Methods Dead-EndOpen accessMedicine

Immunodominance of HIV-1 specific CD8+ T-cell responses is related to disease progression rate in vertically infected adolescents.

Elizabeth R Sharp; Christian B Willberg; Peter J Kuebler; Jacob Abadi; Glenn J Fennelly; Joanna Dobroszycki; Andrew A Wiznia; Michael G Rosenberg · 2011 · PLoS ONE

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Abstract

HIV-1 vertically infected children in the USA are living into adolescence and beyond with the widespread use of antiretroviral drugs. These patients exhibit striking differences in the rate of HIV-1 disease progression which could provide insights into mechanisms of control. We hypothesized that differences in the pattern of immunodomination including breadth, magnitude and polyfunctionality of HIV-1 specific CD8+ T cell response could partially explain differences in progression rate.In this study, we mapped, quantified, and assessed the functionality of these responses against individual HIV

Abstract by Elizabeth R Sharp; Christian B Willberg; Peter J Kuebler; Jacob Abadi; Glenn J Fennelly; Joanna Dobroszycki; Andrew A Wiznia; Michael G Rosenberg, PLoS ONE (2011) — licensed CC BY 4.0.

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