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WASTE Journal

Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Impact of orally and vaginally administered estradiol on live birth and neonatal outcomes in frozen-thawed embryo transfer cycles: A retrospective cohort study.

Liu Y, Sun J, Hu Y et al. · 2026 · Clinical and experimental reproductive medicine

Objective Previous studies have reported a higher rate of small for gestational age (SGA) newborns from fresh embryo transfers compared with frozen-thawed embryo transfers (FET), potentially due to the supraphysiologic serum estradiol…

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Negative / Null Result ReportMedicine

Advanced glycation end-products accumulate preferentially in type I muscle fibers of aging adults but are unchanged by training and polyphenol supplementation.

Flensted-Jensen M, Kleis-Olsen AS, Weinreich CM et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Advanced glycation end-products (AGEs) accumulate with age and may contribute to skeletal muscle decline, yet their distribution within muscle compartments is unknown. Resistance training (RT) and high-intensity interval training (HIIT)…

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Negative / Null Result ReportMedicine

Lipocalin-2 Is Induced by Uromodulin Aggregates without Affecting Kidney Disease Progression in Autosomal Dominant Tubulointerstitial Kidney Disease- UMOD.

Lake J, Mariniello M, Schiano G et al. · 2026 · Journal of the American Society of Nephrology : JASN

Key points Lipocalin-2 upregulation paralleled intracellular uromodulin aggregates in mouse and cellular models of autosomal dominant tubulointerstitial kidney disease because of pathogenic uromodulin. The induction of lipocalin-2 was…

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Negative / Null Result ReportMedicine

Development and Evaluation of a Sham Diet Intended as a Placebo-Control Diet for Food-Based Interventional Trials in Ulcerative Colitis.

Day AS, Ballard TM, Benetti M et al. · 2026 · Journal of the Academy of Nutrition and Dietetics

Background The "gold standard" for successful blinding in controlled food-based dietary interventional trials includes a sham diet. Objective This study aimed to develop and evaluate a sham diet intended for use as a comparator in…

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Negative / Null Result ReportMedicine

Impacts of methionine oxidation on product quality and anti-tumor activity of a therapeutic monoclonal antibody.

Sun Q, Miao Z, Bian L et al. · 2026 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Methionine oxidation in monoclonal antibodies (mAbs) could critically compromise drug stability and efficacy. This investigation comprehensively evaluated the structural and functional impacts of oxidation on a mAb An under long-term…

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Negative / Null Result ReportMedicine

Bi-functional activity of chlorophyllin: Antifungal action against Botrytis cinerea and induction of grapevine defense genes.

Messanh KV, Muhie Ddine M, Ambrosini V et al. · 2026 · Journal of photochemistry and photobiology. B, Biology

Botrytis cinerea (B. cinerea) is a fungus with a high mutation rate and infects more than 200 plant species, causing significant yield losses. Therefore, new strategies to fight against this ubiquitous phytopathogen are highly sought…

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Negative / Null Result ReportMedicine

High dose methyl donor nutrient supplementation fails to prevent the adverse effects of a maternal Western-style diet on depression-related behavior and results in stress-dependent effects on learning.

Farber C, Jackson C, Renteria K et al. · 2026 · Nutrition (Burbank, Los Angeles County, Calif.)

Background Exposure to a Western diet during gestation and lactation adversely impacts offspring mood, learning, and memory. We determined if high dose maternal methyl donor nutrient (MDN) supplementation ameliorated the effects of a high…

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Negative / Null Result ReportMedicine

Platelet-derived mitochondrial preparation did not alter early inflammatory markers in a bilateral lipopolysaccharide-induced model of equine synovitis.

Khaliji E, Marycz K, Horna M et al. · 2025 · American journal of veterinary research

Objective To evaluate IA autologous platelet-derived mitochondrial preparation versus vehicle control in a bilateral lipopolysaccharide (LPS)-induced model of equine synovitis. Methods 2 ng of LPS was injected into bilateral intercarpal…

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Negative / Null Result ReportMedicine

Effects of dietary alpha-ketoglutaric acid on growth performance and intestinal barrier function in Lateolabrax maculatus fed a high soybean meal diet

Quan F, Ma J, Zhao Y et al. · 2025 · Aquaculture international

This study investigated the effects of supplementing high soybean meal diets with alpha-ketoglutaric acid (AKG) on the intestinal health and growth performance of spotted sea bass (Lateolabrax maculatus). A total of 270 fish (average…

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Negative / Null Result ReportMedicine

Vacuolar Protein Sorting 35 Controls Hepatocellular Proliferation Through SRC Signaling and Promotes Diethyl Nitrosamine-Induced Tumor Initiation.

Barbosa MG, Vos DY, Verzijl CRC et al. · 2026 · Cellular and molecular gastroenterology and hepatology

Background & aims Hepatocellular carcinoma is the third leading cause of cancer-related mortality worldwide. Therapeutic options for hepatocellular carcinoma remain limited, and the mechanisms underlying hepatocellular carcinoma are not…

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Replication FailureMedicine

Can Progressive Strength Training Counteract Frailty and Improve Short-Term Autonomic Compensatory Responses During Active Standing Orthostatic Stress? A Pilot Study.

Gama de Matos D, de Santana JL, Aidar FJ et al. · 2026 · Journal of clinical medicine

Background : Frailty is a multifactorial condition that significantly impacts older adults' health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…

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Negative / Null Result ReportMedicine

Effects of percussive massage vs. foam rolling on hamstring function: a comparative study using shear wave elastography, tensiomyography, and MyotonPro.

Fischer J, Seguel JM, Drole K et al. · 2026 · BMC sports science, medicine & rehabilitation

Background This study investigated the comparative acute effects of 3 × 30 s of vibration foam rolling (VFR) or percussive massage (PM) on the hamstring muscles, specifically range of motion (ROM), maximum voluntary isometric contraction…

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Negative / Null Result ReportMedicine

Core Temperature Estimation Using Wearable Earbud-Type Thermometer and Machine Learning During Light-Intensity Cycling Under Varying Indoor Ambient Temperatures.

Fujii N, Katagiri A, Nakagome K et al. · 2026 · Scandinavian journal of medicine & science in sports

Continuous monitoring of core temperature is crucial for optimizing exercise performance, promoting health, and ensuring safety. Here, we evaluated the validity of a machine learning-based earbud-type core temperature sensor during…

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Failed Experiment ReportMedicine

Histomorphometric Evaluation of Socket Preservation Healing Using Xenogeneic Bone Substitute Combined with Statin: A Prospective Split-Mouth Clinical Pilot Study.

Katanec T, Šimunović L, Likić R et al. · 2026 · Acta stomatologica Croatica

Objective Statins exhibit pleiotropic effects on bone metabolism, including osteogenic and angiogenic activity. The aim of this pilot study was to evaluate whether local application of simvastatin combined with a bovine-derived xenogeneic…

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Negative / Null Result ReportMedicine

Development and validation of the OMERACT juvenile idiopathic arthritis MRI- sacroiliac joint score (OMERACT JAMRIS-SIJ): Phase 3.

Maksymowych WP, Weiss PF, Francavilla ML et al. · 2026 · Seminars in arthritis and rheumatism

Objective The OMERACT JAMRIS working group has defined a spectrum of MRI lesions in the sacroiliac joint (SIJ) in pediatric cases with spondyloarthritis (SpA) that match domains for inflammation and structural damage. We aimed to assess…

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Failed Experiment ReportMedicine

Can machine learning predict vessels that encapsulates tumor cluster ptterns and histological differentiation in solitary small (< 5 cm) hepatocellular carcinoma?

Toshida K, Sugitani Y, Itoh S et al. · 2026 · Surgery today

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. Machine learning (ML) may enable the noninvasive prediction of histopathological features using clinical and imaging data. This study evaluated the utility of…

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Negative / Null Result ReportMedicine

The Association of the Social Deprivation Index With the Development of Peripheral Arterial Disease in the Multi-Ethnic Study of Atherosclerosis (MESA).

Brandon AS, Murphy BS, Nam Y et al. · 2026 · The American journal of cardiology

Peripheral arterial disease (PAD) has many established risk factors, but social determinants of health (SDoH) are increasingly recognized as a cardiovascular disease risk factor. The multi-ethnic study of atherosclerosis (MESA) cohort was…

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Negative / Null Result ReportMedicine

Acute Beetroot Juice Supplementation and Repeated Maximal Effort in Elite Swimmers: A Randomized Double-Blind Study.

Arnaoutis G, Vallas G, Toubekis AG et al. · 2026 · International journal of sport nutrition and exercise metabolism

Beetroot juice (BRJ) has been proposed as an ergogenic aid due to its high nitrate content, yet evidence from field-based studies in elite swimmers remains limited. This study investigated the acute effects of concentrated BRJ ingestion on…

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