e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

Effect of injectable platelet-rich fibrin on orthodontically induced apical root resorption following non-extraction-based orthodontic treatment in adults: A randomized controlled clinical trial.

Idris, Burhan, Hajeer et al. · 2026 · The Journal of international medical research

ObjectiveTo investigate the effect of repeated submucosal administration of injectable platelet-rich fibrin in the buccal region of the lower incisors on orthodontically induced apical root resorption in patients with moderate…

View details →
Negative / Null Result ReportMedicine

A pilot study comparing specimen quality of ESR and EMR.

Metter, Dumoulin, Hay et al. · 2026 · Scandinavian journal of gastroenterology

Endoscopic submucosal resection (ESR) is a novel resection technique. ESR is performed with a partially insulated snare, which allows a resection close to the proper muscle layer thus resecting in the deep submucosa. This should have…

View details →
Negative / Null Result ReportMedicine

Effect of an Educational Intervention on Postural Risk Among Endodontic Residents Under Different Magnification Conditions.

García Alcaide, Conde Villar, Pérez Alfayate et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

To assess the impact of a tailored ergonomic lecture on postural risk among second-year endodontic residents depending on the use of no magnification, ergonomic loupes, or an operating microscope. A within-subjects, repeated measures…

View details →
Negative / Null Result ReportMedicine

The Relationship Between Games Missed for Rest or Load Management and Injury in the National Basketball Association, 2014-15 Through 2022-23.

Herzog, Brink, Gondalia et al. · 2026 · Sports medicine (Auckland, N.Z.)

One often-stated aim of load management in elite athletes is injury reduction. However, current literature on the efficacy and effectiveness of specific load management strategies to reduce injury risk is limited. The aim of this study was…

View details →
Negative / Null Result ReportMedicine

Serum fibroblast growth factor-2 and fibroblast growth factor-9 levels in bipolar disorder: Potential biomarkers for mood episodes.

Keskin, Erdoğan, Küçükçetin et al. · 2026 · Psychiatry research

The aim of this study was to compare serum levels of Fibroblast Growth Factor-2 (FGF-2) and Fibroblast Growth Factor-9 (FGF-9) between patients with Bipolar Disorder (BD) and healthy controls (HC), and to evaluate whether these molecules…

View details →
Negative / Null Result ReportMedicine

Long-Term Sedation Effect of Cipepofol Compared to Dexmedetomidine in Patients Receiving Invasive Mechanical Ventilation: A Multicenter, Randomized, Open-Label, Parallel-Controlled Study.

Li, Zhu, Xu et al. · 2026 · Advances in therapy

This study evaluated the efficacy and safety of cipepofol vs. dexmedetomidine for long-term sedation of patients undergoing mechanical ventilation (MV) in an intensive care unit (ICU). Adult patients who required invasive MV for…

View details →
Negative / Null Result ReportMedicine

Impact of emergency medical services on the prognosis in acute ischemic stroke patients receiving reperfusion therapy or usual treatment: a prospective cohort study.

Tao, Pan, Li et al. · 2026 · BMC emergency medicine

The impact of Emergency Medical Service (EMS) on the prognosis of patients with acute ischemic stroke (AIS) remains controversial. This prospective cohort study enrolled AIS patients admitted to the emergency department of the Central…

View details →
Negative / Null Result ReportMedicine

Association between different onset types and clinical outcomes in patients with large ischemic stroke following endovascular therapy.

Cheng, Zhu, Xie et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

This study aimed to explore the association between different stroke onset types [unwitnessed stroke (UWS) vs. witnessed stroke (WS)] and clinical outcomes in patients with large ischemic stroke treated with endovascular therapy (EVT).…

View details →
Negative / Null Result ReportMedicine

The effect of clinical bibliotherapy on self-esteem, hope and depressive symptoms among adolescents living with sickle cell disorder in Ibadan, Nigeria: a non-randomized controlled pilot study.

Adeoye, Ani, Egbokhare et al. · 2026 · Psychology, health & medicine

Sickle Cell Disorder (SCD) is a complex, multi-system blood condition affecting 7.78 million people, with 80% of global cases in sub-Saharan Africa, especially Nigeria. The condition is associated with physical health complications and…

View details →
Negative / Null Result ReportMedicine

Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice.

Kaewmanee, Ganesan, Choochana et al. · 2026 · PloS one

Phy-Blica-O (PBO) is a traditional Thai polyherbal formulation historically regarded as a brain tonic and memory enhancer. Despite its long-standing ethnomedicinal use, its neuroprotective mechanisms have not been scientifically validated.…

View details →
Negative / Null Result ReportMedicine

A Quantitative in Vitro Framework Reveals State-Dependent Pharmacological Responses to Repeated Inflammatory Stimulation in Synovial Fibroblasts.

Yamada, Hosokawa, Mitoma et al. · 2026 · Biological & pharmaceutical bulletin

Rheumatoid arthritis is characterized by chronic synovial inflammation and recurrent flares, which are thought to involve joint-specific inflammatory memory. Synovial fibroblasts (SFs) contribute to this process through altered responses…

View details →
Negative / Null Result ReportMedicine

Cardioprotective role of antihypertensive treatment in chemotherapy-induced cardiotoxicity: umbrella review of meta-analyses of randomised controlled trials.

Rostami, Ashraf, Hosseininasab · 2026 · Open heart

Chemotherapy-induced cardiotoxicity is a major contributor to long-term cardiovascular morbidity among cancer survivors. ACE inhibitors (ACEIs), angiotensin receptor blockers and beta blockers have been proposed as prophylactic therapies;…

View details →
Negative / Null Result ReportMedicine

β-Blockers after myocardial infarction with preserved or mildly reduced left ventricular ejection fraction: Fragility of contemporary evidence.

Zuin, Chopard, Drachman et al. · 2026 · American heart journal plus : cardiology research and practice

β-Blockers have been traditionally prescribed after acute myocardial infarction (MI), but contemporary evidence in patients with preserved or mildly reduced left ventricular ejection fraction (LVEF ≥40%) have not provided…

View details →
Negative / Null Result ReportMedicine

Cerebellar cognitive-affective syndrome in Friedreich Ataxia.

Petit, Sayah, Indelicato et al. · 2026 · Journal of neurology

Increasing evidence suggests that cognition and affect may be affected in Friedreich Ataxia (FA). To investigate the Cerebellar Cognitive Affective Syndrome (CCAS) in patients with FA and evaluate its correlations with speech and clinical…

View details →
Negative / Null Result ReportMedicine

Anti-complement and anticoagulant activities from the salivary glands and gut of Ctenocephalides felis felis (Siphonaptera: Pulicidae) in wild and domestic Carnivora hosts.

Rodrigues, Filho, Alves et al. · 2026 · Insect biochemistry and molecular biology

Ctenocephalides felis felis is an ectoparasite of global relevance, causing impacts at the One Health interface. The process of hematophagy depends on evolutionary adaptations, in which arthropods have evolved inhibitors of host hemostatic…

View details →