12,246 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Komiya T, Huang CH · 2018 · Frontiers in oncology
Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers. Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a…
View details →Ponizovsky AM, Rosca P, Aronovich E et al. · 2015 · Journal of substance abuse treatment
Background Limited clinical trials and case-reports yielded conflicting results regarding the efficacy of baclofen (a GABAB agonist) in the treatment of alcohol dependence. The aim of this study was to test the efficacy and tolerability of…
View details →Park L, Furey M, Nugent AC et al. · 2019 · The international journal of neuropsychopharmacology
Background This randomized, placebo-controlled, crossover trial examined the antidepressant efficacy of the muscarinic antagonist scopolamine in major depressive disorder subjects with more severe and refractory forms of major depressive…
View details →Scheperjans F, Levo R, Bosch B et al. · 2024 · JAMA neurology
Importance Dysbiosis has been robustly demonstrated in Parkinson disease (PD), and fecal microbiota transplantation (FMT) has shown promising effects in preclinical PD models. Objective To assess the safety and symptomatic efficacy of…
View details →Wu CC, Wolfe JM · 2022 · Vision research
During a visual search for a target among distractors, observers do not fixate every location in the search array. Rather processing is thought to occur within a Functional Visual Field (FVF) surrounding each fixation. We argue that there…
View details →Black PC, Tangen CM, Singh P et al. · 2023 · European urology
Background Although radical cystectomy (RC) is the standard of care for patients with bacillus Calmette-Guérin (BCG)-unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC), many patients are ineligible for surgery or elect…
View details →Coxon AT, Johanns TM, Dunn GP · 2020 · Missouri medicine
Glioblastoma is a devastating disease with a dismal prognosis. While recent advancements in cancer immunotherapy have led to improvements in treating other types of cancer, patients with glioblastoma have not benefited from these new…
View details →Tripathy S, Acharya SP, Sahoo AK et al. · 2022 · Critical care explorations
Optimal time for ICU diary delivery and impact on mental health (MH), anxiety-depression, post-traumatic stress symptoms (PTSS), quality of life (QOL), and memories is unclear. We evaluated the effect of ICU diaries, dispatched at…
View details →Pramhas S, Thalhammer T, Terner S et al. · 2023 · The Lancet regional health. Europe
Background Painful knee osteoarthritis (KOA) is common, pharmacological treatment, however, is often hampered by limited tolerability. Cannabidiol, which preclinically showed anti-inflammatory, analgesic activity, could supplement…
View details →Biscaglia S, Tebaldi M, Mele D et al. · 2019 · European heart journal supplements : journal of the European Society of Cardiology
Despite the evolution in pharmacology and devices, recurrent and persistent angina still represent a frequent issue in clinical practice. A 69-year-old Caucasian female patient has history of surgical aortic valve replacement with a…
View details →Brustad N, Garland J, Thorsen J et al. · 2020 · JAMA pediatrics
Importance Studies suggest an association between maternal vitamin D status during pregnancy and offspring anthropometry and bone mineralization, but investigations are few and with mixed results. Objective To investigate the effect of a…
View details →Wu Y, Tan KC, Shiu SW et al. · 2022 · Journal of diabetes investigation
Aims/introduction To examine the association between cholesterol efflux capacity (CEC) of serum high-density lipoprotein (HDL) and cognitive function and brain structures in older people with diabetes mellitus. Materials and methods…
View details →Regan JJ, Wang Z, Phares CR · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background It is not recommended to perform tuberculin skin tests (TSTs) or interferon-γ release assays (IGRAs) in the 4 weeks following live-virus vaccination because these vaccines are thought to increase the risk of false-negative…
View details →Tang TH, Kwong RT, Chan P et al. · 2026 · HIV medicine
Introduction Two-drug regimens (2DRs) may reduce long-term drug toxicities and drug-drug interactions for people with HIV (PWH) on antiretroviral therapy (ART). This study evaluated clinical and laboratory outcomes in PWH who switched from…
View details →Polak M, Wiatrzyk A, Krysztopa-Grzybowska K et al. · 2026 · Biosensors
The translation of nucleic acid amplification into practical point-of-care and biosensor-integrated diagnostics is still significantly impeded by the necessity for rapid sample preparation. For this reason, a broad comparison of seven…
View details →Rizzuto P, Gangat M, Khattab A et al. · 2026 · Journal of clinical research in pediatric endocrinology
21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH). Salt-wasting CAH can present with life-threatening salt-wasting crises, underscoring the importance of universal newborn screening. We present a…
View details →Genis C, Torun Ozel C, Selmanoglu A et al. · 2025 · Allergy and asthma proceedings
Background: Ondansetron is a common antiemetic that rarely causes hypersensitivity. Skin-prick testing (SPT) and intradermal testing (IDT) may assist in diagnosing ondansetron hypersensitivity; however, their sensitivity, specificity, and…
View details →Felländer M, Grandi G, Juremalm M et al. · 2026 · Veterinary parasitology, regional studies and reports
Infections with Fasciola hepatica are most prevalent in south-western Sweden, but climate change may facilitate further spread, as both the parasite and its snail host thrive in humid, mild conditions. Sheep are particularly susceptible,…
View details →Yi P, Ou ZY, Wang MM et al. · 2026 · Zhongguo shi yan xue ye xue za zhi
Objective To explore the simplest scheme for detection of "Asian-type" DEL in clinical blood transfusion and its application effectiveness. Methods 100 pregnant women who tested Rh(D) negative by the saline method were selected. Their…
View details →Lee S, Lee J, Park D et al. · 2026 · NPJ digital medicine
Gastroesophageal reflux disease (GERD) diagnosis traditionally relies on acid exposure time (AET) obtained from 24-h multichannel intraluminal impedance-pH (MII-pH) monitoring, the gold standard for GERD diagnosis. However, a negative…
View details →Galloway NL, Sargeant GA, Powers JG et al. · 2026 · Journal of wildlife diseases
Effective wildlife disease management and research rely on trustworthy disease diagnostics. For chronic wasting disease (CWD), immunohistochemistry (IHC) is recognized as the gold standard, and ELISA is a reliable high-throughput screening…
View details →Rincón-González AM, Galeano-Tamayo DC, Zuluaga LSD · 2025 · Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
Objective To explore the factors associated with the use of the antibiotic implicated in an adverse reaction following a negative challenge test in pediatric patients in a clinical allergology service of a health institution in Medellin.…
View details →Mooghali M, Ramachandran R, Mohammad A et al. · 2026 · Journal of the National Cancer Institute
Industry payments to physician's influence prescribing, raising concern for drugs granted accelerated approval that failed confirmatory studies. We measured industry payments for oncology drugs granted accelerated approval before and after…
View details →Warintaksa P, Youkhong C, Trikasemmart M et al. · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Introduction True labor is characterized by regular uterine contractions and cervical changes. However, the precise diagnosis of the "onset" of true labor is challenging, as the examination of cervical changes requires multiple timepoints,…
View details →Dincer M, Aydin O, Karakus V et al. · 2026 · Laboratory medicine
Introduction Electrophoresis tests are reported as negative, positive, or-rarely-as suspicious for monoclonal band (SfMB). This study aimed to determine the fate of patients with SfMB findings in long-term follow-up. Methods Patients with…
View details →Hidalgo CM, Yin LX, Bogan AW et al. · 2026 · Head and neck pathology
Purpose The uses for circulating tumor high risk human papillomavirus DNA (ctHPVDNA) in the diagnostic work-up and treatment of HPV-associated oropharyngeal squamous cell carcinoma (HPV( +)OPSCC) patients are actively being investigated.…
View details →Omari Y, Nohomovich B, Sallam D et al. · 2026 · Cureus
Multitarget stool DNA-fecal immunochemical testing (mt-sDNA-FIT) is validated for colorectal cancer (CRC) screening in asymptomatic, average-risk adults. However, its application in symptomatic patients represents a misuse of a screening…
View details →Vardanega MJ, Longo T, Aceino A et al. · 2026 · Journal of veterinary internal medicine
Vulvovaginal squamous cell carcinoma (SCC) is an uncommon neoplasm in dogs. An 11-year-old female spayed German Shepherd dog presented with a history of excessive peri-vulvar grooming and a 3 cm × 3 cm irregular mass involving the vagina…
View details →Goubeau L, Curis E, Delavenne X et al. · 2026 · Blood advances
Phase 3 trials evaluating inhibitors of coagulation factor (F) XI and/or its activated form (FXIa) as novel anticoagulant drugs are ongoing. These agents include parenteral monoclonal antibody (abelacimab) and oral small molecules…
View details →Ünal F, Gülhan B, Yüksek SK et al. · 2026 · Diagnostic microbiology and infectious disease
Background This study aimed to evaluate the diagnostic performance of serum galactomannan for invasive fungal infections in children with hematologic malignancies and to assess the impact of mold-active antifungal prophylaxis on test…
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