12,367 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Lingling Fang, Fangjian Guo, Lihua Zhou et al. · 2015 · Adipocyte
AIMS/HYPOTHESIS: Regional deposition of adipose tissue and adipocyte morphology may contribute to increased risk for insulin resistance. The aim of this study was to compare adipocyte cell size and size distribution from multiple fat…
View details →Laura Evgin, Amanda L. Huff, Phonphimon Wongthida et al. · 2020 · Nature Communications
The application of adoptive T cell therapies, including those using chimeric antigen receptor (CAR)-modified T cells, to solid tumors requires combinatorial strategies to overcome immune suppression associated with the tumor microenvironment. Here we test whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells. Contrary to our hypothesis, VSVmIFNβ infection is associated with attrition of murine EGFRvIII CAR T cells in a B16EGFRvIII model, despite inducing a robust proinflam
View details →Stuart Faulkner, Alan Bainbridge, Takenori Kato et al. · 2011 · Annals of Neurology
OBJECTIVE: Additional treatments for therapeutic hypothermia are required to maximize neuroprotection for perinatal asphyxial encephalopathy. We assessed neuroprotective effects of combining inhaled xenon with therapeutic hypothermia after…
View details →Yunzhen Ye, Yu Xiong, Qiongjie Zhou et al. · 2020 · Journal of Diabetes Research
BACKGROUND: Gestational diabetes mellitus (GDM) contributes to adverse pregnancy and birth outcomes. In recent decades, extensive research has been devoted to the early prediction of GDM by various methods. Machine learning methods are flexible prediction algorithms with potential advantages over conventional regression. OBJECTIVE: The purpose of this study was to use machine learning methods to predict GDM and compare their performance with that of logistic regressions. METHODS: We performed a retrospective, observational study including women who attended their routine first hospital visits
View details →Athanassios Argiris, Michalis V. Karamouzis, William E. Gooding et al. · 2011 · Journal of Clinical Oncology
PURPOSE: We hypothesized that bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), will potentiate the activity of pemetrexed, a multitargeted antifolate, in squamous cell carcinoma of the head and neck…
View details →Priya Palta, Elbert S. Huang, Rita R. Kalyani et al. · 2017 · Diabetes Care
OBJECTIVE Hemoglobin A1c (HbA1c) level has been associated with increased mortality in middle-aged populations. The optimal intensity of glucose control in older adults with diabetes remains uncertain. We sought to estimate the risk of…
View details →Harry Sokol, Laurent Beaugerie, Marc Maynadié et al. · 2012 · Inflammatory Bowel Diseases
BACKGROUND: It remains to be shown whether inflammatory bowel disease (IBD) is associated with an increased risk of primary intestinal lymphoproliferative disorders (PILD). We assessed this risk in the CESAME French nationwide prospective…
View details →Andrea L. Roberts, Susan Malspeis, Laura D. Kubzansky et al. · 2017 · Arthritis & Rheumatology
OBJECTIVE: To conduct the first longitudinal study examining whether trauma exposure and posttraumatic stress disorder (PTSD) are associated with increased risk of incident systemic lupus erythematosus (SLE) in a civilian cohort. METHODS:…
View details →Gholam Ali Gholami, Babak Najafi, Fatemeh Mashhadiabbas et al. · 2011 · Clinical Oral Implants Research
OBJECTIVES: The aim of this study was to compare a nanocrystalline hydroxyapatite (NCHA), NanoBone(®) and a deproteinized bovine bone mineral (DBBM), Bio-Oss(®) with a collagen membrane on the horizontal ridge width alterations following…
View details →Rifat Latifi, GeorgeJ Hadeed, Judith Smith et al. · 2016 · Journal of Emergencies Trauma and Shock
OBJECTIVES: Early diagnosis and emergent surgical debridement of necrotizing soft tissue infections (NSTIs) remains the cornerstone of care. We aimed to study the effect of early surgery on patients' outcomes and, in particular, on…
View details →Abha A. Gupta, Alberto S. Pappo, Natasha Saunders et al. · 2010 · Cancer
BACKGROUND: As Ewing sarcoma (EWS) can affect children and adults, these patients can be treated at either a pediatric or an adult institution. This study investigated whether differences in therapeutic strategy undertaken in pediatric and…
View details →Michael R. Perkin, Kirsty Logan, Henry T. Bahnson et al. · 2019 · Journal of Allergy and Clinical Immunology
BACKGROUND: The Enquiring About Tolerance (EAT) study was a randomized trial of the early introduction of allergenic solids into the infant diet from 3 months of age. The intervention effect did not reach statistical significance in the intention-to-treat analysis of the primary outcome. OBJECTIVE: We sought to determine whether infants at high risk of developing a food allergy benefited from early introduction. METHODS: A secondary intention-to-treat analysis was performed of 3 groups: nonwhite infants; infants with visible eczema at enrollment, with severity determined by SCORAD; and infants
View details →Michael Wahl, Joanna J. Phillips, Annette M. Molinaro et al. · 2016 · Neuro-Oncology
Background: Optimal adjuvant management of adult low-grade gliomas is controversial. Recently described tumor classification based on molecular subtype has the potential to individualize adjuvant therapy but has not yet been evaluated as…
View details →Tracey A. Martin, David Wan, Kaveh Hajifathalian et al. · 2020 · The American Journal of Gastroenterology
INTRODUCTION: Although current literature has addressed gastrointestinal presentations including nausea, vomiting, diarrhea, abnormal liver chemistries, and hyperlipasemia as possible coronavirus disease 2019 (COVID-19) manifestations, the…
View details →Elizabeth Chipp, Lisa Charles, Clare Thomas et al. · 2017 · Burns & Trauma
BACKGROUND: It is commonly accepted that burns taking longer than 3 weeks to heal have a much higher rate of hypertrophic scarring than those which heal more quickly. However, some of our patients develop hypertrophic scars despite healing…
View details →Stella Edström Halling, Magnus Söderberg, U. Berg · 2011 · Nephrology Dialysis Transplantation
BACKGROUND: There has been a lack of international consensus on the classification and the predictive value of the histopathology findings in IgA nephropathy (IgAN). Recently, the International IgA Nephropathy Network has developed the…
View details →Merit Cudkowicz, Stacy Lindborg, Namita Goyal et al. · 2021 · Muscle & Nerve
INTRODUCTION/AIMS: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative illness with great unmet patient need. We aimed to evaluate whether mesenchymal stem cells induced to secrete high levels of neurotrophic factors…
View details →Umar Zahid, Preethi Ramachandran, Samuel Spitalewitz et al. · 2020 · American Journal of Nephrology
BACKGROUND: Although diffuse alveolar damage and respiratory failure are the key features of coronavirus disease 2019 (COVID-19), the involvement of other organs such as the kidney has also been reported. The reports of the incidence of…
View details →Dilip R. Karnad, Rakesh Bhadade, Pradeep Kumar Verma et al. · 2014 · Intensive Care Medicine
PURPOSE: Ulinastatin, a serine protease inhibitor, inhibits several pro-inflammatory proteases and decreases inflammatory cytokine levels and mortality in experimental sepsis. We studied the effect of ulinastatin on 28-day all-cause…
View details →Ling Ji, Todd Chaba, Lin-Fu Zhu et al. · 2011 · Hepatology
UNLABELLED: A major predictor of failed liver resection and transplantation is nonalcoholic fatty liver disease (NAFLD). NAFLD is linked to a wide spectrum of diseases including obesity and diabetes that are increasingly prevalent in…
View details →Joel B. Nelson, Karim Fizazi, Kurt Miller et al. · 2012 · Cancer
BACKGROUND: Endothelin-1 and the endothelin A (ET(A) ) receptor have been implicated in prostate cancer progression in bone. This study aimed to determine whether the specific ET(A) receptor antagonist, zibotentan, prolonged overall…
View details →Jared W. Magnani, Carlee Moser, Joanne M. Murabito et al. · 2014 · Circulation Arrhythmia and Electrophysiology
BACKGROUND: Endogenous sex hormones have been related to cardiovascular outcomes and mortality. We hypothesized that sex hormones are related to atrial fibrillation (AF) in a community-based cohort of middle-aged to older men. METHODS AND…
View details →Monique Maas, Patty J. Nelemans, Vincenzo Valentini et al. · 2014 · International Journal of Cancer
Recent literature suggests that the benefit of adjuvant chemotherapy (aCT) for rectal cancer patients might depend on the response to neoadjuvant chemoradiation (CRT). Aim was to evaluate whether the effect of aCT in rectal cancer is…
View details →Sarah E. Boston, Xiaomin Lu, William T. N. Culp et al. · 2014 · Journal of the American Veterinary Medical Association
OBJECTIVE: To determine prognostic factors for and compare outcome among dogs with oral malignant melanoma following excision with or without various systemic adjuvant therapies. DESIGN: Retrospective case series. ANIMALS: 151 dogs with…
View details →Bo Abrahamsen, Henrik L. Jørgensen, Anne Sofie Laulund et al. · 2014 · Journal of Bone and Mineral Research
The relationship between thyrotoxicosis and osteoporotic fractures remains controversial, particularly in men. Register-based cohort study including all patients with a serum thyrotropin (TSH) measurement in the region of Funen 1996-2010.…
View details →Marian L. Kohut, David S. Senchina · 2026 · PubMed
Decreases in immune responsiveness with age are thought to contribute to the increased incidence and severity of infectious disease among the elderly. Several interventions, including exercise, have been proposed to restore immune function…
View details →Yoshio N. Hall, Brett Larive, Patricia Painter et al. · 2012 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Relatively little is known about the effects of hemodialysis frequency on the disability of patients with ESRD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study examined changes in physical performance…
View details →Marius M. Hoeper, Juergen Behr, Matthias Held et al. · 2015 · PLoS ONE
BACKGROUND: Pulmonary hypertension (PH) is a common finding in patients with chronic fibrosing idiopathic interstitial pneumonias (IIP). Little is known about the response to pulmonary vasodilator therapy in this patient population. COMPERA is an international registry that prospectively captures data from patients with various forms of PH receiving pulmonary vasodilator therapies. METHODS: We retrieved data from COMPERA to compare patient characteristics, treatment patterns, response to therapy and survival in newly diagnosed patients with idiopathic pulmonary arterial hypertension (IPAH) and
View details →J. Randolph Hecht, Sara Lonardi, Johanna C. Bendell et al. · 2021 · Journal of Clinical Oncology
PURPOSE SEQUOIA compared efficacy and safety of adding pegilodecakin (PEG), a pegylated recombinant human interleukin (IL)-10, with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) in patients following progression on first-line…
View details →Christian von Bodman, Kazuhito Matsushita, Caroline Savage et al. · 2012 · The Journal of Urology
PURPOSE: We determined whether pelvic soft tissue and bony dimensions on endorectal magnetic resonance imaging influence the recovery of continence after radical prostatectomy, and whether adding significant magnetic resonance imaging…
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