Replication FailureMedicine
Albayrak D, Bulut E, Singer EA · 2026 · Lasers in medical science
This study aimed to compare the clinical effectiveness of extraoral photobiomodulation using laser and light-emitting diode (LED) in reducing postoperative pain, swelling, and improving oral health-related quality of life following…
View details →Negative / Null Result ReportOpen accessMedicine
Bellali YA, Jetté S, Delisle M et al. · 2026 · Journal of burn care & research : official publication of the American Burn Association
Paraffin wax is applied to scar tissue for its proposed benefits of increasing skin pliability and relieving pain. However, limited studies have objectively assessed hypertrophic scar (HSc) response. This study examined immediate HSc…
View details →Negative / Null Result ReportMedicine
Xu Y, Wang H, Wang N et al. · 2026 · Journal of cardiothoracic surgery
Background OBJECTIVE: To explore changes of tumor-infiltrating lymphocytes and the relationship with therapeutic effect before and after neoadjuvant chemoimmunotherapy in patients with esophageal squamous cell carcinoma(ESCC). Method This…
View details →Negative / Null Result ReportMedicine
Çopur İ, Erbay RH, İlhan S et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : This prospective, randomized study aimed to evaluate the effects of different local anesthetic (LA) volume-dose combinations administered during supraclavicular brachial plexus block (SCBPB), a widely used…
View details →Negative / Null Result ReportMedicine
Lu J, Shorey A, Uduba R et al. · 2026 · Clinical transplantation and research
Background Up to 23% of renal transplant recipients may develop transplant renal artery stenosis (TRAS). However, diagnosis requires angiography, and the contrast used may be nephrotoxic. We aimed to identify predictors of TRAS and clarify…
View details →Negative / Null Result ReportMedicine
Feng J, Li S, Li X et al. · 2026 · Journal of agricultural and food chemistry
The effects of dietary supplementation with conjugated linoleic acid (CLA) on broiler duck growth performance and the quality of dry-cured products were investigated. Ten days preslaughter with the supplementation of 2 mL/d CLA was more…
View details →Negative / Null Result ReportOpen accessMedicine
To B, Prasath V, Veney D et al. · 2026 · NPJ breast cancer
Circulating tumor DNA (ctDNA) 'tumor fraction' (TF) may correlate with therapy response, but little is known regarding TF dynamics immediately after therapy initiation. Plasma samples from a single-arm clinical trial enrolling patients…
View details →Negative / Null Result ReportMedicine
Mace C, Deighton R · 2026 · Death studies
Empirical evidence is lacking on the effectiveness of grief telephone counseling, particularly in Australia. This study addresses an important gap by evaluating the effectiveness of the Integrating Grief Program-Victoria (IGP-V), an…
View details →Negative / Null Result ReportMedicine
Ajai S, Agnihotri R · 2026 · Journal of dental hygiene : JDH
Purpose Recently, charcoal-based oral hygiene products, such as toothpastes, have gained popularity due to their whitening and antibacterial properties. However, there is limited data on charcoal-bristle electric toothbrushes. The purpose…
View details →Negative / Null Result ReportMedicine
Lee BC, Lee J, Cho KH et al. · 2026 · Gerontology
Introduction Sarcopenia and osteosarcopenia are increasingly prevalent among older adults. Exercise and nutritional support are key non-pharmacological treatments; however, their benefits may diminish after discontinuation. This study…
View details →Negative / Null Result ReportOpen accessMedicine
Nalbant A, Olgun HE, Hendek M et al. · 2026 · Lasers in medical science
The aim of this study was to compare the effectiveness of diode laser and combined treatment protocols, applied in addition to mechanical debridement, in the treatment of peri-implantitis on clinical periodontal parameters and S100A8…
View details →Negative / Null Result ReportMedicine
Baek CH, Lim C, Kim JG et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
Background Cystic changes within interpositional grafts used for arthroscopy-assisted lower trapezius tendon transfer (aLTT) are occasionally detected on postoperative magnetic resonance imaging (MRI); however, their clinical significance…
View details →Negative / Null Result ReportMedicine
Fattahi F, Abed S, Kouchakali G et al. · 2026 · Molecular neurobiology
Introduction Alzheimer's disease (AD) is a progressive neurological disorder associated with high prevalence. Numerous studies have been conducted to regulate the expression of inflammatory genes, indicating that any changes may ultimately…
View details →Negative / Null Result ReportMedicine
Caple MA, Lau JA · 2025 · Proceedings. Biological sciences
Local adaptation is widely documented, but contributing selective agents are rarely identified or disentangled. Here, we test whether plants are adapted to their local soil nitrogen conditions and whether microbes mediate plant adaptation…
View details →Negative / Null Result ReportMedicine
Hashemi TM, Khami MR, Razeghi S et al. · 2026 · BMC oral health
Introduction Transitioning from a treatment-oriented model to a prevention-focused approach is essential for improving oral health outcomes. This study aimed to assess the feasibility and implementation outcomes of Integrated Oral Health…
View details →Negative / Null Result ReportMedicine
Slowinski J, Lutnick E, Frappa N et al. · 2026 · Foot & ankle international
Background This study aimed to demonstrate long term clinical follow-up and implant survivorship of Salto Talaris-type primary total ankle arthroplasty (TAA) by 1 foot and ankle-trained surgeon at a single institution. Methods Patients…
View details →Negative / Null Result ReportMedicine
Ghiri AA, Cavanaugh SJ, Nuñez AA et al. · 2026 · Annals of biomedical engineering
While American football games are played across a wide range of temperatures, current helmet rating protocols assess performance primarily at room temperature. This study evaluates how temperature influences impact attenuation performance…
View details →Negative / Null Result ReportOpen accessMedicine
Hyun HK, Lee OH, Roh JW et al. · 2026 · Yonsei medical journal
Purpose Patients with acute coronary syndrome (ACS) on ticagrelor-based dual antiplatelet therapy (DAPT) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors…
View details →Negative / Null Result ReportOpen accessMedicine
Li X, Liu C, Wu W et al. · 2026 · Frontiers in neuroscience
Purpose To investigate the short-term effect of a longpass filter on myopic defocus-induced changes in axial length (AL) and choroidal thickness (ChT). Methods This study included 23 young myopic adults. AL and ChT were measured in both…
View details →Failed Experiment ReportMedicine
Shetty PMV, Matzen A, Hille S et al. · 2026 · Scientific reports
Marfan syndrome (MFS) is a connective tissue disorder caused by FBN1 mutations, characterised by aortic aneurysms leading to life-threatening dissections. Asprosin is the C-terminal propeptide of fibrillin-1 that was shown to function as a…
View details →Negative / Null Result ReportMedicine
Lou Z, Yang H · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
OBJECTIVE: The objective of this study was to evaluate the graft success rate, hearing outcomes, and complications associated with three-layer graft myringoplasty for repairing subtotal and total perforations. MATERIALS AND METHODS:…
View details →Negative / Null Result ReportMedicine
Phillipson J, Menson E, Barclay S et al. · 2026 · Archives of disease in childhood
Objective Evaluation of the Medical Mediation Foundation's Conflict Management Programme (CMP)-a structured process for managing conflict. Design Mixed-methods evaluation using Kirkpatrick's framework, a four-level model for evaluating…
View details →Negative / Null Result ReportMedicine
Bachelard L, Blanc N, Michel A · 2026 · BMJ supportive & palliative care
Objective Breast cancer surgery often leads to a high burden of distressing symptoms, underscoring the need for supportive care to help patients throughout the perioperative period. This pilot study aimed to evaluate the feasibility,…
View details →Negative / Null Result ReportOpen accessMedicine
Mosch B, Diers M · 2026 · Pain reports
Introduction Since the outbreak of COVID-19, many studies have investigated long-term consequences associated to the pandemic. Undoubtedly, restrictions and changes in everyday life during that time have had a broad impact on mental health…
View details →Negative / Null Result ReportMedicine
Achar A, Houser P, Cherian J et al. · 2026 · Lupus
ObjectiveTo determine the long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus (pSLE) treated with systematic administration of combination rituximab (RTX) and cyclophosphamide (CYC) at our…
View details →Negative / Null Result ReportOpen accessMedicine
Burger C, Pirotte M, Ray K et al. · 2026 · The western journal of emergency medicine
Introduction Emergency physicians commonly receive feedback in the form of performance metrics such as patients seen per hour. Reviewing metrics has been associated with increased stress and burnout. Although effects on efficiency have…
View details →Negative / Null Result ReportMedicine
Jang YE, Kim Y, Kim HI et al. · 2026 · Journal of endodontics
Introduction Hydraulic calcium silicate cement-based sealers (CSC sealers) are now frequently used with warm vertical compaction in root canal treatment. However, the impact of heat on the biological properties of CSC sealers remains…
View details →Negative / Null Result ReportMedicine
Nakano H, Shiinoki T · 2026 · Journal of neuro-oncology
PURPOSE: The radiosensitivity index (RSI) is a transcriptomic predictor of intrinsic radiosensitivity. The longitudinal behavior of the RSI in glioma and its variation across intratumoral cellular states have been unknown. We investigated…
View details →Abandoned HypothesisOpen accessMedicine
Chang TP, Kuo YH, Bery AK · 2026 · Frontiers in neurology
Background Dizziness is common in older adults, and often presents a diagnostic challenge. Vestibular function declines with age, but the prevalence and diagnostic explanatory value of mild vestibular loss in isolation (i.e., the clinical…
View details →Negative / Null Result ReportMedicine
Silva TR, Poínhos R, Oliveira BMPM et al. · 2026 · The British journal of nutrition
While rapid four-compartment (4C) models have demonstrated cross-sectional validity in diverse populations, including athletes, their longitudinal validity remains unverified. This study aims to evaluate the longitudinal validity of…
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