12,251 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Rubino M, Fan R', Kulesz PA et al. · 2026 · The Laryngoscope
Objectives Complete or relative voice rest is recommended following phonomicrosurgery. Primarily, adherence to rest has been measured using patient reports, but their validity is unknown. Instrumental measures of rest adherence are…
View details →Bertram AM, Lalot F, van der Werff L et al. · 2025 · Frontiers in psychology
Introduction Many daily situations require rapid judgments about whether information is true or false based on limited information. Prior research has predominantly examined how statement and source characteristics influence these…
View details →Alharbi BM, Williams HE, Parr T et al. · 2025 · Mathematical biosciences
We propose a mathematical model based on coupled ordinary differential equations (ODEs) for metabolite concentrations with the aim of investigating how modifications to the rates affects outputs from a regulatory network. Our aim is to…
View details →Poller A, Jha S, Molander L et al. · 2025 · International journal of cardiology
Background It is incompletely understood why patients with takotsubo syndrome (TS) have milder symptoms and a better hemodynamic profile than patients with ST-elevation myocardial infarction (STEMI) despite similar or more extensive…
View details →Maier LE, Vanden Berg ER, Simpson L et al. · 2026 · Physiological reports
This study examined how sex influences blood flow during exercise at altitude and relative contributions of adrenergic mechanisms. Thirteen participants (8 M/5F) were tested at low and high altitude (days 3-11). Participants performed…
View details →Rikken RM, Yaqub M, Coomans EM et al. · 2025 · Alzheimer's research & therapy
Background Neuroinflammation plays a key role in Alzheimer's disease (AD) pathophysiology, but it is not clear how neuroinflammation contributes to disease progression. We aim to investigate the role of neuroinflammation on longitudinal…
View details →Chamoux M, Rakobowchuk M, Gaston AF et al. · 2025 · Journal of sport and health science
Background Interest in clothing that reflects far infrared (FIR) radiation naturally emitted by the body during and after exercise has increased based on the assumption that this can increase arterial and venous blood flow. Indeed, in…
View details →DiSilvestro AN, Wesolowski LT, Williams BD et al. · 2025 · Journal of equine veterinary science
In humans, intestinal microbiota are recognized to play key regulatory roles in inflammation. In horses, addition of dietary starch is known to alter the intestinal microbiome, but the relationship between diet and inflammation in horses…
View details →Nelson TB, Stutts KJ, Nair SS et al. · 2025 · Journal of equine veterinary science
Repetitive concussive forces on joints during exercise may lead to increased inflammation and gait asymmetry. While used to reduce inflammation and symptoms related to joint disease, intra-articular corticosteroids have not been…
View details →Liu Z, Chitoran I, Turco G · 2025 · Language and speech
The present study examines the perceptual salience of tonal speech errors compared with segmental errors (consonant and vowel). Tonal errors are observed less often than segmental errors. We thus hypothesize that tone errors are more…
View details →Munroe S, O'Mara K, Kenyon R et al. · 2025 · Marine environmental research
Wet season freshwater flows deliver catchment nutrients (terrestrial and freshwater) to tropical estuaries that stimulate productivity and support consumers. However, the impact of flows on species in the adjacent nearshore is unclear. We…
View details →Skau S, Karlsson J, Åsberg Johnels J et al. · 2026 · Frontiers in psychology
This study investigates whether visual aids increase or decrease cognitive load during arithmetic tasks in 9-year-old children, using behavioral measures and functional near-infrared spectroscopy (fNIRS). Previous research suggests mixed…
View details →Moore TM, Walker K, Tung E et al. · 2025 · Journal of affective disorders
Depression and PTSD are prevalent psychiatric conditions that often co-occur and significantly impact quality of life. Ketamine has emerged as a promising rapid-acting treatment for both conditions, while traditional treatments like…
View details →Sencan A, Dundar N, Gunel B et al. · 2025 · Medeniyet medical journal
Objective To compare mechanical power (MP) levels among flow-controlled ventilation (FCV), volume-controlled ventilation (VCV), and pressure-controlled volume-guaranteed ventilation (PCV-VG) during laparoscopic surgery and to test the…
View details →Wesolowski LT, DiSilvestro AN, Williams BD et al. · 2025 · Journal of equine veterinary science
Disruption of circadian rhythms contributes to a myriad of health issues. Rhythms can be strengthened using artificial light but whether optimal light patterns support health parameters in horses is unknown. To test the hypothesis that…
View details →Rau J, Joseph R, Weise L et al. · 2025 · Journal of neurotrauma
Previous studies have shown that administration of high doses of morphine in the acute phase of spinal cord injury (SCI) significantly undermines locomotor recovery and increases symptoms of chronic pain in a rat spinal contusion model.…
View details →Pleau J, Tanguay N, Courtemanche Y et al. · 2025 · Maternal and child health journal
Objectives The objectives of this study are to describe cannabis use during pregnancy, identify associated factors, examine the associations between prenatal cannabis use and the cognitive, motor and language development of 2-year-old…
View details →Quaedflieg CWEM, Ashton SM, Beckers T et al. · 2025 · Journal of behavior therapy and experimental psychiatry
Fear is a universal experience and fuels our response to cope with threat. Persistent fear, after the threat is no longer present, is a central symptom seen in a number of clinical conditions. Exposure therapy, the most common treatment to…
View details →Hidding M, van der Stouwe E, Rosema BS et al. · 2025 · Psychological medicine
Background Low self-esteem is an important and potentially modifiable risk factor for the development and outcome of psychotic disorders. The factors involved in low self-esteem in psychotic disorders are not yet fully understood. The…
View details →Tao Z, Fowler K, Trenga-Schein N et al. · 2025 · Journal of palliative medicine
Background: Historically, there have been perceptions that engagement with palliative care (PC) services may preclude potentially curative but high-risk operations. As such, we sought to investigate the relationship between specialty PC…
View details →Harada S, Teraoka R, Kuroda N et al. · 2026 · Experimental brain research
This study investigated audiovisual integration in visual motion perception among both younger and older adults. Participants were asked to discriminate the visual motion direction of a random dot kinematogram in two experiments. The…
View details →Midilli B, Nurten A, Gürtekin B et al. · 2025 · Behavioural brain research
Antimuscarinic administration and food intake cause convulsions in mice and rats after fasting for 48 h or less. Increased M 1 and M 2 muscarinic receptor expression in brain regions during fasting, and reversal of changes by refeeding may…
View details →Rothe J, Thiel T, Roessner V et al. · 2025 · BMC psychiatry
Background Autistic individuals often experience significant difficulties adapting to even slight changes in their routines. The COVID-19 pandemic created an uncertain situation marked by frequent changes in daily life, though some…
View details →Honkanen J, Molnár K, Karhumaa T et al. · 2025 · Journal of endocrinological investigation
Purpose Thyroid surgery is performed for various indications, including goiter, suspected or diagnosed malignancy, and hyperthyroidism. While previous studies have focused on postoperative quality of life (QoL) improvements, limited data…
View details →Borghoff KA, Ounda AE, Swee ML et al. · 2025 · Clinical nephrology
Background and objectives Chronic kidney disease (CKD) is associated with increased cardiovascular risk, which may be mediated by vascular calcification. Based on evidence that bisphosphonates inhibit vascular calcification, we…
View details →Kuan HY, Chang CH · 2024 · Journal of physiological investigation
Abstract Stress is an adaptive response crucial for survival. However, chronic stress can lead to maladaptive behaviors and health issues. Prolonged stress reduces the flexibility of defensive coping behaviors. Previous studies have shown…
View details →Nam J, Bellinger GC, Li J et al. · 2025 · JMIR cardio
Background Wearable activity monitors offer clinicians and researchers accessible, scalable, and cost-effective tools for continuous remote monitoring of functional status. These technologies can complement traditional clinical outcome…
View details →Liu X, Zheng W, Hoon L et al. · 2026 · Npj mental health research
Smartphone-delivered interventions offer a scalable solution for university students experiencing depression, yet outcomes remain inconsistent. This study examined predictors of depression remission and response in the AI-enhanced Vibe Up…
View details →Bakhshinejad JA, Watkins CM, Pelton LM et al. · 2026 · International journal of exercise science
The primary aim of this investigation was to examine the effects of three drop jumps (DJ) on mean velocity (m/s) of subsequent deadlifts at various percentages of 1 RM. A secondary exploratory aim was to evaluate whether protocol order,…
View details →Lewandowski KE, Luo J, Yao B et al. · 2025 · Frontiers in psychiatry
Introduction Motivational impairments are a hallmark symptom of psychotic disorders. However, motivation is a multidimensional construct believed to be underpinned by different neural mechanisms and differentially impaired both between and…
View details →