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Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Greater Emotional and Psychological Well-being Are Associated With Reduced Employee Self-report Illness-Related Absenteeism: A Multi-Industry, Cross-sectional Study Conducted During COVID-19 Pandemic.

Fannin A, Hooley C, Nelson EJ · 2024 · Journal of occupational and environmental medicine

Objective The purpose of this study is to determine the relationship that emotional, psychological, and social well-being has with self-reported illness-related absenteeism. Methods This study examines the relationship between three…

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Negative / Null Result ReportOpen accessMedicine

Impact of Blood Group on Contralateral Suppression of Otoacoustic Emissions, Speech Perception in Noise, and Binaural Integration.

Ponnana S A P, Tauro JP, S NP et al. · 2026 · International archives of otorhinolaryngology

Introduction Understanding the relationship between blood groups (A, B, AB, and O) and auditory functioning can provide valuable insights into individual differences in hearing ability and potential risks for hearing loss. Objective To…

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Negative / Null Result ReportMedicine

Neurocognitive Profile of Avoidant/Restrictive Food Intake Disorder: Cognitive Flexibility, Delay Discounting, and Detail Orientation.

McPherson IK, Dalton AG, Armstrong K et al. · 2026 · The International journal of eating disorders

Objective Neurocognitive deficits are well-documented across psychiatric disorders and may indicate novel treatment targets. However, empirical data on the neurocognitive profile of avoidant/restrictive food intake disorder (ARFID) are…

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Negative / Null Result ReportMedicine

A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats.

Sal-Sarria S, López-Taboada I, González-Pardo H et al. · 2024 · Behavioural brain research

Prolonged consumption of diets high in saturated fat and sugar has been related to obesity and overweight, which in turn are linked to cognitive impairment in both humans and rodents. This has become a current issue, especially in children…

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Negative / Null Result ReportOpen accessMedicine

Neither the number of feature dimensions nor their task relevance necessarily affect interocular grouping in binocular rivalry.

Pedziwiatr MA, Derda M, Bator W et al. · 2026 · Attention, perception & psychophysics

When one eye views half of stimulus A and half of stimulus B, and the other eye views the respective other halves, perception fluctuates. Among percepts reflecting monocular inputs (indicating typical binocular rivalry), percepts of…

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Negative / Null Result ReportMedicine

Is employment status associated with baseline symptoms, engagement, and outcomes in naturalistic psychotherapy? Evaluation in a large community mental health agency.

Jiwani Z, Xie Q, Curtin JJ et al. · 2025 · Psychotherapy (Chicago, Ill.)

Employment status, an essential socioeconomic factor, may be an important driver of disparities in mental health and access to treatment. However, prior research has been inconclusive and utilized broad employment categories. The present…

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Negative / Null Result ReportOpen accessMedicine

Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.

Ahmad R, Zobel G, Hannaford R et al. · 2026 · Brain, behavior, & immunity - health

Adolescent social isolation is a known risk factor for anxiety and depression related disorders, yet its effects on brain-gut communication and potential sex differences remain unclear. We hypothesised that isolation would heighten…

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Negative / Null Result ReportMedicine

Diverse social environments and 10-year all-cause mortality in a cohort of historically excluded racial/ethnic older adults: A latent class analysis of social integration.

Flores M, Boyd SM, O'Neill RM et al. · 2025 · Annals of epidemiology

Purpose The association between social integration and mortality in older adults from historically excluded groups may not align with the patterns observed in predominately white samples. We modeled latent groups of social integration and…

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Negative / Null Result ReportOpen accessMedicine

Crude protein concentration in feedlot cattle growth performance, carcass merit, and nitrogen status of long-fed feedlot steers in response to dietary protein concentrations: a comparison of industry-average and reduced protein diets.

Pittaluga AM, Relling AE · 2026 · Translational animal science

Angus × SimAngus-crossbred steers ( n = 93; body weight [BW] = 342 ± 29 kg) were used in a randomized complete block design to examine the effect of feeding finishing diets with crude protein (CP) contents similar or below industry…

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Negative / Null Result ReportMedicine

Dual-Energy X-Ray Absorptiometry Does Not Confirm Validity of the Craig's Test.

Clark KA, Nielsen S, Heywood T et al. · 2024 · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

The Craig's test is a clinical assessment used to quantify femoral version. The validity of the Craig's test has been called into question due to instances where the test exhibits relatively poor correlation with three-dimensional imaging.…

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Negative / Null Result ReportOpen accessMedicine

Does the number of pages received per hour affect resident productivity?

Mangino A, Stenson BA, Leventhal EL et al. · 2023 · Journal of the American College of Emergency Physicians open

Background Workflow interruptions are common for emergency physicians and are shown to have downstream consequences such as patient dissatisfaction, delay in clinical response, and increase in medical error. However, the impact of passive…

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Negative / Null Result ReportMedicine

Actigraphy-based sleep and muscle sympathetic nerve activity in humans.

Bigalke JA, Greenlund IM, Bigalke JR et al. · 2024 · American journal of physiology. Regulatory, integrative and comparative physiology

Short and insufficient sleep are prevalent and associated with cardiovascular disease, with the sympathetic nervous system as a suspected mediator. The purpose of the present study was to investigate the association between objective,…

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Negative / Null Result ReportMedicine

Food processing according to the NOVA classification is not associated with glycemic index and glycemic load: results from an analysis of 1995 food items.

Basile AJ, Ruiz-Tejada A, Mohr AE et al. · 2024 · The American journal of clinical nutrition

Background Ultraprocessed foods (UPFs) comprise most calories in the United States diet. Glycemic index (GI) and glycemic load (GL) are measures of the quality and quantity of carbohydrates in food based on their effect on postprandial…

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Negative / Null Result ReportMedicine

Daily exposure to combat-related cues and posttraumatic stress symptoms among veterans: Moderating effects of peri- and postdeployment experiences.

Mojallal M, Simons RM, Simons JS et al. · 2024 · Journal of traumatic stress

One of the central symptoms of posttraumatic stress disorder (PTSD) is a heightened reactivity to trauma cues. The current study used experience sampling to investigate the associations between exposure to combat-related cues and PTSD…

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Negative / Null Result ReportOpen accessMedicine

Altering visual feedback during reaching: no mitigating effect on pain for individuals with complex regional pain syndrome, but visuomotor adaptation is preserved.

Dagenais M, Sutter C, Brun C et al. · 2025 · Frontiers in human neuroscience

Introduction Complex regional pain syndrome (CRPS) is often associated with pain-related fear of movement, and virtual reality has been proposed as a potential rehabilitation intervention to overcome this issue. Therefore, this…

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Negative / Null Result ReportMedicine

Primary Care Physicians' and Hospitalists' Experience with Advance Care Planning with South Asian Canadian Older Adults before and during COVID-19.

Vashisht A, Gutman G, Mackey D et al. · 2024 · Canadian journal on aging = La revue canadienne du vieillissement

Few older adults discuss their end-of-life care wishes with their physician, and even fewer minorities do this. We explored physicians' experience with advance care planning (ACP) including the barriers/facilitating factors encountered…

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Negative / Null Result ReportOpen accessMedicine

Association of LR treatment response category with outcome of patients with hepatocellular carcinoma on explant pathology.

Khurana A, Chai N, Gibson A et al. · 2025 · Abdominal radiology (New York)

Objectives Liver transplant (LT) is an effective treatment for hepatocellular carcinoma (HCC) in appropriately selected patients. Locoregional therapy (LRT) is often performed to extend a patient's eligibility for LT. Imaging has a modest…

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Negative / Null Result ReportMedicine

Neonatal hyperoxia exposure does not exacerbate hypertension programmed by maternal obesity.

do Carmo JM, Hall JE, Dai X et al. · 2026 · American journal of physiology. Regulatory, integrative and comparative physiology

Maternal obesity increases the risk of preterm delivery and rapid transition of offspring from a hypoxemic environment to a normal or elevated oxygen environment, especially if the baby receives oxygen therapy. Maternal obesity may also…

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