Negative / Null Result ReportOpen accessMedicine
J. Randolph Hecht, Sara Lonardi, Johanna C. Bendell et al. · 2021 · Journal of Clinical Oncology
PURPOSE SEQUOIA compared efficacy and safety of adding pegilodecakin (PEG), a pegylated recombinant human interleukin (IL)-10, with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) in patients following progression on first-line…
View details →Negative / Null Result ReportMedicine
Hyun Jin Jo, Jaeyeon Kim, Nayoung Kim et al. · 2016 · Helicobacter
BACKGROUND: Little is known about the role of gastric microbiota except for Helicobacter pylori (HP) in human health and disease. We compared the differences of human gastric microbiota according to gastric cancer or control and HP…
View details →Negative / Null Result ReportMedicine
Christian von Bodman, Kazuhito Matsushita, Caroline Savage et al. · 2012 · The Journal of Urology
PURPOSE: We determined whether pelvic soft tissue and bony dimensions on endorectal magnetic resonance imaging influence the recovery of continence after radical prostatectomy, and whether adding significant magnetic resonance imaging…
View details →Negative / Null Result ReportOpen accessMedicine
Charles de Mestral · 2011 · Canadian Journal of Surgery
BACKGROUND: A multidisciplinary tracheostomy team was created in 2005 to follow critically ill patients who had undergone a tracheostomy until their discharge from hospital. Composed of a surgeon, surgical resident, respiratory therapist,…
View details →Negative / Null Result ReportOpen accessMedicine
Deborah H. Ndao, Elena J. Ladas, Bin Cheng et al. · 2010 · Psycho-Oncology
OBJECTIVE: Though often lifesaving, stem cell transplantation (SCT) is a period of great distress for both child and parent. METHODS: We conducted a double-blind, placebo-controlled randomized study evaluating the effect of the respiratory…
View details →Negative / Null Result ReportMedicine
Stewart R. Walsh, S.A.R. Nouraei, Tjun Yip Tang et al. · 2010 · Vascular and Endovascular Surgery
Remote ischemic preconditioning (RIPC) is a physiological mechanism whereby brief ischemia-reperfusion episodes attenuate damage by subsequent prolonged ischemic insults. It reduces myocardial injury following cardiac and aortic aneurysm…
View details →Negative / Null Result ReportMedicine
Lena Koch‐Gallenkamp, Heike Bertram, Andrea Eberle et al. · 2016 · Health Psychology
OBJECTIVE: Fear of recurrence (FoR) is among the most important concerns for cancer survivors. Studies on potentially influencing variables, like time since diagnosis, cancer type, and sex, have yielded heterogeneous results. Also social…
View details →Negative / Null Result ReportOpen accessMedicine
Kathryn G. Ewens, Michelle R. Jones, Wendy Ankener et al. · 2011 · PLoS ONE
Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in women. It is also associated with metabolic disturbances that place women at increased risk for obesity and type 2 diabetes. There is strong evidence for familial clustering of PCOS and a genetic predisposition. However, the gene(s) responsible for the PCOS phenotypes have not been elucidated. This two-phase family-based and case-control genetic study was designed to address the question of whether SNPs identified as susceptibility loci for obesity in genome-wide association studies (GWAS) are also associated w
View details →Negative / Null Result ReportOpen accessMedicine
Dinesh Khanna, Yannick Allanore, Christopher P. Denton et al. · 2020 · Annals of the Rheumatic Diseases
OBJECTIVES: Riociguat is approved for pulmonary arterial hypertension and has antiproliferative, anti-inflammatory and antifibrotic effects in animal models of tissue fibrosis. We evaluated the efficacy and safety of riociguat in patients with early diffuse cutaneous systemic sclerosis (dcSSc) at high risk of skin fibrosis progression. METHODS: In this randomised, double-blind, placebo-controlled, phase IIb trial, adults with dcSSc of <18 months' duration and a modified Rodnan skin score (mRSS) 10-22 units received riociguat 0.5 mg to 2.5 mg orally three times daily (n=60) or placebo (n=61). T
View details →Negative / Null Result ReportOpen accessMedicine
Charles M. Rudin, Stephen V. Liu, Ross A. Soo et al. · 2023 · Journal of Clinical Oncology
PURPOSE The phase III SKYSCRAPER-02 study determined whether the benefits of atezolizumab plus carboplatin and etoposide (CE) could be enhanced by the addition of tiragolumab in untreated extensive-stage small-cell lung cancer (ES-SCLC).…
View details →Failed Experiment ReportOpen accessMedicine
Kaori Kuramitsu, Deanna Sverdlov, Susan B. Liu et al. · 2013 · American Journal Of Pathology
Failure of fibrotic liver to regenerate after resection limits therapeutic options and increases demand for liver transplantation, representing a significant clinical problem. The mechanism underlying regenerative failure in fibrosis is…
View details →Negative / Null Result ReportMedicine
Alexander G. Thompson, Elizabeth Gray, Alexander Bampton et al. · 2019 · Journal of Neurology Neurosurgery & Psychiatry
Objective To evaluate the classifier performance, clinical and biochemical correlations of cerebrospinal fluid (CSF) levels of the chitinase proteins Chitotriosidase-1 (CHIT1), Chitinase-3-like protein 1 (CHI3L1) and Chitinase-3-like…
View details →Negative / Null Result ReportMedicine
Patrick J. Denard, Alexandre Lädermann, Stephen S. Burkhart · 2012 · Arthroscopy The Journal of Arthroscopic and Related Surgery
PURPOSE: The purpose of this study was to determine the long-term functional outcome of anatomic arthroscopic repair of type II SLAP lesions with suture anchors. METHODS: We examined all arthroscopic repairs of isolated type II SLAP…
View details →Negative / Null Result ReportOpen accessMedicine
Yi‐Han Hsiao, Yung‐Tai Chen, Ching-Min Tseng et al. · 2015 · SLEEP
STUDY OBJECTIVES: To explore the association between the non-apnea sleep disorder (NSD) and autoimmune diseases. DESIGN: Cohort study. SETTING: Nationwide database research. PARTICIPANTS: 84,996 adult patients with NSD diagnoses recorded…
View details →Negative / Null Result ReportOpen accessMedicine
Carlos Cruchaga · 2011 · Archives of Neurology
BACKGROUND: Apolipoprotein E (APOE) is the most statistically significant genetic risk factor for late-onset Alzheimer disease (LOAD). The linkage disequilibrium pattern around the APOE gene has made it difficult to determine whether all…
View details →Negative / Null Result ReportOpen accessMedicine
Ioannis Pavlidis, Panagiotis Tsiamyrtzis, Dvijesh Shastri et al. · 2012 · Scientific Reports
In the present study we quantify stress by measuring transient perspiratory responses on the perinasal area through thermal imaging. These responses prove to be sympathetically driven and hence, a likely indicator of stress processes in…
View details →Negative / Null Result ReportMedicine
Étienne Cavaignac, V. Lafontan, Nicolas Reina et al. · 2013 · The Bone & Joint Journal
The significance of weight in the indications for unicompartmental knee replacement (UKR) is unclear. Our hypothesis was that weight does not affect the long-term rate of survival of UKRs. We undertook a retrospective study of 212 UKRs at…
View details →Negative / Null Result ReportMedicine
H. Mike Kim, Leesa M. Galatz, Rosalina Das et al. · 2010 · Connective Tissue Research
The purpose of this study was to examine the role of two of the three transforming growth factor beta (TGF-β) isoforms at the healing tendon-to-bone insertion. The supraspinatus tendons of 64 rats were transected at their bony insertions…
View details →Negative / Null Result ReportOpen accessMedicine
Jennifer L. Dearborn, Yiyi Zhang, Ye Qiao et al. · 2017 · Neurology
OBJECTIVE: To explore the association of intracranial atherosclerotic disease (ICAD) with mild cognitive impairment (MCI) and dementia. METHODS: From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from the…
View details →Failed Experiment ReportOpen accessMedicine
Thomas R. Lerner, Cristiane de Souza Carvalho‐Wodarz, Urška Repnik et al. · 2016 · Journal of Clinical Investigation
In extrapulmonary tuberculosis, the most common site of infection is within the lymphatic system, and there is growing recognition that lymphatic endothelial cells (LECs) are involved in immune function. Here, we identified LECs, which…
View details →Negative / Null Result ReportOpen accessMedicine
D. James Cooper, Jeffrey V. Rosenfeld, Lynnette Murray et al. · 2020 · Journal of Neurotrauma
Functional outcomes at 12 months were a secondary outcome of the randomized DECRA trial of early decompressive craniectomy for severe diffuse traumatic brain injury (TBI) and refractory intracranial hypertension. In the DECRA trial,…
View details →Negative / Null Result ReportMedicine
Daniel S. Thoma, Manuel Sancho‐Puchades, Dominik A. Ettlin et al. · 2011 · Journal Of Clinical Periodontology
AIM: To test whether a collagen matrix (CM) can improve early wound healing and aesthetics, and decrease wound sensitivity compared with spontaneous healing. METHODS: In 15 volunteers, 6-mm punch biopsies were harvested at both palatal…
View details →Replication FailureOpen accessMedicine
Manaf AlQahtani, Abdulkarim Abdulrahman, Abdulrahman Almadani et al. · 2021 · Scientific Reports
Convalescent plasma (CP) therapy in COVID-19 disease may improve clinical outcome in severe disease. This pilot study was undertaken to inform feasibility and safety of further definitive studies. This was a prospective, interventional and randomized open label pilot trial in patients with severe COVID-19. Twenty COVID-19 patients received two 200 ml transfusions of convalescent patient CP over 24-h compared with 20 who received standard of care. The primary outcome was the requirement for ventilation (non-invasive or mechanical ventilation). The secondary outcomes were biochemical parameters
View details →Negative / Null Result ReportOpen accessMedicine
Shiu‐Dong Chung, Hsin‐Tzu Liu, Heng Lin et al. · 2011 · Neurourology and Urodynamics
AIMS: Chronic inflammation has been implicated in the development of overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS). An elevation of C-reactive protein (CRP) has been associated with chronic inflammation…
View details →Negative / Null Result ReportOpen accessMedicine
Christopher T. Chan, Tom Greene, Glenn M. Chertow et al. · 2012 · Circulation Cardiovascular Imaging
BACKGROUND: An increase in left ventricular mass (LVM) is associated with mortality and cardiovascular morbidity in patients with end-stage renal disease. METHODS AND RESULTS: The Frequent Hemodialysis Network (FHN) Daily Trial randomized…
View details →Negative / Null Result ReportMedicine
E. Mahler, M. Blom, Nicol C. Voermans et al. · 2011 · Lara D. Veeken
OBJECTIVE: To assess the efficacy of rituximab on disease activity and muscle strength in patients with inflammatory myopathies refractory to conventional therapy. METHODS; Thirteen patients were treated with rituximab 1000 mg i.v., twice,…
View details →Negative / Null Result ReportMedicine
Harrison G. Pope, Arthur M. Jacobs, Jean-Paul Mialet et al. · 2010 · Psychotherapy and Psychosomatics
BACKGROUND: In an exploratory study, we used a novel computerized battery of neuropsychological tests of attention to assess residual cognitive impairment in marijuana users. METHODS: We compared 25 college students who were heavy…
View details →Negative / Null Result ReportOpen accessMedicine
J. Vermorken, Pol Specenier · 2013 · Biologics
Head and neck cancer is the sixth most common cancer worldwide. At present, globally about 650,000 new cases of squamous cell carcinoma of the head and neck (SCCHN) are diagnosed each year. The epidermal growth factor receptor (EGFR) is…
View details →Negative / Null Result ReportOpen accessMedicine
Martin Mynarek, Katja von Hoff, Torsten Pietsch et al. · 2020 · Journal of Clinical Oncology
PURPOSE The HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children < 4 years of age with nonmetastatic medulloblastoma by systemic chemotherapy, intraventricular methotrexate, and risk-adapted local radiotherapy. PATIENTS AND METHODS From 2001-2011, 87 patients received systemic chemotherapy and intraventricular methotrexate. Until 2006, CSI was reserved for nonresponse or progression. After 2006, local radiotherapy was introduced for nonresponders or patients with classic medulloblastoma (CMB) or large-cell/anaplastic medulloblastoma (LCA). DNA met
View details →Negative / Null Result ReportOpen accessMedicine
Steven H. Kelder, Dale S. Mantey, Duncan Van Dusen et al. · 2020 · Public Health Reports
Objectives: From 2017 to 2018, electronic cigarette (e-cigarette) use increased 78% among high school students and 48% among middle school students in the United States. However, few e-cigarette prevention interventions have been…
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