Negative / Null Result ReportOpen accessMedicine
Tuantuan Li, Jing Xu, Yong Gao et al. · 2023 · European Journal of Medical Research
Abstract Objective To investigate the clinical significance and value of peripheral blood T lymphocyte subset in patients with asymptomatic novel coronavirus variant strains infection (OMICRON). Methods A retrospective analysis of 281 patients with asymptomatic OMICRON infection who were admitted and isolated to the Fuyang Second People's Hospital from March to April 2022 was conducted. With 32 normal people as the control group, T lymphocytes of the two groups (CD3 + T, CD3 + CD4 + T, CD3 + CD8 + T) were analyzed and the differences between the two groups were analyzed. CD4 + T lymphocytes be
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Gerda Trutnovsky, MD, Brigitte Bliem, MD, Elfriede Greimel, PhD et al. · 2021 · Sexual Medicine
ABSTRACT: Introduction: Treatment for vulvodynia is challenging and a multidisciplinary approach is recommended. Aim: To examine the effectiveness, safety and treatment satisfaction of vulvovaginal microablative laser treatment for vulvodynia. Methods: Case study of women who received laser treatment as part of a multidisciplinary treatment program for vulvodynia. Subjective improvement was compared to a retrospective cohort of women treated for vulvodynia without LASER therapy. LASER treatment was offered to women with vulvodynia presenting to a gynecologic pain clinic of a tertiary universit
View details →Negative / Null Result ReportOpen accessMedicine
Waldo Lino Júnior, William Dias Belangero · 2005 · Acta Ortopédica Brasileira
Os autores estudaram os efeitos do laser Hólmio:Ítrio-Alumínio-Granada (Ho: YAG) sobre as dimensões do tendão (comprimento e largura proximal e distal) e sobre a celularidade e arranjo das fibras de colágeno em 20 ratos adultos, machos, brancos (Ratus Novergicus) da varidade Wistar. Os animais foram divididos em dois grupos de acordo com o tempo de seguimento (12 e 24 semanas) e de acordo com a forma de aplicação do laser (contínua e em dois pontos). Utilizou-se aparelho de laser de Hólmio (pulsátil, estado sólido, com ondas de 2,1 microns, com potência de 40 watts, ponteira OmniTip de 30º) .
View details →Negative / Null Result ReportOpen accessMedicine
Ludmila Malariková, Kristýna Machová, Ivona Svobodová et al. · 2023 · PLoS ONE
To increase the effectiveness of education is appropriate to incorporate varied teaching methods with multisensory stimulation and with an emphasis on personal and emotional experiences. This study aims to compare the knowledge of biology subject matter acquired by second and fourth-grade primary students. The lesson occurred at a farm in the experimental group and at school in the control group. Students' knowledge levels were assessed before the lesson, after the lesson, after 14 days, after a month, and after six months. When the levels of knowledge after the lesson were compared between th
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Wiryawan Permadi, Hartanto Bayuaji, Kevin Dominique Tjandraprawira et al. · 2021 · BMC Research Notes
Abstract Objective To compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population. Results This was retrospective study using secondary data of IVF patients at a private fertility centre. Study recruitment was between 3/8/2018 and 31/12/2019. Total sampling included all patients undergoing oocyte retrieval and embryo transfer within recruitment period. Patients undergoing fresh IVF cycles and frozen IVF cycles were compared. 351 patients were recruited: 68.1% (239/351) underwent fresh cycles and 31.9% (
View details →Negative / Null Result ReportOpen accessMedicine
Meiqi Liu, Mengying Xu, Tiantian Tang · 2021 · Scientific Reports
Abstract Hepatectomy and transplantation are the main surgical therapies for HCC patients, and radiotherapy or chemotherapy is often used as adjuvant treatment. Researches have evaluated the independent predictors of HCC, but evidence for factors predicting the efficacy of chemotherapy is rare. Patients diagnosed with HCC between 2010 and 2015 from the SEER database were included and randomly divided into non-chemotherapy and chemotherapy groups. The predictors of CSS and OS were analyzed with the Cox proportional-hazards regression model and Fine and Gray’s competing risk model. Although ther
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Ning Li, Jincai Huang, Yanghe Feng · 2020 · PLoS ONE
Background Cognitive ability refers to the ability to receive, process, store, and extract information. It is the most important psychological condition for people to successfully complete activities. Previous studies have shown that the design of the human-computer interface of the command and control system cannot exceed the cognitive ability of the operator of the command and control system, and it must match the cognitive ability of the operator in order to reduce the mental load intensity, and improve the accuracy, timeliness and work efficiency. However, previous researchers in the field
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Zhongwei Yu, Chenhui Zhao, Anqing Yang et al. · 2025 · Scientific Reports
Abstract To investigate the correlation between serum sex hormone levels and clear cell renal cell carcinoma(ccRCC). The clinical data of male patients diagnosed with ccRCC and with simple renal cysts in our hospital from 2017 to 2023 were collected. The basic clinical data and serum sex hormone levels, including luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol(E2), prolactin (PRL), progesterone(P), and testosterone (T), were compared between patients with ccRCC and patients with simple renal cysts. A total of 56 male patients with ccRCC and 82 male patients with simple
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Ryo Obata, Yasuo Yanagi · 2014 · PLoS ONE
Purpose It has not been clarified whether early age-related macular degeneration (AMD) is associated with cone photoreceptor distribution. We used adaptive optics fundus camera to examine cone photoreceptors in the macular area of aged patients and quantitatively analyzed its relationship between the presence of early AMD and cone distribution. Methods Sixty cases aged 50 or older were studied. The eyes were examined with funduscopy and spectral-domain optical coherence tomography to exclude the eyes with any abnormalities at two sites of measurement, 2° superior and 5° temporal to the fovea.
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Mojtaba Khazaei, Fatemeh Saadati Pour, Masoud Ghiasian et al. · 2024 · مجله علوم پزشکی فیض (پیوسته)
Background and Aim: Edaravone is known for its efficacy in inhibiting free radical formation, activating microglia, and promoting neurogenesis and neuroprotection following acute ischemic stroke. This clinical trial aimed to investigate the effects of Edaravone on clinical symptoms and oxidative stress factors in patients with acute ischemic stroke. Methods: In this clinical trial, fifty-two patients diagnosed with acute ischemic stroke were randomly assigned to receive either Edaravone (120 mg daily up to 3 doses intravenously) or a placebo in addition to standard treatment. Stroke severity w
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CHEN Zhu, LIU Yan, GAO Li-hua, CHEN Bu-you, TANG Ai-hua, LIU Jun · 2021 · Jichu yixue yu linchuang
Objective To evaluate the efficacy and safety of apatinib in the treatment of metastatic colorectal cancer (mCRC). Methods Sixty-five patients with mCRC treated with apatinib were enrolled in this study for retrospective analysis. The factors affecting the recent effective, progression-free survival (PFS) and adverse reactions were evaluated. Results The disease control rate in 63 evaluable patients was 69.9%. The median PFS for patients received first-line, second-line, and third-line and above apatinib treatment were 9.3 months, 5.8 months, and 3.3 months, respectively(P＜0.001). The PFS in t
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Mohammad Reza Zarbakhsh Bahri, Zahra Shoa Hasani, Ziba Zahiri Sorori et al. · 2013 · پژوهان
Introduction: This study aims to evaluate the effectiveness of stress management training and problem-solving training on quality of life and life expectancy of infertile women was conducted.Material and Methods: The method of this study was experimental with pretest – posttest design with a control group. population of 400 infertile women who referred to infertility center in Rasht were randomized to 250 of them were selected and the quality of life and life expectancy of the study were the 45 members of the quality of life and life expectancy lower were more randomly in three groups of 15 pe
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Hanzaleh Jour Ebrahimiyan, Nafise Ansarinejad, Farshid Fardad · 2023 · Disease and Diagnosis
Background: Chemotherapy-induced peripheral neuropathy is one of the most common side effects of chemotherapy. This study aimed to determine the effectiveness of venlafaxine and duloxetine in improving chronic neurotoxicity induced by chemotherapy in cancer patients. Materials and Methods: The study was performed on cancer patients undergoing outpatient chemotherapy or hospitalization in Rasoul Akram hospital. The admitted patients were blindly divided into two groups. The first group was treated with venlafaxine, and the second group was treated with duloxetine. The treatment lasted up until
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Abu Sadat Mohammad Sayeem Bin Shahid, Shahnawaz Ahmed, Tanzina Tazul Renesa et al. · 2022 · PLoS ONE
Background Fibersol-2 has some beneficial effects on human health. We aimed to evaluate the digestive tolerability and acceptability of Fibersol-2 in healthy and diarrheal children, as well as improvement in stool consistencies in young diarrheal children. Methods Sixty children of either sex, aged 1-3 years having four groups (healthy children/low dose, healthy children/high dose, children with diarrhea/low dose and children with diarrhea/high dose) were enrolled into this exploratory study between 1st August to 23rd October 2017. Two presumptive doses, low (2.5g) and high (5g), twice daily w
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Zhang T, Xiang J, Yu N et al. · 2026 · Frontiers in microbiology
Mastitis in dairy cows is one of the most prevalent infectious diseases in the dairy industry, leading to reduced milk production, increased production costs, and substantial economic losses. Antibiotics are commonly used to prevent and…
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Lei Wang, Tingjun Ye, Lianfu Deng et al. · 2014 · PLoS ONE
Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits. The animals were sacrificed at 1 day, 2 weeks, 1 month and 2 months after surgery. Histomorphometric measurement and confocal microscopy were performed on basic fuchsin stained bone sections to examine the morphological characteristics of microdamage, bone resorption activity and spatial relationship between microdamage and bone resorption. Di
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Arslan A, Benli E, Yüce A et al. · 2026 · BMC urology
Background Erectile dysfunction (ED) is a vascular disease associated with systemic inflammation and endothelial dysfunction. The role of inflammatory markers in the pathogenesis of ED is gaining increasing importance. This study aimed to…
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Barjor Gimi, Lara Leoni, Jose Oberholzer et al. · 2006 · Cell Transplantation
The increasing incidence of diabetes and the need to further understand its cellular basis has resulted in the development of new diagnostic and therapeutic techniques. Nonetheless, the quest to noninvasively ascertain β-cell mass and function has not been achieved. Manganese (Mn)-enhanced MRI is presented here as a tool to image β-cell functionality in cell culture and isolated islets. Similar to calcium, extracellular Mn was taken up by glucose-activated β-cells resulting in 200% increase in MRI contrast enhancement, versus nonactivated cells. Similarly, glucose-activated islets showed an in
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Jeremy Chung Bo Chiang, David Goldstein, Azadeh Tavakoli et al. · 2021 · Scientific Reports
Abstract Immune cell infiltration has been implicated in neurotoxic chemotherapy for cancer treatment. However, our understanding of immune processes is still incomplete and current methods of observing immune cells are time consuming or invasive. Corneal dendritic cells are potent antigen-presenting cells and can be imaged with in-vivo corneal confocal microscopy. Corneal dendritic cell densities and nerve parameters in patients treated with neurotoxic chemotherapy were investigated. Patients treated for cancer with oxaliplatin (n = 39) or paclitaxel (n = 48), 3 to 24 months prior to assessme
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Darpan I. Patel, Kira Abuchowski, Bilal Sheikh et al. · 2019 · European Journal of Translational Myology
The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04).
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Jingjing Zhou, Shanshan Wu, Xiaojing Wu et al. · 2023 · PLoS ONE
The cultural landscape in traditional settlements is an important historical and cultural resource created by human beings in the process of historical evolution, and is an important resource for the development of traditional settlement tourism. This paper selected 21 representative traditional settlements for research using online comments from tourists as data and content analytical methods including high-frequency vocabulary, semantic networks and emotional attitudes to explore the public perspective on the connotations of cultural landscape features in traditional settlements. There are f
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Negar Sheikhdavoodi, Maryam Gheraati, Sima Hashemipour et al. · 2022 · The Journal of Qazvin University of Medical Sciences
Background: Electrolyte disorders, particularly hyponatremia, have been reported in a considerable number of patients with Coronavirus Disease 2019 (COVID-19). Objective: The current study aims to evaluate the risk factors, symptoms, and prognosis of hyponatremia in hospitalized patients with COVID-19. Methods: In this retrospective cohort study, 467 patients with COVID-19 were divided into 4 groups based on the sodium level at the time of admission: normal, mild hyponatremia, moderate hyponatremia, and severe hyponatremia. Symptoms, laboratory findings, and prognosis were compared among these
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Azam Ardeh, Elham Goodarzi, Zahra Madadi et al. · 2025 · BMC Research Notes
Abstract Background Marital relationships, like any other interpersonal bond, encompass both positive and negative dimensions. Central to the success of marriage is the level of satisfaction and commitment experienced by the partners. This study aims to compare the efficacy of cognitive-behavioral couple therapy and schema-based couple therapy in reducing the desire for divorce and marital boredom. Methods This experimental study employed a pre-test-post-test design with a control group. The research sample comprised couples experiencing marital issues who sought counseling at various counseli
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Dandan Chen, Huamin Wu, Feifeng Huang et al. · 2025 · PLoS ONE
Objective This study explored the prognosis of high-grade squamous intraepithelial lesion (HSIL) patients with negative margins, investigating the impact of different distances between lesions and incisal margins in conization specimens. Methods This retrospective cohort study included 240 HSIL patients. Patients with negative incisal margins were divided into 3 groups according to the distance between the lesion and the incisal margin in the conization tissue. Group 1 consisted of a distance of 3 mm (n = 202). For patients with lesions close to the incisal margin (≤3 cm), the decision between
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Van de Vyver A, Taylan O, Peersman G et al. · 2026 · Archives of orthopaedic and trauma surgery
Objectives This study aimed to analyze to what extent a novel intraoperative navigation platform (Next-AR, Medacta) for total knee arthroplasty (TKA) allows to restore the native knee joint kinematics and strains in the medial collateral…
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Hassan Talakesh, Alizamen Salehifard Jouneghani, Karamali Kasiri et al. · 2024 · Journal of Shahrekord University of Medical Sciences
Background and aims: Constipation in children is a serious problem that affects both children and their families. We aimed to compare the clinical efficacy of lactulose and polyethylene glycol in the treatment of constipation in children. Methods: This randomized clinical trial was performed on 92 patients referred to a private gastroenterology clinic in Shahrekord, Iran. The patients were randomly assigned into two groups receiving polyethylene glycol or lactulose. Defecation patterns and complications were assessed 0, 3, 7, and 21 days after the intervention. Data were analyzed using the chi
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Fuengfa Khobkhun, Jenjira Thanakamchokchai · 2023 · Scientific Reports
Abstract Biological sexes (male and female) have been reported to influence postural control and balance due to differences in musculoskeletal structures, hormonal factors, and neuromuscular control. These factors can contribute to the turning performance, potentially leading to an increased incidence of falls, particularly during turning. Therefore, this study aimed to explore the whole-body coordination and stepping characteristics and during standing turns in healthy adults to determine the effects of biological sex and turn speed. Fifty participants (25 males and 25 females) completed 180°
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Andres Montealegre, William Jimenez-Leal · 2019 · PLoS ONE
According to the social heuristics hypothesis, people intuitively cooperate or defect depending on which behavior is beneficial in their interactions. If cooperation is beneficial, people intuitively cooperate, but if defection is beneficial, they intuitively defect. However, deliberation promotes defection. Here, we tested two novel predictions regarding the role of trust in the social heuristics hypothesis. First, whether trust promotes intuitive cooperation. Second, whether preferring to think intuitively or deliberatively moderates the effect of trust on cooperation. In addition, we examin
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Sung Hee Lim, Jong-Mu Sun, Joohyun Hong et al. · 2021 · The Korean Journal of Internal Medicine
Background/Aims Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over current chemoradiotherapy (CRT) in patients with hypopharynx and BOT cancer. Methods Treatment-naïve patients with stage III/IV (M0) hypopharynx or BOT cancer were randomly assigned to receive CRT alone (CRT arm: cisplatin 100 mg/m2 on D1 3-weekly, two times plus radiotherapy 68.4 Gy/30 fractions on we
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Derya Sivri Aydın · 2019 · İstanbul Medical Journal
Introduction:To evaluate whether neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) have diagnostic value in endometrioma, which is a chronic inflammatory disease.Methods:A total of 187 patients who underwent surgery for adnexal mass, 97 patients diagnosed with endometrioma and 90 patients with benign cyst (corpus luteum, serous cysts or functional cysts), were included in this retrospective, comparative case series. NLR and PLR values obtained from preoperative complete blood count parameters were compared between the two groups.Results:There was no statistically significan
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