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WASTE Journal

Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Eight weeks of high-intensity interval training is insufficient to prevent sitting-induced endothelial dysfunction and microvascular impairment.

Kasai N, Ihara H, Iemitsu M et al. · 2026 · Experimental physiology

Prolonged sitting disrupts lower-limb endothelial and microvascular function, likely via reduced shear stress and blunted microvascular reactivity. We examined whether Tabata-style high-intensity interval training (HIIT) mitigates this…

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Negative / Null Result ReportMedicine

Sexual health following hyperbaric oxygen treatment in pelvic cancer survivors with radiation injuries: a longitudinal observational study.

Hauken MA, Gjestad R, Sekse RJT et al. · 2026 · The journal of sexual medicine

Background Hyperbaric oxygen therapy (HBOT) is an established treatment for pelvic late radiation tissue injuries (LRTIs) in cancer survivors, yet its impact on sexual health outcomes has previously not been examined. Aim To investigate…

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Negative / Null Result ReportMedicine

Long-term risk of major adverse cardiovascular events after carotid endarterectomy-a 9-year prospective cohort study of the Athero-Express biobank.

Mol BM, de Bresser CJM, de Kleijn PV et al. · 2026 · European stroke journal

Carotid endarterectomy (CEA) is performed to lower the long-term risk of stroke in patients with carotid stenosis. Data evaluating long-term outcomes after CEA are scarce, but crucial for accurately determining long-term benefits. We aimed…

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Negative / Null Result ReportMedicine

Efficacy of Aerobic Exercise on Brain MRI Measures in Parkinson's Disease.

Langeskov-Christensen M, Nygaard MKE, Eskildsen SF et al. · 2026 · Neurorehabilitation and neural repair

Objectives Medical disease-modifying treatments are lacking in Parkinson's disease (PD). Physical exercise is potentially an inexpensive and easily accessible disease-modifying therapy, but this remains to be studied using recent promising…

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Negative / Null Result ReportMedicine

Auditory mismatch-negativity predicts response to dorsomedial prefrontal intermittent theta-burst stimulation in major depressive disorder.

Anderson M, Bodén R, Wass CE et al. · 2026 · Journal of affective disorders

Background Impaired plasticity has been implicated in major depressive disorder (MDD), which is reflected in impaired automatic sensory detection as measured using mismatch negativity (MMN). Intermittent theta-burst stimulation (iTBS) is…

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Negative / Null Result ReportOpen accessMedicine

Increased cytokine production capacity and persistent inflammation after achieving remission of Cushing's syndrome.

van Houten P, van de Ven AC, van Herwaarden AE et al. · 2026 · Journal of clinical & translational endocrinology

Endogenous Cushing's syndrome (CS) is characterized by chronic hypercortisolism. After achieving remission, morbidity remains increased and quality of life remains impaired. Moreover, the incidence of inflammatory disorders increases after…

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Negative / Null Result ReportMedicine

Chronic atorvastatin treatment weakens procontractile influence of NADPH oxidase derived ROS in systemic murine arteries.

Shvetsova AA, Zakirjanova GF, Ostapchuk KP et al. · 2026 · Pflugers Archiv : European journal of physiology

The beneficial effects of statins for cardiovascular system were widely described in various pathologies. However, much less is known about the effects of statins in healthy organism, especially in systemic resistance arteries. We aimed to…

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Negative / Null Result ReportMedicine

Testosterone treatment and respiratory medications and exacerbations in people prescribed inhaled corticosteroids: a nationwide cohort study.

Hansen ESH, Håkansson KEJ, Brustad N et al. · 2026 · Respiratory medicine

Background After puberty asthma is more common and often more severe in females, indicating a potential role of sex steroids. Observational and genetic studies suggest that higher testosterone levels are associated with improved lung…

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Negative / Null Result ReportMedicine

Variation in Management of Children With Coccidioidomycosis.

Michienzie C, Galgiani J, Fitzwater SP · 2026 · Pediatrics

Objective Coccidioidomycosis (CM) is not as well described in children as it is in adults. The Kaiser Permanente Southern California (KPSC) system provides care within an endemic region for CM, affording the opportunity to describe the…

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Negative / Null Result ReportMedicine

Evaluating the indirect interaction between glucagon-like peptide-1 receptor agonists and warfarin using real-world data.

Gilbert SJ, Vazquez SR, Gouripeddi R et al. · 2026 · Journal of thrombosis and thrombolysis

Increasing use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) raises concern for interactions with warfarin. Although GLP-1 RAs do not affect warfarin pharmacokinetics, their appetite-reducing effects may decrease vitamin K…

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Negative / Null Result ReportMedicine

The effect of a cardiac rehabilitation program including moderate-intensity continuous exercise training and high-intensity interval exercise training on sarcopenia and myokines in patients with heart failure.

Sönmez M, Alemdaroğlu E, Ata AM et al. · 2026 · Acta cardiologica

Background Cardiac rehabilitation (CR) has been shown to be beneficial in preventing and treating sarcopenia in those with cardiovascular disease. The aim of the study is to compare the effects of high intensity intermittent aerobic…

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Negative / Null Result ReportMedicine

Post-AI uterine lavage and PRP infusion reduce some uterine inflammation parameters but do not improve fertility in jennies inseminated with frozen semen.

Sancler-Silva YFR, Albino MV, Freitas MS et al. · 2026 · Journal of equine veterinary science

Background The use of cryopreserved semen in donkey jennies induces an exacerbated post-insemination uterine inflammatory response, resulting in low fertility rates. Aims/objectives This study aimed to investigate the effects of different…

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Failed Experiment ReportMedicine

Does Adherence Modify Low-Dose Aspirin Effects in Pregnancy? Post Hoc Analysis From a Multi-Centre Trial.

Mwenechanya M, Tembo AM, Chomba E et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology

Objective To evaluate if the effect of low-dose aspirin (LDA) commenced between 6 and 13 weeks of gestational age (GA) on preterm delivery (PTD) is modified by total exposure. Design Post hoc analysis of a randomized controlled trial.…

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Negative / Null Result ReportMedicine

Crystalline Lens Shape During Accommodation in Children.

Pradhan A, Hughes RPJ, Woodman-Pieterse EC et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose To determine how accommodation affects lens shape in myopic and non-myopic children. Methods Participants included 76 non-myopic (spherical equivalent refraction (SER): 0.00 to +1.75 D) and 18 myopic children (SER = -3.50 to -0.75…

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Negative / Null Result ReportMedicine

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury - a pilot study.

Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology

Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…

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Negative / Null Result ReportMedicine

The effect of antihypertensive treatment on longitudinal changes in PLGF and sFlt-1 in women with new onset hypertension in pregnancy.

Tyrell E, Lau KGY, Bednorz M et al. · 2026 · Acta obstetricia et gynecologica Scandinavica

Introduction To assess longitudinal changes in serum sFlt-1 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control ( Material and methods This was a…

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Negative / Null Result ReportMedicine

Self-disclosure to Peers and Changes in Personal Recovery in Community-dwelling People with Mental Disorders: A One-year Longitudinal Study.

Yokoyama K, Shimokihara S, Miyajima R et al. · 2026 · Community mental health journal

This study examined whether overall and domain-specific self-disclosure to peers at baseline was prospectively associated with changes in personal recovery over one-year among community-dwelling adults with mental disorders in Japan. A…

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