12,260 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Ohlsen SM, Pirkle SB, Yang J et al. · 2026 · JSES reviews, reports, and techniques
Background Machine learning, a subset of artificial intelligence, enables large language models (LLMs) like ChatGPT and Gemini to analyze data, learn from context, and generate responses without explicit programming. While machine learning…
View details →Qiu K, Hang Y, Lv P et al. · 2025 · Translational stroke research
To evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) is more effective than BMM alone in treating mild stroke patients (National Institutes of Health Stroke Scale score pri ) group and the primary…
View details →Wu Y, Xu Y, Bi Z et al. · 2025 · Journal of oral rehabilitation
Background Previous studies have linked sleep quality to temporomandibular joint disorders (TMD), suggesting a role for snoring in this association. However, the directionality of this relationship remains a subject of debate. This…
View details →Yepes Gómez D, Moreno-Bedoya S, Lohle-Rueda S et al. · 2026 · Frontiers in nephrology
Background Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and carries high short-term mortality despite timely antimicrobials and organ support. Adsorptive hemofilters such as the oXiris ® membrane have…
View details →Baumeister A, Schuurmans L, Schultz J et al. · 2025 · Behaviour research and therapy
Background and aim The efficacy of internet-based interventions (IBI) for various psychiatric disorders is widely established, but little is known about the mechanisms or possible influencing factors. One of the most prominent problems in…
View details →Zhan S, Zhang D, Ou Y · 2026 · Frontiers in psychology
Trauma-related distress in adult women often extends beyond posttraumatic stress disorder (PTSD) to include depressive symptoms and dissociation, yet the roles of mindfulness and self-compassion across these symptom domains remain…
View details →Kurimoto M, Nawashiro T, Nagakura M et al. · 2025 · The Journal of craniofacial surgery
Craniosynostosis limits normal cranial growth, significantly affecting the growth and development of children. This increase in intracranial pressure results in significant cosmetic and functional losses. This study investigated the…
View details →Mao J, Gan Y, Tan X et al. · 2025 · International journal of women's health
Objective High basophil count levels are associated with an increased risk of gestational diabetes mellitus (GDM). We used two-sample Mendelian randomisation (MR) to explore a potential causal relationship. It also aims to offer genetic…
View details →Killer HE, Pircher A, Stekhoven DJ · 2026 · Ophthalmology and therapy
Introduction The Collaborative Normal-Tension Glaucoma Study (CNTGS) is frequently cited as evidence that a 30% reduction in intraocular pressure (IOP) slows progression in normal-tension glaucoma (NTG). This study re-examines the…
View details →Yang Z, Su Q, Gao J et al. · 2026 · Acta psychologica
Scholars have emphasized the need for longitudinal research to investigate the reciprocal influence of personal belief in a just world (PBJW) and aggressiveness, yet such investigations remain limited. The current study aimed to examine…
View details →Zheng H, Chen W · 2026 · Frontiers in pediatrics
Background and aims Exclusive enteral nutrition is an established induction therapy for pediatric Crohn's disease, but biochemical response varies across patients. We assessed whether baseline gut microbiome features were associated with…
View details →Che Y, Yuan J, Guo J · 2025 · Archives of dermatological research
Observational studies have shown that the risk of developing herpes zoster (HZ) increases with the use of statins. However, there are many confounding factors in observational studies. Therefore, our Mendelian randomization (MR) study…
View details →Tu Y, Xie D, Qian H · 2025 · Medicine
Observational studies have suggested associations between circulating creatine kinase (CK) levels and gastric cancer (GC), yet causality remains uncertain. To evaluate whether genetically predicted CK levels are causally related to GC…
View details →van Lennep JPA, van Middendorp H, Leong OV et al. · 2025 · Scandinavian journal of pain
Objectives To understand how different individuals respond to placebo effects, it is relevant to disentangle the influence of someone's personality and genetic variations. The aim of this exploratory study was to investigate the role of…
View details →Salehi-Reyhani SM, Saadat M · 2024 · Molecular biology reports
Background It is well known that telomerase activity is suppressed in normal human tissues and reactivated in tumors, suggesting that the human telomerase reverse transcriptase (hTERT, MIM: 187270) gene may be involved in carcinogenesis. A…
View details →Naito R, Hiwa R, Inaba R et al. · 2025 · Modern rheumatology case reports
Vesiculobullous dermatomyositis (VD) is a rare manifestation of dermatomyositis (DM) and has been suggested to be associated with malignancy. Although the myositis-specific autoantibodies are associated with distinct clinical presentations…
View details →O'Connor LE, Thoerig RC, Leta CN et al. · 2026 · Advances in nutrition (Bethesda, Md.)
Infants may be exposed to contaminants from environmental and food sources, including human milk (HM) or infant formula (IF). The objective of this series of systematic reviews (PROSPERO: CRD42024530332, CRD42024530336, CRD42024530339, and…
View details →Coello K, Stanislaus S, Forman JL et al. · 2025 · Free radical biology & medicine
Aims Increased oxidative stress-generated tissue damage seems to play a pivotal role in the pathophysiology and progression of bipolar disorder (BD). Malondialdehyde (MDA), a product of lipid oxidation, may represent a trait marker in BD…
View details →Wade TD, Jabs M, Keegan E et al. · 2024 · The International journal of eating disorders
Objective We examine the small amount of research to date that describes and/or evaluates waitlist interventions as a precursor to treatment for an eating disorder (ED) with the intent to provide recommendations for future research that…
View details →Contente J, Ferreira C, Silva M et al. · 2025 · Journal of bone and joint infection
Introduction : Debridement, antibiotics, and implant retention (DAIR) is recommended for early acute postoperative and late acute periprosthetic joint infections (PJIs). The KLIC and CRIME-80 scores have been proposed to predict DAIR…
View details →Li MS, Wu XQ, Zhou YJ et al. · 2024 · Ying yong sheng tai xue bao = The journal of applied ecology
Species range size is closely related to its ability to migrate and adapt to environmental change. Rapoport's rule predicts that species range size would become larger with increasing latitude or elevation. Empirical evidence for…
View details →Rodriguez-Merchan EC · 2025 · The archives of bone and joint surgery
Periarticular multimodal drug injection (PMDI) is better than FNB (femoral nerve block) in pain relief after total knee arthroplasty (TKA). PMDI of bupivacaine [20 mL 0.5% bupivacaine hydrochloride - HCl (100 mg) following implantation…
View details →Weger HG, Polasek AK, Wright DM et al. · 2024 · The Journal of eukaryotic microbiology
Twenty species/isolates of cyanobacteria and green algae were isolated from cyanobacterial bloom samples in lakes associated with the upper Qu'Appelle River drainage system in southern Saskatchewan, Canada. Three amoebae species…
View details →Wiesenthal J, Schredl M · 2026 · Journal of sleep research
Although about 5% of the German population report having nightmares at least once a week, nightmares are inadequately diagnosed and treated. We therefore examined how people in the general population cope with nightmares in everyday life.…
View details →Stark BC, Alexander JM, Stockrahm E et al. · 2026 · American journal of speech-language pathology
Purpose This study examined the role of inner speech-defined here as the subjective experience of covert lexical access-in naming recovery following semantic feature analysis (SFA) treatment in individuals with aphasia. Specifically, it…
View details →Ercan P, Firlatan Yazgan B, Sendur SN et al. · 2026 · Pituitary
Purpose Long-term renal consequences of acromegaly remain poorly characterized. We assessed prevalence and independent predictors of renal cysts, chronic kidney disease (CKD), and the frequency of urinary-system malignancies, in a large…
View details →Swaid TK, Hamzeh LR, Bukasa LL et al. · 2026 · Intestinal research
Background/aims To determine time to diagnosis (TTD) and its impact on surgery and advanced therapy (AT) burden in inflammatory bowel disease (IBD) in a multi-ethnic United Arab Emirates (UAE) cohort, a region in the acceleration phase of…
View details →Hajibandeh S, Hajibandeh S, Mckittrick H et al. · 2026 · World journal of gastrointestinal surgery
Background Early skeletal muscle wasting has been demonstrated to be associated with chemotherapy-related toxicity in patients with cancer. Hounsfield unit average calculation (HUAC) or psoas muscle index (PMI) can be used to diagnose…
View details →Derégnaucourt S, Le Maguer L, Geberzahn N · 2026 · Animal cognition
Vocal learning in songbirds requires the integration of auditory perception, sensorimotor learning, and performance monitoring, yet its relationship to general cognitive abilities remains unclear. We tested whether interindividual…
View details →Guan M, Yang Q, Carey P et al. · 2026 · Health communication
Despite its significant implications for public health and individual decision-making, research on information avoidance remains limited. In this study, we applied and extended the model of planned risk information avoidance (PRIA) to…
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