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Browse the failure-mode index

12,251 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

Human skeletal muscle mitochondrial responses to single-leg intermittent or continuous cycle exercise training matched for absolute intensity and total work.

Skelly LE, MacInnis MJ, Bostad W et al. · 2023 · Scandinavian journal of medicine & science in sports

There is renewed interest in the potential for interval (INT) training to increase skeletal muscle mitochondrial content including whether the response differs from continuous (CONT) training. Comparisons of INT and CONT exercise are…

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Negative / Null Result ReportMedicine

The Relationship Between Impulse Control, Emotional and Cognitive Regulation Mechanisms and Heart Rate Variability.

Yakut G, Özden HC, Şener YZ et al. · 2025 · Turk psikiyatri dergisi = Turkish journal of psychiatry

Objectives The study aims to compare heart rate variability (HRV) in borderline personality disorder (BPD) with healthy individuals and to investigate the relationships between HRV parameters and impulsivity, emotion regulation, and…

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Negative / Null Result ReportOpen accessMedicine

Validity and Reliability of a Linear Position Transducer to Measure Barbell Velocity, Duration, and Displacement During the Bench Press.

Pinzone AG, Gant RW, Rivera J et al. · 2024 · International journal of exercise science

This investigation evaluated validity and reliability of the HUMAC360 linear position transducer (LPT) compared to the Tendo Sport Weightlifting Analyzer (TENDO) for measuring mean velocity (MV), peak velocity (PV), and displacement (D)…

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Negative / Null Result ReportMedicine

Potential Mediating Roles of Thought-Action Fusion and Schizotypal Traits in the Relationship Between Childhood Maltreatment and Obsessive-Compulsive Disorder.

Karadag B, Sevincok D, Ozbek MM et al. · 2026 · Psychiatry

Objective Although the relationship between childhood maltreatment (CM) and obsessive-compulsive disorder (OCD) is well known, no studies to date have examined the potential mediating roles of thought-action fusion (TAF) and schizotypal…

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Negative / Null Result ReportMedicine

Impact of anger, compassion, and hope on climate action taking.

Zaremba D, Marczak M, Michałowski JM et al. · 2026 · Scientific reports

Climate change is a serious threat to people and ecosystems worldwide, making it increasingly important to understand what drives pro-environmental behavior (PEB). Emotions are recognized as key drivers of PEB, with underlying appraisals…

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Negative / Null Result ReportMedicine

Convergence to Steady State in LLM-Generated Ontological Concepts.

Khatwani N, Wang L, Klein ST et al. · 2026 · Studies in health technology and informatics

Large Language Models (LLMs) offer a scalable method to generate candidate concepts for ontology expansion. However, the outputs depend on LLMs' sampling parameters such as "temperature." A high temperature leads to increased…

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Negative / Null Result ReportMedicine

Using Pharmacy technicians to obtain medication histories for emergency department care among older adults.

Qureshi N, Pevnick JM, Torbati SS et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose Obtaining accurate medication histories for older adults in the emergency department (ED) is essential but challenging due to operational barriers and incomplete electronic health records (EHRs). We implemented a…

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Negative / Null Result ReportMedicine

Bidirectional links between sleep and relationship quality: findings from an 8-year longitudinal study of older couples.

Skoblow HF, Tracy EL, Gilligan M · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives The Model of Dynamic Association Between Relationship Functioning and Sleep positions sleep as a fundamentally dyadic and reciprocal process, underscoring the need to study sleep within its relational context and highlighting…

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Negative / Null Result ReportMedicine

Using the biopsychosocial model of challenge and threat to understand stress-induced alcohol consumption.

Petzel ZW, Sowerby L, Crozier C et al. · 2026 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

Objective University students engage in heavy episodic drinking more frequently than nonuniversity peers. While social activities unique to the university experience likely contribute to heavy episodic drinking, drastic lifestyle changes…

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Negative / Null Result ReportMedicine

A behavioral analysis of reaction time in adolescents.

Buzzelli S, Caprioli L · 2026 · The Journal of sports medicine and physical fitness

Background Fast reaction is critical in sports, and understanding the factors that influence it can be a valuable contribution for coaches and sports scientists. Methods This cross-sectional study presents a descriptive analysis of…

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Negative / Null Result ReportMedicine

Comprehensive multimodal prediction of Alzheimer's disease.

Khan F, Pandit D, Lalan S et al. · 2026 · Biomedical physics & engineering express

Alzheimer's disease (AD) classification using machine learning has increasingly relied on multimodal inputs such as Magnetic Resonance Imaging (MRI), cognitive assessments, and biological markers. This study evaluates whether integrating…

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Negative / Null Result ReportMedicine

Horizontal and vertical distributions of microplastics and their water-sediment partitioning in a macrotidal estuarine embayment: Implications for coastal sequestration potential.

Kim SK, Shin JH, Ji YJ et al. · 2026 · Journal of hazardous materials

Estuarine-coastal regimes are critical links between land and the open ocean, yet their role as microplastics (MPs) sinks and the mechanisms governing MP retention remain poorly constrained. We conducted a coupled water-sediment survey in…

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Negative / Null Result ReportMedicine

Brief Report: Psychological Flexibility, Perceived Stress and Emotion Regulation in Transitional-Age Youth (TAY) With Autism Spectrum Disorder (ASD).

Visser K, Keulen J, Bodden D et al. · 2026 · Journal of autism and developmental disorders

Purpose In clinical practice and research, there is growing interest in transdiagnostic interventions, such as Acceptance and Commitment Therapy (ACT), for patients with autism spectrum disorder (ASD), due to the pervasive nature of the…

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