Negative / Null Result ReportOpen accessMedicine
Stefan D. Anker, Javed Butler, Muhammad Usman et al. · 2022 · Nature Medicine
Abstract The EMPEROR-Preserved trial showed that the sodium–glucose co-transporter 2 inhibitor empagliflozin significantly reduces the risk of cardiovascular death or hospitalization for heart failure (HHF) in heart failure patients with left ventricular ejection fraction (LVEF) > 40%. Here, we report the results of a pre-specified analysis that separately evaluates these patients stratified by LVEF: preserved (≥ 50%) ( n = 4,005; 66.9%) or mid-range (41–49%). In patients with LVEF ≥ 50%, empagliflozin reduced the risk of cardiovascular death or HHF (the primary endpoint) by 17% versus plac
View details →Negative / Null Result ReportOpen accessMedicine
Guodong Sun, Yang Zhang, Shanshan Mo et al. · 2021 · International Journal of General Medicine
PURPOSE: To analyze the risk factors of multiple organ dysfunction syndromes (MODS) caused by sepsis. PATIENTS AND METHODS: A total of 180 patients with sepsis admitted to The First Affiliated Hospital of Harbin Medical University (No. 23,…
View details →Negative / Null Result ReportOpen accessMedicine
Gil Cunha De Santis, Luciana Correa Oliveira de Oliveira, Pedro Manuel Marques Garibaldi et al. · 2022 · Emerging infectious diseases
To assess whether high-dose coronavirus disease (COVID-19) convalescent plasma (CCP) transfusion may benefit patients with severe COVID-19, we conducted a multicenter randomized trial in Brazil. Patients with severe COVID-19 who were within 10 days of initial symptom onset were eligible. Patients in the CCP group received 3 daily doses of CCP (600 mL/d) in addition to standard treatment; control patients received standard treatment only. Primary outcomes were death rates at days 30 and 60 of study randomization. Secondary outcomes were ventilator-free days and hospital-free days. We enrolled 1
View details →Negative / Null Result ReportOpen accessMedicine
Michael Scott Doyle, Bethany N. Swope, Jerome A. Hogsette et al. · 2011 · Journal of Medical Entomology
In 2006-2007, stable flies, Stomoxys calcitrans (L.) (Diptera: Muscidae), were suspected of being enzootic vectors of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) during a die-off of American white pelicans (Pelecanus…
View details →Negative / Null Result ReportMedicine
Alicia K. Klanecky, Dennis E. McChargue, Lindsay Bruggeman · 2012 · American Journal on Addictions
Alcohol use to replace inadequate dissociative capabilities, or chemical dissociation, has been linked to college students with childhood or adolescent sexual abuse (CASA). Insofar as CASA-exposed persons experience a restricted range of…
View details →Negative / Null Result ReportOpen accessMedicine
Luciana Mascia, Vito Fanelli, Alice Mistretta et al. · 2024 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Lung-protective strategies using low Vt and moderate positive end-expiratory pressure (PEEP) are considered best practice in critical care, but interventional trials have never been conducted in patients with acute brain…
View details →Negative / Null Result ReportMedicine
Sergio Leonardi, Pierluigi Tricoci, HD White et al. · 2013 · European Heart Journal
AIMS: The TRA·CER trial compared vorapaxar, a novel platelet protease-activated receptor (PAR)-1 antagonist, with placebo in 12 944 patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACS). In this analysis, we…
View details →Negative / Null Result ReportOpen accessMedicine
Sriram Ramgopal, Cameron Dezfulian, Robert W. Hickey et al. · 2019 · JAMA Network Open
Importance: A high Pao2, termed hyperoxemia, is postulated to have deleterious health outcomes. To date, the association between hyperoxemia during the ongoing management of critical illness and mortality has been incompletely evaluated in children. Objective: To examine whether severe hyperoxemia events are associated with mortality among patients admitted to a pediatric intensive care unit (PICU). Design, Setting, and Participants: A retrospective cohort study was conducted over a 10-year period (January 1, 2009, to December 31, 2018); all 23 719 PICU encounters at a quaternary children's ho
View details →Negative / Null Result ReportMedicine
Isabel Comino, Ana Real, Javier Gil‐Humanes et al. · 2012 · Molecular Nutrition & Food Research
SCOPE: The only treatment available for coeliac disease (CD) is a strict diet in which the intake of wheat, barley, rye, or oats is avoided. Barley is a major cereal crop, grown mainly for its use in brewing, and it has high nutritional…
View details →Replication FailureOpen accessMedicine
John Lowe, David Gillespie, Ali F. Aboklaish et al. · 2024 · The Lancet Respiratory Medicine
BACKGROUND: Systematic reviews have reported conflicting evidence on whether macrolide antibiotics reduce rates of chronic lung disease of prematurity (CLD) in at-risk preterm infants born at less than 30 weeks' gestation, including in those colonised with pulmonary Ureaplasma spp. Since an adequately powered trial has been lacking, we aimed to assess if the macrolide azithromycin improved survival without the development of physiologically defined moderate or severe CLD in preterm infants. METHODS: AZTEC was a multicentre, double-blind, randomised, placebo-controlled trial conducted in 28 ter
View details →Negative / Null Result ReportOpen accessMedicine
Silvia Tietz, Marcel Zwahlen, Neda Haghayegh Jahromi et al. · 2016 · European Journal of Immunology
Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis.…
View details →Negative / Null Result ReportOpen accessMedicine
Erik W. Ingwersen, Wessel T. Stam, Bono J.V. Meijs et al. · 2023 · Surgery
BACKGROUND: Machine learning is increasingly advocated to develop prediction models for postoperative complications. It is, however, unclear if machine learning is superior to logistic regression when using structured clinical data. Postoperative pancreatic fistula and delayed gastric emptying are the two most common complications with the biggest impact on patient condition and length of hospital stay after pancreatoduodenectomy. This study aimed to compare the performance of machine learning and logistic regression in predicting pancreatic fistula and delayed gastric emptying after pancreato
View details →Negative / Null Result ReportMedicine
Albert J. Arias, Joel Gelernter, Ralitza Gueorguieva et al. · 2014 · American Journal on Addictions
BACKGROUND: Disulfiram and naltrexone were evaluated in treatment of individuals with co-occurring alcohol dependence and other Axis I disorders (e.g., Major Depression). We explored pharmacogenetic interactions in genotyped subjects.…
View details →Negative / Null Result ReportMedicine
Verônica Contini, Marcelo M. Victor, Guilherme Pinto Bertuzzi et al. · 2012 · Journal of Clinical Psychopharmacology
Results from pharmacogenetic investigations of methylphenidate (MPH) response in patients with ADHD are still inconsistent, especially among adults. This study investigates the role of genetic variants (SLC6A4, HTR1B, TPH2, DBH, DRD4,…
View details →Methods Dead-EndOpen accessMedicine
Umile Giuseppe Longo, Rocco Papalia, Sergio De Salvatore et al. · 2023 · Journal of Clinical Medicine
Insufficiently treated shoulder pain may cause mental disturbances, including depression and anxiety. The Hospital Anxiety and Depression Scale (HADS) is a patient-reported outcome measure (PROM) that aims to identify depression and anxiety in patients in nonpsychiatric wards. The aim of this study was to identify the minimum clinically important difference (MCID) and patient acceptable symptom state (PASS) scores for the HADS in a cohort of individuals with rotator cuff disease. Using the HADS, participants' degrees of anxiety and depression were assessed at inception and at their final asses
View details →Negative / Null Result ReportOpen accessMedicine
Sergiusz Jóźwiak, Pierangelo Veggiotti, J. Moreira et al. · 2018 · Epilepsy & Behavior
PURPOSE: This was a phase-II, randomized, double-blind (DB), placebo-controlled study aimed to evaluate neurocognitive effects of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset…
View details →Negative / Null Result ReportMedicine
Dhakshana Sivayoganathan, Deivanayagam Maruthini, Julie Glanville et al. · 2011 · Human Fertility
OBJECTIVE: This study aimed to compare the spectrum of polycystic ovary syndrome (PCOS) symptoms in patients from four different specialist clinics. DESIGN: A prospective cross-sectional observational study. SETTING: The study was…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Stewart, Raj K. Maturi, Vincent Chen et al. · 2014 · Clinical ophthalmology
AIMS: To determine if intravitreal bevacizumab combined with the dexamethasone intravitreal implant 0.7 mg improves visual acuity and macular thickness more than bevacizumab monotherapy in eyes with macular edema due to branch and central…
View details →Negative / Null Result ReportOpen accessMedicine
Joel Wight, Mimi Yue, Colm Keane et al. · 2019 · British Journal of Haematology
De novo diffuse large B-cell lymphoma (DLBCL) presenting with synchronous central nervous system (CNS) and systemic disease (synDLBCL) is not well described and is excluded from clinical trials. We performed a retrospective analysis of 80…
View details →Negative / Null Result ReportOpen accessMedicine
Thit Mynster Kronborg, Robert Schierwagen, Kajetan Trôst et al. · 2023 · Hepatology Communications
BACKGROUND: Patients with cirrhosis and portal hypertension face a high risk of complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce portal pressure and thus the risk of complications and mortality.…
View details →Negative / Null Result ReportOpen accessMedicine
Joseph Rigdon, Sanjay Basu · 2019 · BMJ Open
OBJECTIVES: We aimed to test whether or not adding (1) nutrition predictor variables and/or (2) using machine learning models improves cardiovascular death prediction versus standard Cox models without nutrition predictor variables.…
View details →Negative / Null Result ReportOpen accessMedicine
Luke Hodgson, Jo Congleton, Richard Venn et al. · 2018 · Clinical Medicine
ABSTRACT The Royal College of Physicians (RCP) recently published the National Early Warning Score 2 (NEWS2), aiming to improve safety for patients with hypercapnic respiratory failure by suggesting a separate oxygen saturation (SpO2)…
View details →Negative / Null Result ReportOpen accessMedicine
Ilkka Koskivuo, Jukka Kemppainen, Salvatore Giordano et al. · 2016 · Acta Oncologica
BACKGROUND: Whole body positron emission tomography (PET)/computed tomography (CT) is a sensitive imaging technique in patients with metastatic melanoma, but its role in the follow-up of asymptomatic high-risk patients is unclear. The aim…
View details →Negative / Null Result ReportOpen accessMedicine
Kseniia Chernyshova, Keiichi Inoue, Shun‐ichi Yamashita et al. · 2019 · Investigative Ophthalmology & Visual Science
Purpose: Glaucoma results in progressive degeneration of the optic nerve and irreversible vision loss. Several mutations in the gene encoding optineurin (OPTN), the receptor for Parkin-dependent mitochondrial autophagy (mitophagy), are…
View details →Negative / Null Result ReportOpen accessMedicine
Xiaodong Huang, Xiaozhong Chen, Chong Zhao et al. · 2020 · Frontiers in Oncology
Purpose: To explore the efficacy of concomitant chemotherapy in intensity-modulated radiotherapy(IMRT) to treat stage II nasopharyngeal carcinoma (NPC). Methods and Materials: In this randomized phase 2 study (registered with ClinicalTrials.gov, (NCT01187238)), eligible patients with stage II (2010 UICC/AJCC) NPC were randomly assigned to either IMRT alone (RT group) or IMRT combined with concurrent cisplatin (40 mg/m2, weekly) (CCRT group). The primary endpoint was overall survival (OS). The second endpoints included local failure-free survival (LFFS), regional failure-free survival (RFFS), d
View details →Negative / Null Result ReportOpen accessMedicine
Pasquale F. Innominato, Abdoulaye Karaboué, C. Focan et al. · 2020 · International Journal of Cancer
The triplet combination of irinotecan, oxaliplatin and fluorouracil is an active frontline regimen in metastatic colorectal cancer, but scarce data exist on its use as salvage treatment. We aimed at assessing its safety and efficacy profiles with its circadian-based administration (chronoIFLO5) as either first- or second-line treatment, within the time-finding EORTC 05011 trial. Five-day chronoIFLO5 was administered every 3 weeks in patients with PS 0, 1 or 2. It consisted of chronomodulated irinotecan (180 mg/sqm), oxaliplatin (80 mg/sqm) and fluorouracil-leucovorin (2800 and 1200 mg/sqm, res
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Magdalena Paplińska‐Goryca, Paulina Misiukiewicz‐Stępień, Monika Wróbel et al. · 2025 · Scientific Reports
Microplastic particles from the air are inhaled and accumulate in the lungs, potentially causing immunological reactions and airway tissue injury. This study aimed to evaluate the biological effects of polyamide fibres on nasal epithelium…
View details →Replication FailureOpen accessMedicine
M. Roupret, Aurélie Bertaut, G. Pignot et al. · 2025 · Annals of Oncology
BACKGROUND: Standard treatment of high-risk non-muscle-invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor is intravesical instillation with Bacillus Calmette-Guérin (BCG) (induction and maintenance regimens);…
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Felicia C. Goldstein, Angela F. Caveney, Vicki Hertzberg et al. · 2016 · Journal of Neurotrauma
A Phase III, double-blind, placebo-controlled trial (ProTECT III) found that administration of progesterone did not reduce mortality or improve functional outcome as measured by the Glasgow Outcome Scale Extended (GOSE) in subjects with…
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Catarina S. Lobo, Maria Inês P. Mendes, Diogo A. Pereira et al. · 2023 · Scientific Reports
Photodynamic therapy (PDT) with redaporfin stimulates colon carcinoma (CT26), breast (4T1) and melanoma (B16F10) cells to display high levels of CD80 molecules on their surfaces. CD80 overexpression amplifies immunogenicity because it increases same cell (cis) CD80:PD-L1 interactions, which (i) disrupt binding of T-cells PD-1 inhibitory receptors with their ligands (PD-L1) in tumour cells, and (ii) inhibit CTLA-4 inhibitory receptors binding to CD80 in tumour cells. In some cancer cells, redaporfin-PDT also increases CTLA-4 and PD-L1 expressions and virtuous combinations between PDT and immune
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