12,218 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Shari L. Barkin, William J. Heerman, Evan C. Sommer et al. · 2018 · JAMA
Importance: Prevention of obesity during childhood is critical for children in underserved populations, for whom obesity prevalence and risk of chronic disease are highest. Objective: To test the effect of a multicomponent behavioral…
View details →Nichole D. Mahnert, Daniel M. Morgan, Darrell A. Campbell et al. · 2015 · Obstetrics and Gynecology
OBJECTIVE: To define the incidence of unexpected gynecologic malignancies among women who underwent hysterectomy for benign indications. METHODS: We conducted a data analysis of hysterectomy cases from a quality and safety database…
View details →Elizabeth L. Stegemöller, Hollie Radig, Paul R. Hibbing et al. · 2016 · Disability and Rehabilitation
Purpose Interventions focused on singing may provide additional benefits to established voice and respiratory therapies, due to their greater emphasis on the respiratory muscle control system in those with Parkinson's disease (PD)…
View details →Zhonglei He, Kangze Liu, Eline Manaloto et al. · 2018 · Scientific Reports
Gold nanoparticles (AuNP) have potential as both diagnostic and therapeutic vehicles. However, selective targeting and uptake in cancer cells remains challenging. Cold atmospheric plasma (CAP) can be combined with AuNP to achieve synergistic anti-cancer cytotoxicity. To explore synergistic mechanisms, we demonstrate both rate of AuNP uptake and total amount accumulated in U373MG Glioblastoma multiforme (GBM) cells are significantly increased when exposed to 75 kV CAP generated by dielectric barrier discharge. No significant changes in the physical parameters of AuNP were caused by CAP but acti
View details →Teng Moua, Ana Carro Martínez, Misbah Baqir et al. · 2014 · Respiratory Research
BACKGROUND: Although usual interstitial pneumonia (UIP) appears to portend better survival when associated with connective tissue disease (CTD-UIP), little is known about the presenting clinical, radiologic, and pathologic features that differentiate pathologically confirmed UIP with CTD from idiopathic pulmonary fibrosis (IPF). In patients with atypical radiologic and clinical features, what specific findings predict underlying IPF vs. CTD-UIP diagnosis and their respective long term survival? METHODS: A large retrospective cohort analysis was done of consecutive patients seen from 1995 throu
View details →Gabriel Fitzpatrick, Florian Vogt, Osman Gbabai et al. · 2015 · The Journal of Infectious Diseases
This paper describes patient characteristics, including Ebola viral load, associated with mortality in a Médecins Sans Frontières Ebola case management centre (CMC).Out of 780 admissions between June and October 2014, 525 (67%) were…
View details →James Chih‐Hsin Yang, Dae Ho Lee, Jong Seok Lee et al. · 2023 · Journal of Clinical Oncology
LBA9000 Background: EGFR TKIs are standard 1L therapy for metastatic NSCLC with sensitizing EGFR mutations; however, most patients (pts) ultimately experience PD. We report the protocol-specified final analysis (FA) from the randomized,…
View details →Jiang He, Marion R. Wofford, Kristi Reynolds et al. · 2011 · Circulation
BACKGROUND: Observational studies have reported an inverse association between dietary protein intake and blood pressure (BP). We compared the effect of soy protein, milk protein, and carbohydrate supplementation on BP among healthy…
View details →Ahmed M. Elkhatat · 2023 · International Journal for Educational Integrity
Abstract Academic plagiarism is a pressing concern in educational institutions. With the emergence of artificial intelligence (AI) chatbots, like ChatGPT, potential risks related to cheating and plagiarism have increased. This study aims to investigate the authenticity capabilities of ChatGPT models 3.5 and 4 in generating novel, coherent, and accurate responses that evade detection by text-matching software. The repeatability and reproducibility of both models were analyzed, showing that the generation of responses remains consistent. However, a two-sample t-test revealed insufficient evidenc
View details →Sebastian Wolfrum, Kevin Roedl, Alexia Hanebutte et al. · 2022 · Circulation
Background: This study was conducted to determine the effect of hypothermic temperature control after in-hospital cardiac arrest (IHCA) on mortality and functional outcome as compared with normothermia. Methods: An investigator initiated,…
View details →Dong Dong, Nicky Thomas, Benjamin Thierry et al. · 2015 · PLoS ONE
BACKGROUND: Staphylococcus aureus and Pseudomonas aeruginosa are major pathogens in chronic rhinosinusitis (CRS) and their biofilms have been associated with poorer postsurgical outcomes. This study investigated the distribution and anti-biofilm effect of cationic (+) and anionic (-) phospholipid liposomes with different sizes (unilamellar and multilamellar vesicle, ULV and MLV respectively) on S. aureus and P. aeruginosa biofilms. METHOD: Specific biofilm models for S. aureus ATCC 25923 and P. aeruginosa ATCC 15692 were established. Liposomal distribution was determined by observing SYTO9 sta
View details →Ian Y. Wong, Raymond Wong, Paul Zhao et al. · 2012 · Retina
PURPOSE: To investigate the relationship of hypercholesterolemia and choroidal thickness in normal healthy volunteers. METHOD: This was a cross-sectional observational study. Volunteers with no ocular abnormalities were examined using…
View details →Robert D. Boutin, Sara Bamrungchart, Cyrus Bateni et al. · 2017 · American Journal of Roentgenology
OBJECTIVE: Our objective was to determine the association between muscle cross-sectional area and attenuation, as measured on routine CT scans, and mortality in older patients with hip fracture. MATERIALS AND METHODS: A retrospective…
View details →Nancy Kass, Holly A. Taylor, Joseph Ali et al. · 2014 · Clinical Trials
BACKGROUND: Research suggests that participants do not always adequately understand studies. While some consent interventions increase understanding, methodologic challenges have been raised in studying consent outside of actual trial…
View details →Julian Gold, Raph Goldacre, H Maruszak et al. · 2014 · Journal of Neurology Neurosurgery & Psychiatry
OBJECTIVES: Even though multiple sclerosis (MS) and HIV infection are well-documented conditions in clinical medicine, there is only a single case report of a patient with MS and HIV treated with HIV antiretroviral therapies. In this…
View details →Nancy L. Bartlett, Sarit Assouline, Pratyush Giri et al. · 2023 · Blood Advances
As part of a phase 1 or 2 study, this single-arm expansion cohort established the efficacy and safety of mosunetuzumab monotherapy in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) (received ≥2 previous lines…
View details →Daniel Brock Hewitt, Nicholas Nissen, Hassan Hatoum et al. · 2020 · Annals of Surgery
OBJECTIVES: To compare the efficacy and safety of algenpantucel-L [HyperAcute-Pancreas algenpantucel-L (HAPa); IND# 12311] immunotherapy combined with standard of care (SOC) chemotherapy and chemoradiation to SOC chemotherapy and…
View details →Maximilian Salcher‐Konrad, Huseyin Naci, Courtney Davis · 2020 · Milbank Quarterly
Policy Points Regulatory agencies may have limited evidence on the clinical benefits and harms of new drugs when deciding whether new therapeutic agents are allowed to enter the market and under which conditions, including whether approval is granted under special regulatory pathways and obligations to address knowledge gaps through postmarketing studies are imposed. In a matched comparison of marketing applications for cancer drugs of uncertain therapeutic value reviewed by both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA), we found frequent discordance be
View details →Marco Metra, Cathal O’Connor, Beth A. Davison et al. · 2011 · European Heart Journal
AIMS: Dyspnoea and pulmonary and/or peripheral congestion are the most frequent manifestations of acute heart failure (AHF) and are important targets for therapy. We have assessed changes in dyspnoea, their relationship with mortality, and…
View details →Ashley Woodcock, Eugene R. Bleecker, Jan Lötvall et al. · 2013 · CHEST Journal
BACKGROUND: The combination of fluticasone furoate (FF), a novel inhaled corticosteroid (ICS), and vilanterol (VI), a long-acting β2 agonist, is under development as a once-daily treatment of asthma and COPD. The aim of this study was to…
View details →Susanna Wiegand, Dagmar l’Allemand, Hanna Hübel et al. · 2010 · European Journal of Endocrinology
OBJECTIVE: To study whether metformin reduces obesity, homeostasis model assessment for insulin resistance index (HOMA-IR), and the metabolic syndrome (MtS) in obese European adolescents in addition to previous unsuccessful lifestyle…
View details →Claudia Torino, Fabio Manfredini, Davide Bolignano et al. · 2014 · Kidney & Blood Pressure Research
BACKGROUND/AIMS: Scarce physical activity predicts shorter survival in dialysis patients. However, the relationship between physical (motor) fitness and clinical outcomes has never been tested in these patients. METHODS: We tested the…
View details →Leigh L. van den Heuvel, Nathaniel Chishinga, Eugene Kinyanda et al. · 2013 · AIDS Care
We determined the frequency and correlates of current common mental disorders (CMDs) in a consecutive series of 649 adult patients with human immunodeficiency virus (HIV), tuberculosis (TB) or both receiving treatment at 16 primary health…
View details →Wentao Zhao, Fengliang Hu, Yuying Li et al. · 2012 · World Journal of Surgery
BACKGROUND: The aim of the present study was to investigate the usefulness of the transanal drainage tube for prevention of anastomotic leakage and bleeding after anterior resection for rectal cancer. METHODS: Between January 2007 and May…
View details →Rachna T. Shroff, Mark Yarchoan, Ashley O’Connor et al. · 2017 · British Journal of Cancer
BACKGROUND: Cholangiocarcinoma is an aggressive malignancy with limited therapeutic options. MEK inhibition and antiangiogenic therapies have individually shown modest activity in advanced cholangiocarcinoma, whereas dual inhibition of…
View details →Kelly A. Liebman, Steven T. Stoddard, Amy C. Morrison et al. · 2012 · PLoS neglected tropical diseases
BACKGROUND: Knowledge of spatial patterns of dengue virus (DENV) infection is important for understanding transmission dynamics and guiding effective disease prevention strategies. Because movement of infected humans and mosquito vectors plays a role in the spread and persistence of virus, spatial dimensions of transmission can range from small household foci to large community clusters. Current understanding is limited because past analyses emphasized clinically apparent illness and did not account for the potentially large proportion of inapparent infections. In this study we analyzed both c
View details →H Grubek-Jaworska, Magdalena Paplińska‐Goryca, Joanna Hermanowicz-Salamon et al. · 2012 · Respiration
BACKGROUND: IL-6 is strongly implicated in the development of chronic obstructive pulmonary disease (COPD). IL-13 is the well-documented central mediator in allergic asthma. IL-6 is attributed to the proinflammatory activities in COPD as…
View details →Mikkael A. Sekeres, J. E. Lancet, Brent L. Wood et al. · 2012 · Haematologica
Improving outcomes in older adults with acute myeloid leukemia remains a formidable challenge. Lintuzumab (SGN-33; HuM195) is a humanized monoclonal antibody directed against CD33, which is expressed on the majority of myeloblasts in acute…
View details →Francesco Sclafani, Tae‐Yop Kim, David Cunningham et al. · 2015 · JNCI Journal of the National Cancer Institute
BACKGROUND: Insulin-like growth factor type 1 receptor (IGF-1R) mediates resistance to epidermal growth factor receptor (EGFR) inhibition and may represent a therapeutic target. We conducted a multicenter, randomized, double blind, phase…
View details →Edward S. Brewer, B. I. Reznikov, Rebecca F. Liberman et al. · 2010 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: The yield of head computed tomography (CT) for patients who suffered head trauma with a presenting Glasgow Coma Scale (GCS) score of 15 has been reported to be low, even in patients who are anticoagulated or on antiplatelet…
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