12,214 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
P.J. Devereaux, Marko Mrkobrada, Daniel I. Sessler et al. · 2014 · New England Journal of Medicine
BACKGROUND: There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. METHODS: Using a…
View details →Paulina Salminen, Mika Helmiö, Jari Ovaska et al. · 2018 · JAMA
Importance: Laparoscopic sleeve gastrectomy for treatment of morbid obesity has increased substantially despite the lack of long-term results compared with laparoscopic Roux-en-Y gastric bypass. Objective: To determine whether laparoscopic…
View details →Hedy L. Kindler, Donna Niedzwiecki, Donna Hollis et al. · 2010 · Journal of Clinical Oncology
PURPOSE: The combination of gemcitabine plus bevacizumab produced a 21% response rate and a median survival of 8.8 months in a multicenter phase II trial in patients with metastatic pancreatic cancer. These encouraging data led Cancer and…
View details →Antoni Ribas, Richard Kefford, Margaret Marshall et al. · 2013 · Journal of Clinical Oncology
PURPOSE: In phase I/II trials, the cytotoxic T lymphocyte-associated antigen-4-blocking monoclonal antibody tremelimumab induced durable responses in a subset of patients with advanced melanoma. This phase III study evaluated overall…
View details →Mark R. Thursz, Paul Richardson, Michael Allison et al. · 2015 · New England Journal of Medicine
BACKGROUND: Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use. The short-term mortality among patients with severe disease…
View details →Katrina L. Salazar, Haijun Zhou, Jiaqiong Xu et al. · 2015 · Acta Cytologica
OBJECTIVE: Individuals are often infected with multiple genotypes of human papillomavirus (HPV) simultaneously, but the role these infections play in the development of cervical disease is not well established. This study aimed to…
View details →Friedrich Koehler, Sebastian Winkler, Michael Schieber et al. · 2011 · Circulation
BACKGROUND: This study was designed to determine whether physician-led remote telemedical management (RTM) compared with usual care would result in reduced mortality in ambulatory patients with chronic heart failure (HF). METHODS AND…
View details →Thomas G. Brott, George Howard, Gary S. Roubin et al. · 2016 · New England Journal of Medicine
BACKGROUND: In the Carotid Revascularization Endarterectomy versus Stenting Trial, we found no significant difference between the stenting group and the endarterectomy group with respect to the primary composite end point of stroke,…
View details →Marco Valgimigli, Gianluca Campo, Monia Monti et al. · 2012 · Circulation
BACKGROUND: The optimal duration of dual-antiplatelet therapy and the risk-benefit ratio for long-term dual-antiplatelet therapy after coronary stenting remain poorly defined. We evaluated the impact of up to 6 versus 24 months of…
View details →Xiuchan Guo, Cheryl A. Winkler, Ji Li et al. · 2014 · BioMed Research International
UNLABELLED: Genetic factors, as well as environmental factors, play a role in development of nasopharyngeal carcinoma (NPC). A number of single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC. To confirm these genetic associations with NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted. Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3 HLA region were genotyped. To explore the potential clinical application of these genetic markers in NPC, we further evaluate the predictive/diagnostic ro
View details →Bart L. Scott, Marcelo C. Pasquini, Brent R. Logan et al. · 2017 · Journal of Clinical Oncology
Purpose The optimal regimen intensity before allogeneic hematopoietic cell transplantation (HCT) is unknown. We hypothesized that lower treatment-related mortality (TRM) with reduced-intensity conditioning (RIC) would result in improved…
View details →Duncan Young, Sarah E Lamb, Sanjoy Shah et al. · 2013 · New England Journal of Medicine
BACKGROUND: Patients with the acute respiratory distress syndrome (ARDS) require mechanical ventilation to maintain arterial oxygenation, but this treatment may produce secondary lung injury. High-frequency oscillatory ventilation (HFOV)…
View details →Sanjit S. Jolly, John A. Cairns, Salim Yusuf et al. · 2015 · New England Journal of Medicine
BACKGROUND: During primary percutaneous coronary intervention (PCI), manual thrombectomy may reduce distal embolization and thus improve microvascular perfusion. Small trials have suggested that thrombectomy improves surrogate and clinical…
View details →Nereo Segnan, Paola Armaroli, L Bonelli et al. · 2011 · JNCI Journal of the National Cancer Institute
BACKGROUND: A single flexible sigmoidoscopy at around the age of 60 years has been proposed as an effective strategy for colorectal cancer (CRC) screening. METHODS: We conducted a randomized controlled trial to evaluate the effect of…
View details →F.G.R. Fowkes · 2010 · JAMA
CONTEXT: A low ankle brachial index (ABI) indicates atherosclerosis and an increased risk of cardiovascular and cerebrovascular events. Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to…
View details →Aneesh B. Singhal · 2011 · Archives of Neurology
OBJECTIVES: To compare the clinical, laboratory, and imaging features of patients with reversible cerebral vasoconstriction syndromes evaluated at 2 academic centers, compare subgroups, and investigate treatment effects. DESIGN:…
View details →Francis Kim, Graham Nichol, Charles Maynard et al. · 2013 · JAMA
IMPORTANCE: Hospital cooling improves outcome after cardiac arrest, but prehospital cooling immediately after return of spontaneous circulation may result in better outcomes. OBJECTIVE: To determine whether prehospital cooling improves…
View details →Leonard L. Gunderson, Kathryn Winter, Jaffer A. Ajani et al. · 2012 · Journal of Clinical Oncology
PURPOSE: On initial publication of GI Intergroup Radiation Therapy Oncology Group (RTOG) 98-11 [A Phase III Randomized Study of 5-Fluorouracil (5-FU), Mitomycin, and Radiotherapy Versus 5-Fluorouracil, Cisplatin and Radiotherapy in…
View details →Andrew X. Zhu, Olivier Rosmorduc, T.R. Jeffry Evans et al. · 2014 · Journal of Clinical Oncology
PURPOSE: To compare the clinical outcomes of sorafenib plus either erlotinib or placebo in patients with advanced hepatocellular carcinoma (HCC) in a multicenter, multinational, randomized, phase III trial. PATIENTS AND METHODS: Patients…
View details →Eugenia Abaleke, Mustafa Abbas, Sadia Abbasi et al. · 2021 · The Lancet
BACKGROUND: Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. METHODS: In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual st
View details →Kentaro Suzuki, Yuji Matsumaru, Masataka Takeuchi et al. · 2021 · JAMA
IMPORTANCE: Whether intravenous thrombolysis is needed in combination with mechanical thrombectomy in patients with acute large vessel occlusion stroke is unclear. OBJECTIVE: To examine whether mechanical thrombectomy alone is noninferior…
View details →Mark A. Socinski, Makoto Nishio, Robert M. Jotte et al. · 2021 · Journal of Thoracic Oncology
INTRODUCTION: We report the final overall survival (OS) analyses of atezolizumab-carboplatin-paclitaxel (ACP [experimental arm]) and OS data with approximately 39.8 months of median follow-up with…
View details →Obbina Abani, Ali Abbas, Fatima Abbas et al. · 2021 · The Lancet
BACKGROUND: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. METHODS: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care al
View details →The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group · 2019 · New England Journal of Medicine
BACKGROUND: ) and have a high arterial oxygen tension. The conservative use of oxygen may reduce oxygen exposure, diminish lung and systemic oxidative injury, and thereby increase the number of ventilator-free days (days alive and free…
View details →Horng H. Chen, Kevin J. Anstrom, Michael M. Givertz et al. · 2013 · JAMA
IMPORTANCE: Small studies suggest that low-dose dopamine or low-dose nesiritide may enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction; however, neither strategy has been rigorously…
View details →Michael Lim, Michael Weller, Ahmed Idbaïh et al. · 2022 · Neuro-Oncology
BACKGROUND: Nearly all patients with newly diagnosed glioblastoma experience recurrence following standard-of-care radiotherapy (RT) + temozolomide (TMZ). The purpose of the phase III randomized CheckMate 548 study was to evaluate RT + TMZ…
View details →US Preventive Services Task Force, Susan J. Curry, Alex H. Krist et al. · 2019 · JAMA
Importance: Perinatal depression, which is the occurrence of a depressive disorder during pregnancy or following childbirth, affects as many as 1 in 7 women and is one of the most common complications of pregnancy and the postpartum…
View details →Joshua D. Harris, Jefferson C. Brand, Mark P. Cote et al. · 2017 · Arthroscopy The Journal of Arthroscopic and Related Surgery
Patient-reported outcomes (PROs) are increasingly being used in today's rapidly evolving health care environment. The value of care provision emphasizes the highest quality of care at the lowest cost. Quality is in the eye of the beholder,…
View details →T-K Clarke, Mark J. Adams, Gail Davies et al. · 2017 · Molecular Psychiatry
Alcohol consumption has been linked to over 200 diseases and is responsible for over 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for example, ALDH2 and ADH1B , are strongly associated with alcohol consumption but have limited impact in European populations where they are found at low frequency. We performed a genome-wide association study (GWAS) of self-reported alcohol consumption in 112 117 individuals in the UK Biobank (UKB) sample of white British individuals. We report significant genome-wide associations at 14 loci. These include single-nuc
View details →John P. Clancy, Steven M. Rowe, Frank J. Accurso et al. · 2011 · Thorax
BACKGROUND: VX-809, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, has been shown to increase the cell surface density of functional F508del-CFTR in vitro. METHODS: A randomised, double-blind, placebo-controlled…
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