Ultra-Sensitive Detection of Plasmodium falciparum by Amplification of Multi-Copy Subtelomeric Targets
Natalie Hofmann; Felista Mwingira; Seif Shekalaghe; Leanne J. Robinson; Ivo Müeller; Ingrid Felger · 2015 · PLoS Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be identified by surveillance with molecular methods, yet these infections also contribute to onward transmission to mosquitoes. The sensitivity of molecular detection by PCR is limited by the abundance of the target sequence in a DNA sample; thus, detection becomes imperfect at low densities. We aimed to increase PCR diagnostic sensitivity by targeting multi-copy genomic sequences for reliable det
Abstract by Natalie Hofmann; Felista Mwingira; Seif Shekalaghe; Leanne J. Robinson; Ivo Müeller; Ingrid Felger, PLoS Medicine (2015) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pmed.1001788