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Browse the failure-mode index

12,380 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Foetal Exposure to Phthalates and Endocrine Effects on the Leydig Cell.

Nielsen SP, Mathiesen L, Møller P · 2025 · Basic & clinical pharmacology & toxicology

This review examines the association between early life exposure to phthalates in human males and Leydig cell endocrine function. A systematic search was performed in PubMed and EMBASE, identifying 17 studies for analysis. Association…

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Negative / Null Result ReportOpen accessMedicine

Causal effects of single-carbon metabolism and vitamin levels on autism spectrum disorder risk: a bidirectional Mendelian randomized study.

Zhu J, Yi Y, Ma L et al. · 2026 · Italian journal of pediatrics

BACKGROUND: Observational epidemiology studies suggested a relationship between single-carbon metabolism and vitamin levels with autism spectrum disorder (ASD) risk. We aimed to explore the causal relationship between them at the genetic…

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Negative / Null Result ReportMedicine

The association between residential natural vegetation exposure at diagnosis and colorectal cancer-specific mortality among colorectal cancer cases in Kentucky.

Newton JD, Ellis T, Ruther M et al. · 2026 · Environmental research

Living near green areas with high vegetation may contribute to an active lifestyle, stress reduction, and enhance social cohesion, and consequently may be associated with improved cancer survival. Epidemiologic studies focused on greenness…

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Negative / Null Result ReportOpen accessMedicine

The Effect of Myo-Inositol Supplementation During Pregnancy on Fetal and Maternal Outcomes: Results of the Myo-Inositol for the Prevention of Gestational Diabetes Mellitus (MiGDM) Randomized Double-Blind, Placebo-Controlled Pilot Trial.

Okunoye G, George Samuel C, Abdullahi H et al. · 2026 · Cureus

Gestational diabetes mellitus (GDM) is a common pregnancy complication with significant maternal and neonatal risks, and its prevalence is particularly high in Qatar. Myo-inositol has been proposed as an insulin-sensitizing supplement that…

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Negative / Null Result ReportMedicine

Effect of different durations of treatment with antihypertensive drugs with anticholinergic effects on the risk of dementia: a target trial emulation study.

Aguado J, Gutierrez L, Forns J et al. · 2025 · American journal of epidemiology

Studying the effect of duration of treatment on prognostic outcomes using real-world data is challenging because only people who survive for a long time can receive a treatment for a long time. Specifying a target trial helps overcome such…

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Negative / Null Result ReportMedicine

Losing sleep? The effects of exposure to shootings near one's residence on self-reported sleep quantity in Chicago, 2020-2021.

McLone SG, Coleman CM, Matzke HJ et al. · 2026 · American journal of epidemiology

Firearm violence is a public health crisis in the United States and negatively impacts individuals and communities. We used data from The Healthy Chicago Survey, a citywide survey of 8754 respondents from 2020 to 2021, and police-reported…

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Negative / Null Result ReportOpen accessMedicine

Negative news exposure does not affect risk or ambiguity aversion.

Garcia Campos LS, Lempert KM · 2025 · Frontiers in psychology

Introduction Uncertain decisions can be risky (with known probabilities) or ambiguous (with unknown probabilities). Previous studies have found that negative affect can increase risk aversion and ambiguity aversion, but it is unknown if…

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Negative / Null Result ReportOpen accessMedicine

Elusive effects of legalized wolf hunting on human-wolf interactions.

Merz LM, von Hohenberg BC, Bergmann NT et al. · 2025 · Science advances

Expanding gray wolf ( Canis lupus ) populations in Europe and North America contribute to increased risks of livestock predation, which can threaten human livelihoods and lead government agencies to target wolves for lethal removal. Public…

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Negative / Null Result ReportOpen accessMedicine

Examining valproate's potential anticancer effect among patients with bipolar disorder: a territory-wide active-comparator new user study spanning two decades.

Wei C, Ng VWS, Wei Y et al. · 2025 · BMC psychiatry

AIMS: Preclinical studies have suggested potential anticancer effects of valproate, but clinical evidence is limited and inconclusive. This study aims to reexamine the relationship between valproate use and cancer incidence, using lithium…

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Negative / Null Result ReportOpen accessMedicine

Glucagon-like Peptide-1 Receptor Agonists and Colorectal Cancer Risk.

Winkelman JW, Levine MJ · 2026 · AACE endocrinology and diabetes

Type 2 diabetes mellitus is a highly prevalent metabolic disorder and a well-established risk factor for colorectal cancer (CRC), mediated by hyperglycemia, hyperinsulinemia, chronic inflammation, and obesity-related metabolic dysfunction.…

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Negative / Null Result ReportOpen accessMedicine

Sterile-neutrino search based on 259 days of KATRIN data.

· 2025 · Nature

Neutrinos are the most abundant fundamental matter particles in the Universe and play a crucial part in particle physics and cosmology. Neutrino oscillation, discovered about 25 years ago, shows that the three known species mix with each…

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Negative / Null Result ReportMedicine

A Comprehensive Assessment of the Causal Relationship between Atopic Conditions and Pancreatic Cancer Risk: A Two-Sample Mendelian Randomization Study.

He J, Sabroso-Lasa S, Coscia C et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Observational studies consistently report reduced pancreatic ductal adenocarcinoma (PDAC) risk among individuals with atopic conditions (asthma and rhinitis); however, the underlying biological mechanism remains unclear. This…

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