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WASTE Journal

Browse the failure-mode index

12,260 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Association of QTc Dispersion with Mortality, Intensive Care Unit Admission, Intubation, and Hospital Stay Duration in Acute Methadone Poisoning.

Taherkhani A, Yeganegi H, Tavasol A et al. · 2026 · Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir

Objective The objective of this study is to investigate the prognostic significance of QTc dispersion (QTcd) in patients with acute methadone poisoning and its association with critical clinical outcomes, including mortality, Intensive…

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Negative / Null Result ReportMedicine

Systematic reexamination of early verb dominance: Verbal and nonverbal characteristics of caregiver input and their contribution to long-term language outcomes.

Kim M, Mun J, Kim G et al. · 2026 · Developmental psychology

Early language input to infants varies in lexical composition across languages and contexts. For instance, American-English input emphasizes nouns more than verbs, while Mandarin Chinese and Korean inputs provide more verbs than nouns, the…

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Negative / Null Result ReportMedicine

Social attunement and alcohol use: The role of age and gender.

Romein C, Colyer-Patel K, Kroon E et al. · 2026 · Addictive behaviors

Background Alcohol use typically peaks during adolescence and early adulthood, when its social reinforcement value is high, and then decreases as individuals take on more adult-like responsibilities. The present study investigates whether…

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Negative / Null Result ReportMedicine

Personality profiles and trauma history in ketamine therapy for mood and anxiety disorders: A latent profile analysis of short-term outcomes.

Gregoire N, Klukas E, Kaseweter K et al. · 2025 · Psychopharmacology

Rationale Ketamine-assisted therapy is emerging as a fast-acting intervention for treatment-resistant depression and anxiety. However, individual response to treatment varies, and little is known about how personality traits and trauma…

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Negative / Null Result ReportMedicine

Intravenous Bolus Fluid Therapy Versus No Fluid Therapy Prior to Pericardiocentesis in Dogs: A Randomized Controlled Trial in 30 Dogs.

Jones N, Humm K, Tinson EW · 2026 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

Objective To determine the cardiovascular and respiratory effects of bolus IV isotonic crystalloid fluid therapy before pericardiocentesis in dogs with pericardial effusion. Design Prospective, randomized, nonblinded clinical trial…

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Negative / Null Result ReportMedicine

Hemolysis and Acute Kidney Injury Following Cardiac Surgery With Cardiopulmonary Bypass in Patients With Preexisting Renal Dysfunction.

Volleman C, Phelp PG, Dubelaar DPC et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives Acute kidney injury (AKI) is a common complication following cardiac surgery with cardiopulmonary bypass (CPB). This study investigated whether cell-free hemoglobin (CFHb) levels after CPB are associated with endothelial damage…

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Negative / Null Result ReportMedicine

How Do Sex and Family SES Influence the Relation Between School Well-Being and Academic Domains? A Multi-Group Cross-Lagged Panel Analysis from Fifth To Eighth Grade.

Rémeau M, Raffy G, Borst G · 2026 · Journal of youth and adolescence

Although the association between academic achievement and well-being has been widely studied in cross-sectional and correlational studies, prior research has rarely clarified the directionality of these links by adopting a longitudinal…

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Negative / Null Result ReportMedicine

Relative influence of paraspinal muscularity and underlying bone quality on proximal junctional kyphosis and failure mode in patients undergoing thoracolumbar instrumented fusion.

Pennington Z, Mikula AL, Hamouda A et al. · 2026 · Clinical neurology and neurosurgery

Objective To assess paraspinal muscularity and bone quality contribution to PJK risk. Methods Defining PJK as ≥ 10° increase in proximal junctional angle from first upright radiograph, thoracolumbopelvic fusion patients experiencing PJK…

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Negative / Null Result ReportMedicine

Baseline electrophysiological markers of reward and error processing are associated with improved outcomes in prize-based contingency management.

Forster SE, Forman SD, Dickey MW et al. · 2026 · Drug and alcohol dependence

Background Veterans are disproportionately affected by cocaine use disorder (CUD), a condition without approved pharmacotherapies, marked by high return to use rates. Prize-Based Contingency Management (PBCM) is an effective behavioral…

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Negative / Null Result ReportMedicine

Longitudinal Associations between Mattering Dimensions and Loneliness in Adolescents: Bidirectional Effects at between- and Within-Person Levels.

Li HM, Flett GL, Cao CH et al. · 2026 · Journal of youth and adolescence

Although cross-sectional research links mattering to reduced adolescent loneliness, longitudinal studies examining temporal dynamics and distinctions between analytical levels or mattering dimensions are scarce. Without understanding…

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Negative / Null Result ReportMedicine

Harnessing Fear and Promoting Self-Efficacy in Response to Mass Casualty Scenarios: Evaluating Stop the Bleed at an Urban University.

Tong ST, Phillips K, Gomez J et al. · 2026 · Journal of prevention (2022)

Emergency situations range from everyday traffic accidents to incidents of mass gun violence and require individuals to be prepared and willing to act in times of crisis. To encourage people to help one another during such emergencies, the…

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Negative / Null Result ReportMedicine

Persistence of pulmonary hypertension in patients with ventricular septal defect after intracardiac repair: insights from a long-term follow-up study.

Wakisaka Y, Inai K, Harada G et al. · 2025 · Cardiology in the young

Background Ventricular septal defect is the most common CHD and is complicated by pulmonary hypertension in about 5% of cases. Although long-term outcomes after repair are generally good, persistent pulmonary hypertension has been…

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Negative / Null Result ReportMedicine

Subjective well-being mediates the longitudinal effect of insomnia symptoms on internalizing symptoms in community-dwelling older adults.

Ying Y, Meng R, Xu J et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives The associations between insomnia symptoms and internalizing symptoms are well-established, particularly in older adults; however, the mediating factors remain inconsistent. This study seeks to explore the longitudinal…

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Negative / Null Result ReportMedicine

Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.

Zhou DD, Lord SJ, Lin FP et al. · 2026 · Lung cancer (Amsterdam, Netherlands)

Background In NSCLC, TP53 mutations are heterogeneous with varied effects on protein synthesis, function and clinical outcomes. We hypothesize that a refined classification of TP53 mutations, beyond binary categorization, could improve…

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Negative / Null Result ReportMedicine

Computed Tomography Measurement of Optic Nerve Sheath Diameter in Thrombolysis-Treated Ischemic Stroke: Association with Post-Thrombolytic Intracranial Hemorrhage.

Coşkun Yaş S, Üçöz Kocaşaban D, Güler S et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Optic nerve sheath diameter (ONSD) measurement is a non-invasive marker of intracranial pressure. Its role in predicting post-thrombolytic intracranial hemorrhage in acute ischemic stroke patients remains unclear. This study aimed to…

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Negative / Null Result ReportMedicine

Survival implications of computed tomography-derived muscle mass changes in patients with epithelial ovarian cancer undergoing bowel surgery.

Kim J, Lee YY, Kim TJ et al. · 2026 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Objective Sarcopenia is a known adverse prognostic factor in gastrointestinal cancers undergoing bowel resection; however, its prognostic relevance in epithelial ovarian cancer remains unclear. This study aimed to evaluate the prognostic…

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