Negative / Null Result ReportOpen accessMedicine
Michael Weller, Burt Nabors, Thierry Gorlia et al. · 2016 · Oncotarget
// Michael Weller 1 , Louis Burt Nabors 2 , Thierry Gorlia 3 , Henning Leske 4 , Elisabeth Rushing 4 , Pierre Bady 5, 6, 7 , Christine Hicking 8 , James Perry 9 , Yong-Kil Hong 10 , Patrick Roth 1 , Wolfgang Wick 11, 12 , Simon L. Goodman 8 , Monika E. Hegi 7 , Martin Picard 8 , Holger Moch 13 , Josef Straub 8 , Roger Stupp 14 1 Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland 2 University of Alabama at Birmingham, Birmingham, AL, USA 3 EORTC Data Centre, Brussels, Belgium 4 Institute of Neuropathology, University Hospital Zurich, Zurich, Switze
View details →Negative / Null Result ReportMedicine
Margarida Corominas-Roso, Josep Antoni Ramos‐Quiroga, Marta Ribasés et al. · 2013 · The International Journal of Neuropsychopharmacology
It has been hypothesized that brain-derived neurotrophic factor (BDNF) is involved in the pathogenesis of attention-deficit hyperactivity disorder (ADHD), although experimental data regarding the contribution of BDNF gene polymorphisms to…
View details →Negative / Null Result ReportOpen accessMedicine
Howard R. Weeks, Scott C. Tadler, Kelly W. Smith et al. · 2013 · PLoS ONE
BACKGROUND: Many patients have serious depression that is nonresponsive to medications, but refuse electroconvulsive therapy (ECT). Early research suggested that isoflurane anesthesia may be an effective alternative to ECT. Subsequent studies altered drug, dose or number of treatments, and failed to replicate this success, halting research on isoflurane's antidepressant effects for a decade. Our aim was to re-examine whether isoflurane has antidepressant effects comparable to ECT, with less adverse effects on cognition. METHOD: Patients with medication-refractory depression received an average
View details →Negative / Null Result ReportOpen accessMedicine
Christopher M. Jackson, Christina M. Kochel, Christopher J. Nirschl et al. · 2015 · Clinical Cancer Research
PURPOSE: Immune responses to antigens originating in the central nervous system (CNS) are generally attenuated, as collateral damage can have devastating consequences. The significance of this finding for the efficacy of tumor-targeted…
View details →Negative / Null Result ReportOpen accessMedicine
Patrick M. Honoré, Rita Jacobs, Inne Hendrickx et al. · 2015 · Annals of Intensive Care
Sepsis-induced acute kidney injury (SAKI) remains an important challenge in critical care medicine. We reviewed current available evidence on prevention and treatment of SAKI with focus on some recent advances and developments. Prevention of SAKI starts with early and ample fluid resuscitation preferentially with crystalloid solutions. Balanced crystalloids have no proven superior benefit. Renal function can be evaluated by measuring lactate clearance rate, renal Doppler, or central venous oxygenation monitoring. Assuring sufficiently high central venous oxygenation most optimally prevents SAK
View details →Negative / Null Result ReportMedicine
George C.M. Siontis, J. P. A. Ioannidis · 2011 · International Journal of Epidemiology
BACKGROUND: Large studies may identify postulated risk factors and interventions with very small effect sizes. We aimed to assess empirically a large number of statistically significant relative risks (RRs) of tiny magnitude and their…
View details →Negative / Null Result ReportOpen accessMedicine
Jennifer L. Tenor, Stefan H. Oehlers, Jialu L. Yang et al. · 2015 · mBio
UNLABELLED: The human fungal pathogen Cryptococcus neoformans is capable of infecting a broad range of hosts, from invertebrates like amoebas and nematodes to standard vertebrate models such as mice and rabbits. Here we have taken advantage of a zebrafish model to investigate host-pathogen interactions of Cryptococcus with the zebrafish innate immune system, which shares a highly conserved framework with that of mammals. Through live-imaging observations and genetic knockdown, we establish that macrophages are the primary immune cells responsible for responding to and containing acute cryptoco
View details →Negative / Null Result ReportMedicine
Gary S. Solomon, Andrew W. Kuhn, Scott L. Zuckerman et al. · 2016 · The American Journal of Sports Medicine
BACKGROUND: A recent study found that an earlier age of first exposure (AFE) to tackle football was associated with long-term neurocognitive impairment in retired National Football League (NFL) players. PURPOSE: To assess the association…
View details →Negative / Null Result ReportOpen accessMedicine
Joakim Alfredsson, Johan Lindbäck, Lars Wallentin et al. · 2011 · European Heart Journal
AIMS: To assess gender differences in outcome with an early invasive or non-invasive strategy in patients with non-ST-elevation acute coronary syndromes (NSTE ACS). METHODS AND RESULTS: We included 46,455 patients [14 819 women (32%) and…
View details →Negative / Null Result ReportOpen accessMedicine
Agnieszka Broda, Heather Jebbari, Kate Beaton et al. · 2012 · Journal of Clinical Microbiology
The isolation of rapidly growing mycobacteria (RGM), particularly Mycobacterium abscessus, from individuals with cystic fibrosis (CF) is associated with poor clinical outcome due to broad drug resistance and the difficulty of eradicating…
View details →Negative / Null Result ReportOpen accessMedicine
Anna Geke Algera, Luigi Pisani, Ary Serpa Neto et al. · 2020 · JAMA
Importance: It is uncertain whether invasive ventilation can use lower positive end-expiratory pressure (PEEP) in critically ill patients without acute respiratory distress syndrome (ARDS). Objective: To determine whether a lower PEEP…
View details →Negative / Null Result ReportOpen accessMedicine
Wilbur Y.W. Lew, Evelyn Bayna, Erminia Dalle Molle et al. · 2013 · PLoS ONE
BACKGROUND: Circulating subclinical lipopolysaccharide (LPS) occurs in health and disease. Ingesting high fatty meals increases LPS that cause metabolic endotoxemia. Subclinical LPS in periodontal disease may impair endothelial function. The heart may be targeted as cardiac cells express TLR4, the LPS receptor. It was hypothesized that recurrent exposure to subclinical LPS increases mortality and causes cardiac fibrosis. METHODS: C57Bl/6 mice were injected with intraperitoneal saline (control), low dose LPS (0.1 or 1 mg/kg), or moderate dose LPS (10 or 20 mg/kg), once a week for 3 months. Left
View details →Negative / Null Result ReportOpen accessMedicine
Linnet Ongeri, Valentine Wanga, Phelgona Otieno et al. · 2018 · BMC Psychiatry
BACKGROUND: Few longitudinal studies have examined associations between risk factors during pregnancy and mental health outcomes during the postpartum period. We used a cohort study design to estimate the prevalence, incidence and correlates of significant postpartum depressive symptoms in Kenyan women. METHODS: We recruited adult women residing in an urban, resource-poor setting and attending maternal and child health clinics in two public hospitals in Nairobi, Kenya. A translated Kiswahili Edinburgh Postpartum Depression Scale was used to screen for depressive symptoms at baseline assessment
View details →Negative / Null Result ReportOpen accessMedicine
Heikki Joensuu, Filippo de Braud, G Grignagni et al. · 2011 · British Journal of Cancer
BACKGROUND: Vatalanib (PTK787/ZK 222584) inhibits a few tyrosine kinases including KIT, platelet-derived growth factor receptors (PDGFRs) and vascular endothelial growth factor receptors (VEGFRs). We report efficacy and safety results of…
View details →Negative / Null Result ReportOpen accessMedicine
Bart G.P. Koot, Olga H. van der Baan‐Slootweg, Anneloes E. Bohte et al. · 2013 · Obesity
BACKGROUND: Accurate prediction scores for liver steatosis are demanded to enable clinicians to noninvasively screen for nonalcoholic fatty liver disease (NAFLD). Several prediction scores have been developed, however external validation…
View details →Negative / Null Result ReportOpen accessMedicine
Ksenija Vučićević, Vladimir Jakovljević, Nataša Čolović et al. · 2016 · Journal of Medical Biochemistry
Summary Background: In chronic lymphocytic leukemia (CLL), in vivo apoptotic resistance of malignant B lymphocytes results, in part, from the intrinsic defects of their apoptotic machinery. These include genetic alterations and aberrant expression of many apoptosis regulators, among which the Bcl2 family members play a central role. Aim: The aim of this study was to investigate the association of pro-apoptotic Bax gene expression and Bcl2/Bax ratio with the clinical features of CLL patients as well as with molecular prognostic markers, namely the mutational status of rearranged immunoglobulin
View details →Negative / Null Result ReportOpen accessMedicine
Rebecca Abbott, Leon Straker, Svend Erik Mathiassen · 2013 · Obesity
OBJECTIVE: Sedentary behavior in children is positively associated with an increased risk of both obesity and insulin resistance. Children spend a considerable portion of their awake time in sedentary behavior; however, the pattern of…
View details →Negative / Null Result ReportOpen accessMedicine
Sari Mäkelä, Sari Aaltonen, Tellervo Korhonen et al. · 2017 · Scandinavian Journal of Medicine and Science in Sports
Because sustained physical activity is important for a healthy life, this paper examined whether a greater diversity of sport activities during adolescence predicts higher levels of leisure-time physical activity (LTPA) in adulthood. From…
View details →Negative / Null Result ReportOpen accessMedicine
Toby M. Maher, Ulrich Costabel, Marilyn K. Glassberg et al. · 2020 · European Respiratory Journal
This phase 2, randomised, double-blind, placebo-controlled trial evaluated the efficacy and safety of lebrikizumab, an interleukin (IL)-13 monoclonal antibody, alone or with background pirfenidone therapy, in patients with idiopathic pulmonary fibrosis (IPF). Patients with IPF aged ≥40 years with forced vital capacity (FVC) of 40%–100% predicted and diffusing capacity for carbon monoxide of 25%–90% predicted and who were treatment-naïve (cohort A) or receiving pirfenidone (2403 mg·day −1 ; cohort B) were randomised 1:1 to receive lebrikizumab 250 mg or placebo subcutaneously every 4 weeks. The
View details →Negative / Null Result ReportOpen accessMedicine
Matthew Ginks, Anoop Shetty, Pier D. Lambiase et al. · 2012 · Circulation Arrhythmia and Electrophysiology
BACKGROUND: There is considerable heterogeneity in the myocardial substrate of patients undergoing cardiac resynchronization therapy (CRT), in particular in the etiology of heart failure and in the location of conduction block within the…
View details →Negative / Null Result ReportOpen accessMedicine
Mary Beth Callan, Reema Patel, Ann H. Rux et al. · 2013 · Vox Sanguinis
BACKGROUND AND OBJECTIVES: Studies in mice suggest that rapid transfusions of red blood cells (RBCs), refrigerator stored for longer durations, induce a pro-inflammatory cytokine response. Studies in human neonates confirm these findings;…
View details →Negative / Null Result ReportMedicine
Andy Sun, Hung‐Pin Lin, Yi‐Ping Wang et al. · 2011 · Journal of Oral Pathology and Medicine
BACKGROUND: Atrophic glossitis (AG) is considered to be a marker of nutritional deficiency. In this study, we evaluated whether there was an intimate association of the deficiency of hemoglobin, iron, vitamin B12 or folic acid, high blood…
View details →Negative / Null Result ReportOpen accessMedicine
Glauber Ribeiro de Sousa Araújo, Fernanda L. Fonseca, Bruno Pontes et al. · 2012 · PLoS ONE
Capsule production is common among bacterial species, but relatively rare in eukaryotic microorganisms. Members of the fungal Cryptococcus genus are known to produce capsules, which are major determinants of virulence in the highly pathogenic species Cryptococcus neoformans and Cryptococcus gattii. Although the lack of virulence of many species of the Cryptococcus genus can be explained solely by the lack of mammalian thermotolerance, it is uncertain whether the capsules from these organisms are comparable to those of the pathogenic cryptococci. In this study, we compared the characteristic of
View details →Negative / Null Result ReportOpen accessMedicine
Longjiang Xiong, Siyun Li, Min Dai · 2019 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Despite the availability of several biomarkers, the diagnosis of periprosthetic joint infection (PJI) continues to be challenging. Serum D-dimer assessment is a widely available test that detects fibrinolytic activities and has been reported as an inflammatory biomarker. However, quite a few articles have reported the diagnostic efficiency of D-dimer for PJI. METHODS: This prospective study enrolled patients who had undergone total joint arthroplasty, were suspected of PJI, and also prepared for revision arthroplasty. PJI was defined using the Musculoskeletal Infection Society crit
View details →Negative / Null Result ReportOpen accessMedicine
Lai-ping Zhong, Chen-ping Zhang, Guo-xin Ren et al. · 2015 · Oncotarget
// Lai-ping Zhong 1 , Chen-ping Zhang 1 , Guo-xin Ren 1 , Wei Guo 1 , William N. William Jr 2 , Christopher S. Hong 3 , Jian Sun 1 , Han-guang Zhu 1 , Wen-yong Tu 1 , Jiang Li 4 , Yi-li Cai 1 , Qiu-ming Yin 1 , Li-zhen Wang 4 , Zhong-he Wang 1 , Yong-jie Hu 1 , Tong Ji 1 , Wen-jun Yang 1 , Wei-min Ye 1 , Jun Li 1 , Yue He 1 , Yan-an Wang 1 , Li-qun Xu 1 , Zhengping Zhuang 3 , J. Jack Lee 5 , Jeffrey N. Myers 6 and Zhi-yuan Zhang 1 1 Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicin
View details →Replication FailureOpen accessMedicine
Wai‐Ping Yau, Allen A. Mitchell, Kueiyu Joshua Lin et al. · 2013 · American Journal of Epidemiology
Previous studies suggested that early pregnancy exposure to specific oral decongestants increases the risks of several birth defects. Using January 1993-January 2010 data from the Slone Epidemiology Center Birth Defects Study, we tested…
View details →Negative / Null Result ReportMedicine
Cynthia Braden, Lenore Hawley, Jody Newman et al. · 2010 · Brain Injury
OBJECTIVES: To evaluate the feasibility of improving impaired social communication skills in persons with traumatic brain injury (TBI) and concomitant neurological or psychiatric conditions, using an intervention with evidence of efficacy…
View details →Negative / Null Result ReportOpen accessMedicine
Raanan Marants, Elena Qirjazi, Claire Grant et al. · 2019 · Journal of the American Society of Nephrology
Significance Statement Residual renal function (RRF) characteristically declines after patients with ESRD initiate dialysis. Although RRF preservation correlates with improved outcomes, poor understanding of the pathophysiology underlying…
View details →Negative / Null Result ReportMedicine
Piia Seppälä, Saija Mauno, Marja-Liisa Kinnunen et al. · 2011 · The Journal of Positive Psychology
The present study investigated whether work engagement is related to and can explain healthy cardiac autonomic activity as indicated by decreased heart rate (HR; i.e., sympathetic and parasympathetic activity) and increased high-frequency…
View details →Negative / Null Result ReportOpen accessMedicine
Renata Aguiar, Cristina Araújo, G. Martins‐Coelho et al. · 2016 · Arthritis Care & Research
OBJECTIVE: To describe the clinical outcome and safety of rituximab (RTX) treatment in systemic lupus erythematosus (SLE) patients with severe manifestations or whose disease is refractory to standard immunosuppressive therapy, treated at…
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