Chronic estrogen supplementation in the aging castrated male rat is not associated with renal injury or activation of the renin angiotensin system.
Mallette JH; Crudup BF; Oudomrath Speyrer A; Nabors HM; Willis AT; Rawls AZ; Alexander BT · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
The biological effects of chronic estrogen supplementation on renal function and injury with aging in men are unknown. Using an experimental model of feminizing hormone therapy (FHT) induced by 17β-estradiol (E2) (5 mg/kg sc)…
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Metadata source: Europe PMC · DOI 10.1152/japplphysiol.00052.2026