12,250 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Newman A, Hansel S, Gerrard G et al. · 2026 · Cancers
Background Surveillance of non-muscle-invasive bladder cancer (NMIBC) relies on cystoscopy and urine cytology, both of which have well-recognised limitations. Molecular urine assays have been developed to reduce the burden of invasive…
View details →Mints G, Bai J, Evans A · 2025 · American journal of cardiovascular disease
This is letter to the editor: we point to a statistical error in a recent article published in the journal by Movahed MR, Soltani Moghadam A. A normal and particularly small ( , which may have resulted in a biased conclusion.
View details →Eldeeb MEA, Mostafa MA, Nagiub TA et al. · 2025 · BMC cardiovascular disorders
Purpose Prior studies have assessed in-stent diameter restenosis (ISDR) in coronary arteries using 64-slice multidetector computed tomography coronary angiography (MDCT-CA) compared to invasive coronary angiography (ICA), which is the gold…
View details →Follansbee CW, Landstrom AP, Aziz PF · 2025 · Cardiac electrophysiology clinics
Congenital long QT syndrome is the most common inherited arrhythmia syndrome and is characterized by prolongation of the QT interval in the absence of structural heart disease or external factors. Disease will often manifest during…
View details →Trinh AT, McMurray JC, Pittman LM et al. · 2025 · JACC. Case reports
Background IgE-mediated anaphylaxis to iodinated contrast media (ICM) is rare but potentially life threatening. Unlike non-IgE-mediated reactions, cases are often resistant to corticosteroid and antihistamine premedication. Case summary A…
View details →Kim DH, Chun MK, Lim SY et al. · 2026 · Pediatric emergency care
Objectives This retrospective observational study evaluated the diagnostic efficiency of routine magnetic resonance imaging (MRI) in pediatric patients with facial palsy (FP) in the emergency department (ED). Methods Pediatric patients…
View details →Sayeedi I, Goldin J, Widrich J · 2026
The methacholine challenge test is a bronchoprovocation test used to assess airway hyperresponsiveness and aid in the diagnosis of asthma. Methacholine, a derivative of acetylcholine, directly stimulates airway smooth muscle receptors,…
View details →Gürler M, Karaoğlu Ç, Yurtcu EE et al. · 2026 · The Indian journal of medical research
Background and objectives Multiplex molecular panels for meningitis and encephalitis (M&E) allow rapid detection of multiple pathogens directly from cerebrospinal fluid (CSF) samples. Although their use is expanding, real-world data on…
View details →Duan S, Lv T, Zheng L et al. · 2026 · BMC infectious diseases
BACKGROUND: Clostridioides difficile infection (CDI) is a major cause of healthcare-associated diarrhea, with increasing prevalence in China and the Asia-Pacific region. Despite its limited sensitivity, the enzyme immunoassay (EIA) is…
View details →Burdon D, Mullin S, Harris C · 2026 · The British and Irish orthoptic journal
Aim Progressive supranuclear palsy (PSP) is an atypical Parkinsonian disorder which, like other atypical Parkinsonian disorders, displays neurological motor and oculomotor signs at different stages along the disease course. The overlap in…
View details →Deuitch N, Broadbridge E, Cunningham L et al. · 1993
Clinical characteristics RUNX1 familial platelet disorder with associated myeloid malignancies (RUNX1-FPDMM) is characterized by prolonged bleeding and/or easy bruising and an increased risk of developing a hematologic malignancy.…
View details →Tunçez HÇ · 2026 · Polish journal of radiology
Purpose To evaluate the Kaiser score (KS) on magnetic resonance imaging (MRI) in patients diagnosed with breast cancer and to identify clinical, pathological, and radiological factors associated with false-negative Kaiser score. Material…
View details →Song M, Zhang Z, Huang H et al. · 2026 · The American journal of case reports
BACKGROUND Spinal tuberculosis is difficult to diagnose in patients undergoing maintenance hemodialysis (MHD) because of immunosuppression, atypical clinical manifestations, and the limited sensitivity of conventional microbiological…
View details →Sirchia F, Kalantari S, Carli D et al. · 2026 · Pediatric neurology
Background Many patients with rare genetic diseases remain undiagnosed or receive a molecular diagnosis only after years. In this study, we want to evaluate the usefulness of clinical genome sequencing (cGS) in a cohort of complex…
View details →Jo HC, Park JE, Baek JC et al. · 2025 · Taiwanese journal of obstetrics & gynecology
Objective To report a case of mosaic trisomy 17 with inconsistent findings between noninvasive prenatal testing (NIPT) and genetic amniocentesis. Case report A 34-year-old primigravid woman presented for antenatal care at 9 weeks of…
View details →Kataria P, Upadhyay MK, Arya K et al. · 2025 · Journal of family medicine and primary care
Background Antenatal care (ANC) can be defined as the care provided by skilled health-care professionals to pregnant women in order to ensure the best health outcomes. Good quality routine antenatal care forms the foundation of positive…
View details →O'Leary C, Yoong E, Matsika A et al. · 2025 · Asia-Pacific journal of clinical oncology
Aims Castrate-resistant prostate cancer (CRPC) is a common malignancy with poor prognostic outcomes. Breast cancer (BRCA) genes 1 and 2 mutations occur in prostate cancers and confer poorer prognoses. Somatic BRCA testing can lead to…
View details →Makgoka TR, De Villiers M, Van Zyl DG · 2025 · South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Background Tuberculosis (TB) is a major contributor to mortality among patients affected by HIV. TB diagnosis can be challenging, especially in those who are severely ill and unable to produce sputum. Urine lipoarabinomannan (LAM) is a…
View details →Wang T, Park B, Anderson G et al. · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Early diagnosis of invasive fungal disease is essential for optimizing management. Although the clinical utility of fungal polymerase chain reaction (PCR) testing on plasma and bronchoalveolar lavage (BAL) has been established,…
View details →May J, Waturangi DE, Tan WA et al. · 2026 · Scientific reports
Biofilm-forming bacteria, such as Bacillus cereus and Vibrio harveyi are major contributors to food contamination and problems in aquaculture. This study aimed to evaluate the antibiofilm compounds of the phyllosphere bacterial…
View details →Zheng J, Guo Q, Yue G et al. · 2025 · World journal of urology
Objective There is ongoing debate regarding whether patients with a positive urine culture (UC) need to wait for the culture to turn negative following antimicrobial treatment before undergoing percutaneous nephrolithotomy (PCNL). This…
View details →Leech J, Sauer BM, Baduashvili A et al. · 2025 · Neurology. Clinical practice
Background and objectives The presence of oligoclonal bands (OCBs) indicates an augmented immune response within the CNS and is integral to the diagnosis of multiple sclerosis (MS). Expert consensus panels recommend OCB testing for…
View details →Wezenberg BN, Koster M, van Wingen G et al. · 2025 · Schizophrenia research
Objective Sleep disturbances and brain alterations are common in psychotic disorders and individuals at clinical high risk for psychosis (CHR-P). It remains unclear whether gray matter volume changes are inherent to psychosis or partly…
View details →Boardman-Pretty F, Kumar J, Grant C et al. · 2026 · Orphanet journal of rare diseases
BACKGROUND: Accurate and early diagnosis to optimise rare disease care is a global priority. With recent developments in artificial intelligence (AI)-based solutions, a promising area to improve rare disease diagnosis is the application of…
View details →Wells MJ, Casleton BG, Gella MM et al. · 2025 · Open Forum Infectious Diseases
Background All blood donors in the United States are universally screened once for Trypanosoma cruzi antibodies to prevent transfusion-transmitted Chagas disease, but military donors are screened with every donation. Previous studies of…
View details →Montagud AC, Moragues R, Gabaldón-Bravo EM et al. · 2025 · BMC public health
BACKGROUND: The primary immunization against SARS-CoV-2 has yielded protection rates of up to 95%. The evolution of the original strain of SARS-CoV-2 towards emerging variants which have higher transmissibility, severity of disease and…
View details →Butler D, O'Flaherty N, Coyne D et al. · 2026 · Epidemiology and infection
Cytomegalovirus (CMV) is a ubiquitous virus with significant public health implications, including severe morbidity and mortality in neonates and immunosuppressed individuals. Substantial variation in CMV prevalence has been reported…
View details →Andersson Å, Ferrari P, Bakó I et al. · 2026 · The journal of physical chemistry. A
The gas-phase structures of capped phenylated polyalanine peptides, Ac-Ala-Ala-Phe-Ala-NH 2 (AAFA) and Ac-Ala-Ala-Phe-Ala-Ala-NH 2 (AAFAA), were investigated using conformer-selective IR-UV ion dip spectroscopy employing the IR light of…
View details →Russo V, Comune A, Parente E et al. · 2025 · The American journal of cardiology
The impairment of baroreflex sensitivity (BRS) has been hypothized in patients with vasovagal syncope (VVS). The aim of our study was to assess the baroreflex sensitivity in patients with suspected vasovagal syncope who underwent head up…
View details →Ali M, Baban Y, Kumar G · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research
To retrospectively examine the outcome of the antinuclear antibody (ANA) screen by comparing the performance of BioPlex 2200 and immunofluorescence assay (IFA). We reviewed the ANA screening results performed on the BioPlex 2200 using…
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