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Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Masticatory Muscle Activity in a Group of Thai Children with Skeletal and Dental Malocclusions: A Pilot Study Using Surface Electromyography.

Saleechan, Pumklin, Puapichartdumrong et al. · 2026 · European journal of dentistry

This pilot study aimed to investigate masseter muscle (MM) and anterior temporal muscle activity, symmetry, synergy, and effort in Thai children with skeletal and dental malocclusions. Children aged 9 to 12 years were recruited ( N…

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Negative / Null Result ReportMedicine

Extracorporeal Membrane Oxygenation Support Before Pediatric Heart Transplantation: A Comparison of Two Eras.

Bilgili, Abu-Mowis, Jeng et al. · 2026 · ASAIO journal (American Society for Artificial Internal Organs : 1992)

The United Network for Organ Sharing (UNOS) Database was studied to evaluate the state of extracorporeal membrane oxygenation (ECMO) utilization before pediatric heart transplantation and to compare outcomes over the last two decades. A…

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Negative / Null Result ReportMedicine

Effectiveness of Forum Play to promote respectful maternity care: A pilot intervention investigating self-reported perception and behaviour among care providers in urban Nepal.

Paudel Ghimire, Dahal, Joshi et al. · 2026 · PloS one

Ensuring respectful maternity care is crucial to promote positive childbirth experiences among women. Globally, 22-100% women report experiencing at least one form of disrespect and abuse during facility-based birth, with a study in Nepal…

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Negative / Null Result ReportMedicine

The Effect of Isotonic Versus Isometric Strength Exercise for Pain and Strength in Proximal Hamstring Tendinopathy: A Randomized Crossover Trial.

Rich, Ford, Cook et al. · 2026 · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

The effect of isometric exercise on pain and strength for various tendinopathies has been investigated but there are no published studies on proximal hamstring tendinopathy (PHT). The objective of this trial was to determine the…

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Negative / Null Result ReportMedicine

Multiparametric MRI-Based Habitat Radiomics Combined with Deep Transfer Learning for Predicting Extrathyroidal Extension in Papillary Thyroid Carcinoma.

Li, Zeng, Wang et al. · 2026 · Journal of imaging informatics in medicine

The objective of the study is to develop and validate a multiparametric MRI (mpMRI)-based model that integrated with habitat-based radiomics, deep transfer learning (DTL), and quantitative parameters for the preoperative prediction of…

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Negative / Null Result ReportMedicine

Early orthodontic traction does not compromise root development in inversely impacted maxillary central incisors: a three-year cone-beam computed tomography evaluation.

Yang, Dong, Cheng et al. · 2026 · Clinical oral investigations

To evaluate whether early orthodontic traction of inversely impacted maxillary central incisors with curved roots affects subsequent root development and labial/palatal alveolar bone support. A retrospective cone-beam computed tomography…

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Negative / Null Result ReportMedicine

Venous thromboembolic events in traumatic brain injury. Does timing of prophylaxis matter? A single-center retrospective cohort study.

Hernandez, Christensen, Shumaker et al. · 2026 · Proceedings (Baylor University. Medical Center)

Patients with traumatic brain injury (TBI) are at increased risk for venous thromboembolism (VTE) due to immobilization and a hypercoagulable state. The administration and optimal timing for chemoprophylaxis remain unclear because of…

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Negative / Null Result ReportMedicine

Phacoemulsification with IOL implantation combined with goniosynechialysis and goniotomy in primary angle-closure glaucoma following failed trabeculectomy: short-term effectiveness and safety outcomes.

Zhou, Ge, Jin et al. · 2026 · Frontiers in medicine

To evaluate the short-term effectiveness and safety of Phacoemulsification with intraocular lens implantation combined with goniosynechialysis and goniotomy (PEI-GSL-GT) in eyes with prior failed trabeculectomy compared to surgically…

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Negative / Null Result ReportMedicine

Efficacy and cost-effectiveness of intraoperative cell salvage for patients with placenta previa during cesarean section: a retrospective comparison analysis.

Zhang, Lu, Hua et al. · 2026 · Open medicine (Warsaw, Poland)

This study aimed to evaluate whether intraoperative cell salvage (ICS) and retransfusion reduce allogeneic blood transfusion (ABT) requirement and treatment costs in patients with placenta previa undergoing cesarean section. We…

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Negative / Null Result ReportMedicine

Endoscopic versus open flexor hallucis longus tendon transfer for reconstruction of chronic achilles tendon rupture: A prospective randomized pilot trial.

Afifi, Hewaidy, El Shazly et al. · 2026 · Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

Chronic Achilles tendon rupture often requires surgical reconstruction. Flexor hallucis longus (FHL) tendon transfer is widely used, and endoscopic techniques may reduce soft-tissue morbidity and facilitate early recovery. Thirty patients…

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Negative / Null Result ReportMedicine

The environmental cost of learning: CO 2 emission comparisons of virtual reality, online, and alternative distance education.

Istrate, Van Gelder, Szőllősi et al. · 2026 · Intensive care medicine

Environmental sustainability has become a critical concern across various sectors, including education and healthcare. Professional training programmes, particularly in intensive care medicine, are essential for maintaining competency but…

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Negative / Null Result ReportMedicine

Lumbar Function and Muscle Preservation Following Hybrid Surgery Versus Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis: A Preliminary Comparative Study.

Tasdemir, Korkmaz, Durak et al. · 2026 · Turkish neurosurgery

To investigate lumbar motion and muscle change following hybrid surgery in adolescent idiopathic scoliosis (AIS). We conducted a prospective study design including 16 patients (14 female, 2 male) who underwent either hybrid surgery or…

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Failed Experiment ReportMedicine

Evaluation of Neonatal Sprague-Dawley Rats as a Potential Animal Model for the Neurovirulence Test of an Iranian Mumps Vaccine Strain, RS-12.

Mohammad Kazem, Mohammad, Mohammad Hasan et al. · 2025 · Archives of Razi Institute

Mumps virus (MuV), a neurotropic member of paramyxoviridae, causes mumps disease. Since the 1960s, when the first live-attenuated vaccine against the MuV was developed, mumps outbreaks have dramatically decreased. A monkey-based…

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