12,246 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Shankar DA, Bosch NA, Jafarzadeh SR et al. · 2025 · CHEST pulmonary
Background Corticosteroids are a mainstay of treatment for acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF), but dosing practices vary. We leveraged between-hospital variation in propensity to administer pulse dose…
View details →Saithna A · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Evaluations of practice patterns after rotator cuff repair reveal that both simple slings and abduction braces are commonly used, with the latter most frequently preferred in the United States. A preference for a shoulder abduction brace…
View details →Stróżyk A, Horvath A, Kozłowska-Jalowska A et al. · 2026 · Frontiers in pediatrics
Objective Evidence supporting the effectiveness of a low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (low-FODMAP) diet in treating functional abdominal pain disorders remains limited. We aimed to assess the…
View details →Tabaru A, Yigit O, Akyel S et al. · 2025 · Ear, nose, & throat journal
Objective The use of mastoid pressure dressings (MPDs) after otologic surgery has been a standard practice for decades, believed to minimize complications such as hematoma and wound infection. However, the efficacy of MPDs in improving…
View details →Tsubakimoto Y, Takahara M, Soga Y et al. · 2025 · Cardiovascular intervention and therapeutics
Drug-coated balloon (DCB) angioplasty is an effective endovascular therapy for femoropopliteal artery (FPA) disease in patients with peripheral artery disease (PAD). However, the long-term impact of statin and anticoagulant therapy on…
View details →Feliberti J, Alam A, Maulion C · 2025 · Current opinion in cardiology
Purpose of review Hypertension is one of the most common comorbidities affecting patients after solid organ transplantation. Here we review the mechanisms leading to hypertension, along with common practices in terms of medical management.…
View details →Jamal F, Sahvan O, Junior PLSU et al. · 2025 · The oncologist
Background The increasing reliance on accelerated approvals and surrogate endpoints for Food and Drug Administration (FDA) approvals of gastrointestinal (GI) cancer therapies raises concerns about their clinical benefit and long-term…
View details →Cristarella E, Ambrosini M, Di Maio M et al. · 2025 · European journal of cancer (Oxford, England : 1990)
Background In the ARMANI trial, switch maintenance with paclitaxel plus ramucirumab improved progression-free survival and overall survival versus continuation of oxaliplatin-based chemotherapy in patients with HER2-negative advanced…
View details →Vang K, Panich J, Folz C et al. · 2025 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
IntroductionImmune checkpoint inhibitors (CPIs) work by engaging the patient's immune system against tumor cells and have demonstrated a significant benefit in the treatment of cancers. Activation of the patient's immune system can lead to…
View details →Corbett A, Taylor R, Llewellyn D et al. · 2025 · Journal of the American Medical Directors Association
Objectives Preserved cognitive health with ageing is a public health imperative. Vitamin D deficiency is associated with poor cognition, but it is unclear whether supplementation would provide benefit, particularly in individuals with…
View details →Kallash M, Frishman WH · 2025 · Cardiology in review
Tadalafil is a phosphodiesterase inhibitor currently approved for use in erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). While tadalafil's benefits in ED and BPH have been…
View details →Elscot JJ, Kakar H, den Dekker WK et al. · 2025 · International journal of cardiology
Background Recent randomized trials have suggested that immediate complete revascularization (ICR) is a viable alternative to staged complete revascularization (SCR) in patients with acute coronary syndrome (ACS) and multivessel disease.…
View details →Šitum I, Mihaljević S, Blivajs I et al. · 2026 · Acta stomatologica Croatica
Objectives To compare the quality of recovery between total intravenous anaesthesia (TIVA) with propofol and balanced inhalational anaesthesia with sevoflurane in patients undergoing intraoral surgical procedures. Materials and methods We…
View details →Viswanath YKS, Mbarushimana S, Ammar A et al. · 2025 · Surgical endoscopy
Background Gastroesophageal reflux disease (GERD) is a common chronic condition affecting millions all over the world. It occurs due to the reflux of gastric acid into the oesophagus. Endoscopic therapies like STRETTA offer minimally…
View details →Villanova V, Martinino A, Stanzani E et al. · 2025 · Surgical oncology
Extended pelvic lymph node dissection (EPLND) for rectal cancer is common in Asian countries to reduce local recurrence and improve survival. This umbrella review investigates the benefit of adding extended lymphadenectomy to the standard…
View details →Kooli N, Ben Mansour H, Zenzri Y et al. · 2026 · Frontiers in oncology
Background Ewing's sarcoma (ES) is the second most common malignant bone tumor in patients under 20 years of age. The "Euro-Ewing 2012" trial established induction therapy with the 2-week-interval VDC/IE…
View details →Dixit NM, Chau E, Schaefer S · 2024 · American journal of preventive cardiology
Screening trials for cardiovascular disease have not demonstrated a reduction in all-cause mortality. The Danish Cardiovascular Screening trial (DANCAVAS) involved men aged 65-74 years old who were randomized to an invitation to undergo…
View details →Cardoso A, Naghibi M, Climent E et al. · 2026 · Allergy
Background Allergic rhinitis (AR) is an increasingly common chronic inflammatory condition of the nasal mucosa. While conventional anti-allergy treatments are widely used, they can come with side effects and are not always effective. As a…
View details →Wang AI, Duong MP, Frohlich JR et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS
Systemic analgesics, such as opioids and nonsteroidal anti-inflammatory drugs, may be contraindicated in certain studies due to their mechanisms of action and risk for systemic effects. Local anesthetics (LAs) are therefore crucial in…
View details →Mongia N, Mohammed AI, McCullough M et al. · 2026 · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Background Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease…
View details →Guo P, Yang Y, Chen X et al. · 2026 · PLoS neglected tropical diseases
Objectives This study seeks to investigate the characteristics, dynamics, and association with disease progression of monocyte inflammation in patients with AIDS/Talaromycosis Marneffei (TSM). The findings are expected to contribute to a…
View details →de Marcos Carpio I, de Vicente F, Vallefuoco R · 2026 · Veterinary and comparative orthopaedics and traumatology : V.C.O.T
Objectives (1) To describe and compare the morphometric changes of the tibia following four virtual proximal tibial osteotomies for treatment of canine cranial cruciate ligament deficiency and (2) to determine how these changes are…
View details →Tan-Ho G, Choo PY, Ma SHXY et al. · 2026 · Psychological trauma : theory, research, practice and policy
Objective Caring for a loved one with dementia imposes significant physical strain, emotional burden, and psychological trauma on family caregivers. Singaporean caregivers face added pressures under cultural norms that emphasize familial…
View details →Ortíz Aguirre MJ, Barrientos Chinchilla AC, León-Velásquez M et al. · 2026 · Journal of gynecology obstetrics and human reproduction
Objective To assess the efficacy of topical lidocaine versus placebo in reducing pain during manual vacuum aspiration (MVA) for endometrial sampling in patients with endometrial thickening, as measured by the visual analog scale (VAS).…
View details →Gadapani Pathak B, Vats P, Manna S et al. · 2026 · BMJ open
Objectives To collate and appraise evidence from existing systematic reviews and meta-analyses on interventions to prevent stillbirth and reduce perinatal mortality across the reproductive continuum, including preconception, antenatal,…
View details →Celik C, Celik MS · 2026 · Human psychopharmacology
Background and objective Isotretinoin is a systemic agent widely used in the treatment of severe acne vulgaris. Previous studies have reported that isotretinoin use may be associated with depression, anxiety, and sleep disorders. The aim…
View details →Ayerbe L, Barbero-Pablos E, Foguet-Boreu Q et al. · 2026 · Journal of psychosomatic research
Introduction Evidence on the clinical outcomes of stroke for patients with psychiatric disorders is poor. It is also unclear if the prognosis of stroke has improved over the last two decades for those with mental health conditions. The…
View details →Silberlust J, Roberts B, Leybov V et al. · 2026 · Journal of telemedicine and telecare
Virtual urgent care (VUC) has become an increasingly utilized resource for acute care delivery. Frequent utilization of VUC may reflect unmet longitudinal care needs and contribute to fragmented care. While high-utilizer patterns are well…
View details →Song Z, Wang H, Jin M et al. · 2026 · Psychiatry research. Neuroimaging
This study investigates the pathogenic mechanisms underlying major depressive disorder (MDD) and the therapeutic mechanisms of vortioxetine in treatment-naive, first-episode MDD patients. 22 treatment -naive, first-episode MDD patients and…
View details →de Lima Wachholz P, Bierhals ES, de Lima CM et al. · 2026 · Veterinary research communications
The aim of this study was to evaluate the tolerance and efficacy of ezetimibe in reducing cholesterol and/or triglycerides in dogs with hyperlipidemia. Twenty-three dogs with hyperlipidemia were randomly distributed into three groups:…
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