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Browse the failure-mode index

12,248 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Reward learning and attention in risky alcohol use: Absence of Pavlovian influences but altered response bias in high-risk drinkers.

Van der Wielen I, Mrkonja L, Wiers R et al. · 2026 · Behavioural brain research

Reward learning can contribute to addictive behaviors by shaping attention and action selection. While reward-associated stimuli are known to capture attention, it remains unclear whether such learning can also guide behavior without…

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Negative / Null Result ReportMedicine

Vitamin Supplementation and Cardiovascular Disease.

Lipman ET, Frishman WH · 2026 · Cardiology in review

Cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Given the global burden, the potential role of micronutrients-particularly vitamins-in modifying cardiovascular risk has been a topic of intense…

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Negative / Null Result ReportOpen accessMedicine

Healthy Food Voucher Programs: Global Evidence on Structure, Implementation, and Nutrition-Related Outcomes.

Lara-Arevalo J, Corvalan C, Pemjean I et al. · 2025 · Advances in nutrition (Bethesda, Md.)

Healthy food voucher programs (HFVPs) provide lower-income participants with benefits to purchase healthy, nutrient-dense foods and are a promising strategy for improving dietary and nutritional outcomes. HFVPs can complement policies…

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Negative / Null Result ReportMedicine

Do Anti-immigration Rhetoric and Policy Impact Reporting of Intimate Partner Violence To Police Among Latina/e Survivors in the United States? A Comparative Interrupted Time Series Study.

Bevilacqua K, Gemmill A, Jackson D et al. · 2026 · Journal of immigrant and minority health

Latina/e women in the United States (US) experience intimate partner violence (IPV) at similar or lower rates than other women but worse IPV-related health outcomes, perhaps due to barriers to help-seeking. IPV reporting to police is one…

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Negative / Null Result ReportMedicine

Is selenate a diabetogenic form of selenium? Evidence from a natural experiment in Northern Italy.

Vinceti M, Vicentini M, Ottone M et al. · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Background Consistent evidence from randomized controlled trials has shown that overexposure to selenium induces type 2 diabetes. However, uncertainties remain about the specific species and doses of selenium that trigger such diabetogenic…

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Negative / Null Result ReportMedicine

Geomagnetic Constraints on Millicharged Dark Matter.

Arza A, Gong Y, Shu J et al. · 2026 · Physical review letters

Millicharged particles are well-motivated dark matter candidates arising in many extensions of the standard model. We show that, despite their tiny coupling e_{m} to photons, millicharged dark matter (mDM) in the Earth's geomagnetic field…

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Negative / Null Result ReportMedicine

Association of oral metoprolol exposure during heart failure hospitalization with death or readmission at 28-days and 6-months using a propensity score overlap-weighted EHR analysis.

Ishaqui AA, Alsaleh EA, Khalil AAA et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology

Heart failure (HF) hospitalization is a high-risk transition period with frequent early post-discharge events; we evaluated whether oral metoprolol exposure during the index HF hospitalization is associated with lower all-cause death…

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Negative / Null Result ReportOpen accessMedicine

No Evidence That Women's Sociosexuality or Self-Perceived Mate Value Predict Their Preferences for Men's Face-Shape Masculinity.

Lee P, Li J, Jones BC et al. · 2025 · Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior

Researchers have suggested that men with more masculine facial characteristics have stronger immune systems but are perceived to be less likely to invest resources in partners and offspring. How women resolve this putative trade-off…

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Negative / Null Result ReportOpen accessMedicine

Foetal Exposure to Phthalates and Endocrine Effects on the Leydig Cell.

Nielsen SP, Mathiesen L, Møller P · 2025 · Basic & clinical pharmacology & toxicology

This review examines the association between early life exposure to phthalates in human males and Leydig cell endocrine function. A systematic search was performed in PubMed and EMBASE, identifying 17 studies for analysis. Association…

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Negative / Null Result ReportOpen accessMedicine

Causal effects of single-carbon metabolism and vitamin levels on autism spectrum disorder risk: a bidirectional Mendelian randomized study.

Zhu J, Yi Y, Ma L et al. · 2026 · Italian journal of pediatrics

BACKGROUND: Observational epidemiology studies suggested a relationship between single-carbon metabolism and vitamin levels with autism spectrum disorder (ASD) risk. We aimed to explore the causal relationship between them at the genetic…

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Negative / Null Result ReportMedicine

The association between residential natural vegetation exposure at diagnosis and colorectal cancer-specific mortality among colorectal cancer cases in Kentucky.

Newton JD, Ellis T, Ruther M et al. · 2026 · Environmental research

Living near green areas with high vegetation may contribute to an active lifestyle, stress reduction, and enhance social cohesion, and consequently may be associated with improved cancer survival. Epidemiologic studies focused on greenness…

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Negative / Null Result ReportOpen accessMedicine

The Effect of Myo-Inositol Supplementation During Pregnancy on Fetal and Maternal Outcomes: Results of the Myo-Inositol for the Prevention of Gestational Diabetes Mellitus (MiGDM) Randomized Double-Blind, Placebo-Controlled Pilot Trial.

Okunoye G, George Samuel C, Abdullahi H et al. · 2026 · Cureus

Gestational diabetes mellitus (GDM) is a common pregnancy complication with significant maternal and neonatal risks, and its prevalence is particularly high in Qatar. Myo-inositol has been proposed as an insulin-sensitizing supplement that…

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