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WASTE Journal

Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of oral health education by audio aids, braille, tactile models on the oral health status of visually impaired adults: a 6-month follow-up study.

Yıldırım D, Zorluoğlu SL, Navruz ES et al. · 2026 · BMC oral health

Background Oral and dental health education is typically delivered using visual methods on jaw models. However, these methods are insufficient for individuals with visual impairments. This study aims to contribute to the oral and dental…

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Negative / Null Result ReportOpen accessMedicine

Focus on comfort: the effect of focus language on postoperative hospital stay compared to the Numeric Rating Scale in children receiving postoperative care-a pre-post study.

Angenent A, Maaskant JM, Nieland L et al. · 2026 · European journal of pediatrics

This study evaluates the effect of a comfort assessment using focus language compared with pain assessment using the Numeric Rating Scale (NRS) on postoperative length of stay (LOS), analgesic use and patient and parental satisfaction.…

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Negative / Null Result ReportOpen accessMedicine

Early outcomes of transverse perineal support in obstructed defecation syndrome with pathological perineal descent; a prospective cohort study.

Azmy Basiouny HM, Shafik AA, Elbarmelgi MY et al. · 2026 · BMC surgery

Background While current surgical approaches for obstructed defecation syndrome (ODS) primarily target rectocele and rectal intussusception, excessive perineal descent (PD) may contribute to persistent symptoms and suboptimal surgical…

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Negative / Null Result ReportOpen accessMedicine

Assessment of changes in selected parameters of Arnett's soft tissue cephalometric analysis (STCA) in patients undergoing SARME/SARPE.

Nowak R, Olejnik A, Zawiślak E et al. · 2026 · Head & face medicine

Background Maxillary constriction in adults often requires surgically assisted maxillary expansion. While skeletal and dental changes are well described, soft-tissue effects remain less clear. This study evaluated soft-tissue changes using…

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Negative / Null Result ReportOpen accessMedicine

Impact of therapeutic oral health education program in individuals with systemic sclerosis: A prospective study.

Mahajan A, Upadhyay M, Reddy RN et al. · 2026 · Journal of education and health promotion

Background Systemic sclerosis is an autoimmune disorder characterized by progressive fibrosis which affects skin and internal organs. There is also involvement of oral cavity seen as microstomia which affects oral hygiene and subsequently,…

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Negative / Null Result ReportOpen accessMedicine

Assessment of apical debris extrusion with three nickel-titanium rotary systems using conventional and lyophilization-based quantification methods.

Hegde NN, Attavar S, Banerjee A et al. · 2026 · Journal of conservative dentistry and endodontics

Background Apical extrusion of debris during root canal preparation is inevitable and may contribute to postoperative pain and periapical inflammation. The extent of extrusion varies with instrument design and motion. ProTaper Next (PTN),…

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Negative / Null Result ReportOpen accessMedicine

Shear Bond Strength of a Light-Cured and a Dual-Cured Universal Adhesive to Primary and Permanent Dentin: An In Vitro Study.

Fousekis E, Arhakis A, Arapostathis K et al. · 2026 · Biomimetics (Basel, Switzerland)

The aim of the study was to evaluate the immediate and aged shear bond strength (SBS) of a dual-cured and a light-cured universal adhesive to primary and permanent dentin. Twenty caries-free primary molars and twenty permanent third molars…

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Negative / Null Result ReportOpen accessMedicine

Intraperitoneal Polypropylene Mesh in Clean, Potentially Septic, and Controlled Contamination Fields: An Experimental Rat Study.

Makrantonakis A, Mantzoros I, Ioannidis O et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Intraperitoneal onlay mesh (IPOM) reduces ventral/incisional hernia recurrence but raises concern for adhesions and infection, particularly when the operative field is not strictly clean. We aimed to determine…

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Negative / Null Result ReportOpen accessMedicine

Prognostic Value of the Platelet-to-Lymphocyte Ratio in Patients With Acute Coronary Syndrome and Its Correlation With Angiographic Findings.

Seetharama DB, Prasad K, Prakash VR et al. · 2026 · Cureus

Introduction Acute coronary syndrome (ACS) is a major manifestation of coronary heart disease and is associated with significant morbidity and mortality. Inflammatory and thrombotic mechanisms play an important role in its pathogenesis.…

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Failed Experiment ReportOpen accessMedicine

A Non-randomized Clinical Trial on the Effectiveness and Complications of Two Different Streptokinase Dosages in Elderly Patients With ST-Elevation Myocardial Infarction (STEMI).

Chandra S, Rai PJ, Singh N et al. · 2026 · Cureus

Background Streptokinase is widely used for thrombolysis in acute myocardial infarction (AMI), but concerns about complications have led to its underutilization in elderly patients. This study aimed to compare the efficacy and safety of…

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Negative / Null Result ReportMedicine

The effect of three different root canal filling materials on postoperative pain in teeth with irreversible pulpitis: a randomized clinical trial.

Eminsoy Avcı AT, Yavuz B, Karakaya B et al. · 2026 · BMC oral health

Background This randomized clinical trial aimed to compare postoperative pain (PP) and analgesic consumption following single-visit root canal treatment using two calcium silicate-based sealers (BioMTA + and Well-Root PT) and one epoxy…

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Negative / Null Result ReportOpen accessMedicine

The Reciprocal Risk Relationship of Dental Caries with NAFLD and Liver Fibrosis: Combined Evidence from the NHANES Study and Mendelian Randomization Analysis.

Xu L, Wang X, Meng X et al. · 2026 · Oral health & preventive dentistry

Purpose To explore the relationship between dental caries and non-alcoholic fatty liver disease (NAFLD) and its advanced stage of liver fibrosis, and to confirm causality by employing a bidirectional two-sample Mendelian Randomization (MR)…

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Negative / Null Result ReportMedicine

Analysis of US Pediatric Pharmacists Incomes: A Gender Comparison Survey Study by the Pediatric Pharmacy Association, Practice-Based Research Network.

Popovici I, Carvajal MJ, Higgins T et al. · 2026 · The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Objectives While gender disparities in the US workforce have received substantial attention, income inequalities among subspecialty pharmacists remain understudied. This study aimed to develop a professional profile of pediatric…

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Negative / Null Result ReportOpen accessMedicine

The potential clinical significance of immunomodulation of immune and inflammatory responses involving selected adipokines in patients with ovarian cancer - preliminary studies.

Stępień S, Morawiec ML, Smycz-Kubańska M et al. · 2026 · Frontiers in oncology

Ovarian cancer (OC) is a major clinical problem in gynaecological oncology, characterised by difficulties in early diagnosis, which contributes to the high mortality rate from OC. Therefore, the search for new biological markers continues,…

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Negative / Null Result ReportOpen accessMedicine

Validation of the C-WATCH score for predicting severity in patients with upper gastrointestinal bleeding at a tertiary public hospital in Lima, Peru.

Espinoza-Ríos J, Ruiz-Cortez R, Santiago B et al. · 2026 · BMC gastroenterology

Background Upper gastrointestinal bleeding (UGIB) remains one of the most common emergencies in gastroenterology, with mortality rates reaching 14% in some settings. Despite advances in management, mortality has remained relatively…

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Negative / Null Result ReportOpen accessMedicine

Cytomorphometric and Clinical Analysis of the Effects of Azithromycin and Platelet-Rich Fibrin on Wound Healing After Surgical Removal of an Impacted Mandibular Third Molar.

Spasić M, Todorović K, Živković N et al. · 2026 · Journal of functional biomaterials

Impacted mandibular third molars present a common challenge in oral surgery, often associated with postoperative complications such as delayed healing and periodontal defects; therefore, optimizing adjunctive therapies is clinically…

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Negative / Null Result ReportOpen accessMedicine

A Comparative Study of Intra-articular Steroid Injection Alone Versus Steroid Injection Combined with Hydroplasty and Manipulation in the Treatment of Frozen Shoulder.

Thakur A, Singh BP, Parihar YS · 2026 · Cureus

Background Frozen shoulder (adhesive capsulitis) is a common cause of shoulder pain and disability in middle-aged adults, characterized by progressive pain and restriction of both active and passive range of motion. Despite multiple…

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Negative / Null Result ReportOpen accessMedicine

Bony Path Assisted Suturing and Tendon-to-Tendon Suturing Technique for External Rotator Repair After Hip Arthroplasty: A Randomized-Controlled Trial.

Wen Z, Ye Y, Chen H et al. · 2026 · Indian journal of orthopaedics

Objective To compare and verify the effectiveness of tendon-to-bone suture technique for the repair of external rotator injuries after hip arthroplasty. Methods This was a prospective, randomized, controlled study including 178 patients…

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Negative / Null Result ReportMedicine

Which Residual Symptoms Predict Relapse in major Depression? A Scoping Review: Quels symptômes résiduels constituent des prédicteurs de rechute de dépression majeure? Un examen de la portée.

Borghgraef D, Sienaert P, Lambrichts S · 2026 · Canadian journal of psychiatry. Revue canadienne de psychiatrie

BackgroundPreventing relapse following a successful acute treatment of major depressive disorder (MDD) remains a clinical challenge. The presence of residual depressive symptoms seems to be a reliable predictor of relapse. However, few…

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