was conducted over a 10-year period (January 1, 2009, to December 31, 2018); all 23 719 PICU encounters at a quaternary children's ho
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Isabel Comino, Ana Real, Javier Gil‐Humanes et al. · 2012 · Molecular Nutrition & Food Research
SCOPE: The only treatment available for coeliac disease (CD) is a strict diet in which the intake of wheat, barley, rye, or oats is avoided. Barley is a major cereal crop, grown mainly for its use in brewing, and it has high nutritional…
View details →Replication FailureOpen accessMedicine
John Lowe, David Gillespie, Ali F. Aboklaish et al. · 2024 · The Lancet Respiratory Medicine
BACKGROUND: Systematic reviews have reported conflicting evidence on whether macrolide antibiotics reduce rates of chronic lung disease of prematurity (CLD) in at-risk preterm infants born at less than 30 weeks' gestation, including in those colonised with pulmonary Ureaplasma spp. Since an adequately powered trial has been lacking, we aimed to assess if the macrolide azithromycin improved survival without the development of physiologically defined moderate or severe CLD in preterm infants. METHODS: AZTEC was a multicentre, double-blind, randomised, placebo-controlled trial conducted in 28 ter
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Silvia Tietz, Marcel Zwahlen, Neda Haghayegh Jahromi et al. · 2016 · European Journal of Immunology
Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis.…
View details →Negative / Null Result ReportOpen accessMedicine
Erik W. Ingwersen, Wessel T. Stam, Bono J.V. Meijs et al. · 2023 · Surgery
BACKGROUND: Machine learning is increasingly advocated to develop prediction models for postoperative complications. It is, however, unclear if machine learning is superior to logistic regression when using structured clinical data. Postoperative pancreatic fistula and delayed gastric emptying are the two most common complications with the biggest impact on patient condition and length of hospital stay after pancreatoduodenectomy. This study aimed to compare the performance of machine learning and logistic regression in predicting pancreatic fistula and delayed gastric emptying after pancreato
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Albert J. Arias, Joel Gelernter, Ralitza Gueorguieva et al. · 2014 · American Journal on Addictions
BACKGROUND: Disulfiram and naltrexone were evaluated in treatment of individuals with co-occurring alcohol dependence and other Axis I disorders (e.g., Major Depression). We explored pharmacogenetic interactions in genotyped subjects.…
View details →Negative / Null Result ReportMedicine
Verônica Contini, Marcelo M. Victor, Guilherme Pinto Bertuzzi et al. · 2012 · Journal of Clinical Psychopharmacology
Results from pharmacogenetic investigations of methylphenidate (MPH) response in patients with ADHD are still inconsistent, especially among adults. This study investigates the role of genetic variants (SLC6A4, HTR1B, TPH2, DBH, DRD4,…
View details →Methods Dead-EndOpen accessMedicine
Umile Giuseppe Longo, Rocco Papalia, Sergio De Salvatore et al. · 2023 · Journal of Clinical Medicine
Insufficiently treated shoulder pain may cause mental disturbances, including depression and anxiety. The Hospital Anxiety and Depression Scale (HADS) is a patient-reported outcome measure (PROM) that aims to identify depression and anxiety in patients in nonpsychiatric wards. The aim of this study was to identify the minimum clinically important difference (MCID) and patient acceptable symptom state (PASS) scores for the HADS in a cohort of individuals with rotator cuff disease. Using the HADS, participants' degrees of anxiety and depression were assessed at inception and at their final asses
View details →Negative / Null Result ReportOpen accessMedicine
Sergiusz Jóźwiak, Pierangelo Veggiotti, J. Moreira et al. · 2018 · Epilepsy & Behavior
PURPOSE: This was a phase-II, randomized, double-blind (DB), placebo-controlled study aimed to evaluate neurocognitive effects of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset…
View details →Negative / Null Result ReportMedicine
Dhakshana Sivayoganathan, Deivanayagam Maruthini, Julie Glanville et al. · 2011 · Human Fertility
OBJECTIVE: This study aimed to compare the spectrum of polycystic ovary syndrome (PCOS) symptoms in patients from four different specialist clinics. DESIGN: A prospective cross-sectional observational study. SETTING: The study was…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Stewart, Raj K. Maturi, Vincent Chen et al. · 2014 · Clinical ophthalmology
AIMS: To determine if intravitreal bevacizumab combined with the dexamethasone intravitreal implant 0.7 mg improves visual acuity and macular thickness more than bevacizumab monotherapy in eyes with macular edema due to branch and central…
View details →Negative / Null Result ReportOpen accessMedicine
Joel Wight, Mimi Yue, Colm Keane et al. · 2019 · British Journal of Haematology
De novo diffuse large B-cell lymphoma (DLBCL) presenting with synchronous central nervous system (CNS) and systemic disease (synDLBCL) is not well described and is excluded from clinical trials. We performed a retrospective analysis of 80…
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