Powering Bias and Clinically Important Treatment Effects in Randomized Trials of Critical Illness.
Abrams D; Montesi SB; Moore SKL; Manson DK; Klipper KM; Case MA; Brodie D; Beitler JR · 2020 · Critical care medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Objectives Recurring issues in clinical trial design may bias results toward the null, yielding findings inconclusive for treatment effects. This study evaluated for powering bias among high-impact critical care trials and the associated…
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Metadata source: Europe PMC · DOI 10.1097/ccm.0000000000004568