Negative / Null Result ReportOpen accessMedicine· cited by 498

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)

T-K Clarke; Mark J. Adams; Gail Davies; David M. Howard; Lynsey S. Hall; Sandosh Padmanabhan; Alison D. Murray; Blair H. Smith · 2017 · Molecular Psychiatry

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Alcohol consumption has been linked to over 200 diseases and is responsible for over 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for example, ALDH2 and ADH1B , are strongly associated with alcohol consumption but have limited impact in European populations where they are found at low frequency. We performed a genome-wide association study (GWAS) of self-reported alcohol consumption in 112 117 individuals in the UK Biobank (UKB) sample of white British individuals. We report significant genome-wide associations at 14 loci. These include single-nuc

Abstract by T-K Clarke; Mark J. Adams; Gail Davies; David M. Howard; Lynsey S. Hall; Sandosh Padmanabhan; Alison D. Murray; Blair H. Smith, Molecular Psychiatry (2017) — licensed CC BY 4.0.

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