Negative / Null Result ReportOpen accessMedicine
Salah Uddin Khan, Henrik Salje, Abu Sayeed Md. Abdul Hannan et al. · 2014 · PLoS neglected tropical diseases
BACKGROUND: Japanese encephalitis (JE) virus infection can cause severe disease in humans, resulting in death or permanent neurologic deficits among survivors. Studies indicate that the incidence of JE is high in northwestern Bangladesh. Pigs are amplifying hosts for JE virus (JEV) and a potentially important source of virus in the environment. The objectives of this study were to describe the transmission dynamics of JEV among pigs in northwestern Bangladesh and estimate the potential impact of vaccination to reduce incidence among pigs. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a comprehe
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Sumit K. Subudhi, Bilal A. Siddiqui, Ana M. Aparicio et al. · 2021 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Immune checkpoint therapy (ICT) has low response rates in patients with metastatic castration-resistant prostate cancer (mCRPC), in part due to few T cells in the tumor microenvironment (TME). Anti-cytotoxic T…
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Emily N. C. Manoogian, Michael J. Wilkinson, Monica A. O'Neal et al. · 2024 · Annals of Internal Medicine
BACKGROUND: Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits. OBJECTIVE: To determine the effects of TRE as a lifestyle…
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Troy C. Sutton, Elaine W. Lamirande, Kevin W. Bock et al. · 2017 · Journal of Virology
ABSTRACT Influenza viruses of the H1N1, H2N2, and H3N2 subtypes have caused previous pandemics. H2 influenza viruses represent a pandemic threat due to continued circulation in wild birds and limited immunity in the human population. In…
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Gil Awada, Laïla Ben Salama, Jennifer Cremer et al. · 2020 · Journal for ImmunoTherapy of Cancer
BACKGROUND: No treatment demonstrated to improve survival in patients with recurrent glioblastoma (rGB) in a randomized trial. Combining axitinib with the programmed cell death ligand 1 blocking monoclonal antibody avelumab may result in…
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Katja Werlenius, Sara Kinhult, Tora S. Solheim et al. · 2023 · JAMA Network Open
Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized phase II/III clinical trial with parallel group design. Patients were recruited at 7 study sites in Sweden and 2 sites in Norway between January 2017 and November 2020. Eligible patients were 18 years
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Simone Baldi, Marta Menicatti, Giulia Nannini et al. · 2021 · Nutrients
Altered circulating levels of free fatty acids (FFAs), namely short chain fatty acids (SCFAs), medium chain fatty acids (MCFAs), and long chain fatty acids (LCFAs), are associated with metabolic, gastrointestinal, and malignant diseases. Hence, we compared the serum FFA profile of patients with celiac disease (CD), adenomatous polyposis (AP), and colorectal cancer (CRC) to healthy controls (HC). We enrolled 44 patients (19 CRC, 9 AP, 16 CD) and 16 HC. We performed a quantitative FFA evaluation with the gas chromatography-mass spectrometry method (GC-MS), and we performed Dirichlet-multinomial
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Tom Koeman, Pauline Slottje, Leo J. Schouten et al. · 2017 · Occupational and Environmental Medicine
OBJECTIVE: To prospectively study suspected occupational risk factors for amyotrophic lateral sclerosis (ALS). METHODS: For this case-cohort analysis within the prospective Netherlands Cohort Study, 58 279 men and 62 573 women aged 55-69…
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Yoshimasa Miyagawa, Kazuhiro Araki, Ayako Bun et al. · 2018 · Clinical Breast Cancer
INTRODUCTION: Although eribulin and nab-paclitaxel are chemotherapy agents widely used for locally advanced or metastatic breast cancer (MBC), their predictive factors remain unknown. Because the absolute neutrophil-to-lymphocyte ratio…
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Sae‐Won Han, Hyun‐Jung Lee, Jeong Mo Bae et al. · 2012 · International Journal of Cancer
The prognostic impact of CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the treatment outcome of colon cancer patients receiving adjuvant 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) is unclear. We…
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Ann M. Farese, Cassandra R. Brown, Cassandra P. Smith et al. · 2013 · Health Physics
The identification of the optimal administration schedule for an effective medical countermeasure is critical for the effective treatment of individuals exposed to potentially lethal doses of radiation. The efficacy of filgrastim…
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Kevin J. McHale, Joshua C. Rozell, Andrew H. Milby et al. · 2016 · The American Journal of Sports Medicine
BACKGROUND: Tarsometatarsal (Lisfranc) joint injuries commonly occur in National Football League (NFL) competition; however, the career effect of these injuries is unknown. PURPOSE: To define the time to return to competition for NFL…
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Hyehyun Jeong, Kyu‐pyo Kim, Jae Ho Jeong et al. · 2023 · Hepatology
BACKGROUND AND AIMS: The effectiveness of gemcitabine-based adjuvant chemotherapy is unclear in cholangiocarcinoma. We investigated the role of adjuvant gemcitabine plus cisplatin (GemCis) in a homogeneous group of high-risk patients with…
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Shigeyuki Tamura, Atsushi Takeno, Hirofumi Miki · 2011 · International Journal of Surgical Oncology
Gastric cancer is one of the most common causes of cancer-related death worldwide. Surgical resection with lymph node dissection is the only potentially curative therapy for gastric cancer. However, the appropriate extent of lymph node dissection accompanied by gastrectomy for cancer remains controversial. In East Asian countries, especially in Japan and Korea, D2 lymph node dissection has been regularly performed as a standard procedure. In Western countries, surgeons perform gastrectomy with D1 dissection only because D2 is associated with high mortality and morbidity compared to those assoc
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Shoji Kawakami, Yoshio Tahara, Teruo Noguchi et al. · 2016 · Circulation Journal
BACKGROUND: Prehospital ECG improves survival following ST-segment elevation myocardial infarction (STEMI). Although a new International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment…
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Yong‐Hao Pua, Hakmook Kang, Julian Thumboo et al. · 2019 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Machine-learning methods are flexible prediction algorithms with potential advantages over conventional regression. This study aimed to use machine learning methods to predict post-total knee arthroplasty (TKA) walking limitation,…
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Juliana C.N. Chan, Béatrice Sauvé, Sonya Tokmakejian et al. · 2014 · Experimental and Clinical Endocrinology & Diabetes
OBJECTIVE: Hair analysis has been demonstrated to accurately reflect exposure to drug abuse, environmental toxins and exogenous hormones. We tested the feasibility of measuring cortisol and testosterone in hair of healthy and obese…
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Kristi McIntyre, Joyce O’Shaughnessy, Lee S. Schwartzberg et al. · 2014 · Breast Cancer Research and Treatment
Eribulin mesylate, a novel non-taxane microtubule dynamics inhibitor, is approved for treatment of metastatic breast cancer (MBC) in patients who have previously received at least 2 chemotherapeutic regimens for MBC that should have…
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Pras Pathmanathan, Gary R. Mirams, James Southern et al. · 2011 · International Journal for Numerical Methods in Biomedical Engineering
Abstract Finite element (FE) cardiac electro‐physiology solvers commonly have ionic current determined at mesh nodes but required element interiors. We consider two interpolation approaches: (i) ionic current interpolation (ICI), where nodal ionic currents are linearly interpolated into the element and (ii) state variable interpolation (SVI), where cell model state variables are interpolated instead, from which the ionic current is evaluated. We explain why SVI leads to a method which is massively more computationally demanding than ICI (more than might originally be expected), and then demons
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Marco Colombo, Stuart J. McGurnaghan, Luke A. K. Blackbourn et al. · 2020 · Diabetologia
Abstract Aims/hypothesis We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression in type 1 diabetes beyond prior eGFR, comparing their performance with urinary albumin/creatinine ratio (ACR). Methods From the population-representative Scottish Diabetes Research Network Type 1 Bioresource (SDRNT1BIO) we sampled 50% and 25% of those with starting eGFR below and above 75 ml min −1 [1.73 m] −2 , respectively ( N = 1629), and with median 5.1 years of follow-up. Multiplexed ELISAs and single molecule array technology were used to measure nin
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David J. Cohen, Tara A. Lavelle, Ben van Hout et al. · 2011 · Catheterization and Cardiovascular Interventions
OBJECTIVES: To evaluate the cost-effectiveness of alternative approaches to revascularization for patients with three-vessel or left main coronary artery disease (CAD). BACKGROUND: Previous studies have demonstrated that, despite higher…
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Abhishek Mathur, Sharona Ross, Kenneth Luberice et al. · 2014 · The American Surgeon
Negative margins are the goal with pancreaticoduodenectomy for pancreatic adenocarcinoma. Thereby, margins are assessed intraoperatively with frozen section analysis and negative margins are pursued. This study was undertaken to determine…
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Wen-Shan Wu, Li-Ru Chen, Kuo-Hu Chen · 2025 · International Journal of Molecular Sciences
Platelet-rich plasma (PRP) is an autologous blood-derived concentrate increasingly utilized in regenerative medicine for its ability to accelerate healing and tissue repair. PRP is broadly classified by leukocyte content, fibrin architecture, and platelet concentration, with classification systems developed to standardize characterization. Preparation methods, including single- or double-spin centrifugation and buffy coat techniques, influence the final composition of PRP, determining the relative proportions of platelets, leukocytes, plasma proteins, and extracellular vesicles. These componen
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Nicole M. Warrington, Rebecca C. Richmond, Bjarke Fenstra et al. · 2017 · International Journal of Obesity
BACKGROUND: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. PARTICIPANTS AND METHODS: A genome-wide association study was used to
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Andrew Poppe, Deanna M. Barch, Cameron S. Carter et al. · 2016 · Schizophrenia Bulletin
Patients with schizophrenia (SZ) previously demonstrated specific deficits in an executive function known as goal maintenance, associated with reduced middle frontal gyrus (MFG) activity. This study aimed to validate a new tool-the Dot…
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Clarissa S. Whiting, Wouter Hoogkamer, Rodger Kram · 2021 · Journal of sport and health science/Journal of Sport and Health Science
BACKGROUND: Compared to conventional racing shoes, Nike Vaporfly 4% running shoes reduce the metabolic cost of level treadmill running by 4%. The reduction is attributed to their lightweight, highly compliant, and resilient midsole foam…
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Sanjay Yadla, George M. Ghobrial, Peter G. Campbell et al. · 2015 · Journal of Neurosurgery Spine
OBJECT: Complications after spine surgery have an impact on overall outcome and health care expenditures. The increased cost of complications is due in part to associated prolonged hospital stays. The authors propose that certain…
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Seulkee Lee, Seonyoung Kang, Yeonghee Eun et al. · 2021 · Arthritis Research & Therapy
BACKGROUND: Few studies on rheumatoid arthritis (RA) have generated machine learning models to predict biologic disease-modifying antirheumatic drugs (bDMARDs) responses; however, these studies included insufficient analysis on important features. Moreover, machine learning is yet to be used to predict bDMARD responses in ankylosing spondylitis (AS). Thus, in this study, machine learning was used to predict such responses in RA and AS patients. METHODS: Data were retrieved from the Korean College of Rheumatology Biologics therapy (KOBIO) registry. The number of RA and AS patients in the traini
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Elaine Ku, Dawei Xie, Michael G. Shlipak et al. · 2015 · Journal of the American Society of Nephrology
Measured GFR (mGFR) has long been considered the gold standard measure of kidney function, but recent studies have shown that mGFR is not consistently superior to eGFR in explaining CKD-related comorbidities. The associations between…
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Nicole Armbruster, Annalisa Lattanzi, M. Jeavons et al. · 2016 · Molecular Therapy — Methods & Clinical Development
Spinal muscular atrophy (SMA) is an autosomal recessive disease of variable severity caused by mutations in the SMN1 gene. Deficiency of the ubiquitous SMN function results in spinal cord α-motor neuron degeneration and proximal muscle…
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