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Browse the failure-mode index

12,251 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Insights into the role of common sulfur precursors in hydrothermally synthesized N,S-doped carbon dots: fluorescence modulation <i>via</i> surface oxidation rather than sulfur doping.

Fernandes S, Algarra M, Brandão ATSC et al. · 2026 · Nanoscale

While heteroatom doping is widely used to enhance the fluorescence of carbon dots, the actual mechanism underlying this claimed enhancement remains unclear. Herein, we report a systematic comparison between nitrogen-doped carbon dots…

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Negative / Null Result ReportMedicine

Unresponsive to change: Ectotherms fail to adjust physiology to daily temperature variation.

Gomez Isaza D, Rodgers E · 2026 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Daily temperature fluctuations are a ubiquitous feature of natural environments, yet our understanding of how ectotherms respond to thermal variability remains incomplete. Previous frameworks have predicted that exposure to variable…

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Negative / Null Result ReportMedicine

EncQA: Benchmarking Vision-Language Models on Visual Encodings for Charts.

Mukherjee K, Ren D, Moritz D et al. · 2026 · IEEE transactions on visualization and computer graphics

Multimodal vision-language models (VLMs) continue to achieve ever-improving scores on chart understanding benchmarks. Yet, we find that this progress does not fully capture the breadth of visual reasoning capabilities essential for…

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Negative / Null Result ReportMedicine

Didn't Even Blink: Dissociation, Complex Trauma Exposure and Decreased Startle Reactivity.

D'Andrea W, Freed S, DePierro J et al. · 2024 · Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD)

The startle eyeblink reflex is thought to function as a means of orienting to salient stimuli, and, by proxy, sensitivity to threat cues. The absence or attenuation of this reflex may thus suggest disengagement from one's environment,…

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Negative / Null Result ReportOpen accessMedicine

Maternal systemic iron homeostasis in diabetes-in-pregnancy: A cross-sectional analytical study from a tertiary health care centre of South India.

Thalapalliyil K, Bobby Z, Dorairajan G et al. · 2025 · Saudi medical journal

Objectives To explore whether uniform supplementation causes iron overload among a cohort of South Indian non-anemic pregnant women with diabetes-in-pregnancy (DIP). Methods The study took place between May 2022 and May 2024 and consisted…

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Negative / Null Result ReportOpen accessMedicine

A global perspective on cold wave disasters.

Öcal M · 2025 · Scientific reports

Cold-wave disasters cause substantial loss of life and property, yet their global patterns remain poorly understood in a warming climate. Using EM-DAT records (1951-2023), we quantified cold-wave disaster frequency, mortality, and damages…

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Negative / Null Result ReportOpen accessMedicine

The impact of completion time on the reliability and validity of online electronic questionnaires: a preliminary study of the FABQ and ODI scales.

Bi S, Wang C, Liu H et al. · 2026 · Frontiers in psychology

This study uses secondary analysis of a health survey dataset to explore the impact of completion time on the reliability and validity of online questionnaires. A total of 1,758 chronic low back pain patients recruited online were included…

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Negative / Null Result ReportMedicine

Assessing Perpetrator Responses to Confrontation: Associations with a DARVO-SF and Posttrauma Symptoms in Two Different Populations.

Durland M, Harsey SJ, Freyd JJ · 2026 · Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD)

DARVO (Deny, Attack, Reverse Victim and Offender) is a common tactic used by perpetrators of interpersonal violence to deflect blame and responsibility. Individuals' exposure to perpetrator DARVO has previously been measured using the…

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Negative / Null Result ReportMedicine

Parental knowledge, attitudes, and behaviors toward childhood headache: the impact of parental migraine.

Bayır BRH, Ulutaş C, Nazlı E et al. · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Introduction Headache is one of the most common neurological complaints in children and adolescents. Headache especially migraine in childhood significantly impacts daily life activities, including academic performance, and social…

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Negative / Null Result ReportMedicine

Driving habits and difficulties in people with epilepsy: A survey.

Guillermier L, Sabourdy C, Four E et al. · 2026 · Epilepsy & behavior : E&B

Epilepsy is a neurological condition that can interfere with driving abilities through seizures and cognitive impairments. While legal frameworks often regulate driving eligibility, little is known about how people with epilepsy perceive…

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