12,214 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Markus Waldén, I. Atroshi, Henrik Magnusson et al. · 2012 · BMJ
OBJECTIVE: To evaluate the effectiveness of neuromuscular training in reducing the rate of acute knee injury in adolescent female football players. DESIGN: Stratified cluster randomised controlled trial with clubs as the unit of…
View details →J. Michael Wells, George R. Washko, MeiLan K. Han et al. · 2012 · New England Journal of Medicine
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization,…
View details →Tiffany N. Castillo, Michael A. Pouliot, Hyeon Joo Kim et al. · 2010 · The American Journal of Sports Medicine
BACKGROUND: Clinical studies claim that platelet-rich plasma (PRP) shortens recovery times because of its high concentration of growth factors that may enhance the tissue repair process. Most of these studies obtained PRP using different…
View details →Eva Haglind, Stefan Carlsson, Johan Stranne et al. · 2015 · European Urology
BACKGROUND: Robot-assisted laparoscopic radical prostatectomy (RALP) has become widely used without high-grade evidence of superiority regarding long-term clinical outcomes compared with open retropubic radical prostatectomy (RRP), the…
View details →Roberto Castricini, Umile Giuseppe Longo, Massimo De Benedetto et al. · 2010 · The American Journal of Sports Medicine
BACKGROUND: After reinsertion on the humerus, the rotator cuff has limited ability to heal. Growth factor augmentation has been proposed to enhance healing in such procedure. PURPOSE: This study was conducted to assess the efficacy and…
View details →Abdulaziz N. Alagaili, Thomas Briese, Nischay Mishra et al. · 2014 · mBio
The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where the disease has emerged have antibodies to the virus, and viral sequences have been recovered from camels in association with outbreaks of the disease among humans. Nonetheless, whether camels mediate transmission to humans is unresolved. Here we provide evidence from a geographic
View details →Karen Kelly, Nasser K. Altorki, Wilfried Eberhardt et al. · 2015 · Journal of Clinical Oncology
PURPOSE: Epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitors have proven efficacy in advanced non-small-cell lung cancer (NSCLC). We hypothesized that erlotinib would be efficacious in the adjuvant setting. PATIENTS AND…
View details →Jodie M Dodd, Deborah Turnbull, Andrew J McPhee et al. · 2014 · BMJ
OBJECTIVE: To determine the effect of antenatal dietary and lifestyle interventions on health outcomes in overweight and obese pregnant women. DESIGN: Multicentre randomised trial. We utilised a central telephone randomisation server, with…
View details →Patrick Mismetti, Silvy Laporte, Olivier Pellerin et al. · 2015 · JAMA
IMPORTANCE: Although retrievable inferior vena cava filters are frequently used in addition to anticoagulation in patients with acute venous thromboembolism, their benefit-risk ratio is unclear. OBJECTIVE: To evaluate the efficacy and…
View details →Maria Grazia Bongiorni, Charles Kennergren, Christian Butter et al. · 2017 · European Heart Journal
AIMS: The European Lead Extraction ConTRolled Registry (ELECTRa), is a prospective registry of consecutive transvenous lead extraction (TLE) procedures conducted by the European Heart Rhythm Association (EHRA) in order to identify the…
View details →Neil A. Smart, Mark Waldron, Hashbullah Ismail et al. · 2015 · International Journal of Evidence-Based Healthcare
INTRODUCTION: Several established tools are available to assess study quality and reporting of randomized controlled trials; however, these tools were designed with clinical intervention trials in mind. In exercise training intervention…
View details →Sabine L. Vriezinga, Renata Auricchio, E. Bravi et al. · 2014 · New England Journal of Medicine
BACKGROUND: A window of opportunity has been suggested for reducing the risk of celiac disease by introducing gluten to infants at 4 to 6 months of age. METHODS: We performed a multicenter, randomized, double-blind, placebo-controlled…
View details →Daniel F. McAuley, John G. Laffey, Cecilia O’Kane et al. · 2014 · New England Journal of Medicine
BACKGROUND: Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS). This study tested the hypothesis that treatment with…
View details →Stan B. Kaye, Jan Lubiński, Ursula A. Matulonis et al. · 2011 · Journal of Clinical Oncology
PURPOSE: Olaparib (AZD2281), an orally active poly (ADP-ribose) polymerase inhibitor that induces synthetic lethality in BRCA1- or BRCA2-deficient cells, has shown promising clinical efficacy in nonrandomized phase II trials in patients…
View details →Nazlı Dizman, Luís Meza, Paulo Gustavo Bergerot et al. · 2022 · Nature Medicine
Previous studies have suggested that the gut microbiome influences the response to checkpoint inhibitors (CPIs) in patients with cancer. CBM588 is a bifidogenic live bacterial product that we postulated could augment CPI response through modulation of the gut microbiome. In this open-label, single-center study (NCT03829111), 30 treatment-naive patients with metastatic renal cell carcinoma with clear cell and/or sarcomatoid histology and intermediate- or poor-risk disease were randomized 2:1 to receive nivolumab and ipilimumab with or without daily oral CBM588, respectively. Stool metagenomic s
View details →A. A. de Graaff, Thomas D’Hooghe, G.A.J. Dunselman et al. · 2013 · Human Reproduction
STUDY QUESTION: To what extent do the management of endometriosis and the symptoms that remain after treatment affect the quality of life in women with the disease? SUMMARY ANSWER: Many women with endometriosis had impaired quality of life…
View details →Christiane Maria Prado Jerônimo, Maria Eduarda Leão de Farias, Fernando Val et al. · 2020 · Clinical Infectious Diseases
BACKGROUND: Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by severe acute respiratory syndrome coronavirus 2…
View details →Janine Giese‐Davis, Kate Collie, Kate M. Rancourt et al. · 2010 · Journal of Clinical Oncology
PURPOSE: Numerous studies have examined the comorbidity of depression with cancer, and some have indicated that depression may be associated with cancer progression or survival. However, few studies have assessed whether changes in…
View details →Mary E. Tinetti, Ling Han, David S. H. Lee et al. · 2014 · JAMA Internal Medicine
IMPORTANCE The effect of serious injuries, such as hip fracture and head injury, on mortality and function is comparable to that of cardiovascular events. Concerns have been raised about the risk of fall injuries in older adults taking…
View details →Alan Pollack, Gail Walker, Eric M. Horwitz et al. · 2013 · Journal of Clinical Oncology
PURPOSE: To determine if escalated radiation dose using hypofractionation significantly reduces biochemical and/or clinical disease failure (BCDF) in men treated primarily for prostate cancer. PATIENTS AND METHODS: Between June 2002 and…
View details →MVE Veenendaal, R.C. Painter, Susanne R. de Rooij et al. · 2013 · BJOG An International Journal of Obstetrics & Gynaecology
OBJECTIVE: We previously showed that maternal under-nutrition during gestation is associated with increased metabolic and cardiovascular disease in the offspring. Also, we found increased neonatal adiposity among the grandchildren of women…
View details →Natalie Hofmann, Felista Mwingira, Seif Shekalaghe et al. · 2015 · PLoS Medicine
BACKGROUND: Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be identified by surveillance with molecular methods, yet these infections also contribute to onward transmission to mosquitoes. The sensitivity of molecular detection by PCR is limited by the abundance of the target sequence in a DNA sample; thus, detection becomes imperfect at low densities. We aimed to increase PCR diagnostic sensitivity by targeting multi-copy genomic sequences for reliable det
View details →Amir Englund, Paul D. Morrison, Judith Nottage et al. · 2012 · Journal of Psychopharmacology
Community-based studies suggest that cannabis products that are high in Δ⁹-tetrahydrocannabinol (THC) but low in cannabidiol (CBD) are particularly hazardous for mental health. Laboratory-based studies are ideal for clarifying this issue…
View details →Bradley C. Leibovich, Christine M. Lohse, Paul L. Crispen et al. · 2010 · The Journal of Urology
PURPOSE: There are significant differences in clinicopathological features among renal cell carcinoma histological subtypes but controversy exists regarding the independent impact of histological subtype on patient outcome after…
View details →Dan Frampton, Tommy Rampling, Aidan Cross et al. · 2021 · The Lancet Infectious Diseases
BACKGROUND: Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of monoclonal antibodies. We aimed to describe the emergence of…
View details →Silvana Galderisi, Alessandro Rossi, Paola Rocca et al. · 2014 · World Psychiatry
In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital…
View details →Nitin Shivappa, James R. Hébert, Ernst Rietzschel et al. · 2015 · British Journal Of Nutrition
Previous research has shown that nutrients and certain food items influence inflammation. However, little is known about the associations between diet, as a whole, and inflammatory markers. In the present study, we examined the ability of…
View details →Sarah R. Preis, Joseph M. Massaro, Udo Hoffmann et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
BACKGROUND: Neck circumference, a proxy for upper-body sc fat, may be a unique fat depot that confers additional cardiovascular risk above and beyond central body fat. METHODS AND RESULTS: Participants with neck circumference measures who…
View details →Sèverine Sabia, Aline Dugravot, Jean‐François Dartigues et al. · 2017 · BMJ
This study found no evidence of a neuroprotective effect of physical activity. Previous findings showing a lower risk of dementia in physically active people may be attributable to reverse causation-that is, due to a decline in physical activity levels in the preclinical phase of dementia.
View details →Almudena Marí Sáez, Sabrina Weiß, Kathrin Nowak et al. · 2014 · EMBO Molecular Medicine
The severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2-year-old boy in Meliandou, Guinea. We investigated the zoonotic origins of the epidemic using wildlife surveys, interviews, and molecular analyses of bat and environmental samples. We found no evidence for a concurrent outbreak in larger wildlife. Exposure to fruit bats is common in the region, but the index case may have been infected by playing in a hollow tree housing a colony of insectivorous free-tailed bats (Mops condylurus). Bats in this family have previously been dis
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