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Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Similar secondary patellar resurfacing but higher tibial revision risk with posterior stabilized versus medial pivot total knee arthroplasty: A registry analysis.

Pflüger, Pedrazzini, Jud et al. · 2026 · Journal of experimental orthopaedics

Patellar complications are among the most frequent causes of revision after primary total knee arthroplasty (TKA). The primary study objective is to compare the rate of secondary patellar resurfacing between medial pivot (MP) and posterior…

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Negative / Null Result ReportMedicine

Long-Term Outcomes After Catheter-Directed Thrombolysis or Mechanical Thrombectomy in Intermediate-High-Risk Pulmonary Embolism: A Propensity-Matched Analysis From a TriNetX Database.

Giorgi, Bertoletti, Luis et al. · 2026 · Pulmonary circulation

Catheter-directed thrombolysis (CDL) and mechanical thrombectomy (MT) are increasingly used for intermediate-high-risk pulmonary embolism (PE), yet comparative long-term outcomes remain uncertain. We aimed to compare the effectiveness and…

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Failed Experiment ReportMedicine

Survival Outcomes in Early Onset Appendiceal Adenocarcinoma (EOAA).

Gujarathi, Belmont, Rodman et al. · 2026 · Annals of surgical oncology

The incidence of early onset (age&#x2009;<&#x2009;50 years at diagnosis) appendiceal adenocarcinoma (EOAA) is rising alarmingly. Reported data on etiology, treatment, and outcomes is scarce. In this study, we report clinical outcomes for…

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Failed Experiment ReportMedicine

Age-dependent alterations in anterior cingulate excitation-inhibition balance in major depressive disorder revealed by 7-Tesla magnetic resonance spectroscopy.

Yoshihara, Suwa, Kubota et al. · 2026 · NeuroImage. Clinical

Altered excitation-inhibition (E/I) balance has been implicated in the pathophysiology of major depressive disorder (MDD), but previous magnetic resonance spectroscopy (MRS) findings have been inconsistent, partly due to methodological…

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Negative / Null Result ReportMedicine

Efficacy of a digitally designed anatomical repositioning splint for adolescent temporomandibular joint anterior disc displacement with reduction: a randomized controlled trial.

Wang, Wang, Wu et al. · 2026 · BMC oral health

Anterior disc displacement with reduction (ADDwR) is a common temporomandibular joint disorder in adolescents. Conventional anterior repositioning splints (ARS) often lack anatomical adaptation, which may limit their therapeutic precision…

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Negative / Null Result ReportMedicine

Clinical characteristics and outcomes of tandem lesions involving internal carotid artery occlusion and distal middle cerebral artery occlusion.

Tomari, Lillicrap, Garcia-Esperon et al. · 2026 · Clinical neurology and neurosurgery

Tandem lesions involving internal carotid artery occlusion (ICAO) and distal middle cerebral artery occlusion (MCAO) are rare, and evidence regarding their clinical characteristics, management strategies, and outcomes remains limited. We…

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Negative / Null Result ReportMedicine

Laboratory evaluation of mixed-species biofilm formation by Streptococcus mutans and Lactobacillus casei on three dental resin-based restorative materials.

Conner, AbdulAzees, Chen et al. · 2026 · American journal of dentistry

To evaluate the biofilm-forming potential of mixed-species bacteria on three commercially available dental restorative composites and compare their resistance to biofilm accumulation. Given the increasing emphasis on bioactive and…

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Negative / Null Result ReportMedicine

Management of Rope Friction Injuries of the Hand.

Evin, Parlak, Okan et al. · 2026 · Annals of plastic surgery

Rope friction injuries result from rapid, repetitive contact with coarse ropes or chains, causing combined mechanical and thermal damage. These injuries commonly affect young individuals during activities such as tug-of-war, climbing, air…

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Negative / Null Result ReportMedicine

Profile of deliberate self-poisoning admissions in KwaZulu-Natal Province, South Africa (2018 - 2023) and the impact of COVID-19.

Pillay · 2026 · South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Deliberate self-poisoning (DSP) is a common method of attempted suicide globally, particularly among young adults and women. In South Africa (SA), DSP is the second most frequent method of attempted suicide, after hanging. The COVID-19…

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Negative / Null Result ReportMedicine

Sensory Organization and Postural Control Strategies During Quiet Standing in People with Acute Low Back Pain: A Case-Control Study.

Fatehi Peykani, Saadat, Monjezi et al. · 2026 · The archives of bone and joint surgery

This study aimed to compare posturographic measures between acute low back pain patients (LBP) and healthy controls. A total of 20 participants with acute LBP were compared with a group of matched, healthy participants. Sensory…

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Negative / Null Result ReportMedicine

First Covid-19 Vaccination Rates Among Pregnant Tennessee Women by Month of Conception and Urbanization Level: March 2021 - November 2021.

Valenzuela, Driscoll, Harvey et al. · 2026 · Journal of Appalachian health

Throughout the pandemic, COVID-19 vaccination coverage was lower for the general population living in rural counties than in urban counties. In Tennessee (TN), COVID-19 vaccinations became available to pregnant women in March 2021. Little…

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Negative / Null Result ReportMedicine

MRI Evaluation of Graft Remodeling After Transphyseal Anterior Cruciate Ligament Reconstruction in Pediatric Patients: A 5-Year Follow-up.

de Pesters, Staali, Laval et al. · 2026 · Orthopaedic journal of sports medicine

Anterior cruciate ligament (ACL) reconstruction (ACLR) is increasingly performed in children and adolescents, yet mid- to long-term graft ligamentization remains poorly understood. To characterize the magnetic resonance imaging (MRI)…

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Negative / Null Result ReportMedicine

VR preoperative education with sensory information alleviates perioperative anxiety and enhances delivery experience in primiparas undergoing cesarean section: a randomized controlled trial.

Ran, Wei, Huang et al. · 2025 · Frontiers in psychology

To investigate the effectiveness of a VR preoperative education program with sensory information support in reducing perioperative anxiety and improving the delivery experience among primiparas undergoing cesarean section (CS). A total of…

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Negative / Null Result ReportMedicine

Thoracic Duct Branch Identification Is Comparable Between T2-W 3D Fat-Suppressed Magnetic Resonance Imaging and Computed Tomography Lymphangiography in Normal Dogs.

Griffith, Hecht, Lux et al. · 2026 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

In dogs with chylothorax that are refractory to medical management, surgical intervention is often recommended. Computed tomographic lymphangiography (CTL) is the most commonly used preoperative imaging study, but it has the disadvantages…

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