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WASTE Journal

Browse the failure-mode index

12,254 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Adding free leucine to a balanced essential amino acid mixture suppresses intracellular transamination of isoleucine and valine in healthy older adults.

Knezek SB, Engelen MPKJ, Coyle KS et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)

Background Adding leucine (LEU) to protein meals enhances protein anabolism, but excess LEU reduces valine (VAL) and isoleucine (ILE) plasma concentrations. We examined in older adults whether additional LEU added to an essential amino…

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Negative / Null Result ReportMedicine

Zinc deficiency is associated with erythropoietin-stimulating agents hyporesponsive anemia in peritoneal dialysis patients: a cross-sectional study.

Kuwahara F, Harada K, Nagata M et al. · 2026 · Clinical and experimental nephrology

Background Zinc deficiency is widely recognized as a cause of anemia, but no studies have clarified the impact of zinc deficiency on achieving target hemoglobin levels in patients undergoing peritoneal dialysis (PD) and receiving high-dose…

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Negative / Null Result ReportMedicine

Risk factors for asseptic loosening after revision total knee replacement (rTKR): a component-specific analysis of femoral and tibial reconstruction.

Souto CS, Pereira F, Carvalho A et al. · 2026 · The Knee

Background Revision total knee arthroplasty (rTKA) remains a technically demanding procedure, with re-revision representing a major clinical challenge. The role of reconstruction strategies, particularly the use of augments and metaphyseal…

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Negative / Null Result ReportMedicine

Similar Outcomes in Proximal Humerus Fractures Treated With Conventus Intramedullary Cage Device and Open Reduction Internal Fixation.

Kurkowski SC, Taleghani ER, McMillan P et al. · 2026 · Journal of orthopaedic trauma

Objectives To compare clinical outcomes between open reduction and internal fixation (ORIF) with or without Conventus intramedullary cage (CC) for proximal humerus fractures. Methods Design Retrospective cohort study. Setting Level 1…

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Negative / Null Result ReportMedicine

A comparative experimental study on the impact of radiotherapy dose rate and melatonin pretreatment in tongue and esophageal tissues.

Hacımustafaoğlu F, Aras S, Çaykara Peran B et al. · 2026 · International journal of radiation biology

Aim This study aimed to investigate the differential biological responses in tongue and esophageal tissues induced by flattening filter (FF) and flattening filter-free (FFF) beams at varying dose rates, and to assess the radioprotective…

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Negative / Null Result ReportMedicine

Contralateral vs. ipsilateral hemilaminectomy for spinal meningiomas: impact on resection completeness, stability, and recurrence.

Yavuz AY, Can F, Avci İ et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Aim Spinal meningiomas (SMs) account for approximately 25-40% of intradural extramedullary spinal tumors [1]. The classical symptomatology typically begins with pain, followed by motor and/or sensory deficits, gait disturbances, and…

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Negative / Null Result ReportMedicine

Data-Driven Discovery of Plant-Based Dietary Subtypes and Their Association with Cancer, Cardiovascular diseases, and Type 2 diabetes in Postmenopausal Women: Insights from the Women's Health Initiative.

Moosavi D, Nejati N, Arcan C et al. · 2026 · Journal of the Academy of Nutrition and Dietetics

Background Plant-based diets have been associated with lower risks of chronic diseases; however, not all plant-based diets confer equal health benefits. Data-driven methods provide an opportunity to empirically identify distinct…

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Negative / Null Result ReportMedicine

Early outcomes of facilitated transfemoral versus alternative access for transcatheter aortic valve replacement in patients with peripheral arterial disease.

Mustafa A, Wang D, Dutton C et al. · 2026 · The Journal of invasive cardiology

Objectives Transfemoral (TF) access for transcatheter aortic valve replacement (TAVR) may be challenging in patients with peripheral arterial disease (PAD). Alternative access through intra- and extrathoracic approaches can be performed.…

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Negative / Null Result ReportOpen accessMedicine

Predictors of <i>Candida auris</i> Infection in Previously Colonized Patients: A Retrospective Cohort Study from a Large Tertiary Reference Center.

Ergün N, Karabulut SS, Türken M et al. · 2026 · Journal of fungi (Basel, Switzerland)

Candida auris is a multidrug-resistant fungal pathogen associated with high mortality in healthcare settings. Although colonization is recognized as the harbinger of invasive infection, predicting which patients will develop bloodstream…

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Negative / Null Result ReportOpen accessMedicine

Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis: A Retrospective Cohort Study.

Abid H, Khan Y, Khan N et al. · 2026 · Journal of clinical medicine

Background: Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) were historically considered contraindicated in severe aortic stenosis (AS) due to theoretical haemodynamic risks. Contemporary evidence…

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Negative / Null Result ReportMedicine

Art v 3 sensitization is associated with increased immunological complexity but not clinical severity in lipid transfer protein syndrome.

Carbonell Martínez A · 2026 · European annals of allergy and clinical immunology

Summary Background. Lipid transfer protein (LTP)-mediated food allergy represents one of the most severe and heterogeneous forms of IgE-mediated food allergy in Mediterranean populations. Although Pru p 3 is the main marker of LTP…

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Negative / Null Result ReportMedicine

Surface Texture of Taste Carriers Modulates Bitter Taste Identification.

Brothánková P, Faitlová H, Sitina M et al. · 2026 · ORL; journal for oto-rhino-laryngology and its related specialties

Aim The aim of this study was to assess the relationship between texture and the correct identification of gustatory stimuli (sweet, salty, bitter, and sour) in both healthy participants and patients with taste disorders. Patients and…

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Negative / Null Result ReportMedicine

Fostering a Reflecting Processing of the Academic Crisis: The Effectiveness of Group Counselling for Underachieving University Students.

Esposito G, Passeggia R, Cannata A et al. · 2026 · Healthcare (Basel, Switzerland)

Background: University counselling services provide essential support for students navigating critical academic phases. These services have proven to be successful in promoting long-term psychological well-being and student retention.…

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Negative / Null Result ReportOpen accessMedicine

Comparison of the Effects of Intraoperative Dexmedetomidine and Fentanyl Infusion on Postoperative Agitation and Analgesia in Pediatric Patients Undergoing Tonsillectomy and Adenoidectomy: A Prospective Randomized Trial.

Gul YG, Yildiz S, Güngör H et al. · 2026 · Children (Basel, Switzerland)

Background/Objectives: Postoperative agitation (PA) and postoperative pain in pediatric patients following sevoflurane anesthesia are challenging clinical scenarios. This study aimed to evaluate the effects of intraoperative…

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Negative / Null Result ReportOpen accessMedicine

Subfoveal Choroidal Thickness in Clinically Significant Pseudophakic Cystoid Macular Edema: An Interocular Comparison with Contralateral Pseudophakic Eyes.

Demir K, Çelik E · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose To evaluate subfoveal choroidal thickness (SCT) in eyes with clinically significant pseudophakic cystoid macular edema (PCME) and compare it with the contralateral pseudophakic eyes that underwent uncomplicated cataract surgery…

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Negative / Null Result ReportMedicine

Are In-Home and Foster Care Services Associated With Risk of Maltreatment-Related Fatality and Near Fatality Following a Child Protection Case? Evidence From Pennsylvania.

Jones DM, Connell CM, Font SA · 2026 · Child maltreatment

Many children who experience child maltreatment fatalities (CMF) or near fatalities (CMNF) are previously known to the child welfare system (CWS). Although in-home services and foster care (FC) are tools for preventing CMF/CMNF, relatively…

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