Negative / Null Result ReportOpen accessMedicine
Pramhas S, Thalhammer T, Terner S et al. · 2023 · The Lancet regional health. Europe
Background Painful knee osteoarthritis (KOA) is common, pharmacological treatment, however, is often hampered by limited tolerability. Cannabidiol, which preclinically showed anti-inflammatory, analgesic activity, could supplement…
View details →Failed Experiment ReportOpen accessMedicine
Biscaglia S, Tebaldi M, Mele D et al. · 2019 · European heart journal supplements : journal of the European Society of Cardiology
Despite the evolution in pharmacology and devices, recurrent and persistent angina still represent a frequent issue in clinical practice. A 69-year-old Caucasian female patient has history of surgical aortic valve replacement with a…
View details →Negative / Null Result ReportOpen accessMedicine
Finlay CJ, Jackson MJ, Fisher R et al. · 2024 · Journal of Parkinson's disease
Background Increased activity across corticostriatal glutamatergic synapses may contribute to L-DOPA-induced dyskinesia in Parkinson's disease. Given the weak efficacy and side-effect profile of amantadine, alternative strategies to reduce…
View details →Negative / Null Result ReportOpen accessMedicine
Ghomrawi HMK, Marx RG, Pan TJ et al. · 2018 · Contemporary clinical trials communications
Publication of 2 (negative) randomized clinical trials (RCTs) in 2002 and 2008 demonstrating inefficacy of arthroscopic debridement of the knee (ADK) for osteoarthritis, and a 2004 national non-coverage Medicare determination, have…
View details →Negative / Null Result ReportOpen accessMedicine
Pochon C, Laroye C, Kimmoun A et al. · 2023 · Frontiers in medicine
Background The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal…
View details →Negative / Null Result ReportOpen accessMedicine
Goudman L, Jansen J, Vets N et al. · 2021 · Journal of clinical medicine
The increased awareness of discrepancies between self-reporting outcome measurements and objective outcome measurements within the field of neuromodulation has accelerated the search towards more objective measurements. The aim of this…
View details →Failed Experiment ReportOpen accessMedicine
Hsu CT, Sato W · 2023 · Sensors (Basel, Switzerland)
Although electromyography (EMG) remains the standard, researchers have begun using automated facial action coding system (FACS) software to evaluate spontaneous facial mimicry despite the lack of evidence of its validity. Using the facial…
View details →Negative / Null Result ReportMedicine
Sanderson C, Hardy J, Spruyt O et al. · 2013 · Journal of pain and symptom management
Placebo and nocebo effects are known to contribute significantly to the response to symptom control, including analgesia. Clinical trial methodologies using placebo controls are designed to identify the magnitude of these effects in the…
View details →Negative / Null Result ReportOpen accessMedicine
Farooqi AS, Guadagnolo BA, Mitra D et al. · 2023 · Current oncology (Toronto, Ont.)
Locoregional recurrence (LRR) is the predominant pattern of relapse and often the cause of death in patients with retroperitoneal sarcomas (RPS). As a result, reducing LRR is a critical objective for RPS patients. However, unlike soft…
View details →Negative / Null Result ReportOpen accessMedicine
Ou SL, Luo J, Wei H et al. · 2023 · Frontiers in pharmacology
Background: Evidence of efficacy and safety of programmed cell death 1 (PD-1) and programmed death ligand-1 (PD-L1) checkpoint inhibitors in oesophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC) was inconsistent,…
View details →Negative / Null Result ReportOpen accessMedicine
Petrylak DP, Ratta R, Matsubara N et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose The standard of care for metastatic castration-resistant prostate cancer (mCRPC) after second-generation androgen receptor pathway inhibitor (ARPI) therapy is still docetaxel. The randomized, double-blind, phase III KEYNOTE-921…
View details →Negative / Null Result ReportOpen accessMedicine
Mitting RB, Ray S, Raffles M et al. · 2019 · PloS one
Background Methylprednisolone remains a commonly used ancillary therapy for paediatric acute respiratory distress syndrome (PARDS), despite a lack of level 1 evidence to justify its use. When planning prospective trials it is useful to…
View details →Negative / Null Result ReportMedicine
Brustad N, Garland J, Thorsen J et al. · 2020 · JAMA pediatrics
Importance Studies suggest an association between maternal vitamin D status during pregnancy and offspring anthropometry and bone mineralization, but investigations are few and with mixed results. Objective To investigate the effect of a…
View details →Negative / Null Result ReportOpen accessMedicine
Wu Y, Tan KC, Shiu SW et al. · 2022 · Journal of diabetes investigation
Aims/introduction To examine the association between cholesterol efflux capacity (CEC) of serum high-density lipoprotein (HDL) and cognitive function and brain structures in older people with diabetes mellitus. Materials and methods…
View details →Failed Experiment ReportOpen accessMedicine
Regan JJ, Wang Z, Phares CR · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background It is not recommended to perform tuberculin skin tests (TSTs) or interferon-γ release assays (IGRAs) in the 4 weeks following live-virus vaccination because these vaccines are thought to increase the risk of false-negative…
View details →Failed Experiment ReportMedicine
Tang TH, Kwong RT, Chan P et al. · 2026 · HIV medicine
Introduction Two-drug regimens (2DRs) may reduce long-term drug toxicities and drug-drug interactions for people with HIV (PWH) on antiretroviral therapy (ART). This study evaluated clinical and laboratory outcomes in PWH who switched from…
View details →Methods Dead-EndOpen accessMedicine
Polak M, Wiatrzyk A, Krysztopa-Grzybowska K et al. · 2026 · Biosensors
The translation of nucleic acid amplification into practical point-of-care and biosensor-integrated diagnostics is still significantly impeded by the necessity for rapid sample preparation. For this reason, a broad comparison of seven…
View details →Failed Experiment ReportOpen accessMedicine
Rizzuto P, Gangat M, Khattab A et al. · 2026 · Journal of clinical research in pediatric endocrinology
21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH). Salt-wasting CAH can present with life-threatening salt-wasting crises, underscoring the importance of universal newborn screening. We present a…
View details →Negative / Null Result ReportMedicine
Genis C, Torun Ozel C, Selmanoglu A et al. · 2025 · Allergy and asthma proceedings
Background: Ondansetron is a common antiemetic that rarely causes hypersensitivity. Skin-prick testing (SPT) and intradermal testing (IDT) may assist in diagnosing ondansetron hypersensitivity; however, their sensitivity, specificity, and…
View details →Negative / Null Result ReportMedicine
Felländer M, Grandi G, Juremalm M et al. · 2026 · Veterinary parasitology, regional studies and reports
Infections with Fasciola hepatica are most prevalent in south-western Sweden, but climate change may facilitate further spread, as both the parasite and its snail host thrive in humid, mild conditions. Sheep are particularly susceptible,…
View details →Negative / Null Result ReportMedicine
Yi P, Ou ZY, Wang MM et al. · 2026 · Zhongguo shi yan xue ye xue za zhi
Objective To explore the simplest scheme for detection of "Asian-type" DEL in clinical blood transfusion and its application effectiveness. Methods 100 pregnant women who tested Rh(D) negative by the saline method were selected. Their…
View details →Negative / Null Result ReportMedicine
Galata Z, Limoncu O, Tunakan Dalgıc C et al. · 2026 · Allergy and asthma proceedings
Introduction: Local anesthetics (LAs) are commonly used to provide regional insensitivity in dentistry, minor surgical procedures, and general anesthesia but may rarely cause allergic reactions. Methods: The file data of 101 patients who…
View details →Negative / Null Result ReportMedicine
Laird G, Calinger-Yoak A, Zhang Q · 2026 · EcoHealth
Wild Eastern Gray Squirrels (Sciurus carolinensis) rehabilitated at a Midwestern facility, the Ohio Wildlife Center, were experiencing an increased mortality rate due to unknown respiratory illness in 2022-2023. A qPCR test was developed…
View details →Negative / Null Result ReportOpen accessMedicine
Kunitsu T, Hamanaka K, Tagaya M et al. · 2026 · The journal of allergy and clinical immunology. Global
Background Food protein-induced enterocolitis syndrome (FPIES) caused by egg yolk is increasingly recognized in Japan, yet the optimal timing for oral food challenge (OFC) and the process of tolerance acquisition remain unclear. Objective…
View details →Negative / Null Result ReportMedicine
Hosokawa T, Uchiyama M, Namba S et al. · 2026 · Annals of nuclear medicine
Objective Lymphoscintigraphy has been used to diagnose chylopericardium; however, systematic studies on its detection rate for pediatric patients are lacking. We assessed the detection rate of lymphoscintigraphy with technetium-99 m for…
View details →Negative / Null Result ReportMedicine
Dawson ZP, Curtis A, Cross S et al. · 2026 · Cureus
To report a rare presentation of endogenous methicillin-resistant Staphylococcus aureus (MRSA) endophthalmitis with necrotizing scleritis manifesting as an anterior chamber (AC) abscess, and to highlight the diagnostic value of repeating…
View details →Negative / Null Result ReportMedicine
Li X, Peng Y, Liu W et al. · 2025 · Taiwanese journal of obstetrics & gynecology
Objective To investigate the cause of a false-negative result in prenatal amniotic fluid karyotype analysis for a fetus with mosaic trisomy 15, and to propose a cytomolecular genetic strategy for detecting mosaicism in amniotic fluid. Case…
View details →Negative / Null Result ReportMedicine
Hogg JP 3rd · 2026 · AJP reports
Background Prenatal cell-free DNA (cfDNA) screening has revolutionized the prenatal detection of fetal aneuploidy and other conditions. Originally designed to identify risk for trisomy 21, cfDNA screening has expanded to other fetal…
View details →Negative / Null Result ReportMedicine
Sachner L, Flynn JS, Hsu CW et al. · 2026 · Journal of pediatric psychology
Objective Children with cancer increasingly undergo germline genetic testing to identify genetic predispositions and inform clinical care options. Parents of children with pathogenic/likely pathogenic (P/LP) germline results have reported…
View details →Negative / Null Result ReportMedicine
Lee S, Lee J, Park D et al. · 2026 · NPJ digital medicine
Gastroesophageal reflux disease (GERD) diagnosis traditionally relies on acid exposure time (AET) obtained from 24-h multichannel intraluminal impedance-pH (MII-pH) monitoring, the gold standard for GERD diagnosis. However, a negative…
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