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Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

DNA metabarcoding for food authentication: identification of freshwater, marine, and terrestrial gastropods in commercial food products.

Andronache J, Cichna-Markl M, Dobrovolny S et al. · 2026 · NPJ science of food

Food fraud through species substitution has been reported for edible gastropods, particularly in processed products where morphological identification is not feasible. DNA-based methods have been used to identify gastropod species in food…

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Negative / Null Result ReportOpen accessMedicine

Reality check: testing the <i>in silico</i> predictions of false negative results due to mutations in SARS-CoV-2 PCR assays using templates with mismatches <i>in vitro</i>.

Otwell T, Knight B, Coryell M et al. · 2025 · Frontiers in cellular and infection microbiology

Molecular diagnostic assays are critical tools to test, diagnose and treat infectious and other diseases. For example, PCR test results have been extremely valuable during the COVID-19 pandemic, not only to provide appropriate health care…

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Negative / Null Result ReportMedicine

Diagnostic performance of somatostatin receptor positron emission tomography in preoperative evaluation of pancreatic neuroendocrine tumor lymph node metastases.

Gudmundsdottir H, Hernandez-Delima FJ, McDowell BC et al. · 2026 · Surgery

Background Regional lymph node involvement impacts prognosis for patients with pancreatic neuroendocrine tumors and may influence management decisions for small tumors. Conventional cross-sectional imaging modalities have low sensitivity…

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Negative / Null Result ReportOpen accessMedicine

Endogenous Biomarkers Analysis and False-Negative Results for SARSCov2 Using two Commercial RT-PCR Diagnostic Kits.

Khoshakhlagh M, Dehghani T, Alizadeh A et al. · 2026 · Iranian journal of pathology

Background & objective Real-time PCR is widely used to detect SARS-CoV-2, the virus responsible for COVID-19, but false-negative results can occur even with internal controls. This study aimed to investigate the impact of using alternative…

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Negative / Null Result ReportOpen accessMedicine

False-negative results of combined endobronchial and endoscopic ultrasound in mediastinal staging of lung cancer.

Gambuś K, Moszczyński K, Popovchenko S et al. · 2026 · Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

Introduction Accurate assessment of mediastinal lymph node involvement is crucial for treatment planning in lung cancer. Combined endobronchial and endoscopic ultrasound (CUS) offers high sensitivity and negative predictive value (NPV),…

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Negative / Null Result ReportMedicine

The Usefulness of Antinuclear Antibody Multiplex Immunoassay for Screening of Rheumatological Diseases: A Real-World Population-Based Study.

Hijaze E, Razi T, Arbel R et al. · 2026 · Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

Objective To evaluate the diagnostic performance of BioPlex 2200 multiplex immunoassay (BI) for detecting antinuclear antibodies (ANA), compared with the gold standard, the indirect immunofluorescence assay (IIF), as a screening…

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Negative / Null Result ReportMedicine

Early computed tomography may miss main pancreatic duct injury in distal pancreatic trauma: a prospective surgically verified diagnostic accuracy study.

Tri PM, Hung NT, Liet DH et al. · 2026 · Emergency radiology

Purpose To assess the diagnostic performance of computed tomography (CT) for predicting main pancreatic duct injury in surgically explored patients with distal pancreatic trauma. Methods We conducted a prospective single-center diagnostic…

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Negative / Null Result ReportMedicine

[Evaluation of the screening performance of ultrasound for fatty liver using transient elastography in the elderly population of Shanghai communities].

Wei XT, Zhu LY, Wu YL et al. · 2026 · Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

Objective: To evaluate the screening performance and related factors of ultrasound for hepatic steatosis in community-based elderly populations using controlled attenuation parameter (CAP) measured by transient elastography as the…

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Negative / Null Result ReportOpen accessMedicine

Diagnostic and therapeutic impact of PCR in uveitis: real-world data from intraocular fluid analysis of 45 uveitis patients in a tertiary referral center in Turkey.

Zorlutuna Kaymak N, Pekel İ, Demir Tekol S et al. · 2026 · BMC ophthalmology

Purpose To evaluate the diagnostic utility and real-world clinical impact of polymerase chain reaction (PCR) analysis of aqueous humor (AH) and vitreous samples in patients with uveitis including suspected infectious and mixed…

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Negative / Null Result ReportMedicine

[Expert consensus on newborn genetic screening process, interpretation of results, and recall (2026 Edition)].

Genetic And Metabolic Disorders Screening Subgroup Of The Birth Defects Prevention And Control Committee Chinese Preventive Medicine Association, Rare Diseases Branch Of Shandong Medical Association, Genetic Metabolism Branch Of Shandong Provincial Rare Disease Association et al. · 2026 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

High-throughput sequencing technology has recently been used in neonatal disease screening. To address the issues related to the screening process, interpretation of screening results, and recall of positive cases in neonatal genetic…

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Negative / Null Result ReportMedicine

18F choline PET/MR to assess clinically significant disease in prostate cancer: correlation with maximum and total cancer core length obtained via template mapping biopsies.

Haroon A, Almuhaideb A, Adeleke S et al. · 2026 · Nuclear medicine communications

Objective To assess the accuracy of 18F choline PET/magnetic resonance (MR) when compared with the reference standard MRI-guided template mapping (TPM) biopsies for evaluation of biochemical relapse of prostate cancer in patients with…

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Negative / Null Result ReportOpen accessMedicine

The sonographic Murphy sign: does analgesia matter?

Goldstein EL, Marcelo KR, Harjes WR et al. · 2025 · Emergency radiology

Purpose Controversy exists regarding analgesia premedication prior to right upper quadrant ultrasound (RUQUS) in the setting of abdominal pain when evaluating for acute cholecystitis (AC). The purpose of this study was to examine the…

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Failed Experiment ReportOpen accessMedicine

Comprehensive Cytogenetic Analysis Reveals Mosaicism in Newborn with Negative Prenatal Down Syndrome Screening: A Case Report.

Puppo I, Vardanyan A, Shahsuvaryan G et al. · 2025 · The American journal of case reports

BACKGROUND Down syndrome, or trisomy 21, is one of the most common chromosomal disorders associated with intellectual disability. Prenatal screening is a proactive approach to identify fetuses with common chromosomal abnormalities.…

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Negative / Null Result ReportMedicine

Underutilization of fentanyl testing masks substantial fentanyl exposure in routine urine drug screens in Indiana.

Olaniyan H, Beckman J, Crosby E et al. · 2026 · Clinica chimica acta; international journal of clinical chemistry

Objectives Timely and locally relevant drug testing is helpful for overdose assessment; however, immunoassay (IA)-based urine drug screens (UDS) often fail to detect emerging substances. This study assesses fentanyl screen utilization and…

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