Voxel-wise case-control analysis of dose, linear energy transfer and symptomatic brainstem necrosis in pediatric brain tumors treated with proton therapy.
Handeland AH; Indelicato DJ; Engeseth GM; Fjæra LF; Grewal HS; Ytre-Hauge KS; Muren LP; Lassen-Ramshad Y · 2026 · International journal of radiation oncology, biology, physics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Introduction Brainstem necrosis is a rare but serious toxicity following radiotherapy for pediatric brain tumors. In proton therapy (PT), concerns have emerged around elevated linear energy transfer (LET) and the relative biological…
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Metadata source: Europe PMC · DOI 10.1016/j.ijrobp.2026.05.054