12,248 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Galloway NL, Sargeant GA, Powers JG et al. · 2026 · Journal of wildlife diseases
Effective wildlife disease management and research rely on trustworthy disease diagnostics. For chronic wasting disease (CWD), immunohistochemistry (IHC) is recognized as the gold standard, and ELISA is a reliable high-throughput screening…
View details →Rincón-González AM, Galeano-Tamayo DC, Zuluaga LSD · 2025 · Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
Objective To explore the factors associated with the use of the antibiotic implicated in an adverse reaction following a negative challenge test in pediatric patients in a clinical allergology service of a health institution in Medellin.…
View details →Mooghali M, Ramachandran R, Mohammad A et al. · 2026 · Journal of the National Cancer Institute
Industry payments to physician's influence prescribing, raising concern for drugs granted accelerated approval that failed confirmatory studies. We measured industry payments for oncology drugs granted accelerated approval before and after…
View details →Warintaksa P, Youkhong C, Trikasemmart M et al. · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Introduction True labor is characterized by regular uterine contractions and cervical changes. However, the precise diagnosis of the "onset" of true labor is challenging, as the examination of cervical changes requires multiple timepoints,…
View details →Dincer M, Aydin O, Karakus V et al. · 2026 · Laboratory medicine
Introduction Electrophoresis tests are reported as negative, positive, or-rarely-as suspicious for monoclonal band (SfMB). This study aimed to determine the fate of patients with SfMB findings in long-term follow-up. Methods Patients with…
View details →Hidalgo CM, Yin LX, Bogan AW et al. · 2026 · Head and neck pathology
Purpose The uses for circulating tumor high risk human papillomavirus DNA (ctHPVDNA) in the diagnostic work-up and treatment of HPV-associated oropharyngeal squamous cell carcinoma (HPV( +)OPSCC) patients are actively being investigated.…
View details →Omari Y, Nohomovich B, Sallam D et al. · 2026 · Cureus
Multitarget stool DNA-fecal immunochemical testing (mt-sDNA-FIT) is validated for colorectal cancer (CRC) screening in asymptomatic, average-risk adults. However, its application in symptomatic patients represents a misuse of a screening…
View details →Bhangu G, Greutert S, Robert-Ebadi H et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Background Pregnancy and the postpartum period increase the risk of venous thromboembolism including pulmonary embolism (PE), which is an important cause of maternal morbidity and mortality. While diagnostic strategies for suspected PE in…
View details →Ten Have L, Buil JB, van Dijk K · 2026 · Medical mycology
In this article, we evaluate a possible postzone effect for the Histoplasma antigen lateral flow assay (LFA). We re-tested urine samples that were Histoplasma-positive with the LFA, both for an undiluted and diluted sample. Of the 12…
View details →Safiejko K, Juchimiuk M, Pierko J et al. · 2026 · Cancers
Background: Liquid biopsy using circulating tumor DNA (ctDNA) is rapidly reshaping gastrointestinal (GI) oncology. The highest-impact applications are molecular residual disease (mRD) detection after curative-intent therapy and early…
View details →Bruce ATI, Faria MGBF, Andrade RLP et al. · 2026 · Revista brasileira de epidemiologia = Brazilian journal of epidemiology
Objective To analyze the factors associated with the frequency of false negative results for the RMT-TB test for the diagnosis of pulmonary tuberculosis in the state of São Paulo. Methods Cross-sectional study using pulmonary tuberculosis…
View details →Cengiz SK, Demirer E, Baysal T et al. · 2026 · Annals of Saudi medicine
Background Managing small Lung-RADS 4 pulmonary nodules is clinically challenging. While CT-guided TTFNAB is standard, its efficacy and safety for lesions ≤2 cm require further evaluation to optimize outcomes and reduce unnecessary…
View details →Seyama S, Uwamino Y, Yoshihara K et al. · 2026 · Diagnostic microbiology and infectious disease
Accurate subspecies identification and determination of macrolide resistance status are crucial for the treatment of Mycobacterium abscessus complex (MABC) infections. In recent years, a kit that uses DNA chromatography to differentiate…
View details →Knasmüller S, Nersesyan A, Mišík M et al. · 2026 · Mutagenesis
We describe the impact of lifestyle related factors on the formation of micronuclei (MN) in buccal cells. It is known that consumption of alcohol and of other drugs including tobacco and other plants cause damage of the genetic material…
View details →Vardanega MJ, Longo T, Aceino A et al. · 2026 · Journal of veterinary internal medicine
Vulvovaginal squamous cell carcinoma (SCC) is an uncommon neoplasm in dogs. An 11-year-old female spayed German Shepherd dog presented with a history of excessive peri-vulvar grooming and a 3 cm × 3 cm irregular mass involving the vagina…
View details →Goubeau L, Curis E, Delavenne X et al. · 2026 · Blood advances
Phase 3 trials evaluating inhibitors of coagulation factor (F) XI and/or its activated form (FXIa) as novel anticoagulant drugs are ongoing. These agents include parenteral monoclonal antibody (abelacimab) and oral small molecules…
View details →Ünal F, Gülhan B, Yüksek SK et al. · 2026 · Diagnostic microbiology and infectious disease
Background This study aimed to evaluate the diagnostic performance of serum galactomannan for invasive fungal infections in children with hematologic malignancies and to assess the impact of mold-active antifungal prophylaxis on test…
View details →Schouten CS, Guarda V, Stadler TM et al. · 2026 · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Background Human papillomavirus (HPV)-16 is the most commonly found HPV-type in HPV-induced oropharyngeal squamous cell carcinomas (OPSCC). The serological response to HPV oncoproteins could be a way to detect HPV-driven OPSCC early. A…
View details →Khan A, Jaynes A, Ali F et al. · 2025 · Journal of translational gastroenterology
Background and objectives Guaiac fecal occult blood test (gFOBT) is often used to evaluate evidence of food protein-induced allergic proctocolitis (FPIAP) in children in primary care and gastroenterology settings; however, it has not been…
View details →Yin J, Wang Q, Lan T et al. · 2026 · Frontiers in pediatrics
Background Copy number variants of uncertain significance (VUS-CNVs) pose significant challenges in prenatal counseling for congenital heart malformations (CHMs). Their clinical relevance remains poorly defined, particularly in the absence…
View details →Iwata K, Mori N, Ogasawara K · 2025 · Cureus
Introduction Noninvasive methods for assessing liver fibrosis are increasingly important for early detection of advanced liver fibrosis (ALF), particularly in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).…
View details →Zych-Krekora K, Sylwestrzak O, Krekora M · 2026 · Journal of clinical medicine
Background/Objectives : Maternal rectovaginal carriage of Group B Streptococcus (GBS, Streptococcus agalactiae ) is a major risk factor for vertical transmission and early-onset neonatal infection. Intrapartum antibiotic prophylaxis…
View details →Galván CA, Durán R, Larco JI et al. · 2026 · Immunity, inflammation and disease
Background Accurate identification of respiratory allergen sensitization is essential for managing asthma and allergic rhinitis (AR). While Skin Prick Test (SPT) and ImmunoCAP are standard diagnostic tools, exploratory comparative data for…
View details →Nakai Y, Onishi K, Asakawa I et al. · 2026 · The Prostate
Background Long-term clinical data evaluating oncological outcomes and patient-reported quality of life (QOL) after combining celecoxib with radiotherapy are lacking. Therefore, we aimed to assess oncological outcomes and QOL with extended…
View details →Oshiro Y, Kawashima A, Akashi M et al. · 2026 · Tropical medicine and health
Background Giardiasis and cryptosporidiosis are often misdiagnosed by stool ova and parasite test (classical O&P). Multiplex PCR and rapid antigen immunochromatography (rapid-IC) could offer high diagnostic accuracy; however, their cost…
View details →Espigares LF, Panadero AF, Sánchez MD et al. · 2026 · Multiple sclerosis and related disorders
Objective Accurate anti-JC virus (JCV) antibody testing is essential for progressive multifocal leukoencephalopathy (PML) risk stratification in natalizumab-treated patients. This study assessed evaluated inter-assay concordance between…
View details →Grynkiewicz M, Buffi NM, Fasulo V et al. · 2025 · Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques
Introduction Research results suggest that high-resolution ultrasonography (microUS) can be used to estimate the risk of prostate cancer (PCa) and identify suspicious areas, enabling precise biopsy during examination. Aim The aim of the…
View details →van Rooij JLM, Wessels PH, Niers JM et al. · 2026 · The Lancet. Haematology
Background Primary CNS lymphoma is typically diagnosed by brain biopsy, a procedure with risks and diagnostic delay. Emerging cerebrospinal fluid (CSF) biomarkers, including the myeloid differentiation primary response 88 (MYD88) L265P…
View details →Newman A, Hansel S, Gerrard G et al. · 2026 · Cancers
Background Surveillance of non-muscle-invasive bladder cancer (NMIBC) relies on cystoscopy and urine cytology, both of which have well-recognised limitations. Molecular urine assays have been developed to reduce the burden of invasive…
View details →Mints G, Bai J, Evans A · 2025 · American journal of cardiovascular disease
This is letter to the editor: we point to a statistical error in a recent article published in the journal by Movahed MR, Soltani Moghadam A. A normal and particularly small ( , which may have resulted in a biased conclusion.
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