Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion
Jennifer L. Tenor; Stefan H. Oehlers; Jialu L. Yang; David M. Tobin; John R. Perfect · 2015 · mBio
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
UNLABELLED: The human fungal pathogen Cryptococcus neoformans is capable of infecting a broad range of hosts, from invertebrates like amoebas and nematodes to standard vertebrate models such as mice and rabbits. Here we have taken advantage of a zebrafish model to investigate host-pathogen interactions of Cryptococcus with the zebrafish innate immune system, which shares a highly conserved framework with that of mammals. Through live-imaging observations and genetic knockdown, we establish that macrophages are the primary immune cells responsible for responding to and containing acute cryptoco
Abstract by Jennifer L. Tenor; Stefan H. Oehlers; Jialu L. Yang; David M. Tobin; John R. Perfect, mBio (2015) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1128/mbio.01425-15