12,222 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Weiyi Guo, Li Zhu, Sijun Meng et al. · 2017 · Journal of the American Society of Nephrology
IgA nephropathy (IgAN) is characterized by infections followed by episodic gross hematuria. Deficiency of mannose-binding lectin (MBL) is associated with recurrent infection in many diseases, but controversy exists regarding the role of…
View details →Axel Finckh, Geraldine M Mc Carthy, Anne Madigan et al. · 2014 · Arthritis Research & Therapy
INTRODUCTION: Calcium pyrophosphate deposition (CPPD) may cause severe arthropathy, major joint destruction and treatment options are limited. The aim of this study was to test the therapeutic efficacy of methotrexate (MTX) in chronic or recurrent CPPD arthropathy. METHODS: Patients with CPPD arthropathy were randomized to receive either weekly subcutaneous injections of 15 mg/week of MTX or placebo (PBO) for three months, in a double-blind, crossover randomized controlled trial. Inclusion criteria comprised definite CPPD disease, recurrent arthritis or persistent polyarthritis, and an insuffi
View details →Shannon Rhodes, Janet S. Sinsheimer, Yvette Bordelon et al. · 2010 · Annals of Human Genetics
In the investigation of disease aetiology, the genome-wide association study (GWAS) provides a hypothesis-free investigation of the broader human genome and, as with all scientific investigations, replication is essential to validate any…
View details →Yoshiyuki Suzuki, Katsuyuki Shirai, Kuniyuki Oka et al. · 2010 · Journal of Radiation Research
phosphorylated-Akt (pAkt) plays an important role in tumorigenesis through promotion of cell survival by inhibiting apoptosis and mediating cell proliferation. Higher expression of pAkt has been reported to be associated with an…
View details →Jong‐Min Kim, Soo-Heon Hong, Jong‐Min Kim et al. · 2014 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: The aim of this study was to determine (1) variations in the shape of the proximal, middle, and distal femur in a series of Korean patients who had undergone total knee arthroplasty (TKA), (2) the preoperative relationship between…
View details →Paul B. Perrin, Andrew J. Johnston, Bruce Vogel et al. · 2010 · The Journal of Rehabilitation Research and Development
This study developed and implemented the Transition Assistance Program (TAP) for stroke caregivers. The program is composed of (1) skill development, (2) education, and (3) supportive problem solving. Sixty-one dyads (n = 122)…
View details →Ilker Uçkay, Benjamin Kressmann, Sarah Malacarne et al. · 2018 · BMC Infectious Diseases
BACKGROUND: An adjunctive topical therapy with gentamicin-sponges to systemic antibiotic therapy might improve the healing of infected diabetic foot ulcers (DFUI). METHODS: Single-center, investigator-blinded pilot study, randomizing (1:1) the gentamicin-sponge with systemic antibiotic versus systemic antibiotics alone for patients with DFUI. RESULTS: We included 88 DFUI episodes with 43 patients in the gentamicin-sponge arm and 45 in the control arm. Overall, 64 (64/88; 73%) witnessed total clinical cure, 13 (15%) significant improvement, and 46 (52%) showed total eradication of all pathogens
View details →Darryl Falzarano, David Safronetz, Joseph Prescott et al. · 2015 · Emerging infectious diseases
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.
View details →Ira J. Dunkel, François Doz, Nicholas K. Foreman et al. · 2023 · Neuro-Oncology
BACKGROUND: Therapeutic options are limited in pediatric CNS malignancies. CheckMate 908 (NCT03130959) is an open-label, sequential-arm, phase 1b/2 study investigating nivolumab (NIVO) and NIVO + ipilimumab (IPI) in pediatric patients with…
View details →Mazen Hanna, W.H. Wilson Tang, Boon Wee Teo et al. · 2011 · Congestive Heart Failure
Compared with conventional diuretic (CD) therapy, ultrafiltration (UF) is associated with greater weight loss and fewer re-hospitalizations in patients admitted with decompensated heart failure (HF). Concerns have been raised regarding its…
View details →C. Lennartz, John W. Pickering, Sarah Seiler-Mußler et al. · 2016 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Progression of CKD toward ESRD is heterogeneous. The Kidney Failure Risk Equation (KFRE) was developed to identify CKD patients at high risk of ESRD. We aimed to externally validate KFRE and to test whether the…
View details →Nagla Abdel Karim, James Schuster, Ihab Eldessouki et al. · 2017 · Oncotarget
// Nagla Abdel Karim 1 , James Schuster 2 , Ihab Eldessouki 1 , Ola Gaber 1 , Tariq Namad 3 , Jiang Wang 4 , Changchun Xie 5 and John C. Morris 1 1 Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45219, USA 2 University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA 3 Military Hospital of Mohammed V, Department of Medical Oncology, Quartier Irfane, Rabat 10080, Morocco 4 UC Health University Hospital, Department of Pathology and Laboratory Medicine, Cincinnati, OH 45219, USA 5 Division of Biostatistics and Bioinformatics, Department of Environmental H
View details →John P Grogan, Demitra Tsivos, Laura Smith et al. · 2017 · eLife
Emerging evidence suggests that dopamine may modulate learning and memory with important implications for understanding the neurobiology of memory and future therapeutic targeting. An influential hypothesis posits that dopamine biases reinforcement learning. More recent data also suggest an influence during both consolidation and retrieval. Eighteen Parkinson's disease patients learned through feedback ON or OFF medication, with memory tested 24 hr later ON or OFF medication (4 conditions, within-subjects design with matched healthy control group). Patients OFF medication during learning decre
View details →J. Michael Jumper, Pravin U. Dugel, Sanford Chen et al. · 2018 · Clinical ophthalmology
PURPOSE: To evaluate the efficacy, safety, and injection frequency of vascular endothelial growth factor (VEGF) antagonists in the treatment of macular edema secondary to retinal vein occlusion (RVO) in clinical practice. PATIENTS AND…
View details →Carolyn Tam, Deborah L. O’Connor, Gideon Koren · 2012 · Obstetrics and Gynecology International
There are increasing concerns that exposure to unmetabolized folic acid, which results from folic acid intakes that overwhelm the liver's metabolic capacity, may be associated with adverse effects. In this paper, we examined the folic acid status of women of reproductive age in relation to dietary intake and the effect of folic acid supplementation (1.1 mg or 5 mg). Plasma unmetabolized folic acid was not significantly correlated with folate intake estimated by food frequency questionnaire or biomarkers. The proportion of women with detectable levels of unmetabolized folic acid increased from
View details →Carolina Barroso, Pedro Carvalho, M.C. Nunes et al. · 2021 · Frontiers in Immunology
The current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeutic agents, with vaccines being available for a limited number of fish species and pathogens. Antimicrobial peptides are considered as promising novel substances to be used in aquaculture, due to their antimicrobial and immunomodulatory activities. Hepcidin, the major iron metabolism regulator, is found as a single gene in most mammals, but in certain fish species, including the European sea bass ( Dicentrarchus labrax ), two different hepci
View details →Stefan Buettner, Bas Groot Koerkamp, Aslam Ejaz et al. · 2017 · Journal of Surgical Oncology
INTRODUCTION: While preoperative chemotherapy (pCT) is utilized in many intra-abdominal cancers, the use of pCT among patients with intrahepatic cholangiocarcinoma (ICC) remains ill defined. As such, the objective of the current study was…
View details →Paolo Capodaglio, Shirley A. De Souza, Cinzia Parisio et al. · 2012 · Disability and Rehabilitation
PURPOSE: The 6-Min Walking Test (6MWT) is widely used to measure the performance in various chronic conditions, such as in obese subjects. Reference equations for predicting distance walked during 6MWT specifically in adult obese subjects…
View details →Yang Zhang, Chaoqiang Deng, Qiang Zheng et al. · 2023 · Journal of Thoracic Oncology
INTRODUCTION: We aimed to prospectively evaluate our previously proposed selective mediastinal lymph node (LN) dissection strategy for peripheral clinical T1N0 invasive NSCLC. METHODS: This is a multicenter, prospective clinical trial in…
View details →Yi-Chieh Perng, Zhikang Qian, Anthony R. Fehr et al. · 2011 · Journal of Virology
In this study, we adopted a conditional protein genetic approach to characterize the role of the human cytomegalovirus (HCMV) gene UL79 during virus infection. We constructed ADddUL79, a recombinant HCMV in which the annotated UL79 open…
View details →Benoît Tyl, Meriam Kabbaj, Sara M. Azzam et al. · 2011 · The Journal of Clinical Pharmacology
The effect of bilastine on cardiac repolarization was studied in 30 healthy participants during a multiple-dose, triple-dummy, crossover, thorough QT study that included 5 arms: placebo, active control (400 mg moxifloxacin), bilastine at…
View details →Harri Merisaari, Parisa Movahedi, Ileana Montoya Perez et al. · 2016 · Magnetic Resonance in Medicine
Purpose To evaluate different fitting methods for intravoxel incoherent motion (IVIM) imaging of prostate cancer in the terms of repeatability and Gleason score prediction. Methods Eighty‐one patients with histologically confirmed prostate…
View details →Fabrício Pereira, Alexandra Martini de Oliveira, Breno S. Diniz et al. · 2010 · Archives of Clinical Neuropsychology
The Direct Assessment of Functional Status-Revised (DAFS-R) is an instrument developed to objectively measure functional capacities required for independent living. The objective of this study was to translate and culturally adapt the…
View details →Michael H. Roh, Vickie Y. Jo, Edward B. Stelow et al. · 2010 · American Journal of Clinical Pathology
A fine-needle aspiration sample composed exclusively of Hürthle cells is interpreted as "suspicious for a follicular neoplasm, Hürthle cell type" (SFNHCT). Because some nonneoplastic Hürthle cell proliferations in Hashimoto thyroiditis…
View details →J Kjaergaard, Carsten Bogh Juhl, Peter Lange et al. · 2020 · ERJ Open Research
OBJECTIVES: The aim of this study was to establish whether early pulmonary rehabilitation after severe exacerbation of chronic obstructive pulmonary disease (COPD) reduces mortality and hospital admissions, and increases physical…
View details →Mona Ståhle‐Bäckdahl · 2026 · Acta Dermato Venereologica
The aim of the study was to investigate clinical aspects of pruritus in maintenance hemodialysis patients and to evaluate factors of putative pathogenic importance. 60-65% of the patients in a maintenance hemodialysis program during a…
View details →Florian Thibord, Melissa V. Chan, Ming‐Huei Chen et al. · 2022 · Human Genetics and Genomics Advances
Host genetic variants influence the susceptibility and severity of several infectious diseases, and the discovery of genetic associations with coronavirus disease 2019 (COVID-19) phenotypes could help to develop new therapeutic strategies…
View details →Cheng‐Yu Long, Kun‐Ling Lin, Chin-Ru Shen et al. · 2021 · Scientific Reports
The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wall where mid-urethra locates. Self-reported questionnaires were used to measure pre-treatment, 1 month and 6 months post-treatment symptom severity. Secondary outcomes of sexual function and treatment effect sorted by age were analyzed with valid statistical methods. A-PRP is effe
View details →Vladimir Lazarević, A-S Hörstedt, Bertil Johansson et al. · 2014 · Blood Cancer Journal
The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively…
View details →Lionel A. Marzette, Leon W. Herndon · 2011 · Ophthalmic surgery, lasers & imaging retina
BACKGROUND AND OBJECTIVE: To compare the success and complication rates of patients with glaucoma who had an Ex-PRESS mini glaucoma shunt device implantation (Optonol, Ltd., Neve Ilan, Israel) to those who had conventional trabeculectomy.…
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