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Browse the failure-mode index

12,379 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

X-rays and gamma rays do not differ in their effectiveness for sterilizing pupae and adults of the mosquito Aedes aegypti (Diptera: Culicidae).

Chen C, Qualls WA, Xue RD et al. · 2026 · Journal of economic entomology

The sterile insect technique (SIT) is increasingly used as an alternative or supplemental tool in the integrated mosquito management toolbox to protect human health worldwide. SIT programs targeting mosquitoes such as Aedes aegypti (L.)…

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Methods Dead-EndMedicine

Measurement error, minimal detectable change, and responsiveness of the Brazilian-Portuguese Reaching Performance Scale for Stroke under usual care conditions.

Binda AC, Padula RS, Vianna de Andrade FPP et al. · 2026 · Journal of bodywork and movement therapies

Objectives The Reaching Performance Scale for Stroke (RPSS) is a clinically relevant tool to assess movement quality and compensatory strategies during reach-to-grasp tasks to a Close and Far targets. This study aimed to investigate the…

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Methods Dead-EndOpen accessMedicine

Measurement properties of the SARC-T: test-retest reliability, agreement and minimal detectable change in older adults with sarcopenia.

Pedauyé-Rueda B, Maté-Muñoz JL, Hernández-Lougedo J et al. · 2026 · Frontiers in aging

Background The Sarcopenia Optoelectronic Chair-Rise Velocity Test (SARC-T) has been proposed as an instrumented chair-rise measure related to physical function in sarcopenia; however, its test-retest measurement properties have not been…

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Failed Experiment ReportMedicine

Comparative analysis of the toxicity of fragmented and fibrous microplastics versus natural particles in the sea squirt Ciona intestinalis type A (Ciona robusta).

Saad R, Sekiguchi T, Takai Y et al. · 2026 · Marine environmental research

Microplastics (MPs) are ubiquitous in marine environments and readily ingested by filter-feeding organisms, yet the ecotoxicological effects of irregularly shaped MPs remain poorly understood. This study assessed the accumulation and…

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Failed Experiment ReportMedicine

Gestational timing and vaccine platform shape maternally derived neutralizing immunity and vaccine RNA detection in piglets following maternal vaccination with C-strain or FlagT4G against classical swine fever.

Coronado L, Muñoz-Aguilera A, Puente-Marin S et al. · 2026 · Frontiers in veterinary science

Control of classical swine fever (CSF) in endemic regions relies heavily on vaccination of breeding herds. Optimizing vaccination strategies is essential for sustainable disease control covering pigs belonging to different categories. Data…

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Negative / Null Result ReportOpen accessMedicine

Association between anti-Mullerian hormone and antithyroid antibodies detectability and positivity in women assisted at a fertility clinic.

Oliveira YIL, Couto A, Sá PG et al. · 2025 · JBRA assisted reproduction

Objective To evaluate the association between antithyroid antibodies detectability and positivity and ovarian reserve. Additionally, we aimed to evaluate the correlation between TSH levels and parameters of ovarian reserve [anti-Mullerian…

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Negative / Null Result ReportMedicine

Detection capabilities of a single dried blood spot for recombinant erythropoietin micro-dose testing in sport.

Requena-Tutusaus L, Anselmo I, Coll S et al. · 2026 · Journal of pharmacological and toxicological methods

Objectives Dried blood spot (DBS) micro-sampling is gaining prominence in anti-doping testing, particularly for the detection of erythropoietin-receptor agonists (ERAs) such as recombinant erythropoietin (rEPO). However, detecting…

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Negative / Null Result ReportOpen accessMedicine

Early Transplantation After Pretransplant Reduction of <i>TP53</i>-Altered Clones and Prolonged Dose-Adjusted Azacitidine Maintenance: A Three-Case Series.

Yamagata F, Yoshihara K, Nannya Y et al. · 2026 · EJHaem

TP53 -altered myeloid neoplasms are associated with an extremely high risk of relapse even after allogeneic hematopoietic cell transplantation (allo-HCT), and the optimal pretransplant and posttransplant strategies remain undefined. We…

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Negative / Null Result ReportOpen accessMedicine

Liver Transplantation for HBV-Related Disease in France: NUC Type Before LT Is Associated With Patient Survival.

Bienvenue I, Roux O, Coilly A et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver

Background & aims Liver transplantation (LT) is indicated for liver complications related to hepatitis B virus (HBV) infection: acute liver failure (ALF), decompensated cirrhosis or hepatocellular carcinoma (HCC). The present study aimed…

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Negative / Null Result ReportMedicine

Reliability of Inertial Sensors for Measuring Scapular Kinematics in Individuals With Shoulder Pain and Scapular Dyskinesis.

Oliveira FADS, Santos LRH, Silva HAD et al. · 2026 · Journal of sport rehabilitation

Context Scapular dyskinesis is frequently associated with subacromial pain syndrome (SAPS), and clinicians increasingly use inertial sensors as a portable, low-cost option to assess scapular kinematics. However, the reliability of these…

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Negative / Null Result ReportOpen accessMedicine

Pattern-Matched Powered Gait Orthosis Training in Patients with Neurological Gait Impairment: A Multicenter Prospective Pilot Study of Hip and Knee-Ankle-Foot Orthoses.

Yun YJ, Moon C, Kim KH et al. · 2026 · Journal of clinical medicine

Background : Wearable powered gait orthoses offer a clinically flexible alternative to treadmill-based robotic systems, yet evidence on different device configurations matched to the site of neuromuscular impairment remains limited.…

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Negative / Null Result ReportMedicine

Detectable global temperature responses to wildfires and volcanic eruptions.

Li Y, Santer BD, Solomon S et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America

Large volcanic eruptions and intense wildfires perturb Earth's atmospheric temperature. Understanding the climate response to such natural forcings is essential for obtaining reliable estimates of its response to anthropogenic greenhouse…

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Negative / Null Result ReportOpen accessMedicine

Association of caffeine levels with myocardial perfusion during pharmacological stress cardiac magnetic resonance imaging.

Iribarren A, Obrutu O, Maughan J et al. · 2026 · American heart journal plus : cardiology research and practice

Background Caffeine, a nonselective adenosine A2 receptor antagonist, blunts adenosine-induced coronary hyperemia. Despite recommended abstinence before adenosine stress cardiac magnetic resonance imaging (CMRi), residual caffeine may…

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Negative / Null Result ReportMedicine

Aminoglycosides induce immune activation but is insufficient for systemic viral control: a double-blind randomized-controlled clinical trial.

Sivanandam P, Syenina A, Chan YF et al. · 2026 · Communications medicine

Background Mucosally-applied aminoglycosides have demonstrated host-directed antiviral activity in preclinical models through induction of interferon-stimulated genes (ISGs). However, it remains unknown if systemically administered…

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Negative / Null Result ReportOpen accessMedicine

Concurrent chemoradiotherapy plus nimotuzumab versus chemoradiotherapy alone for locoregionally advanced nasopharyngeal carcinoma with a suboptimal response to induction chemotherapy: a randomized phase 2 trial.

Liu LT, Sun XS, Quan TT et al. · 2026 · Nature communications

Induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) is the standard treatment for locoregionally advanced nasopharyngeal carcinoma (LA-NPC); however, patients with a suboptimal response to IC, defined as detectable…

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Negative / Null Result ReportOpen accessMedicine

Pre-Post Motor-Cognitive and Shooting Performance Patterns in Security-Force Applicants During a Fixed-Order Acute-Load Protocol: A Descriptive Pilot Study.

Němá K, Kačúr P, Kozák T et al. · 2026 · Journal of functional morphology and kinesiology

Background: Operational performance in security-force settings depends on maintaining accurate motor-cognitive and shooting performance under acute physical strain. This descriptive pilot study examined pre-post performance patterns during…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of the FMDV 2.1 dry RT-rtPCR prototype assay for detection of foot-and-mouth disease virus in lymph nodes.

Moabelo KC, Rauh R, Loots A et al. · 2026 · Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

We evaluated the performance of the FMDV 2.1 dry RT-rtPCR prototype assay (Tetracore) to detect foot-and-mouth disease virus (FMDV) in lymph nodes. Various masses (20-100 mg) of FMDV-negative lymph node tissue were homogenized, diluted,…

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