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WASTE Journal

Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Comparison of effective phacoemulsification times used in cataract surgery between the Veritas Vision System and the Centurion Vision System.

Choi JY, Song WS, Won YK et al. · 2026 · Korean journal of ophthalmology : KJO

Purpose To compare the effective phacoemulsification time used in cataract surgery and postoperative outcomes between the Veritas and the Centurion Vision System. Methods A retrospective analysis was conducted on 90 eyes from 82 patients…

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Negative / Null Result ReportMedicine

Effective population size and N e /N ratio for two populations of Northern chamois (Rupicapra rupicapra) on the edge of the species' distribution range.

Jacobs S, Edelhoff H, Ebert C et al. · 2026 · BMC ecology and evolution

Effective population size (Ne) is a fundamental parameter in conservation genetics, providing relevant information on the adaptability and long-term viability of populations. In contrast, wildlife management strategies, particularly for…

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Negative / Null Result ReportMedicine

Missed Opportunities for Timely Diagnosis and Effective Therapeutic Management of Prolonged Fever: A Case Study of Confirmed Lassa Fever in N'Zérékoré, Guinea, 2022.

Cherif IS, Essis EML, Diallo MA et al. · 2026 · Case reports in infectious diseases

Background Lassa fever is a potentially fatal viral hemorrhagic disease caused by a ribonucleic acid (RNA) virus of the Arenaviridae family, endemic in West Africa. It is highly virulent and contagious in several countries, with a…

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Failed Experiment ReportMedicine

Operative Cultures Rarely Necessitate Change to Periprosthetic Joint Infection Antibiotic Plan Based on Monomicrobial Preoperative Aspiration.

Ducharme MT, Elmenawi KA, Poilvache H et al. · 2026 · The Journal of arthroplasty

Introduction Periprosthetic joint infections (PJI) are complex to manage and frequently result in prolonged hospitalization while awaiting outpatient antibiotic therapy coordination. Moving this work to the preoperative setting for…

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Negative / Null Result ReportOpen accessMedicine

Vessel diameter as a potential predictor of pulsed dye laser response in port wine stain: a retrospective exploratory reflectance confocal microscopy study.

Ran X, Shang Y, Yang X et al. · 2026 · Lasers in medical science

To investigate whether noninvasive reflectance confocal microscopy (RCM)-derived vascular parameters can serve as objective predictors of therapeutic response to pulsed dye laser (PDL) treatment in patients with port wine stain (PWS),…

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Negative / Null Result ReportOpen accessMedicine

The Median Effective Dose of Phenylephrine Infusion for Prevention of Spinal-Induced Hypotension During Cesarean Delivery in the 15° Left-Tilt vs. Supine Positions: A Randomised Control Study.

Yu XQ, Drzymalski DM, Qian J et al. · 2026 · Drug design, development and therapy

Background Left uterine displacement is presumed to decrease vasopressor requirements during cesarean delivery due to decreased aortocaval compression, but studies have been equivocal. Our primary aim was to determine the median effective…

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Negative / Null Result ReportOpen accessMedicine

Drug supply shortages and their perceived consequences for patients: a questionnaire survey of German and Austrian physicians.

Rotter JM, Seifert R · 2026 · European journal of clinical pharmacology

Purpose Drug supply shortages are a recurring issue in developed countries, with consequences for patients even before the COVID-19 pandemic. Questions arise regarding the effectiveness and tolerability of alternative treatments chosen by…

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Methods Dead-EndOpen accessMedicine

Cost-effectiveness analysis based on two models of sacituzumab tirumotecan versus platinum-based chemotherapy as second-line treatment in EGFR-mutant non-small-cell lung cancer.

Jin L, Han L, Zeng J · 2026 · Frontiers in public health

Background For patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC) who progress after first-line therapy, effective subsequent options are urgently needed. From the perspective of China's healthcare system, this study…

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Methods Dead-EndOpen accessMedicine

Cost utility and cost-effectiveness of the APPLE-Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce: economic evaluation embedded within a randomised controlled trial.

Demnitz-King H, Cooper C, Poppe M et al. · 2026 · Age and ageing

Background Previous studies have modelled long-term cost-effectiveness of dementia prevention but seldom within trials. APPLE-Tree (Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build…

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Negative / Null Result ReportOpen accessMedicine

Pre-TIPS Liver and Spleen Volumetry Are Not Associated With Liver-Related Outcomes After TIPS Placement for Refractory Ascites.

Bedoya JU, Wagner M, Malézieux E et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver

Background & aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before…

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Abandoned HypothesisMedicine

Descriptive oxidative and lipid-related fluorescence observations associated with Esketamine treatment in a high-concentration NMDA-exposed HT-22/C8-D1A co-culture model.

Ni X, Zhou S, He X et al. · 2026 · Toxicology in vitro : an international journal published in association with BIBRA

Background In HT-22 cells, 500 μM NMDA was used as a high-concentration oxidative stressor rather than a classical NMDA receptor-mediated excitotoxic stimulus. Because HT-22 cells lack functional ionotropic NMDA receptors, this model…

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Negative / Null Result ReportMedicine

Early Endoscopic Retrograde Cholangiopancreatography is Associated With Improved Health Care Resource Utilization in Acute Biliary Pancreatitis Without Cholangitis.

Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology

Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…

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Negative / Null Result ReportMedicine

Genetic Association and Clinical Relevance of TNFSF13B/BAFF and PADI4 Polymorphisms in ANCA-Associated Vasculitis: A Case-Control Study with Genetic Model Analysis in Guangxi Population.

Lu J, Huang S, Wei S et al. · 2026 · Genes

Objective: TNFSF13B , which encodes B-cell-activating factor ( BAFF ) and peptidylarginine deiminase 4 ( PADI4 ), plays crucial roles in the pathogenesis of ANCA-associated vasculitis (AAV). This study investigated the associations of…

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Negative / Null Result ReportOpen accessMedicine

No benefit of adding glucocorticoids to maintenance treatment in reducing the risk of major relapses in ANCA-associated vasculitis: real life data from a longitudinal cohort study.

Chavatza K, Gialouri CG, Drougkas K et al. · 2026 · RMD open

Objective To examine the role of low-dose glucocorticoids (GCs) in major relapse, hospitalisation and damage accumulation risk during maintenance therapy in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAVs). Methods…

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Negative / Null Result ReportMedicine

Replacing stationary time or light physical activity with moderate-to-vigorous physical activity is associated with improved metabolic health in adults with or at risk of knee osteoarthritis.

Halliwell C, Courish M, Moyer R et al. · 2026 · Clinical rheumatology

Background Individuals with knee osteoarthritis are at an increased risk of poor metabolic health. We tested if cross-sectionally replacing stationary time with light or moderate-to-vigorous physical activity would be associated with lower…

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Negative / Null Result ReportOpen accessMedicine

Maternal Health and Sociodemographic Characteristics Influence Infant Growth to 24 Months in the Tunza Mwana Cohort: A Prospective Cohort Study.

Hendrixson DT, Tiwari R, James P et al. · 2026 · Maternal & child nutrition

Upstream pathways influencing child growth are complex. Weight-for-age z-score (WAZ) reflects both ponderal and linear growth and can identify children at high mortality risk. Using data from a prospective cohort of 326 mother-child pairs…

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Abandoned HypothesisMedicine

Is active surveillance of CIN2 always appropriate? Clinical outcomes and factors associated with progression and regression over 48 months in an HPV-positive cohort.

Bruno MT, Pagana A, Aiello T et al. · 2026 · BMC cancer

Background Active surveillance of cervical intraepithelial neoplasia grade 2 (CIN2) is increasingly adopted to reduce the risk of overtreatment, particularly in young women. However, the appropriateness of this approach remains debated,…

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